Intelligence and video games: beyond “brain-games”

Video games are among the most popular leisure activities in current Western societies. Psychology research has shown correlations, at the latent level, between intelligence and video games ranging from 0.60 to 0.93. Here we analyze whether video games genre can account for this range of correlations by testing one hundred and thirty-four participants playing ten video games of different genres for iPad® and WiiU® (Art of Balance®, Blek, Crazy Pool, EDGE®, Hook, Rail Maze, SkyJump, Space Invaders, Splatoon® and Unpossible) within a controlled playing environment. Gaming performance was correlated with standard measures of fluid reasoning, visuospatial ability, and processing speed. Results revealed a correlation value of 0.79 between latent factors representing general intelligence (g) and video games general performance (gVG). This finding leads to conclude that: (1) performance intelligence tests and video games is supported by shared cognitive processes and (2) brain-games are not the only genre able to produce performance measures comparable to intelligence standardized tests. From a theoretical perspective, the observed result supports the principle of the indifference of the indicator that has been addressed in intelligence research across decade

The effects of electron cyclotron heating and current drive on toroidal Alfven eigenmodes in tokamak plasmas

Dedicated studies performed for toroidal Alfvén eigenmodes (TAEs) in ASDEX-Upgrade (AUG) discharges with monotonic q-profiles have shown that electron cyclotron resonance heating (ECRH) can make TAEs more unstable. In these AUG discharges, energetic ions driving TAEs were obtained by ion cyclotron resonance heating (ICRH). It was found that off-axis ECRH facilitated TAE instability, with TAEs appearing and disappearing on timescales of a few milliseconds when the ECRH power was switched on and off. On-axis ECRH had a much weaker effect on TAEs, and in AUG discharges performed with co- and counter-current electron cyclotron current drive (ECCD), the effects of ECCD were found to be similar to those of ECRH. Fast ion distributions produced by ICRH were computed with the PION and SELFO codes. A significant increase in Te caused by ECRH applied off-axis is found to increase the fast ion slowing-down time and fast ion pressure causing a significant increase in the TAE drive by ICRH-accelerated ions. TAE stability calculations show that the rise in Te causes also an increase in TAE radiative damping and thermal ion Landau damping, but to a lesser extent than the fast ion drive. As a result of the competition between larger drive and damping effects caused by ECRH, TAEs become more unstable. It is concluded, that although ECRH effects on AE stability in present-day experiments may be quite significant, they are determined by the changes in the plasma profiles and are not particularly ECRH specific.EURATOM 633053RCUK Energy Programme P012450/

Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I

We have previously shown that the administration of low doses of insulin-like growth factor-I (IGF-I) to CCl4-cirrhotic rats improves liver function and reduces fibrosis. To better understand the mechanisms behind the hepatoprotective effects of IGF-I, and to identify those genes whose expression is affected in cirrhosis and after IGF-1 treatment, we have performed differential display of mRNA analysis by means of polymerase chain reaction (PCR) in livers from control and CCl4-cirrhotic rats treated or not with IGF-I. We have identified 16 genes that were up- or down-regulated in the cirrhotic liver. IGF-I treatment partially normalized the expression of eight of these genes, including serine proteinase inhibitors such as serpin-2 and alpha-1-antichymotripsin, alpha-1-acid glycoprotein, and alpha-2u-globulin. Additionally, we show that IGF-I enhanced the regenerative activity in the cirrhotic liver, as determined by the increased expression of the proliferating cell nuclear antigen (PCNA). Finally, IGF-I treatment partially restored the expression of growth hormone receptor (GHR) and the levels of global genomic DNA methylation, which are reduced in human and experimental cirrhosis. Taken together, our observations confirm the hepatoprotective effects of IGF-I, and suggest that this action can be exerted in part through the normalization of liver gene expression, growth hormone (GH) responsiveness and global genomic DNA methylation

Entrenamiento en habilidades básicas de gestión de grupos para la mejora de la competencia transversal de hablar en público: protocolo para alumnos de posgrado de Psicología

