Future fuels and engines for railroad locomotives. Volume 1: Summary

The potential for reducing the dependence of railroads on petroleum fuel, particularly Diesel No. 2 was investigated. Two approaches are studied: (1) to determine how the use of Diesel No. 2 can be reduced through increased efficiency and conservation, and (2) to use fuels other than Diesel No. 2 both in Diesel and other types of engines. Because synthetic hydrocarbon fuels are particularly suited to medium speed diesel engines, the first commercial application of these fuels may be by the railroad industry

Effect of Planting Density on Growth Parameters and Fruit Yield in Guava (Psidium guajava L.) cv. Allahabad Safeda Cultivated under Mild Humid Conditions of Coorg

A study was carried out in 'Allahabad Safeda' guava (Psidium guajava L.) to standardize the effect of planting densities on growth parameters viz., scion girth, plant height, and spread (East - West and North - South), canopy area, canopy volume and fruit yield over a ten years period. The trial was laid out with five planting densities viz., 6x3, 6x4, 6x6, 8x4, 8x3m accommodating 555, 416, 277, 312 and 416 plants/ha respectively with four replications having sixteen plants per treatment in a randomized block design during 1988-89 season. The grafted plants on seedling rootstock were planted and the yield data were recorded from 1992 to 1997. The results indicated that the scion girth was significantly higher in 8x3 or 8x4m configurations. There were no significant differences among treatments for plant height. The plant spread across East-West direction was however significant in 8x3m. The fruit yield in Mrig bahar was significantly higher as compared to that of Hasth bahar in terms of fruit number and weight. Land Use Index (LUI) values exceeding 50% had bearing on the productivity of different configurations. The productivity was nearly double in 6x3m where, the planting density was twice as much in recommended spacing (6x6m) by sixth year of planting after which, yield levels declined. Thus, it was concluded that a spacing of 6x3m having 555 plants/ha, gives the highest productivity in 'Allahabad Safeda' guava by sixth year of planting under North Coorg conditions

What is Information Worth for an Extra Quintal of Grain?: Randomised Experimental Evidence from Farmers in India

This study evaluates whether access to real-time customised idiosyncratic agricultural information over extended seasons improves the value of such information among farmers. We conduct a controlled randomised experiment in the Indian state of Karnataka. The study employs the difference-in-difference method to a panel of households comparing the differential valuation of information during the post-intervention period between treatment (participant) and control (non-participant) farmers relative to the outcomes observed during a pre-intervention period. We find robust evidence of the intervention showing significantly positive impacts on the valuation of agricultural information among treatment farmers relative to the control farmers. A difference of each one unit improvement in information access is found to be associated with 53 percent average increase in the mean valuation of the information. The result indicates that farmers value information that is comprehensive, reliable, real-time and idiosyncratic as opposed to the more generic or piecemeal information

Annual radial growth cycle of grapevine trunk in the tropics

The annual radial trunk growth cycle in V. vinifera var. Anab-e-Shahi was studied in the tropics where the vines are pruned twice a year. Although vines grow continuously without any period of dormancy, a consistant pattern of maximum girth increment from April to September altemating with negligible increment from October to March was observed. The rate of annual girth increment was high during juvenile period and steadily decreased later. There is further need to study the physiology of growth and fruiting of tropical grapevines under conditions of nondormancy as modified by two prunings in a year.Der jährliche Wachstumszyklus der Stammdicke von Reben in den TropenDie Rebensorte Anab-e-Shahi (Vitis vinifera) wird in den Tropen jährlich zweimal geschnitten. Der jährliche Wachstumszyklus der Stammdicke unter diesen Bedingungen wurde untersucht. Obgleich die Reben kontinuierlich - ohne jede Ruheperiode - wachsen, wurde durchweg von April bis September ein maximaler Zuwachs des Stammumfanges und von Oktober bis März nur ein unbedeutendes Dickenwachstum festgestellt. Die jährliche Zuwachsrate des Stammumfanges war beim jungen Weinstock hoch; später nahm sie ständig ab. Weitere Untersuchungen zur Physiologie des Wachstums und der Fruchtentwicklung von Reben unter tropischen Bedingungen, d. h. ohne Zwischenschaltung einer Ruheperiode und modifiziert durch zweimaligen Rebschnitt, sind erforderlich

