Effect of permanent plots on the relative efficiency of spatially balanced sampling in a national forest inventory

Article 20201

Sensitivity of Surface Urban Energy and Water Balance Scheme (SUEWS) to downscaling of reanalysis forcing data

Often the meteorological forcing data required for urban hydrological models are unavailable at the required temporal resolution or for the desired period. Although reanalysis data can provide this information, the spatial resolution is often coarse relative to cities, so downscaling is required prior to use as realistic forcing. In this study, WATCH WFDEI reanalysis data are used to force the Surface Urban Energy and Water Balance Scheme (SUEWS). From sensitivity tests in two cities, Vancouver and London with different orography, we conclude precipitation is the most important meteorological variable to be properly downscaled to obtain reliable surface hydrology results, with relative humidity being the second most important. Overestimation of precipitation in reanalysis data at the three sites gives 6-21% higher annual modelled evaporation, 26-39% higher runoff at one site and 4% lower value at one site when compared to modelled values using observed forcing data. Application of a bias correction method to the reanalysis precipitation reduces the model bias compared to using observed forcing data, when evaluated using eddy covariance evaporation measurements. (c) 2017 Elsevier B.V. All rights reserved.Often the meteorological forcing data required for urban hydrological models are unavailable at the required temporal resolution or for the desired period. Although reanalysis data can provide this information, the spatial resolution is often coarse relative to cities, so downscaling is required prior to use as realistic forcing. In this study, WATCH WFDEI reanalysis data are used to force the Surface Urban Energy and Water Balance Scheme (SUEWS). From sensitivity tests in two cities, Vancouver and London with different orography, we conclude precipitation is the most important meteorological variable to be properly downscaled to obtain reliable surface hydrology results, with relative humidity being the second most important. Overestimation of precipitation in reanalysis data at the three sites gives 6-21% higher annual modelled evaporation, 26-39% higher runoff at one site and 4% lower value at one site when compared to modelled values using observed forcing data. Application of a bias correction method to the reanalysis precipitation reduces the model bias compared to using observed forcing data, when evaluated using eddy covariance evaporation measurements. (c) 2017 Elsevier B.V. All rights reserved.Often the meteorological forcing data required for urban hydrological models are unavailable at the required temporal resolution or for the desired period. Although reanalysis data can provide this information, the spatial resolution is often coarse relative to cities, so downscaling is required prior to use as realistic forcing. In this study, WATCH WFDEI reanalysis data are used to force the Surface Urban Energy and Water Balance Scheme (SUEWS). From sensitivity tests in two cities, Vancouver and London with different orography, we conclude precipitation is the most important meteorological variable to be properly downscaled to obtain reliable surface hydrology results, with relative humidity being the second most important. Overestimation of precipitation in reanalysis data at the three sites gives 6-21% higher annual modelled evaporation, 26-39% higher runoff at one site and 4% lower value at one site when compared to modelled values using observed forcing data. Application of a bias correction method to the reanalysis precipitation reduces the model bias compared to using observed forcing data, when evaluated using eddy covariance evaporation measurements. (c) 2017 Elsevier B.V. All rights reserved.Peer reviewe

Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children

Genetic variants may predispose children to recurrent respiratory infections (RRIs) but studies on genotype-environment interaction are rare. We hypothesized that the risk for RRIs is elevated in children with innate immune gene variants, and that prenatal exposure to maternal psychological distress further increases the risk. In a birth cohort, children with RRIs (n=96) were identified by the age of 24 months and compared with the remaining cohort children (n=894). The risk for RRIs in children with preselected genetic variants and the interaction between maternal distress during pregnancy and child genotype were assessed with logistic regression. The IL6 minor allele G was associated with elevated risk for RRIs (OR 1.55; 95% CI 1.14-2.12). Overall, there was no interaction between maternal psychological distress and child genotype. Exploratory analyses showed that, the association between the variant type of IL6 and the risk for RRIs was dependent on prenatal exposure to maternal psychological distress in males (OR 1.96; 95% CI 1.04-3.67). Our study didn't find genotype-environment interaction between prenatal maternal distress and child genotype. Exploratory analyses suggest sex differences in gene-environment interaction related to susceptibility to RRIs.Peer reviewe

Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood

Background. Genetic heterogeneity in type I interferon (IFN)-related gene IFI44L may account for variable susceptibility to respiratory tract infections (RTIs) in children. Methods. In 2 prospective, population-based birth cohorts, the STEPS Study and the FinnBrain Birth Cohort Study, IFI44L genotypes for rs273259 and rs1333969 were determined in relation to the development of RTIs until 1 or 2 years of age, respectively. At age 3 months, whole-blood transcriptional profiles were analyzed and nasal samples were tested for respiratory viruses in a subset of children. Results. In the STEPS Study (n=1135), IFI44L minor/minor gene variants were associated with lower rates of acute otitis media episodes (adjusted incidence rate ratio, 0.77 [95% confidence interval, .61-.96] for rs273259 and 0.74 [.55-.99] for rs1333969) and courses of antibiotics for RTIs (0.76 [.62-.95] and 0.73 [.56-.97], respectively. In the FinnBrain cohort (n=971), IFI44L variants were associated with lower rates of RTIs and courses of antibiotics for RTIs. In respiratory virus-positive 3-month-old children, IFI44L gene variants were associated with decreased expression levels of IFI44L and several other IFN-related genes. Conclusions. Variant forms of IFI44L gene were protective against early-childhood RTIs or acute otitis media, and they attenuated IFN pathway activation by respiratory viruses.Peer reviewe

Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children

Genetic variants may predispose children to recurrent respiratory infections (RRIs) but studies on genotype-environment interaction are rare. We hypothesized that the risk for RRIs is elevated in children with innate immune gene variants, and that prenatal exposure to maternal psychological distress further increases the risk. In a birth cohort, children with RRIs (n = 96) were identified by the age of 24 months and compared with the remaining cohort children (n = 894). The risk for RRIs in children with preselected genetic variants and the interaction between maternal distress during pregnancy and child genotype were assessed with logistic regression. The IL6 minor allele G was associated with elevated risk for RRIs (OR 1.55; 95% CI 1.14–2.12). Overall, there was no interaction between maternal psychological distress and child genotype. Exploratory analyses showed that, the association between the variant type of IL6 and the risk for RRIs was dependent on prenatal exposure to maternal psychological distress in males (OR 1.96; 95% CI 1.04–3.67). Our study didn’t find genotype-environment interaction between prenatal maternal distress and child genotype. Exploratory analyses suggest sex differences in gene-environment interaction related to susceptibility to RRIs. © 2021, The Author(s).</p

A minor role of asparaginase in predisposing to cerebral venous thromboses in adult acute lymphoblastic leukemia patients

Cerebral venous thrombosis (CVT) covers up to a third of all venous thromboses (VTs) detected in patients with acute lymphoblastic leukemia (ALL). It usually hampers patients' lives and may also endanger efficient leukemia treatment. Although many factors have been suggested to account for an elevated risk of VTs in patients with ALL, there still is a lack of studies focusing on CVTs and especially in the setting of adult ALL patients. We studied in our retrospective population-based cohort the occurrence, characteristics, as well as risk factors for VTs in 186 consecutively diagnosed Finnish adult ALL patients treated with a national pediatric-inspired treatment protocol ALL2000. In the risk factor analyses for VTs we found a distinction of the characteristics of the patients acquiring CVT from those with other kinds of VTs or without thrombosis. In contrast to previous studies we were also able to compare the effects of asparaginase in relation to CVT occurrence. Notably, more than half of the CVTs were diagnosed prior the administration of asparaginase which accentuates the role of other risk factors on the pathophysiology of CVT compared to truncal or central venous line (CVL) VTs in adult ALL patients

Reframing gender and feminist knowledge construction in marketing and consumer research: missing feminisms and the case of men and masculinities

Gender has been theorised and studied in many ways and across different disciplines. Although a number of these theorisations have been recognised and adopted in marketing and consumer research, the significance of feminism in knowledge construction has largely remained what we would call ‘unfinished’. Based on a critical reframing of gender research in marketing and consumer research, in dialogue with feminist theory, this article offers theoretical and practical suggestions for how to reinvigorate these research efforts. The analysis highlights dominant theorisations of gender, relating to gender as variable, difference and role; as fundamental difference and structuring; and as cultural and identity constructions. This reframing emphasises various neglected or ‘missing feminisms’, including queer theory; critical race, intersectional and transnational feminisms; material-discursive feminism; and critical studies on men and masculinities. A more detailed discussion of the latter, as a relatively new, growing and politically contentious area, is further developed to highlight more specifically which feminist and gender theories are mainly in use in marketing and consumer research and which are little or not used. In the light of this, it is argued that marketing and related disciplines have thus far largely neglected several key contemporary gender and feminist theorisations, particularly those that centre on gender power relations. The potential impact of these theoretical frames on transdisciplinary studies in marketing and consumer research and research agenda(s) is discussed