El presente proyecto se enmarca en la mejora educativa de dos grandes bloques: 1)La mejora de competencias transversales indispensables en la carrera académica de cualquier alumno universitario. En este proyecto en concreto, se abordará la tarea de hablar en público, que ostenta un papel central en el desempeño de los alumnos en la práctica totalidad de asignaturas y en la potenciación de sus destrezas básicas a ofrecer en su futuro profesional. 2)La mejora educativa de alumnos del Master Oficial en Psicología General Sanitaria, como parte aplicada de su formación. Atendiendo al primer bloque, son múltiples las situaciones en las que los alumnos han de enfrentarse a un público y exponer o defender un trabajo, opinión etc… Ante esta situación, tradicionalmente se ha dado mayor peso a cuestiones de contenido (lo que se expone) y no tanto a cuestiones de forma (cómo se hace). La demanda de servicios que presten atención y ayuda en este ámbito va en aumento. Desde un punto de vista comunitario cada vez son más las asociaciones, fundaciones, escuelas que se dirigen a potenciar esta destreza (p. ej. ToastMaster). En el mismo sentido, desde un contexto clínico, se observa la misma tendencia de demanda de ayuda, en este caso profesional, para hacer frente a este tipo de situaciones, fundamentalmente por parte de alumnos universitarios. La ansiedad a exponer es un fenómeno ampliamente estudiado y relacionados con síndromes clínicos, como por ejemplo la Fobia Social. La carrera universitaria exige a sus alumnos tareas, ejercicios, exámenes… que requieren la puesta en práctica de esta competencia. Además, no es un fenómeno exclusivo de ninguna disciplina concreta, por lo que esta competencia es transversal a diferentes asignaturas y ramas del conocimiento. Un enfoque comunitario (desde la universidad) y focalizado (para universitarios) supondría atender a la competencia transversal de hablar en público de una manera formal y sistematizada, centrándose en el aprendizaje de la forma (cómo se hace) y de aquellos factores que pudieran interferir (ansiedad, timidez…). El segundo bloque que define este proyecto va dirigido a la mejora educativa de los alumnos del Máster Oficial en Psicología General Sanitaria. Parte de su formación práctica supone la confección, planificación y ejecución de planes de psicoeducativos de salud. Todos los miembros de este proyecto guardamos relación, de una u otra manera con la Clínica Universitaria de Psicología de la UCM (CUP-UCM), centro de prácticas del itinerario del citado master. Esto supone una excepcional oportunidad de añadir a su plan formativo de rotación por la CUP-UCM, el diseño y ejecución de estos talleres, siempre bajo estrecha supervisión y acompañamiento de miembros del proyecto

Non-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea

Background Non-invasive ventilation (NIV) is an effective form of treatment in patients with obesity hypoventilation syndrome (OHS) who have concomitant severe obstructive sleep apnoea (OSA). However, there is a paucity of evidence on the efficacy of NIV in patients with OHS without severe OSA. We performed a multicentre randomised clinical trial to determine the comparative efficacy of NIV versus lifestyle modification (control group) using daytime arterial carbon dioxide tension (PaCO2) as the main outcome measure. Methods Between May 2009 and December 2014 we sequentially screened patients with OHS without severe OSA. Participants were randomised to NIV versus lifestyle modification and were followed for 2 months. Arterial blood gas parameters, clinical symptoms, health-related quality of life assessments, polysomnography, spirometry, 6-min walk distance test, blood pressure measurements and healthcare resource utilisation were evaluated. Statistical analysis was performed using intention-to-treat analysis. Results A total of 365 patients were screened of whom 58 were excluded. Severe OSA was present in 221 and the remaining 86 patients without severe OSA were randomised. NIV led to a significantly larger improvement in PaCO2 of -6 (95% CI -7.7 to -4.2) mm Hg versus -2.8 (95% CI -4.3 to -1.3) mm Hg, (p<0.001) and serum bicarbonate of -3.4 (95% CI -4.5 to -2.3) versus -1 (95% CI -1.7 to -0.2 95% CI) mmol/L (p<0.001). PaCO2 change adjusted for NIV compliance did not further improve the inter-group statistical significance. Sleepiness, some health-related quality of life assessments and polysomnographic parameters improved significantly more with NIV than with lifestyle modification. Additionally, there was a tendency towards lower healthcare resource utilisation in the NIV group. Conclusions NIV is more effective than lifestyle modification in improving daytime PaCO2, sleepiness and polysomnographic parameters. Long-term prospective studies are necessary to determine whether NIV reduces healthcare resource utilisation, cardiovascular events and mortality

