The population of donkeys and mules in Brazil according to agricultural censuses from 1960 to 2017

Para entender e gerenciar melhor a população de jumentos e mulas é essencial saber informações sobre seu tamanho. Em países em desenvolvimento, esses animais são frequentemente usados como animais de trabalho, principalmente por populações pobres na agricultura e pecuária, mas seu uso está diminuindo no Brasil. Os dados oficiais brasileiros sobre jumentos e mulas começaram a ser mensurados no censo agrícola de 1960 e a partir dessa época foram realizados oito censos agrícolas. Até a redação deste artigo, porém, nenhum trabalho científico analisou os resultados dos censos agropecuários quanto à população de jumentos e mulas no Brasil. Deste modo, nosso objetivo é compilar e analisar os dados oficiais brasileiros de 1960 até 2017, para aprimorar as ações dos stakeholders, pesquisadores e tomadores de decisão preocupados com os jumentos e mulas brasileiras.To better understand and manage the population of donkeys and mules, it is essential to know information about its size. In developing countries, these animals are often used as working animals, mainly by poor populations in agricultural and livestock labor, but their use is decreasing in Brazil. Brazilian official data regarding donkeys and mules started to be measured at the agricultural census of 1960 and, from that time, eight agricultural censuses were published. But until the writing of this paper, no scientific paper was dedicated to the analysis of the results of the official agricultural censuses on the population of donkeys and mules in Brazil. Thus, we aim to compile and analyze the official Brazilian data from 1960 until 2017 to enhance the actions of stakeholders, researchers, and decision-makers concerned with Brazilian donkeys and mules

High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil

The role of human papillomavirus (HPV) in oral carcinogenesis is still controversial as detection rates of the virus in oral cavity reported in the literature varies greatly. Objective The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil. Material and Methods We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers. Genotyping was performed by multiplex PCR. Results Benign, premalignant and malignant lesions were diagnosed by histopathology. HPV was detected in 17 samples. Of these, HPV-6 was detected in 10 samples, HPV-18 in four and HPV-16 in one sample. When samples were categorized by lesion types, HPV was detected in two papilloma cases (2/3), five carcinomas (5/6), one hyperplasia (1/1) and nine dysplasia cases (9/11). Conclusion Unlike other studies in the literature, we reported high occurrence of HPV in oral lesions. Further studies are required to enhance the comprehension of natural history of oral lesions

Deregulated expression of Nucleophosmin 1 in gastric cancer and its clinicopathological implications

