Searching for Anomalous Higgs Couplings in Peripheral Heavy Ion Collisions at the LHC

We investigate the sensitivity of the heavy ion mode of the LHC to anomalous Higgs boson couplings to photons, H-photon-photon, through the analysis of the processes photon photon to b anti-b and photon photon to photon photon in peripheral heavy ion collisions. We suggest cuts to improve the signal over background ratio and determine the capability of LHC to impose bounds on anomalous couplings by searching for a Higgs boson signal in these modes.Comment: 10 pages, RevTeX, 4 figures included using epsfig, revised versio

Testing Anomalous Higgs Couplings in Triple Photon Production at the Tevatron Collider

We derive bounds on Higgs and gauge--boson anomalous interactions using the CDF data for the process $p \bar{p} \to \gamma\gamma\gamma + X$. We use a linearly realized $SU_L(2) \times U_Y(1)$ invariant effective Lagrangian to describe the bosonic sector of the Standard Model, keeping the fermionic couplings unchanged. All dimension--six operators that lead to anomalous Higgs interactions involving $\gamma$ and $Z$ are considered. We also show the sensitivity that can be achieved for these couplings at Fermilab Tevatron upgrades.Comment: 13 pages, RevTeX, 2 figures included using epsfi

Evaluation of Sedentary Behavior and Physical Activity Levels Using Different Accelerometry Protocols in Children from the GENOBOX Study

Background Physical activity (PA) has acquired a significant relevance due to the health benefits associated with its practice. Accelerometers are an effective tool to assess PA; however, the diversity of cut-off points used to define different PA intensities through accelerometry could interfere in the interpretation of the findings among studies. Objectives The present study aimed to examine the sedentary behavior (SB) and physical activity (PA) levels in children using six selected accelerometry protocols based on diverse cut-off points. Methods Clinical examination, anthropometric measurements, and PA evaluation by accelerometry were assessed in 543 selected children (10 +/- 2.4 years old) from the Spanish GENOBOX study. The ActiLife data scoring program was used to determine daily min spent in SB, and light, moderate, vigorous and moderate-vigorous PA using six validated accelerometry protocols differing in their cut-off points. Results Very different estimations for SB and PA intensity levels were found in children, independently of the non-wear-time algorithm selected, and considering puberty stages, age and body mass index. The time spent in daily SB varied from 471 to 663.7 min, PA ranged from 141 to 301.6 min, and the moderate-vigorous PA was reported between 20.7 and 180.2 min. Conclusion The choice of a particular accelerometry protocol considering these factors is important to evaluate SB or PA intensities to suit the characteristics of the sample researched. It seems necessary to establish future lines of research that include different analytical approaches to measure SB and PA by accelerometry based on standardized and validated methodology

Lower prevalence of drug resistance mutations at first-line virological failure to first-line therapy with atripla vs. tenofovirRemtricitabine/lamivudineRefavirenz administered on a multiple tablet therapy

Fixed-dose combination antiretroviral therapy administered as a single-tablet regimen (STR) may improve virologic suppression rates. The effect of STRs on development of resistance when virologic failure occurs on STRs is not known

Influence of pH and ionic strength on the color parameters and antioxidant properties of an ethanolic red grape marc extract

The aim of present study was to investigate the influences of pH and several salts on the antioxidant activity and color of an ethanolic grape marc extract. Furthermore, the phenolic content of the extract was analyzed using HPLC and spectrophotometric methods while the total antioxidant activity was assessed by the reaction with ABTS radical. Gallic acid, procyanidins B1, B2, polydatin, catechin, epicatechin, hyperoside, ferulic, chlorogenic, and salicylic acids were among the main identified polyphenols. Different pH values had slight influence on the antioxidant activity, the highest value being determined for pH 3.7. The redness, chroma, and hue were significantly enhanced at pH 3.7 and 2.6. The chromaticity decreased at pH = 5.5 and pH = 7.4, so the extract should be used with care in products with such media. The presence of salts did not noticeably affect the antioxidant activity, except the higher concentrations of CaCl2, which decreased the antioxidant activity but enhanced the color intensity

Some Implications of a Supersymmetric Model with R-Parity Breaking Bilinear Interactions

