2,297 research outputs found
Landauer's principle in multipartite open quantum system dynamics
We investigate the link between information and thermodynamics embodied by
Landauer's principle in the open dynamics of a multipartite quantum system.
Such irreversible dynamics is described in terms of a collisional model with a
finite temperature reservoir. We demonstrate that Landauer's principle holds,
for such a configuration, in a form that involves the flow of heat dissipated
into the environment and the rate of change of the entropy of the system. Quite
remarkably, such a principle for {\it heat and entropy power} can be explicitly
linked to the rate of creation of correlations among the elements of the
multipartite system and, in turn, the non-Markovian nature of their reduced
evolution. Such features are illustrated in two exemplary cases.Comment: 5 pages, 3 figures, RevTeX4-1; Accepted for publication in Phys. Rev.
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Cost Effective Computational Approach for Generation of Polymeric Composite Material Allowables for Reduced Testing
Future exposure modelling for risk-informed decision making in urban planning
Population increases and related urban expansion are projected to occur in various parts of the world over the coming decades. These future changes to the urban fabric could fundamentally alter the exposure to natural hazards and the associated vulnerability of people and the built environment with which they interact. Thus, modelling, quantifying, and reducing future urban disaster risk require forward-looking insights that capture the dynamic form of cities. This paper specifically focuses on the exposure component of dynamic natural-hazard disaster risk, by considering urban planning as the centre of future exposure characterisation in a given region. We use the information provided by urban plans and propose an integrated data structure for capturing future exposure to hazards. The proposed data structure provides the necessary detailing for both future physical and socio-demographic exposure in disaster risk modelling. More specifically, it enables users to develop a comprehensive multi-level, multi-scale exposure dataset, characterising attributes of land use, buildings, households and individuals. We showcase the proposed data schema using the virtual urban testbed Tomorrowville. In this case study, we also demonstrate how simplified algorithmic procedures and disaggregation methods can be used to populate the required data. This implementation demonstrates how the proposed exposure data structure can effectively support the development of forward-looking urban visioning scenarios to support decision-making for risk-sensitive and pro-poor urban planning and design in tomorrow's cities
Antidiabetic actions of GPR55 agonist Abn-CBD and sitagliptin in obese-diabetic high fat fed mice
Efficacy of weekly teriparatide does not vary by baseline fracture probability calculated using FRAX
Summary
The aim of this study was to determine the efficacy of once-weekly teriparatide as a function of baseline fracture risk. Treatment with once-weekly teriparatide was associated with a statistically significant 79 % decrease in vertebral fractures, and in the cohort as a whole, efficacy was not related to baseline fracture risk.
Introduction
Previous studies have suggested that the efficacy of some interventions may be greater in the segment of the population at highest fracture risk as assessed by the FRAX® algorithms. The aim of the present study was to determine whether the antifracture efficacy of weekly teriparatide was dependent on the magnitude of fracture risk.
Methods
Baseline fracture probabilities (using FRAX) were computed from the primary data of a phase 3 study (TOWER) of the effects of weekly teriparatide in 542 men and postmenopausal women with osteoporosis. The outcome variable comprised morphometric vertebral fractures. Interactions between fracture probability and efficacy were explored by Poisson regression.
Results
The 10-year probability of major osteoporotic fractures (without BMD) ranged from 7.2 to 42.2 %. FRAX-based hip fracture probabilities ranged from 0.9 to 29.3 %. Treatment with teriparatide was associated with a 79 % (95 % CI 52–91 %) decrease in vertebral fractures assessed by semiquantitative morphometry. Relative risk reductions for the effect of teriparatide on the fracture outcome did not change significantly across the range of fracture probabilities (p = 0.28). In a subgroup analysis of 346 (64 %) participants who had FRAX probabilities calculated with the inclusion of BMD, there was a small but significant interaction (p = 0.028) between efficacy and baseline fracture probability such that high fracture probabilities were associated with lower efficacy.
