Propiedades mecánicas del hormigón reciclado con áridos procedentes de piezas prefabricadas desechadas.

La necesidad de disminuir la cantidad final de residuos de construcción y demolición que se producen en las plantas de prefabricados de hormigón, nos ha llevado a analizar el comportamiento mecánico de un hormigón elaborado con áridos reciclados procedentes de piezas prefabricadas de hormigón, con la finalidad de un posible futuro uso como árido en dosificaciones de hormigón armado y pretensado para piezas prefabricadas. Se ha trabajado con áridos reciclados en dos situaciones: estado natural y sometidos a presaturación, con hormigones H40 y H50 autocompactantes, tomando como única variable la sustitución de fracción gruesa del árido con los siguientes porcentajes, 0%, 20%, 50% y 100%. Los ensayos realizados en la parametrización del árido reciclado presentaron un excelente comportamiento, quedando únicamente la absorción y la resistencia a la helada con sustituciones del 100% con valores algo superiores a los máximos exigidos por la Instrucción de Hormigón Estructural EHE-08. Los hormigones elaborados con áridos sin someterlos a saturación previa mostraron aumentos de resistencia a compresión con respecto al hormigón de comparación, alcanzando valores de resistencia superiores a 70 N/mm 2 , invirtiéndose esta tendencia para los hormigones con árido presaturado. Los resultados de los ensayos realizados indican que hormigones elaborados con áridos reciclados procedentes de elementos prefabricados pueden presentar una excelente calidad como hormigón estructural para su futuro uso como autoconsumo

REPLY: Answer to the comment of Casas et al. about González Acebrón et al.’s (2011) paper

Depto. de Mineralogía y PetrologíaFac. de Ciencias GeológicasTRUEpu

Henoch-Schönlein purpura in northern Spain: clinical spectrum of the disease in 417 patients from a single center

The severity of clinical features and the outcomes in previous series of patients reported with Henoch-Schönlein purpura (HSP) vary greatly, probably due to selection bias. To establish the actual clinical spectrum of HSP in all age groups using an unselected and wide series of patients diagnosed at a single center, we performed a retrospective review of 417 patients classified as having HSP according to the criteria proposed by Michel et al. Of 417 patients, 240 were male and 177 female, with a median age at the time of disease diagnosis of 7.5 years (interquartile range [IQR], 5.3-20.1 yr). Three-quarters of the patients were children or young people aged 20 years or younger (n = 315), and one-quarter were adults (n = 102). The most frequent precipitating events were a previous infection (38%), usually an upper respiratory tract infection, and/or drug intake (18.5%) shortly before the onset of the vasculitis. At disease onset the most common manifestations were skin lesions (55.9%), nephropathy (24%), gastrointestinal involvement (13.7%), joint symptoms (9.1%), and fever (6.2%). Cutaneous involvement occurring in all patients, mainly purpuric skin lesion, was the most common manifestation when the vasculitis was fully established, followed by gastrointestinal (64.5%), joint (63.1%), and renal involvement (41.2%). The main laboratory findings were leukocytosis (36.7%), anemia (8.9%), and increased serum IgA levels (31.7%). The most frequent therapies used were corticosteroids (35%), nonsteroidal antiinflammatory drugs (14%), and cytotoxic agents (5%). After a median follow-up of 12 months (IQR, 2-38 mo), complete recovery was observed in most cases (n = 346; 83.2%), while persistent, usually mild, nephropathy was observed in only 32 (7.7%) cases. Relapses were observed in almost a third of patients (n = 133; 31.9%).In conclusion, although HSP is a typical vasculitis affecting children and young people, it is not uncommon in adults. The prognosis is favorable in most cases, depending largely on renal involvement

Mapa de series, geoseries y geopermaseries de vegetación de España (Memoria del mapa de vegetación potencial de España). Parte II

Peer Reviewe

Reelin expression in Creutzfeldt-Jakob disease and experimental models of transmissible spongiform encephalopathies