Background: the process of gastric carcinogenesis still remains to be elucidated. the identification of genes related to this process may help to reduce mortality rates through early diagnosis and the development of new anticancer therapies. Nucleophosmin 1 (NPM1) acts in ribosome biogenesis, centrosome duplication, maintenance of genomic stability, and embryonic development. Recently, NPM1 has been implicated in the tumorigenesis processes. Here, we evaluated NPM1 gene and protein expression in gastric tumors and in corresponding non-neoplastic gastric samples.Methods: NPM1 protein expression was determined by Western blot in 17 pairs of gastric tumors and corresponding non-neoplastic gastric tissue. the protein immunoreactivity was observed in 12 tumor samples. mRNA expression was evaluated by reverse transcription quantitative polymerase chain reaction (RT-qPCR) in 22 pairs of gastric tumors and in matched non-neoplastic gastric tissue.Results: NPM1 protein expression was significantly reduced in gastric cancer samples compared to matched non-neoplastic gastric samples (P = 0.019). the protein level of NPM1 was reduced at least 1.5-fold in 35% of tumors compared to paired non-neoplastic gastric tissue. However, NPM1 immunoreactivity was detected in neoplastic and non-neoplastic cells, including in intestinal metaplastic, gastritis and inflammatory cells. NPM1 was mainly expressed in nucleus and nucleolus subcellular compartments. the staining intensity and the percentage of immunoreactive cells varied among the studied cases. the NPM1 mRNA level was reduced at least 1.5-fold in 45.5% of samples and increased in 27.3% of samples. An inverse correlation between protein and mRNA expression was detected (r = -0.509, P = 0.037). Intestinal-type gastric cancer presented higher mRNA levels than diffuse-type (P = 0.026). However, reduced NPM1 protein expression was associated with intestinal-type gastric cancer compared to matched non-neoplastic gastric samples (P = 0.018). in addition, tumors from patients with known distant metastasis presented reduced NPM1 protein levels compared to tumors from patients without distant metastasis (P < 0.001).Conclusion: Although the expression of NPM1 is heterogeneous in gastric tumors, our results suggest that NPM1 down-regulation may have a role in gastric carcinogenesis and may help in the selection of anticancer treatment strategies.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Dept Morphol & Genet, Div Genet, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Orthoped & Traumatol, BR-04038031 São Paulo, BrazilUniv São Paulo, Sch Med, Dept Radiol, Expt Oncol Lab, BR-01246903 São Paulo, BrazilSão Paulo State Canc Inst, Ctr Translat Oncol, BR-01246000 São Paulo, BrazilFed Univ Para, Joao de Barros Barreto Univ Hosp, Oncol Res Ctr, BR-60673000 Belem, Para, BrazilFed Univ Para, Inst Biol Sci, Human Cytogenet Lab, BR-66073000 Belem, Para, BrazilUniversidade Federal de São Paulo, Dept Morphol & Genet, Div Genet, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Orthoped & Traumatol, BR-04038031 São Paulo, BrazilWeb of Scienc

Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3 ' Untranslated Region 1630 C > T Polymorphism and Copy Number Variation

PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. the T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Disciplina Genet, Dept Morfol & Genet, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ortopedia & Traumatol, São Paulo, BrazilUniversidade Federal de São Paulo, Fac Med, Dept Radiol, Lab Oncol Expt, São Paulo, BrazilInst Canc Estado São Paulo, Ctr Invest Translat Oncol, São Paulo, BrazilFed Univ Para, Hosp Univ Joao Barros Barreto, BR-66059 Belem, Para, BrazilFed Univ Para, Inst Ciencias Biol, Lab Citogenet Humana, BR-66059 Belem, Para, BrazilUniversidade Federal de São Paulo, Disciplina Genet, Dept Morfol & Genet, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ortopedia & Traumatol, São Paulo, BrazilUniversidade Federal de São Paulo, Fac Med, Dept Radiol, Lab Oncol Expt, São Paulo, BrazilWeb of Scienc

Staphylococcal scalded skin syndrome: case report

A síndrome da pele escaldada estafilocócica é um distúrbio bolhoso induzido por toxinas esfoliativas associado à infecção por Staphylococcus aureus, cujo exato mecanismo ainda é incerto manifestando-se com a formação de lesões bolhosas difusas pelo corpo que, usualmente, afeta crianças menores de 5 anos. O caso relatado apresenta uma criança de 4 meses de idade que manifestou lesões na pele de início recente, com hiperemia e bolhas no tronco, membros superiores e face, as quais evoluíram com descamação, além de edema peripalpebral, secreção ocular bilateral e crostas em região perioral. O prognóstico é favorável e o tratamento consiste em antibioticoterapia sistêmica ou oral, além de terapia de suporte na vigência de alterações hidroeletrolíticas e da termorregulação. Como o paciente apresentou melhora das lesões e encontrava-se em bom estado geral, o esquema foi trocado por Sulfametoxazol + Trimetoprima após o antibiograma evidenciar sensibilidade, por mais 7 dias a nível ambulatorial. O paciente apresentou boa resposta ao tratamento e evoluiu sem cicatrizes.Staphylococcal scalded skin syndrome is a bullous disorder induced by exfoliative toxins associated with Staphylococcus aureus infection, its exact mechanism of which is still uncertain, manifesting itself with the formation of diffuse bullous lesions throughout the body, that usually affects children under 5 years. The case reported presents a 4-month-old child who presented skin lesions of recent onset, with hyperemia and blisters on the trunk, upper limbs and face, which evolved with scaling, in addition to peripalpebral edema, bilateral eye secretion and crusts in the perioral region. The prognosis is favorable and the treatment consists of systemic or oral antibiotic therapy, in addition to supportive therapy in the presence of hydroelectrolytic changes and thermoregulation. As the patient had improved lesions and was in good general condition, the scheme was replaced by Sulfamethoxazole + Trimethoprim, after the antibiogram showed sensitivity, for another 7 days on an outpatient basis. The patient presented good response to treatment and evolved without scars