The Metabolic and Hepatic Impact of Two Personalized Dietary Strategies in Subjects with Obesity and Nonalcoholic Fatty Liver Disease: The Fatty Liver in Obesity (FLiO) Randomized Controlled Trial

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. NAFLD management is mainly focused on weight loss, but the optimal characteristics of the diet demand further investigation. This study aims to evaluate the effects of two personalized energy-restricted diets on the liver status in overweight or obese subjects with NAFLD after a 6 months follow-up. Ninety-eight individuals from the Fatty Liver in Obesity (FLiO) study were randomized into two groups and followed different energy-restricted diets. Subjects were evaluated at baseline and after 6 months. Diet, anthropometry, body composition, and biochemical parameters were evaluated. Liver assessment included ultrasonography, Magnetic Resonance Imaging, elastography, and determination of transaminases. Both dietary groups significantly improved their metabolic and hepatic markers after the intervention, with no significant differences between them. Multivariate regression models evidenced a relationship between weight loss, adherence to the Mediterranean Diet (MedDiet), and a decrease in liver fat content, predicting up to 40.9% of its variability after 6 months. Moreover, the antioxidant capacity of the diet was inversely associated with liver fat content. Participants in the group with a higher adherence to the MedDiet showed a greater reduction in body weight, total fat mass, and hepatic fat. These results support the benefit of energy-restricted diets, high adherence to the MedDiet, and high antioxidant capacity of the diet for the management of NAFLD in individuals with overweight or obesity

Zolmitriptan: a novel portal hypotensive agent which synergizes with propranolol in lowering portal pressure

OBJECTIVE: Only a limited proportion of patients needing pharmacological control of portal hypertension are hemodynamic responders to propranolol. Here we analyzed the effects of zolmitriptan on portal pressure and its potential interaction with propranolol. METHODS: ZOLMITRIPTAN, PROPRANOLOL OR BOTH WERE TESTED IN TWO RAT MODELS OF PORTAL HYPERTENSION: common bile duct ligation (CBDL) and CCl4-induced cirrhosis. In these animals we measured different hemodynamic parameters including portal venous pressure, arterial renal flow, portal blood flow and cardiac output. We also studied the changes in superior mesenteric artery perfusion pressure and in arterial wall cAMP levels induced by zolmitriptan, propranolol or both. Moreover, we determined the effect of splanchnic sympathectomy on the response of PVP to zolmitriptan. RESULTS: In both models of portal hypertension zolmitriptan induced a dose-dependent transient descent of portal pressure accompanied by reduction of portal flow with only slight decrease in renal flow. In cirrhotic rats, splanchnic sympathectomy intensified and prolonged zolmitriptan-induced portal pressure descent. Also, propranolol caused more intense and durable portal pressure fall when combined with zolmitriptan. Mesenteric artery perfusion pressure peaked for about 1 min upon zolmitriptan administration but showed no change with propranolol. However propranolol enhanced and prolonged the elevation in mesenteric artery perfusion pressure induced by zolmitriptan. In vitro studies showed that propranolol prevented the inhibitory effects of β2-agonists on zolmitriptan-induced vasoconstriction and the combination of propranolol and zolmitriptan significantly reduced the elevation of cAMP caused by β2-agonists. CONCLUSION: Zolmitriptan reduces portal hypertension and non-selective beta-blockers can improve this effect. Combination therapy deserves consideration for patients with portal hypertension failing to respond to non-selective beta-blockers