Speed of Sound in the Mass Varying Neutrinos Scenario

We discuss about the speed of sound squared in the Mass Varying Neutrinos scenario (MaVaNs). Recently, it was argued that the MaVaNs has a catastrophic instability which is the emergence of an imaginary speed of sound at the non-relativistic limit of neutrinos. As the result of this instability, the neutrino-acceleron fluid cannot act as the dark energy. However, it is found that the speed of sound squared in the neutrino-acceleron fluid could be positive in our model. We examine the speed of sound in two cases of the scalar potential. One is the small fractional power-law potential and another is the logarithmic one. The power-law potential model with the right-handed neutrinos gives a stable one.Comment: 17 pages, References added, minor modification

Binomial Ideals and Congruences on Nn

Producción CientíficaA congruence on Nn is an equivalence relation on Nn that is compatible with the additive structure. If k is a field, and I is a binomial ideal in k[X1,…,Xn] (that is, an ideal generated by polynomials with at most two terms), then I induces a congruence on Nn by declaring u and v to be equivalent if there is a linear combination with nonzero coefficients of Xu and Xv that belongs to I. While every congruence on Nn arises this way, this is not a one-to-one correspondence, as many binomial ideals may induce the same congruence. Nevertheless, the link between a binomial ideal and its corresponding congruence is strong, and one may think of congruences as the underlying combinatorial structures of binomial ideals. In the current literature, the theories of binomial ideals and congruences on Nn are developed separately. The aim of this survey paper is to provide a detailed parallel exposition, that provides algebraic intuition for the combinatorial analysis of congruences. For the elaboration of this survey paper, we followed mainly (Kahle and Miller Algebra Number Theory 8(6):1297–1364, 2014) with an eye on Eisenbud and Sturmfels (Duke Math J 84(1):1–45, 1996) and Ojeda and Piedra Sánchez (J Symbolic Comput 30(4):383–400, 2000).National Science Foundation (grant DMS-1500832)Ministerio de Economía, Industria y Competitividad (project MTM2015-65764-C3-1)Junta de Extremadura (grupo de investigación FQM-024

A Process for Improving Course Quality based on Mid-Semester Feedback

Proceedings of: First International Conference on Reforming Education, Quality of Teaching and Technology-Enhanced Learning: Learning Technologies, Quality of Education, Educational Systems, Evaluation, Pedagogies (TECH-EDUCATION 2010). Athens, Greece, May 19-21, 2010.Quality control mechanisms are becoming more important in higher educational institutions. Student evaluation of teaching is typically used to obtain feedback from students about a learning experience but its effect in the course may take too long. Fast feedback mechanisms, in exchange, look at obtaining feedback in order to apply corrective measures quickly. In this paper a process is described to obtain feedback from the students about a course, analyze the received results, and identify the most significant aspects. The process has been applied to a course and led to some adjustments that had immediate impact on the course.The authors are truly indebted to Miguel Valero for his guidance during the design of this process. Work partially funded by the Learn3 project, “Plan Nacional de I+D+I TIN2008-05163/TSI”, the Best Practice Network ICOPER (Grant No. ECP-2007-EDU-417007), the Flexo Project “Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica” (Ref. TSI-020301-2008-19), and the “Emadrid: Investigación y desarrollo de tecnologías para el e-learning en la Comunidad de Madrid” project (S2009/TIC-1650).Publicad

Evidence for two protein-lipoylation activities in Escherichia coli

AbstractThe lipoate acyltransferase subunits of the 2-oxo acid dehydrogenase complexes are post-translationally modified with one or more covalently-bound lipoyl cofactors. Two distinct lipoate-protein ligase activities, LPL-A and LPL-B, have been detected in E. coli by their ability to modify purified lipoyl apo-domains of the bacterial pyruvate dehydrogenase complex. Both enzymes require ATP and Mg2+, use L-lipoate, 8-methyllipoate, lipoyl adenylate and octanoyl adenylate as substrates, and both activate lipoyl-deficient pyruvate dehydrogenase complexes. In contrast, only LPL-B uses D-lipoate and octanoate and there are differences in the metal-ion and phosphate requirements. It is suggested that LPL-B may be responsible for the octanoylation of lipoyl domains observed previously under lipoate-deficient conditions

Reliability assessment of null allele detection: inconsistencies between and within different methods

Microsatellite loci are widely used in population genetic studies, but the presence of null alleles may lead to biased results. Here we assessed five methods that indirectly detect null alleles, and found large inconsistencies among them. Our analysis was based on 20 microsatellite loci genotyped in a natural population of Microtus oeconomus sampled during 8 years, together with 1200 simulated populations without null alleles, but experiencing bottlenecks of varying duration and intensity, and 120 simulated populations with known null alleles. In the natural population, 29% of positive results were consistent between the methods in pairwise comparisons, and in the simulated dataset this proportion was 14%. The positive results were also inconsistent between different years in the natural population. In the null-allele-free simulated dataset, the number of false positives increased with increased bottleneck intensity and duration. We also found a low concordance in null allele detection between the original simulated populations and their 20% random subsets. In the populations simulated to include null alleles, between 22% and 42% of true null alleles remained undetected, which highlighted that detection errors are not restricted to false positives. None of the evaluated methods clearly outperformed the others when both false positive and false negative rates were considered. Accepting only the positive results consistent between at least two methods should considerably reduce the false positive rate, but this approach may increase the false negative rate. Our study demonstrates the need for novel null allele detection methods that could be reliably applied to natural population