ACCURACY OF FNAC IN FEMALE BREAST LESIONS

Background: Various breast lesions are common lesions in females with a wide range of variability from inflammatory lesions, benign and malignant breast lesions. FNAC is first diagnostic test, as it has high sensitivity and specificity. Lesions were categorized on FNA into inflammatory lesions, benign neoplastic lesions, malignant neoplastic lesions, and suspicious for malignancy. Methods: This was a retrospective study done in the Department of Pathology, P.D.U. Medical College, Rajkot, Gujarat State, India from Aug-2013 to July 2014. FNAC of 392 cases of breast lesions were done and reported by expert pathologist. The histopathological specimens when available were reported by other pathologist without prior knowledge of FNA diagnosis. Sensitivity, Specificity and Accuracy of FNA diagnosis were then analyzed. Results: A total of 392 cases of breast lesions were diagnosed on FNA, out of them histopathological correlation was available in 87 cases. Benign breast lesions are more common in younger patients in 21-30 yrs age group and malignant lesions are more common in old age group patients of 41-60 yrs with few exceptions. In our setup fibroadenoma is the most common benign breast lesion (26.53%) and ductal carcinoma (17.86%) is the most common malignant lesion. The sensitivity, specificity and accuracy of FNAC for malignant lesions were found to be 91.43%, 100% and 96.25% respectively. Conclusion: FNAC is an effective and valid tool as the first line diagnostic modality in the preoperative diagnosis of the malignant and benign breast lesions.KEYWORDS: FNAC; Breast lesions; Fibroadenoma; Ductal carcinoma

ACCURACY OF FNAC IN FEMALE BREAST LESIONS

Background: Various breast lesions are common lesions in females with a wide range of variability from inflammatory lesions, benign and malignant breast lesions. FNAC is first diagnostic test, as it has high sensitivity and specificity. Lesions were categorized on FNA into inflammatory lesions, benign neoplastic lesions, malignant neoplastic lesions, and suspicious for malignancy. Methods: This was a retrospective study done in the Department of Pathology, P.D.U. Medical College, Rajkot, Gujarat State, India from Aug-2013 to July 2014. FNAC of 392 cases of breast lesions were done and reported by expert pathologist. The histopathological specimens when available were reported by other pathologist without prior knowledge of FNA diagnosis. Sensitivity, Specificity and Accuracy of FNA diagnosis were then analyzed. Results: A total of 392 cases of breast lesions were diagnosed on FNA, out of them histopathological correlation was available in 87 cases. Benign breast lesions are more common in younger patients in 21-30 yrs age group and malignant lesions are more common in old age group patients of 41-60 yrs with few exceptions. In our setup fibroadenoma is the most common benign breast lesion (26.53%) and ductal carcinoma (17.86%) is the most common malignant lesion. The sensitivity, specificity and accuracy of FNAC for malignant lesions were found to be 91.43%, 100% and 96.25% respectively. Conclusion: FNAC is an effective and valid tool as the first line diagnostic modality in the preoperative diagnosis of the malignant and benign breast lesions.KEYWORDS: FNAC; Breast lesions; Fibroadenoma; Ductal carcinoma

