Farnesyl diphosphate synthase may determine the accumulation level of (−)-rotundone in 'Syrah' grapes

(−)-Rotundone is an oxygenated sesquiterpene responsible for the peppery aroma in grapes, wines, herbs, and spices, and it was first identified in 'Syrah' wine from Australia. In this study, we demonstrated the expression profiles of genes related to (−)-rotundone biosynthesis during the maturation of 'Syrah' grapes from two different vineyards, namely, the Iwaimura and Johnohira vineyards in Japan. The α-guaiene and (−)-rotundone accumulation levels in the grape exocarp from the Johnohira vineyard, which has a cool climatic condition located at a high altitude, were extremely higher than those from the Iwaimura vineyard. Among the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway genes, the transcript levels of 1-deoxy-D-xylulose-5-phosphate synthase gene (DXS) in the grape exocarp from the Johnohira vineyard were higher than those from the Iwaimura vineyard after véraison. The expression levels of the mevalonate pathway genes, Vitis vinifera terpene synthase gene (VvTPS24) and cytochrome P450 gene (CYP71BE5) in the final step of (−)-rotundone biosynthesis were not significantly different between samples from the two vineyards during grape maturation. In contrast, the farnesyl diphosphate synthase gene (FPPS) expression level was considerably higher in the grape exocarp from the Johnohira vineyard than in that from the Iwaimura vineyard. Consistent with these observations, FPPS was constantly expressed at higher level in 'Syrah' grape exocarp compared with 'Merlot' grape which is a low-rotundone cultivar. These findings suggest that FPPS may play a key role in determining the accumulation level of (−)-rotundone, which can provide abundant substrates for VvTPS24 catalysis to produce α-guaiene as a precursor of (−)-rotundone. In addition, among the MEP pathway genes, DXS may have a regulatory role for a precursor supply from the plastids to (−)-rotundone biosynthesis

First Record of \u3ci\u3eAgonostomus monticola\u3c/i\u3e (Family: Mugilidae) in Mississippi Freshwaters with Notes of its Distribution in the Southern United States

An individual of Agonostomus monticola (Mountain Mullet) was collected in southern Mississippi while conducting a series of community surveys on 7 November 2007. This is the first documented report of Mountain Mullet in Mississippi freshwaters, even though there are reports of three specimens collected in Mississippi estuarine waters in 1937. Given its life history and difficulties in sampling, it is likely that Mountain Mullet has a broader distribution and more frequently occurs in Gulf Coast drainages in the southern US than was previously thought

Origin of the Different Architectures of the Jovian and Saturnian Satellite Systems

The Jovian regular satellite system mainly consists of four Galilean satellites that have similar masses and are trapped in mutual mean motion resonances except for the outer satellite, Callisto. On the other hand, the Saturnian regular satellite system has only one big icy body, Titan, and a population of much smaller icy moons. We have investigated the origin of these major differences between the Jovian and Saturnian satellite systems by semi-analytically simulating the growth and orbital migration of proto-satellites in an accreting proto-satellite disk. We set up two different disk evolution/structure models that correspond to Jovian and Saturnian systems, by building upon previously developed models of an actively-supplied proto-satellite disk, the formation of gas giants, and observations of young stars. Our simulations extend previous models by including the (1) different termination timescales of gas infall onto the proto-satellite disk and (2) different evolution of a cavity in the disk, between the Jovian and Saturnian systems. We have performed Monte Carlo simulations and show that in the case of the Jovian systems, four to five similar-mass satellites are likely to remain trapped in mean motion resonances. This orbital configuration is formed by type I migration, temporal stopping of the migration near the disk inner edge, and quick truncation of gas infall caused by Jupiter opening a gap in the Solar nebula. The Saturnian systems tend to end up with one dominant body in the outer regions caused by the slower decay of gas infall associated with global depletion of the Solar nebula. The total mass and compositional zoning of the predicted Jovian and Saturnian satellite systems are consistent with the observed satellite systems.Comment: Accepted to ApJ, 33pages, 6figures, 2table

The growth and hydrodynamic collapse of a protoplanet envelope

We have conducted three-dimensional self-gravitating radiation hydrodynamical models of gas accretion onto high mass cores (15-33 Earth masses) over hundreds of orbits. Of these models, one case accretes more than a third of a Jupiter mass of gas, before eventually undergoing a hydrodynamic collapse. This collapse causes the density near the core to increase by more than an order of magnitude, and the outer envelope to evolve into a circumplanetary disc. A small reduction in the mass within the Hill radius (R_H) accompanies this collapse as a shock propagates outwards. This collapse leads to a new hydrostatic equilibrium for the protoplanetary envelope, at which point 97 per cent of the mass contained within the Hill radius is within the inner 0.03 R_H which had previously contained less than 40 per cent. Following this collapse the protoplanet resumes accretion at its prior rate. The net flow of mass towards this dense protoplanet is predominantly from high latitudes, whilst at the outer edge of the circumplanetary disc there is net outflow of gas along the midplane. We also find a turnover of gas deep within the bound envelope that may be caused by the establishment of convection cells.Comment: 16 pages, 16 figures. Accepted for publication in MNRA