Rearranging the centromere of the human Y chromosome with φC31 integrase

We have investigated the ability of the integrase from the Streptomyces φC31 ‘phage to either delete or invert 1 Mb of DNA around the centromere of the human Y chromosome in chicken DT40 hybrid somatic cells. Reciprocal and conservative site-specific recombination was observed in 54% of cells expressing the integrase. The sites failed to recombine in the remaining cells because the sites had been damaged. The sequences of the damaged sites indicated that the damage arose as a result of repair of recombination intermediates by host cell pathways. The liability of recombination intermediates to damage is consistent with what is known about the mechanism of serine recombinase reactions. The structures of the products of the chromosome rearrangements were consistent with the published sequence of the Y chromosome indicating that the assembly of the highly repeated region between the sites is accurate to a resolution of about 50 kb. Mini-chromosomes lacking a centromere were not recovered which also suggested that neo-centromere formation occurs infrequently in vertebrate somatic cells. No ectopic recombination was observed between a φC31 integrase attB site and the chicken genome

Re-Focusing - Building a Future for Entrepreneurial Education & Learning

The field of entrepreneurship has struggled with fundamental questions concerning the subject’s nature and purpose. To whom and to what means are educational and training agendas ultimately directed? Such questions have become of central importance to policy makers, practitioners and academics alike. There are suggestions that university business schools should engage more critically with the lived experiences of practising entrepreneurs through alternative pedagogical approaches and methods, seeking to account for and highlighting the social, political and moral aspects of entrepreneurial practice. In the UK, where funding in higher education has become increasingly dependent on student fees, there are renewed pressures to educate students for entrepreneurial practice as opposed to educating them about the nature and effects of entrepreneurship. Government and EU policies are calling on business schools to develop and enhance entrepreneurial growth and skill sets, to make their education and training programmes more proactive in providing innovative educational practices which help and facilitate life experiences and experiential learning. This paper makes the case for critical frameworks to be applied so that complex social processes become a source of learning for educators and entrepreneurs and so that innovative pedagogical approaches can be developed in terms both of context (curriculum design) and process (delivery methods)

Equilibrium and stability of neutrino lumps as TOV solutions

We report about stability conditions for static, spherically symmetric objects that share the essential features of mass varying neutrinos in cosmological scenarios. Compact structures of particles with variable mass are held together preponderantly by an attractive force mediated by a background scalar field. Their corresponding conditions for equilibrium and stability are given in terms of the ratio between the total mass-energy and the spherical lump radius, $M/R$. We show that the mass varying mechanism leading to lump formation can modify the cosmological predictions for the cosmological neutrino mass limits. Our study comprises Tolman-Oppenheimer-Volkoff solutions of relativistic objects with non-uniform energy densities. The results leave open some questions concerning stable regular solutions that, to an external observer, very closely reproduce the preliminary conditions to form Schwarzschild black holes.Comment: 20 pages, 5 figure

Land, cane and coconuts : papers on the rural economy of Fiji

The three papers contained in this volume are the outcome of research into various aspects of employment generation and income distribution in Fiji agriculture, undertaken in 1982 and 1983. The papers were originally prepared as Working Papers for the Fiji Employment and Development Mission, which submitted its final report to the Fiji Government in 1984. Revised versions are published together here in order to make available to a wider readership the result of the research

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

The actin and microtubule cytoskeletons are critically important for cancer cell proliferation, and drugs that target microtubules are widely-used cancer therapies. However, their utility is compromised by toxicities due to dose and exposure. To overcome these issues, we characterized how inhibition of the actin and microtubule cytoskeleton regulatory LIM kinases could be used in drug combinations to increase efficacy. A previously-described LIMK inhibitor (LIMKi) induced dose-dependent microtubule alterations that resulted in significant mitotic defects, and increased the cytotoxic potency of microtubule polymerization inhibitors. By combining LIMKi with 366 compounds from the GSK Published Kinase Inhibitor Set, effective combinations were identified with kinase inhibitors including EGFR, p38 and Raf. These findings encouraged a drug discovery effort that led to development of CRT0105446 and CRT0105950, which potently block LIMK1 and LIMK2 activity in vitro, and inhibit cofilin phosphorylation and increase αTubulin acetylation in cells. CRT0105446 and CRT0105950 were screened against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells were identified as significantly sensitive to both LIMK inhibitors. These large-scale screens have identified effective LIMK inhibitor drug combinations and sensitive cancer types. In addition, the LIMK inhibitory compounds CRT0105446 and CRT0105950 will enable further development of LIMK-targeted cancer therapy