Conclusion
Weekly teriparatide significantly decreased the risk of morphometric vertebral fractures in men and postmenopausal women with osteoporosis. Overall, the efficacy of teriparatide was not dependent on the level of fracture risk assessed by FRAX in the cohort as a whole
Reinventing College Physics for Biologists: Explicating an epistemological curriculum
The University of Maryland Physics Education Research Group (UMd-PERG)
carried out a five-year research project to rethink, observe, and reform
introductory algebra-based (college) physics. This class is one of the Maryland
Physics Department's large service courses, serving primarily life-science
majors. After consultation with biologists, we re-focused the class on helping
the students learn to think scientifically -- to build coherence, think in
terms of mechanism, and to follow the implications of assumptions. We designed
the course to tap into students' productive conceptual and epistemological
resources, based on a theoretical framework from research on learning. The
reformed class retains its traditional structure in terms of time and
instructional personnel, but we modified existing best-practices curricular
materials, including Peer Instruction, Interactive Lecture Demonstrations, and
Tutorials. We provided class-controlled spaces for student collaboration, which
allowed us to observe and record students learning directly. We also scanned
all written homework and examinations, and we administered pre-post conceptual
and epistemological surveys. The reformed class enhanced the strong gains on
pre-post conceptual tests produced by the best-practices materials while
obtaining unprecedented pre-post gains on epistemological surveys instead of
the traditional losses.Comment: 35 pages including a 15 page appendix of supplementary material
Experimental behaviour of a compacted silt used in a flood defence embankment in Indonesia
A flood embankment in East Java, Indonesia with a recurrent history of geotechnical failure is the focus of this research. The site was visited in May 2006 and this paper describes the study site and presents the relevant in-situ data. Laboratory characterisation of the sampled material was carried out and presented herein are the soil properties, particle size distribution curve and x-ray diffraction results. Soil water retention curves were determined through the use of three different methods: filter paper, tensiometer and pressure plate allowing a comparison of these methods. Four series of oedometer tests were carried out under: (i) dry-of-optimum, (ii) wet-of-optimum, (iii) prepared wet and then dried and (iv) close to optimum initial conditions. Where collapse was observed, the collapse potential for the specimen was evaluated and severity of collapse determined. These preliminary results show the importance of good compaction control at the site and help to explain some failures observed at the site
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Effects of classification context on categorization in natural categories
The patterns of classification of borderline instances of eight common taxonomic categories were examined under three different instructional conditions to test two predictions: first, that lack of a specified context contributes to vagueness in categorization, and second, that altering the purpose of classification can lead to greater or lesser dependence on similarity in classification. The instructional conditions contrasted purely pragmatic with more technical/quasi-legal contexts as purposes for classification, and these were compared with a no-context control. The measures of category vagueness were between-subjects disagreement and within-subjects consistency, and the measures of similarity based categorization were category breadth and the correlation of instance categorization probability with mean rated typicality, independently measured in a neutral context. Contrary to predictions, none of the measures of vagueness, reliability, category breadth, or correlation with typicality were generally affected by the instructional setting as a function of pragmatic versus technical purposes. Only one subcondition, in which a situational context was implied in addition to a purposive context, produced a significant change in categorization. Further experiments demonstrated that the effect of context was not increased when participants talked their way through the task, and that a technical context did not elicit more all-or-none categorization than did a pragmatic context. These findings place an important boundary condition on the effects of instructional context on conceptual categorization
The Effects of Tropical Cyclone-Generated Deposition on the Sustainability of the Pearl River Marsh, Louisiana: The Importance of the Geologic Framework
Shoreline retreat is a tremendously important issue along the coast of the northern Gulf of Mexico, especially in Louisiana. Although this marine transgression results from a variety of causes, the crucial factor is the difference between marsh surface elevation and rising sea levels. In most cases, the primary cause of a marsh's inability to keep up with sea level is the lack of input of inorganic material. Although tropical cyclones provide an important source of such sediment, little effort has been made to determine the point of origin of the deposited material. In this study we use sedimentary, geochemical and biogeochemical data to identify the bed of the Pearl River and/or Lake Borgne as the source of a ~5 cm thick clastic layer deposited on the surface of the Pearl River marsh on the Louisiana/Mississippi border. Radiochemical chronologies and sedimentary evidence indicate that this layer was associated with the passage of Hurricane Katrina in 2005. As this material would otherwise have been lost to the system, this deposition indicates a net gain to marsh surface elevation. Accretion rates, determined from 137Cs and 14C profiles and the use of the Katrina layer as a stratigraphic marker, indicate that short-term (~50 years) rates are as much as an order of magnitude higher than the long- term (1000s of years) rates. We suggest that the marsh's geologic setting in an incised river valley with steep vertical constraints and a large fluvial discharge, promotes rapid accretion rates, with rates accelerating as the sea moves inland, due to extended hydroperiods and the input of clastic material from both the marine and terrestrial sides. These rates are especially large when compared to accretion occurring in the more common open marshes fringing the Gulf that lack fluvial input. The difference is particularly large when related to marsh recovery/regrowth following the deposition of thick hurricane-generated clastic layers. Given the number of similar incised river valleys along the Gulf Coast, we believe that understanding the processes controlling marsh accretion in such environments is essential in evaluating marsh sustainability on a regional basis
The ‘Coase Theorem’ vs. Coase Theorem Proper: How an Error Emerged and Why it Remained Uncorrected so Long
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