1,155 research outputs found
A composite score combining waist circumference and body mass index more accurately predicts body fat percentage in 6- to 13-year-old children
Purpose: Body mass index (BMI) and waist circumference (WC) are widely used to predict % body fat (BF) and classify degrees of pediatric adiposity. However, both measures have limitations. The aim of this study was to evaluate whether a combination of WC and BMI would more accurately predict %BF than either alone. Methods: In a nationally representative sample of 2,303 6- to 13-year-old Swiss children, weight, height, and WC were measured, and %BF was determined from multiple skinfold thicknesses. Regression and receiver operating characteristic (ROC) curves were used to evaluate the combination of WC and BMI in predicting %BF against WC or BMI alone. An optimized composite score (CS) was generated. Results: A quadratic polynomial combination of WC and BMI led to a better prediction of %BF (r 2=0.68) compared with the two measures alone (r 2=0.58-0.62). The areas under the ROC curve for the CS [0.6*WC-SDS+0.4*BMI-SDS] ranged from 0.962±0.0053 (overweight girls) to 0.982±0.0046 (obese boys) and were somewhat greater than the AUCs for either BMI or WC alone. At a given specificity, the sensitivity of the prediction of overweight and obesity based on the CS was higher than that based on either WC or BMI alone, although the improvement was small. Conclusion: Both BMI and WC are good predictors of %BF in primary school children. However, a composite score incorporating both measures increased sensitivity at a constant specificity as compared to the individual measures. It may therefore be a useful tool for clinical and epidemiological studies of pediatric adiposit
Non-newtonian flow and pressure drop of pineapple juice in a plate heat exchanger
The study of non-Newtonian flow in plate heat exchangers (PHEs) is of great importance for the food industry. The objective of this work was to study the pressure drop of pineapple juice in a PHE with 50º chevron plates. Density and flow properties of pineapple juice were determined and correlated with temperature (17.4 < T < 85.8ºC) and soluble solids content (11.0 < Xs < 52.4 ºBrix). The Ostwald-de Waele (power law) model described well the rheological behavior. The friction factor for non-isothermal flow of pineapple juice in the PHE was obtained for diagonal and parallel/side flow. Experimental results were well correlated with the generalized Reynolds number (20 < Re g < 1230) and were compared with predictions from equations from the literature. The mean absolute error for pressure drop prediction was 4% for the diagonal plate and 10% for the parallel plate.(FAPESP) São Paulo Research Foundatio
Reorganization of a hospital catering system increases food intake in patients with inadequate intake
A Bose-Einstein Approach to the Random Partitioning of an Integer
Consider N equally-spaced points on a circle of circumference N. Choose at
random n points out of on this circle and append clockwise an arc of
integral length k to each such point. The resulting random set is made of a
random number of connected components. Questions such as the evaluation of the
probability of random covering and parking configurations, number and length of
the gaps are addressed. They are the discrete versions of similar problems
raised in the continuum. For each value of k, asymptotic results are presented
when n,N both go to infinity according to two different regimes. This model may
equivalently be viewed as a random partitioning problem of N items into n
recipients. A grand-canonical balls in boxes approach is also supplied, giving
some insight into the multiplicities of the box filling amounts or spacings.
