Eruptive Keratoacanthomas in a Red Tattoo

MEDICAL IMAG

Trends in stabilisation of Criegee intermediates from alkene ozonolysis

Criegee Intermediates (CI), formed in the ozonolysis of alkenes, play a central role in tropospheric chemistry as an important source of radicals, with stabilised CI (SCI) able to participate in bimolecular reactions, affecting climate through the formation of inorganic and organic aerosol. However, total SCI yields have only been determined for a few alkene systems, while speciated SCI yields from asymmetrical alkenes are almost entirely unknown. Here we report for the first time a systematic experimental exploration of the stabilisation of CH2OO and (CH3)2COO CI, formed from ten alkene–ozone systems with a range of different sizes and structures, under atmospherically relevant conditions in the EUPHORE chamber. Experiments in the presence of excess SO2 (an SCI scavenger) determined total SCI yields from each alkene–ozone system. Comparison of primary carbonyl yields in the presence/absence of SO2 determined the stabilisation fraction of a given CI. The results show that the stabilisation of a given CI increases as the size of the carbonyl co-product increases. This is interpreted in terms of the nascent population of CI formed following decomposition of the primary ozonide (POZ) having a lower mean energy distribution when formed with a larger carbonyl co-product, as more of the energy from the POZ is taken by the carbonyl. These findings have significant implications for atmospheric modelling of alkene ozonolysis. Higher stabilisation of small CI formed from large alkenes is expected to lead to lower radical yields from CI decomposition, and higher SCI concentrations, increasing the importance of SCI bimolecular reactions

Estudio longitudinal del crecimiento postraumatico y la calidad de vida en mujeres supervivientes de cancer de mama

Objective: The purpose of this study is to describe the relationship between posttraumatic growth (CPT) and Quality of Life (QoL) in a sample of women survivors of Breast Cancer, over three years after completion of treatment. Method: A sample of outpatients (N=156) completed the Argentinean adaptation of Posttraumatic Growth Inventory (PTGI) and Scale for the evaluation of chronic disease (FACIT-B). A longitudinal descriptive correlational study with a non-experimental design was used. The psychometric properties of the questionnaires used in the sample were evaluated. Pearson correlation was used to relate the two constructs and the Friedman test for assessing the existence of significant differences in the values of CPT and CV over time. Results: The median age was 60,7 (DT=9,0). The 54,5%, 50% and 53.9% of participants had moderate to high CPT in the first, second and third visits respectively. There were no significant differences among the three views (PTGI Total p=0,153). The highest levels of CPT are associated with better CV. This relationship is also maintained in the first visit (r =0,227; p=0,022), second (r=0,317; p=0,001) and third (r=0,304; p=0,002). CV was deficient and decreased over time. Conclusions: The CPT remained stable. It was found positive relations between the CPT and the CV, which were maintained over time.Objetivo: Describir la relación entre el Cre­cimiento Postraumático (CPT) y la Calidad de Vida (CV) en una muestra de mujeres supervi­vientes de Cáncer de Mama, a lo largo de tres años tras la finalización de los tratamientos. Método: A una muestra de pacientes ambu­latorios (N=156) administramos la adaptación Argentina del Inventario de Crecimiento Pos­traumático (PTGI) y de la Escala para la eva­luación de enfermedades crónicas (FACIT-B). Se realizó un estudio descriptivo correla­cional longitudinal con un diseño no experi­mental. Se valoraron las propiedades psico­métricas de los cuestionarios utilizados en la muestra. Se aplicó Correlación de Pearson para relacionar ambos constructos y el Test de Friedman para valorar la existencia de diferen­cias significativas en los valores de CPT y la CV a lo largo del tiempo. Resultados: La media de edad es de 60,7; (DT=9,0). Se encontró que el 54,5%, 50%, y 53,9% de las participantes presentaron CPT de moderado a alto a lo largo de las tres evaluaciones realizadas. No hubo diferencias significativas entre las tres visitas (p=0,153).  Los mayores niveles de CPT estuvieron rela­cionados con una mejor CV. Dicha relación se mantuvo además en la primera visita (r=0,227; p=0,022), en la segunda (r=0,317; p=0,001) y en la tercera (r=0,304; p=0,002). La CV fue deficitaria y empeoró a lo largo del tiempo. Conclusiones: El CPT permaneció estable. La CV fue disminuyendo. Se encontraron rela­ciones positivas entre el CPT y la CV, las cuales se mantuvieron a lo largo del tiempo