Rarity of monodominance in hyperdiverse Amazonian forests.

Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence of monodominance in a massive, basin-wide database of forest-inventory plots from the Amazon Tree Diversity Network (ATDN). Utilizing a simple defining metric of at least half of the trees ≥ 10 cm diameter belonging to one species, we found only a few occurrences of monodominance in Amazonia, and the phenomenon was not significantly linked to previously hypothesized life history traits such wood density, seed mass, ectomycorrhizal associations, or Rhizobium nodulation. In our analysis, coppicing (the formation of sprouts at the base of the tree or on roots) was the only trait significantly linked to monodominance. While at specific locales coppicing or ectomycorrhizal associations may confer a considerable advantage to a tree species and lead to its monodominance, very few species have these traits. Mining of the ATDN dataset suggests that monodominance is quite rare in Amazonia, and may be linked primarily to edaphic factors

Abordagem endovascular na terapêutica da coarctação de aorta / Endovascular approach in aortic coarctation therapy

INTRODUÇÃO: A coarctação de aorta (CoA) é uma cardiopatia congênita que se define por um estreitamento da aorta, com altas taxas de morbidade e mortalidade. Os procedimentos de tratamento disponíveis incluem cirurgia e dilatação de balão endovascular com ou sem colocação de stent. O atual manejo endovascular da doença da aorta torácica conseguiu diminuir a mortalidade de 40% para 14%.METODOLOGIA: Foi realizada a busca por literaturas nas bases de dados MEDLINE/PubMed, LILACS e SciELO. Utilizou-se o recorte temporal entre os anos de 2011 e 2021 e os descritores “Coarctação Aórtica”, “Procedimentos Endovasculares” e “Terapêutica”. Foram selecionados artigos que melhor se encaixavam na busca.RESULTADOS: O tratamento endovascular reduziu significativamente a morbidade intra-hospitalar e pós-operatória quando comparado a outras técnicas de tratamento.DISCUSSÃO: O tratamento cirúrgico de coarctação da aorta está associado a complicações potenciais, como aneurisma, hipertensão e doença cerebral crônica durante o período de acompanhamento. Diante disso, o desejo de reduzir a morbimortalidade associada ao procedimento cirúrgico motivou a terapia endovascular para a doença. Ambas as opções de tratamento da CoA possuem particularidades que devem ser levadas em consideração no tratamento dessa patologia.CONCLUSÃO: O tratamento endovascular apresentou benefícios em relação ao tratamento cirúrgico, visto que houve a redução das complicações, morbidade intra-hospitalar e pós-operatória

Estudos Artísticos

A arte inclui no seu sistema os mesmos processos que reproduzem o poder ou que renovam as suas retóricas através de astúcias de resistência. Criou-se me tempos a proposta radical de uma arte emancipada, independente de referencialidade para além dos valores plásticos. Esta radicalidade escondia afinal um conformismo otimista e modernista: a arte “abstrata” era conservadora, decorativa, e não incomodava afinal ninguém. Aqui se mostra a oportunidade deste desafio, da chamada de artigos que esta Revista Croma 14 convocou: o desafio é entrar no caleidoscópio das ilusões sem perder o norte, sem abdicar do sentido último da cultura, que é mais humanidade, mais inteira, mais consciente.info:eu-repo/semantics/publishedVersio