Centrosome defects and genetic instability in malignant tumors

Genetic instability is a common feature of many human cancers. This condition is frequently characterized by an abnormal number of chromosomes, although little is known about the mechanism that generates this altered genetic state. One possibility is that chromosomes are missegregated during mitosis due to the assembly of dysfunctional mitotic spindles. Because centrosomes are involved in spindle assembly, they could contribute to chromosome missegregation through the organization of aberrant spindles. As an initial test of this idea, we examined malignant tumors for centrosome abnormalities using antibodies to the centrosome protein pericentrin. We found that centrosomes in nearly all tumors and tumor-derived cell lines were atypical in shape, size, and composition and were often present in multiple copies. In addition, virtually all pericentrin-staining structures in tumor cells nucleated microtubules, and they participated in formation of disorganized mitotic spindles, upon which chromosomes were missegregated. All tumor cell lines had both centrosome defects and abnormal chromosome numbers, whereas neither was observed in nontumor cells. These results indicate that centrosome defects are a common feature of malignant tumors and suggest that they may contribute to genetic instability in cancer

Molecular Mechanisms of Proteinuria in Minimal Change Disease

Minimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome in childhood and represents about 15% cases in adults. It is characterized by massive proteinuria, edema, hypoalbuminemia, and podocyte foot process effacement on electron microscopy. Clinical and experimental studies have shown an association between MCD and immune dysregulation. Given the lack of inflammatory changes or immunocomplex deposits in the kidney tissue, MCD has been traditionally thought to be mediated by an unknown circulating factor(s), probably released by T cells that directly target podocytes leading to podocyte ultrastructural changes and proteinuria. Not surprisingly, research efforts have focused on the role of T cells and podocytes in the disease process. Nevertheless, the pathogenesis of the disease remains a mystery. More recently, B cells have been postulated as an important player in the disease either by activating T cells or by releasing circulating autoantibodies against podocyte targets. There are also few reports of endothelial injury in MCD, but whether glomerular endothelial cells play a role in the disease remains unexplored. Genome-wide association studies are providing insights into the genetic susceptibility to develop the disease and found a link between MCD and certain human haplotype antigen variants. Altogether, these findings emphasize the complex interplay between the immune system, glomerular cells, and the genome, raising the possibility of distinct underlying triggers and/or mechanisms of proteinuria among patients with MCD. The heterogeneity of the disease and the lack of good animal models of MCD remain major obstacles in the understanding of MCD. In this study, we will review the most relevant candidate mediators and mechanisms of proteinuria involved in MCD and the current models of MCD-like injury

Gating at the Mouth of the Acetylcholine Receptor Channel: Energetic Consequences of Mutations in the αM2-Cap

Gating of nicotinic acetylcholine receptors from a C(losed) to an O(pen) conformation is the initial event in the postsynaptic signaling cascade at the vertebrate nerve-muscle junction. Studies of receptor structure and function show that many residues in this large, five-subunit membrane protein contribute to the energy difference between C and O. Of special interest are amino acids located at the two transmitter binding sites and in the narrow region of the channel, where C↔O gating motions generate a low↔high change in the affinity for agonists and in the ionic conductance, respectively. We have measured the energy changes and relative timing of gating movements for residues that lie between these two locations, in the C-terminus of the pore-lining M2 helix of the α subunit (‘αM2-cap’). This region contains a binding site for non-competitive inhibitors and a charged ring that influences the conductance of the open pore. αM2-cap mutations have large effects on gating but much smaller effects on agonist binding, channel conductance, channel block and desensitization. Three αM2-cap residues (αI260, αP265 and αS268) appear to move at the outset of channel-opening, about at the same time as those at the transmitter binding site. The results suggest that the αM2-cap changes its secondary structure to link gating motions in the extracellular domain with those in the channel that regulate ionic conductance

Renaissance of the ~1 TeV Fixed-Target Program

This document describes the physics potential of a new fixed-target program based on a ~1 TeV proton source. Two proton sources are potentially available in the future: the existing Tevatron at Fermilab, which can provide 800 GeV protons for fixed-target physics, and a possible upgrade to the SPS at CERN, called SPS+, which would produce 1 TeV protons on target. In this paper we use an example Tevatron fixed-target program to illustrate the high discovery potential possible in the charm and neutrino sectors. We highlight examples which are either unique to the program or difficult to accomplish at other venues.Comment: 31 pages, 11 figure