The latter model is a k-nearest neighbor random graph with N vertices and kn
edges. We shall also briefly consider the covering problem in the context of a
random graph model with N vertices and n (out-degree 1) edges whose endpoints
are no more bound to be neighbors
Evaluating the validity and applicable domain of the toxic load model: Impact of concentration vs. time profile on inhalation lethality of hydrogen cyanide
The ten Berge model (or ‘‘toxic load’’ model) is often used to estimate the acute toxicity for varying combinations of inhaled concentration and duration. Expressed as Cn X t = toxic load (TL), TLs are assumed constant for various combinations of concentration (C) and time (t). Experimental data in a recent acute inhalation study of rats exposed to time-varying concentrations of hydrogen cyanide (HCN) supported the validity of the toxic load model except under very brief, discontinuous, high concentration exposures. In the present investigation, experiments were conducted to extend the evaluation of the applicable domain of the model for acute lethality of HCN in the rat (cumulative exposure range of 2900–11,000 ppm min). The lethality of HCN over very short (\u3c5 min) durations of high concentrations did not conform to the toxic load model. A value of n = 1.57 was determined for uninterrupted exposures P5 min. For 30-min exposures, the presence or absence of a gap between two exposure pulses of different concentrations, the relative duration, relative height, and the ordering of the pulses (low then high, vs. high then low) did not appear to have a meaningful impact on the toxic load required for median lethality
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials
A series of cinnamic acid/4-aminoquinoline conjugates conceived to link, through a proper retro-enantio dipeptide, a heterocyclic core known to prevent hemozoin formation, to a trans-cinnamic acid motif capable of inhibiting enzyme catalytic Cys residues, were synthesized as potential dual-action antimalarials. The effect of amino acid configuration and the absence of the dipeptide spacer were also assessed. The replacement of the D-amino acids by their natural L counterparts led to a decrease in both anti-plasmodial and falcipain inhibitory activity, suggesting that the former are preferable. Molecules with such spacer were active against blood-stage Plasmodium falciparum, in vitro, and hemozoin formation, implying that the dipeptide has a key role in mediating these two activities. In turn, compounds without spacer were better falcipain-2 inhibitors, likely because these compounds are smaller and have their vinyl bonds in closer vicinity to the catalytic Cys, as suggested by molecular modeling calculations. These novel conjugates constitute promising leads for the development of new antiplasmodials targeted at blood-stage malaria parasites
Low-Impedance 3D PEDOT:PSS Ultramicroelectrodes
The technology for producing microelectrode arrays (MEAs) has been developing since the 1970s and extracellular electrophysiological recordings have become well established in neuroscience, drug screening and cardiology. MEAs allow monitoring of long-term spiking activity of large ensembles of excitable cells noninvasively with high temporal resolution and mapping its spatial features. However, their inability to register subthreshold potentials, such as intrinsic membrane oscillations and synaptic potentials, has inspired a number of laboratories to search for alternatives to bypass the restrictions and/or increase the sensitivity of microelectrodes. In this study, we present the fabrication and in vitro experimental validation of arrays of PEDOT:PSS-coated 3D ultramicroelectrodes, with the best-reported combination of small size and low electrochemical impedance. We observed that this type of microelectrode does not alter neuronal network biological properties, improves the signal quality of extracellular recordings and exhibits higher selectivity toward single unit recordings. With fabrication processes simpler than those reported in the literature for similar electrodes, our technology is a promising tool for study of neuronal networks. \ua9 Copyright \ua9 2020 Jones, Moskalyuk, Barthold, Gut\uf6hrlein, Heusel, Schr\uf6ppel, Samba and Giugliano
On an Asymptotic Series of Ramanujan
An asymptotic series in Ramanujan's second notebook (Entry 10, Chapter 3) is
concerned with the behavior of the expected value of for large
where is a Poisson random variable with mean and
is a function satisfying certain growth conditions. We generalize this by
studying the asymptotics of the expected value of when the
distribution of belongs to a suitable family indexed by a convolution
parameter. Examples include the problem of inverse moments for distribution
families such as the binomial or the negative binomial.Comment: To appear, Ramanujan
Anatomy of F_D-Term Hybrid Inflation
We analyze the cosmological implications of F-term hybrid inflation with a
subdominant Fayet--Iliopoulos D-term whose presence explicitly breaks a
D-parity in the inflaton-waterfall sector. This scenario of inflation, which is
called F_D-term hybrid model for brevity, can naturally predict lepton number
violation at the electroweak scale, by tying the mu-parameter of the MSSM to an
SO(3)-symmetric Majorana mass m_N, via the vacuum expectation value of the
inflaton field. We show how a negative Hubble-induced mass term in a
next-to-minimal extension of supergravity helps to accommodate the present CMB
data and considerably weaken the strict constraints on the theoretical
parameters, resulting from cosmic string effects on the power spectrum P_R. The
usual gravitino overabundance constraint may be significantly relaxed in this
model, once the enormous entropy release from the late decays of the ultraheavy
waterfall gauge particles is properly considered. As the Universe enters a
second thermalization phase involving a very low reheat temperature, which
might be as low as about 0.3 TeV, thermal electroweak-scale resonant
leptogenesis provides a viable mechanism for successful baryogenesis, while
thermal right-handed sneutrinos emerge as new possible candidates for solving
the cold dark matter problem. In addition, we discuss grand unified theory
realizations of F_D-term hybrid inflation devoid of cosmic strings and
monopoles, based on the complete breaking of an SU(2) subgroup. The F_D-term
hybrid model offers rich particle-physics phenomenology, which could be probed
at high-energy colliders, as well as in low-energy experiments of lepton
flavour or number violation.Comment: 73 pages, LaTeX, minor rewordings, references added, to appear in
JHE
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