Near-resonance in a System of Sub-Neptunes from TESS

We report the Transiting Exoplanet Survey Satellite detection of a multi-planet system orbiting the V = 10.9 K0 dwarf TOI-125. We find evidence for up to five planets, with varying confidence. Three transit signals with high signal-to-noise ratio correspond to sub-Neptune-sized planets (2.76, 2.79, and 2.94 R ⊕), and we statistically validate the planetary nature of the two inner planets (P b = 4.65 days, P c = 9.15 days). With only two transits observed, we report the outer object (P .03 = 19.98 days) as a planet candidate with high signal-to-noise ratio. We also detect a candidate transiting super-Earth (1.4 R ⊕) with an orbital period of only 12.7 hr and a candidate Neptune-sized planet (4.2 R ⊕) with a period of 13.28 days, both at low signal-to-noise ratio. This system is amenable to mass determination via radial velocities and transit-timing variations, and provides an opportunity to study planets of similar size while controlling for age and environment. The ratio of orbital periods between TOI-125 b and c (P c /P b = 1.97) is slightly lower than an exact 2:1 commensurability and is atypical of multiple planet systems from Kepler, which show a preference for period ratios just wide of first-order period ratios. A dynamical analysis refines the allowed parameter space through stability arguments and suggests that despite the nearly commensurate periods, the system is unlikely to be in resonance

Ferry Management Document, Rutherford County, NC, 2 January 1828

https://egrove.olemiss.edu/aldrichcorr_a/1043/thumbnail.jp

Towns and Cities as Multifunctional Centres

Whilst omni-channel retailing and the digital high street may be two of the latest talking points in the retail property industry, our towns and city centres have always been shaped by a series of technological, social and political revolutions. The purpose of this report is to examine how, after many years of mono-functionality focused upon retailing, our centres are experiencing something of a renaissance, and remerging as multi-functional ones, supporting leisure and recreation, employment, tourism, heritage, culture, housing, employment, education, health and wellbeing as well as retail. A multi-functional centre means a diverse offer, and, therefore, traditional economic indicators will not, on their own, act as a sensible yardstick of performance or tool for decision-making. For the multi-functional centre, activity levels are the key performance indicators. How much is the centre used, when and for what? Multi-functional centres draw people in for a much wider ‘bundle of benefits’ than just shopping. This requires all stakeholders to work together much more effectively to deliver a better collective experience in locations, to the commuter who may want to choose and collect at different times of the day, depending on their personal transport options and shift patterns, to the carer who may want to combine exercise and top-up shopping near to reliable respite care. Many of the newfound uses for underused or redundant retail space have resulted from structural changes in the retail sector, as well as from a more tightly gripped public purse. This has opened up the possibility for much more community involvement in the redevelopment and reuse of space. Sometimes this influx of creativity is only temporary, but it still demonstrates what an important asset an engaged community can be to a place, and what a difference it can make to vitality and viability. We think the retail property sector should work harder to integrate more local entrepreneurship and civic practice into both the development of new centres and the management of existing ones. The successful multi-functional centre will have both a multitude of users as well as a multitude of caretakers. Most of all, our report argues that all retail developments (both new and existing) have to integrate more effectively into the overall offer of the multi-functional centre. Decision making and management must become less hierarchical and myopic and more place-based and ‘porous’ to allow more intelligence and input from the location

High Street UK 2020 Interim Project Report: Identifying factors that influence vitality and viability

The purpose of this document is to report the progress of the High Street UK2020 (HSUK2020) project. Started in January 2014, HSUK2020 aims to bring evidence to 10 UK High Streets, to improve local decision making that will improve vitality and viability. The 10 partner locations are Alsager, Altrincham, Ballymena, Barnsley, Bristol (St George), Congleton, Holmfirth, Market Rasen, Morley and Wrexham. The report outlines the background to the project, the methods we have employed, the results we have found and a brief overview of how some of our partner towns are using these findings. By undertaking a systematic review of the literature and, through adopting a more ‘engaged’ model of scholarship, the project has identified 201 factors that influence the performance of the UK High Street. This has enabled us to classify the top 25 priorities for action our partner towns should focus on

High Street UK 2020 Project Report

The purpose of this document is to report the progress of the High Street UK2020 (HSUK2020) project. Started in January 2014, HSUK2020 aims to bring evidence to 10 UK High Streets, to improve local decision making that will improve vitality and viability. The 10 partner locations are Alsager, Altrincham, Ballymena, Barnsley, Bristol (St George), Congleton, Holmfirth, Market Rasen, Morley and Wrexham. The report outlines the background to the project, the methods we have employed, the results we have found and a brief overview of how some of our partner towns are using these findings. By undertaking a systematic review of the literature and, through adopting a more ‘engaged’ model of scholarship, the project has identified 201 factors that influence the performance of the UK High Street. This has enabled us to classify the top 25 priorities for action our partner towns should focus on

Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

Depolarization of an individual mitochondrion or small clusters of mitochondria within cells has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the mitochondrion by an alkyltriphenylphosphonium lipophilic cation and releases the protonophore 2,4-dinitrophenol locally in predetermined regions in response to directed irradiation with UV light via a local photolysis system. This also provides a proof of principle for the general temporally and spatially controlled release of bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity

Detection of interstellar oxidaniumyl: abundant H2O+ towards the star-forming regions DR21, Sgr B2, and NGC6334

We identify a prominent absorption feature at 1115 GHz, detected in first HIFI spectra towards high-mass star-forming regions, and interpret its astrophysical origin. The characteristic hyperfine pattern of the H2O+ ground-state rotational transition, and the lack of other known low-energy transitions in this frequency range, identifies the feature as H2O+ absorption against the dust continuum background and allows us to derive the velocity profile of the absorbing gas. By comparing this velocity profile with velocity profiles of other tracers in the DR21 star-forming region, we constrain the frequency of the transition and the conditions for its formation. In DR21, the velocity distribution of H2O+ matches that of the [CII] line at 158\mu\m and of OH cm-wave absorption, both stemming from the hot and dense clump surfaces facing the HII-region and dynamically affected by the blister outflow. Diffuse foreground gas dominates the absorption towards Sgr B2. The integrated intensity of the absorption line allows us to derive lower limits to the H2O+ column density of 7.2e12 cm^-2 in NGC 6334, 2.3e13 cm^-2 in DR21, and 1.1e15 cm^-2 in Sgr B2.Comment: Accepted for publication in A&

Evidence for Irradiation Triggered Nonuniform Defect Distribution In Multiharmonic Magnetic Susceptibility of Neutron Irradiated YBa2Cu3O7-x

Multiharmonic ac-magnetic susceptibility \ch11,\chi2,chi3, of neutron irradiated Li-doped YBa2Cu3O7-x has revealed a nonmonotonic dependence of all harmonics on the neutron fluence. The irradiation has a strongly depressive influence on the intergrain connection suggesting an increase of the effective thickness of the intergranular Josephson junction at aneutron fluence of 0.98x10$^{17}$ cm$_{-2}$. Less damaged are the intragrain properties. A spectacular enhancement of the superconducting intragranular properties reflected in the characteristics of all harmonics was observed at highest fluence \Phi = 9.98x10$^{17}$ cm$_{-2}$. We assume that this effect results from the development of a space inhomogeneous distribution with alternating defectless and defect rich regions.Comment: 24 pages, 9 figures, accepted to J. Supercon

Transfer of immunoglobulins through the mammary endothelium and epithelium and in the local lymph node of cows during the initial response after intramammary challenge with E. coli endotoxin

<p>Abstract</p> <p>Background</p> <p>The first hours after antigen stimulation, interactions occur influencing the outcome of the immunological reaction. Immunoglobulins originate in blood and/or are locally synthesized. The transfer of Ig isotypes (Igs) in the udder has been studied previously but without the possibility to distinguish between the endothelium and the epithelium. The purpose of this study was to map the Ig transfer through each barrier, separately, and Ig transfer in the local lymph nodes of the bovine udder during the initial innate immune response.</p> <p>Methods</p> <p>The content of IgG1, IgG2, IgM, IgA and albumin (BSA) was examined in peripheral/afferent mammary lymph and lymph leaving the supramammary lymph nodes, and in blood and milk before (0 h) and during 4 hours after intramammary challenge with <it>Esherichia coli </it>endotoxin in 5 cows.</p> <p>Results</p> <p>Igs increased most rapidly in afferent lymph resulting in higher concentrations than in efferent lymph at postinfusion hour (PIH) 2, contrary to before challenge. Ig concentrations in milk were lower than in lymph; except for IgA at 0 h; and they increased more slowly. <it>Afferent lymph:serum </it>and <it>efferent lymph:serum </it>concentration ratios (CR) of Igs were similar to those of BSA but slightly lower. <it>Milk:afferent lymph </it>(M:A) CRs of each Ig, except for IgG2, showed strikingly different pattern than those of BSA. The M:A CR of IgG1, IgM and IgA were higher than that of BSA before challenge and the CR of IgA and IgG1 remained higher also thereafter. At PIH 2 there was a drop in Ig CRs, except for IgG2, in contrast to the BSA CR which gradually increased. The M:A CR of IgM and Ig A <it>decreased </it>from 0 h to PIH 4, in spite of increasing permeability.</p> <p>Conclusion</p> <p>The transfer of Igs through the <it>endothelium </it>appeared to be merely a result of diffusion although their large molecular size may hamper the diffusion. The transfer through the <it>epithelium </it>and the Ig concentrations in milk seemed more influenced by selective mechanisms and local sources, respectively. Our observations indicate a selective mechanism in the transfer of IgG1 through the epithelium also in lactating glands, not previously shown; a local synthesis of IgA and possibly of IgM, released primarily into milk, not into tissue fluid; that IgG2 transfer through both barriers is a result of passive diffusion only and that the content of efferent lymph is strongly influenced by IgG1, IgM and IgA in the mammary tissue, brought to the lymph node by afferent lymph.</p