Multifactorial assessment and targeted intervention in nutritional status among the older adults: a randomized controlled trial: the Octabaix study

Background: Malnutrition is frequent among older people and is associated with morbi-mortality.he aim of the study is to assess the effectiveness of a multifactorial and multidisciplinary intervention in the nutritional status among the elderly. Methods: Randomized, single-blind, parallel-group, clinical trial conducted from January 2009 to December 2010 in seven primary health care centers in Baix Llobregat (Barcelona). Of 696 referred people, born in 1924, 328 subjects were randomized to an intervention group or a control group. The intervention model used an algorithm and was multifaceted for both the patients and their primary care providers. The main outcome was improvement in nutritional status assessed by Mini Nutritional Assessment (MNA). Data analyses were done by intention-to-treat. Results: Two-year assessment was completed for 127 patients (77.4%) in the intervention group and 98 patients (59.7%) in the control group. In the adjusted linear mixed models for MNA, intervention showed no significant effect during all follow-up period with −0.21 (CI: − 0.96; 0.26). In subjects with nutritional risk (MNA ≤ 23.5 / 30) existed a tendency towards improvement in MNA score 1.13 (95% CI −0.48; 2.74) after 2 years. Conclusion: A universal multifactorial assessment and target intervention over a two year period in subjects at nutritional risk showed a tendency to improve nutrition but not in the rest of community-dwelling studied subjects. Cognitive impairment was an independent factor strongly associated with a decline in nutritional status

Sexual Dysfunction and Atopic Dermatitis: A Systematic Review

Atopic dermatitis (AD) is a chronic inflammatory disease of the skin whose main symptom is pruritus and may affect all age ranges. Regarding the prevalence, it has been estimated at around 10% of the world population. Many concomitant diseases have been associated with AD, but the causal relationship between AD and psychological impairment has not been clearly established. Scientific literature studying the probable association between male or female sexual dysfunction and dermatological pathology is limited, even more so in AD. This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines and the Cochrane Collaboration methodology for systematic reviews. All relevant articles in English were identified through a search from inception to 10 December 2020, including the following databases: Medline (via PubMed), Scopus,Web of Science Core Collection, and SciELO. The results of the search were compiled using the COVIDENCE software for systematic reviews. The methodological quality of the included studies was done using the “Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies” and the “Quality Assessment of Case- Control Studies” developed by the National Heart, Lung, and Blood Institute, National Institutes of Health (NIH). Our search yielded potentially relevant studies. Five studies that evaluated the prevalence of sexual dysfunction in atopic dermatitis were retrieved after applying the selection criteria. The present systematic review achieved data from 8088 patients with atopic dermatitis from four articles. Sample sizes for atopic dermatitis patients ranged from 266 to 3997. We identified one cohort study with four years of follow-up, three studies with a cross-sectional design, and one casecontrol study. Three studies reported data disaggregated by the severity of atopic dermatitis. Two studies included healthy controls with a total sample size of 1,747,755 subjects. Two studies compared data with other dermatological conditions such as psoriasis. In conclusion, we can establish that unlike other psychological comorbidities such as anxiety and depression, sexual dysfunction is a field scarcely explored in the literature. This sexual dysfunction focuses on the male sex in large population studies and in clinical diagnoses without exploring it through specific and validated questionnaires in this regard. Further studies focused on both genders are needed. It is important to correlate this sexual dysfunction with the severity of the disease, previous treatments, and cardiovascular comorbidities

'REOFUT' as an observation tool for tactical analysis on offensive performance in soccer: Mixed method perspective

Performance analysis in complex sports like soccer requires the study of the influence of the interaction between both teams during the game on final performance. The mixed methods approach involves the collection, analysis, and interpretation of qualitative and quantitative data for the same purpose and within the framework of the same study. To build certain observation tools, mixed methods are necessary in order to take advantage of integration between qualitative and quantitative elements. The aim of this study was to develop a new no standard observation tool to analyze soccer offensive performance considering not only the observed team but also some aspects of the opponent behavior, as well as to test its reliability. The process consisted in expert meetings and exploratory observations. Experts carried out several design and re-design steps of the observation tool to its final form which includes two macro-criteria and 31 dimensions. The basic unit of analysis was the 'team possession' and the main aims of study were: (a) technical, tactical and spatial characteristics of the start, the development and the end of the team possession and its offensive performance, (b) the behavior of the observed team just after losing the ball possession and its defensive performance. Inter-observer and intra-observer analysis were carried out and kappa coefficient was calculated to test the observation tool reliability and improve the quality of data. Results indicate that optimal inter and intra-reliability levels obtained in this work are high enough as for suggesting that the observation tool for offensive performance in soccer (REOFUT) could be an adequate tool for analyzing offensive play actions and their performance in soccer