We investigate a supersymmetric scenario where R-parity is explicitly broken through a term bilinear in the lepton and Higgs superfields in the superpotential. We show that keeping such a term alone can lead to trilinear interactions, similar to those that are parametrized by $\lambda$-and ${\lambda}'$ in the literature, involving the physical fields. The upper limits of such interactions are predictable from the constraints on the parameter space imposed by the lepton masses and the neutrino mass limits. It is observed that thus the resulting trilinear interactions are restricted to values that are smaller than the existing bounds on most of the $\lambda$-and ${\lambda}'$-parameters. Some phenomenological consequences of such a scenario are discussed.Comment: 26 Pages, 6 Postscript figures, Latex. An additional set of references has been included. Typographic corrections have been made. Figures remain all unchanged. An additional typographic correction has been mad

Spontaneous R-Parity violation bounds

We investigate bounds from tree-level and one-loop processes in generic supersymmetric models with spontaneous R-parity breaking in the superpotential. We analyse the bounds from a general point of view. The bounds are applicable both for all models with spontaneous R-parity violation and for explicit bilinear R-parity violation based on general lepton-chargino and neutrino-neutralino mixings. We find constraints from semileptonic B, D and K decays, leptonic decays of the mu and tau, electric dipole moments, as well as bounds for the anomalous magnetic moment of the muon.Comment: 22 page

Evaluation of the Predictive Ability, Environmental Regulation and Pharmacogenetics Utility of a BMI-Predisposing Genetic Risk Score during Childhood and Puberty

The authors would like to thank the Spanish children and parents who participated in the study.Polygenetic risk scores (pGRSs) consisting of adult body mass index (BMI) genetic variants have been widely associated with obesity in children populations. The implication of such obesity pGRSs in the development of cardio-metabolic alterations during childhood as well as their utility for the clinical prediction of pubertal obesity outcomes has been barely investigated otherwise. In the present study, we evaluated the utility of an adult BMI predisposing pGRS for the prediction and pharmacological management of obesity in Spanish children, further investigating its implication in the appearance of cardio-metabolic alterations. For that purpose, we counted on genetics data from three well-characterized children populations (composed of 574, 96 and 124 individuals), following both cross-sectional and longitudinal designs, expanding childhood and puberty. As a result, we demonstrated that the pGRS is strongly associated with childhood BMI Z-Score (B = 1.56, SE = 0.27 and p-value = 1.90 × 10−8 ), and that could be used as a good predictor of obesity longitudinal trajectories during puberty. On the other hand, we showed that the pGRS is not associated with cardio-metabolic comorbidities in children and that certain environmental factors interact with the genetic predisposition to the disease. Finally, according to the results derived from a weight-reduction metformin intervention in children with obesity, we discarded the utility of the pGRS as a pharmacogenetics marker of metformin response.Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) PI1102042 PI1102059 PI1601301 PI1600871Spanish Ministry of Health, Social and Equality, General Department for Pharmacy and Health Products EC10-243 EC10-056 EC10-281 EC10-227Regional Government of Andalusia ("Plan Andaluz de investigacion, desarrollo e innovacion (2018)") P18-RT-2248Mapfre Foundation ("Research grants by Ignacio H. de Larramendi 2017")Instituto de Salud Carlos III IFI17/0004

Neutrino Masses and Mixings from Supersymmetry with Bilinear R--Parity Violation: A Theory for Solar and Atmospheric Neutrino Oscillations

The simplest unified extension of the MSSM with bi-linear R--Parity violation naturally predicts a hierarchical neutrino mass spectrum, in which one neutrino acquires mass by mixing with neutralinos, while the other two get mass radiatively. We have performed a full one-loop calculation of the neutralino-neutrino mass matrix in the bi-linear \rp MSSM, taking special care to achieve a manifestly gauge invariant calculation. Moreover we have performed the renormalization of the heaviest neutrino, needed in order to get meaningful results. The atmospheric mass scale and maximal mixing angle arise from tree-level physics, while solar neutrino scale and oscillations follow from calculable one-loop corrections. If universal supergravity assumptions are made on the soft-supersymmetry breaking terms then the atmospheric scale is calculable as a function of a single \rp violating parameter by the renormalization group evolution due to the non-zero bottom quark Yukawa coupling. The solar neutrino problem must be accounted for by the small mixing angle (SMA) MSW solution. If these assumptions are relaxed then one can implement large mixing angle solutions, either MSW or just-so. The theory predicts the lightest supersymmetic particle (LSP) decay to be observable at high-energy colliders, despite the smallness of neutrino masses indicated by experiment. This provides an independent way to test this solution of the atmospheric and solar neutrino anomalies.Comment: 46 pages, references added + several misprints correcte