ESPRESSO Mass determination of TOI-263b: An extreme inhabitant of the brown dwarf desert

The TESS mission has reported a wealth of new planetary systems around bright and nearby stars amenable for detailed characterization of the planet properties and their atmospheres. However, not all interesting TESS planets orbit around bright host stars. TOI-263b is a validated ultra-short period substellar object in a 0.56-day orbit around a faint (V=18.97) M3.5 dwarf star. The substellar nature of TOI-263b was explored using multi-color photometry, which determined a true radius of 0.87+-0.21 Rj, establishing TOI-263b's nature ranging from an inflated Neptune to a brown dwarf. The orbital period-radius parameter space occupied by TOI-263b is quite unique, which prompted a further characterization of its true nature. Here, we report radial velocity measurements of TOI-263 obtained with 3 VLT units and the ESPRESSO spectrograph to retrieve the mass of TOI-263b. We find that TOI-263b is a brown dwarf with a mass of 61.6+-4.0 Mj. Additionally, the orbital period of the brown dwarf is found to be synchronized with the rotation period of the host star, and the system is found to be relatively active, possibly revealing a star--brown dwarf interaction. All these findings suggest that the system's formation history might be explained via disc fragmentation and later migration to close-in orbits. If the system is found to be unstable, TOI-263 is an excellent target to test the migration mechanisms before the brown dwarf becomes engulfed by its parent star.Comment: Accepted for Publication in Astronomy and Astrophysic

Ariel planetary interiors White Paper

The recently adopted Ariel ESA mission will measure the atmospheric composition of a large number of exoplanets. This information will then be used to better constrain planetary bulk compositions. While the connection between the composition of a planetary atmosphere and the bulk interior is still being investigated, the combination of the atmospheric composition with the measured mass and radius of exoplanets will push the field of exoplanet characterisation to the next level, and provide new insights of the nature of planets in our galaxy. In this white paper, we outline the ongoing activities of the interior working group of the Ariel mission, and list the desirable theoretical developments as well as the challenges in linking planetary atmospheres, bulk composition and interior structure

Analysis of new high-precision transit light curves of WASP-10 b: starspot occultations, small planetary radius, and high metallicity

The WASP-10 planetary system is intriguing because different values of radius have been reported for its transiting exoplanet. The host star exhibits activity in terms of photometric variability, which is caused by the rotational modulation of the spots. Moreover, a periodic modulation has been discovered in transit timing of WASP-10 b, which could be a sign of an additional body perturbing the orbital motion of the transiting planet. We attempt to refine the physical parameters of the system, in particular the planetary radius, which is crucial for studying the internal structure of the transiting planet. We also determine new mid-transit times to confirm or refute observed anomalies in transit timing. We acquired high-precision light curves for four transits of WASP-10 b in 2010. Assuming various limb-darkening laws, we generated best-fit models and redetermined parameters of the system. The prayer-bead method and Monte Carlo simulations were used to derive error estimates. Three transit light curves exhibit signatures of the occultations of dark spots by the planet during its passage across the stellar disk. The influence of stellar activity on transit depth is taken into account while determining system parameters. The radius of WASP-10 b is found to be no greater than 1.03 Jupiter radii, a value significantly smaller than most previous studies indicate. We calculate interior structure models of the planet, assuming a two-layer structure with one homogeneous envelope atop a rock core. The high value of the WASP-10 b's mean density allows one to consider the planet's internal structure including 270 to 450 Earth masses of heavy elements. Our new mid-transit times confirm that transit timing cannot be explained by a constant period if all literature data points are considered. They are consistent with the ephemeris assuming a periodic variation of transit timing...Comment: Accepted for publication in A&

Mutational Profile and Pathological Features of a Case of Interleukin-10 and RGS1-Positive Spindle Cell Variant Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma with spindle cell morphology is a rare variant. We present the case of a 74-year-old male who initially presented with a right supraclavicular (lymph) node enlargement. Histological analysis showed a proliferation of spindle-shaped cells with narrow cytoplasms. An immunohistochemical panel was used to exclude other tumors, such as melanoma, carcinoma, and sarcoma. The lymphoma was characterized by a cell-of-origin subtype of germinal center B-cell-like (GCB) based on Hans’ classifier (CD10-negative, BCL6-positive, and MUM1-negative); EBER negativity, and the absence of BCL2, BCL6, and MYC rearrangements. Mutational profiling using a custom panel of 168 genes associated with aggressive B-cell lymphomas confirmed mutations in ACTB, ARID1B, DUSP2, DTX1, HLA-B, PTEN, and TNFRSF14. Based on the LymphGen 1.0 classification tool, this case had an ST2 subtype prediction. The immune microenvironment was characterized by moderate infiltration of M2-like tumor-associated macrophages (TMAs) with positivity of CD163, CSF1R, CD85A (LILRB3), and PD-L1; moderate PD-1 positive T cells, and low FOXP3 regulatory T lymphocytes (Tregs). Immunohistochemical expression of PTX3 and TNFRSF14 was absent. Interestingly, the lymphoma cells were positive for HLA-DP-DR, IL-10, and RGS1, which are markers associated with poor prognosis in DLBCL. The patient was treated with R-CHOP therapy, and achieved a metabolically complete response