Multifactorial assessment and targeted intervention to reduce falls among the oldest-old: a randomized controlled trial

Background: The purpose of this study was to assess the effectiveness of a multifactorial intervention to reduce falls among the oldest-old people, including individuals with cognitive impairment or comorbidities. Methods: A randomized, single-blind, parallel-group clinical trial was conducted from January 2009 to December 2010 in seven primary health care centers in Baix Llobregat (Barcelona). Of 696 referred people who were born in 1924, 328 were randomized to an intervention group or a control group. The intervention model used an algorithm and was multifaceted for both patients and their primary care providers. Primary outcomes were risk of falling and time until falls. Data analyses were by intention-to-treat. Results: Sixty-five (39.6%) subjects in the intervention group and 48 (29.3%) in the control group fell during follow-up. The difference in the risk of falls was not significant (relative risk 1.28, 95% confidence interval [CI] 0.94-1.75). Cox regression models with time from randomization to the first fall were not significant. Cox models for recurrent falls showed that intervention had a negative effect (hazard ratio [HR] 1.46, 95% CI 1.03-2.09) and that functional impairment (HR 1.42, 95% CI 0.97-2.12), previous falls (HR 1.09, 95% CI 0.74-1.60), and cognitive impairment (HR 1.08, 95% CI 0.72-1.60) had no effect on the assessment. Conclusion: This multifactorial intervention among octogenarians, including individuals with cognitive impairment or comorbidities, did not result in a reduction in falls. A history of previous falls, disability, and cognitive impairment had no effect on the program among the community-dwelling subjects in this study

Una forma más equitativa de medir el desarrollo de género en España y sus comunidades autónomas

Antecedentes/Objetivos: Además del desarrollo de género, la equidad de género es un determinante estructural de la salud, importante para las políticas de salud pública. El índice de equidad de género (IEG) mide la distancia entre ambos sexos en las dimensiones empoderamiento, actividad económica y educación. Objetivo: Explorar la variabilidad en la inequidad de género en las comunidades autónomas (CC.AA.) de España en el año 2006, mediante la descripción del IEG modificado. Métodos: Estudio transversal ecológico. Dado que el IEG sólo hace visible la inequidad cuando es desfavorable a las mujeres, se calcula el IEG modificado que puede hacer visibles aquellos casos, de haberlos actualmente o en el futuro, en los que las mujeres están, en términos relativos, mejor que los hombres. Para ello, en lugar de calcular las diferencias de género en las dimensiones del IEG mediante un cociente de proporciones, estas se comparan en términos absolutos (diferencias en las proporciones). IEGm oscila entre –1 (inequidad hacia las mujeres), 0 (equidad) y 1 (inequidad hacia los hombres). Resultados: La inequidad desfavorable a las mujeres está presente en todas las CC.AA. de España (IEGm de España = –0,162). La más equitativa: País Vasco (–0,086). La menos, Navarra (–0,184). En actividad económica, todas las CC.AA. presentan inequidad desfavorable a las mujeres. Baleares es la más equitativa (–0,221). Castilla-La Mancha la menos (–0,355). Inversamente, en actividad económica, todas las CC.AA. presentan valores de inequidad desfavorables a los hombres. Castilla-La Mancha es la única CA donde el valor de la dimensión de empoderamiento es desfavorable a los hombres (0,033). Conclusiones: No contando el índice de equidad de género con dimensión de salud/esperanza de vida, su uso es útil en la búsqueda de asociaciones con la mortalidad. Dadas las diferencias interregionales en la equidad de género en España, la Ley de Igualdad y los Planes de Igualdad en las CC.AA. deben trabajar para asegurar la equidad entre mujeres y hombres en todas sus dimensiones. En España persisten las desigualdades interregionales este-oeste en el desarrollo de género, principalmente debido al peso del empoderamiento político en el IEGm

Pyogenic Granuloma in an Atypical Location Following Isotretinoin Treatment

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