Reelin is an extracellular glycoprotein involved in key cellular processes in developing and adult nervous system, including regulation of neuronal migration, synapse formation, and plasticity. Most of these roles are mediated by the intracellular phosphorylation of disabled-1 (Dab1), an intracellular adaptor molecule, in turn mediated by binding Reelin to its receptors. Altered expression and glycosylation patterns of Reelin in cerebrospinal and cortical extracts have been reported in Alzheimer's disease. However, putative changes in Reelin are not described in natural prionopathies or experimental models of prion infection or toxicity. With this is mind, in the present study, we determined that Reelin protein and mRNA levels increased in CJD human samples and in mouse models of human prion disease in contrast to murine models of prion infection. However, changes in Reelin expression appeared only at late terminal stages of the disease, which prevent their use as an efficient diagnostic biomarker. In addition, increased Reelin in CJD and in in vitro models does not correlate with Dab1 phosphorylation, indicating failure in its intracellular signaling. Overall, these findings widen our understanding of the putative changes of Reelin in neurodegeneration

Nuevos datos de actividad tectónica durante el Pleistoceno Superior-Holoceno en el sector oriental de la plataforma continental del Golfo de Cádiz (SO de Iberia)

La realización de dos campañas de adquisición de datos geofísicos del suelo y subsuelo marino en el año 2010, mediante la utilización de técnicas acústicas de muy alta resolución, ha permitido ampliar el conocimiento de dos sectores de la plataforma continental española en el Golfo de Cádiz, comprendidos entre la desembocadura del río Guadalquivir y la Bahía de Cádiz, y entre Cádiz y Chiclana de la Frontera, respectivamente. En el primero se han localizado varias zonas de fracturas que se caracterizan en los perfiles de sísmica de muy alta resolución por fallas normales de alto ángulo y pequeño salto que desplaza claramente las unidades sedimentarias de edad Holoceno, se trata por tanto de fallas que se pueden considerar activas, si bien deben ser el reflejo en superficie de fallas profundas de mayor entidad. Mientras que en el segundo se ha analizado la morfología asociada a la actividad emergente de una estructura diapirica principal.Two oceanographic surveys have been carried out using very high resolution acoustic techniques in 2010. These surveys have allowed us to improve the knowledge of two sectors of the Spanish continental shelf in the Gulf of Cadiz: the first one, from the mouth of the Guadalquivir River to the Bay of Cadiz, and the second one, between Cadiz and Chiclana de la Frontera. In the first sector, we have located several fracture zones which are characterized in the seismic profiles as high angle normal faults of small vertical displacement. These faults displace clearly the Holocene sedimentary units. Therefore, these faults could be considered currently actives, although should be the surface expression of deeper and more significance faults. In the second sector, we have analyzed the associated morphology with the emerging activity of a main diapi

Evaluación del modelo comunitario de atención a los trastornos mentales en España

Introducción: El objetivo de este trabajo consiste en evaluar la implementación del modelo comunitario de atención en salud mental en el Estado español en 2014. Secundariamente, se analizan los cambios que el modelo experimentó en 2008, en relación con la recesión económica. Material y Método: Se adoptó la definición de modelo comunitario que se propone en la Estrategia en Salud Mental del SNS, según la cual el modelo se rige por 8 principios y se implementa mediante 39 prácticas asistenciales. Se elaboró una encuesta dirigida a las Juntas Autonómicas de Gobierno de la Asociación Española de Neuropsiquiatría sobre el grado de cumplimiento del modelo comunitario en cada comunidad. Resultados: Se obtuvieron respuestas de 13 Juntas Autonómicas que incluyeron información sobre el 93% de la población española. Conclusión: Las carencias más importantes en la implementación del modelo comunitario en 2014 se relacionaron con la ausencia de una perspectiva de salud pública, con la mala gestión y rendición de cuentas, y la ralentización del desarrollo de equipos, servicios y redes de servicios de orientación comunitaria. El modelo se modificó poco globalmente entre 2008 y 2014, pero algunas prácticas clave, como la universalidad y gratuidad del sistema, la atención sectorizada, el acortamiento de los tiempos de espera, las subvenciones a las asociaciones de usuarios y familiares, y la aplicación de la “ley de dependencia” se contrajeron de forma sustancial en muchas comunidades. Otras prácticas, como la historia clínica informatizada, los planes Individualizados de atención y el tratamiento asertivo comunitario, incrementaron su cobertura en algunas comunidades a pesar de la recesión

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain : Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery