Efectividad de la aplicacion del programa FLIPN adaptado en la estimulacion de antonimos en ninos de primer ano de ensenanza basica

43 p.El programa FLIPN fue creado en el año 2007 en Estados Unidos con el fin de estimular el desarrollo del lenguaje en niños ya sea con dificultades o con desarrollo típico. Fue diseñado para estimular todos los niveles del lenguaje. desde aquí surge la necesidad de comprobar su efectividad en niños de habla hispana, específicamente chilenos y si realmente es aplicable en todos los niveles del lenguaje. Esta investigación se basa principalmente en comprobar la efectividad del programa FLIPN en niños de la ciudad de Talca, Chile, específicamente en alumnos de primer año básico que se encuentran adquiriendo la lecto escritura. Se escoge al azar y por medio de procedimientos estadísticos, el establecimiento educacional en el cual se aplicará el programa. Además se selecciona un grupo control, el cual es monitoreado sólo con evaluaciones para corrobar de manera más precisa la efectividad del programa. De igual manera se intenta comprobar su efectividad específicamente en el nivel semántico, a través de tareas de habilidades de antonimia, aplicadas antes y después del tratamiento donde se espera incrementar el vocabulario de los niños. El proceso se realiza con una adaptación del programa FLIPN, donde algunas tareas fueron modificadas debido a la diferencia de idiomas entre países

L’analyse multidimensionnelle de textes académiques pour l’enseignement du français à l’université

Notre approche d’enseignement-apprentissage du français à l’université se structure sur l’oralité et la lecture scientifiques, ce qui impose une étude approfondie des genres académiques. Pour ce faire, nous menons une recherche sur le discours scientifique-académique à travers une analyse contrastive entre genres oraux et écrits en français. Le modèle d’analyse multidimensionnelle (Ciapuscio, Kugel, 2002) nous permet l’abordage de trois genres écrits —le manuel, l’article de vulgarisation scientifique et l’article scientifique— autour d’un même sujet spécifique des sciences humaines et sociales : la pensée foucaldienne. La caractérisation sémantique et formelle que nous présentons dans cet article est un exemple d’articulation entre recherche et enseignement du français en Argentine

Safety and outcome of children, adolescents and young adults participating in phase I/II clinical oncology trials: a 9-year center experience

Access to innovation; Drug development; Pediatric hematology and oncologyAccés a la innovació; Desenvolupament de fàrmacs; Hematologia i oncologia pediàtricaAcceso a la innovación; Desarrollo de fármacos; Hematología y oncología pediátricaIntroduction: Enrolling children with cancer in early phase trials is crucial to access innovative treatments, contributing to advancing pediatric oncology research and providing tailored therapeutic options. Our objective is to analyze the impact of these trials on patient outcomes and safety, and to examine the evolution and feasibility of trials in pediatric cancer over the past decade. Methods: All patients recruited in pediatric anticancer phase I/II clinical trials from January 2014 to December 2022 were included. Clinical records and trial protocols were analyzed. Results: A total of 215 patients (median age 11.2 years, range 1–29.5) were included in 52 trials (258 inclusions). Patients with extracranial solid tumors (67%), central nervous system (CNS) tumors (24%), and leukemia (9%) were included. The most common investigational drugs were small molecules (28.3%) and antibodies (20.5%). Serious adverse events were experienced by 41% of patients, 4.4% discontinued treatment because of toxicity and two had toxic deaths. Median event-free survival was 3.7 months (95%CI: 2.8–4.5), longer in phase II trials than in phase I (2 vs. 6.3 months; p ≤ 0.001). Median overall survival was 12 months (95%CI: 9–15), higher in target-specific vs. non-target-specific trials (14 vs. 6 months; p ≤ 0.001). Discussion: A significant and increasing number of patients have been included in early clinical trials, suggesting that both oncologists and families consider it valuable to be referred to specialized Units to access new therapies. Moreover, our data suggests that participation in early clinical trials, although not without potential toxicities, might have a positive impact on individual outcomes

Observational constraints on inflationary potentials within the quantum collapse framework

The physical mechanism responsible for the emergence of primordial cosmic seeds from a perfect isotropic and homogeneous Universe has not been fully addressed in standard cosmic inflation. To handle this shortcoming, D. Sudarsky et al have developed a proposal: the self-induced collapse hypothesis. In this scheme, the objective collapse of the inflaton’s wave function generates the inhomogeneity and anisotropy at all scales. In this paper we analyze the viability of a set of inflationary potentials in both the context of the collapse proposal and within the standard inflationary framework. For this, we perform a statistical analysis using recent CMB and BAO data to obtain the prediction for the scalar spectral index ns in the context of a particular collapse model: the Wigner scheme. The predicted ns and the tensor-to-scalar ratio r in terms of the slow roll parameters is different between the collapse scheme and the standard inflationary model. For each potential considered we compare the prediction of ns and r with the limits established by observational data in both pictures. The result of our analysis shows in most cases a difference in the inflationary potentials allowed by the observational limits in both frameworks. In particular, in the standard approach the more concave a potential is, the more is favored by the data. On the other hand, in the Wigner scheme, the data favors equally all type of concave potentials, including those at the border between convex and concave families.Facultad de Ciencias Astronómicas y Geofísica

Development of a predictor for human brain tumors based on gene expression values obtained from two types of microarray technologies

Development of molecular diagnostics that can reliably differentiate amongst different subtypes of brain tumors is an important unmet clinical need in postgenomics medicine and clinical oncology. A simple linear formula derived from gene expression values of four genes (GFAP, PTPRZ1, GPM6B, and PRELP) measured from cDNA microarrays (n=35) have distinguished glioblastoma and meningioma cases in a previous study. We herein extend this work further and report that the above predictor formula showed its robustness when applied to Affymetrix microarray data acquired prospectively in our laboratory (n=80) as well as publicly available data (n=98). Importantly, GFAP and GPM6B were both retained as being significant in the predictive model upon using the Affymetrix data obtained in our laboratory, whereas the other two predictor genes were SFRP2 and SLC6A2. These results collectively indicate the importance of the expression values of GFAP and GPM6B genes sampled from the two types of microarray technologies tested. The high prediction accuracy obtained in these instances demonstrates the robustness of the predictors across microarray platforms used. This result would require further validation with a larger population of meningioma and glioblastoma cases. At any rate, this study paves the way for further application of gene signatures to more stringent biopsy discrimination challenges. © 2010, Mary Ann Liebert, Inc.This work was funded by the EU-funded grants eTUMOUR (FP6-2002-LIFESCIHEALTH503094),HealthAgents (IST-2004-27214) and the Spanish grant MEDIVO2 (SAF 2005-03650). CIBER-BNN is an initiative of ‘‘Instituto de Salud Carlos III’’ (ISCIII, Spain).Peer Reviewe

Regulation of the MDM2-p53 pathway by the ubiquitin ligase HERC2

The p53 tumor suppressor protein is a transcription factor that plays a prominent role in protecting cells from malignant transformation. Protein levels of p53 and its transcriptional activity are tightly regulated by the ubiquitin E3 ligase MDM2, the gene expression of which is transcriptionally regulated by p53 in a negative feedback loop. The p53 protein is transcriptionally active as a tetramer, and this oligomerization state is modulated by a complex formed by NEURL4 and the ubiquitin E3 ligase HERC2. Here, we report that MDM2 forms a complex with oligomeric p53, HERC2, and NEURL4. HERC2 knockdown results in a decline in MDM2 protein levels without affecting its protein stability, as it reduces its mRNA expression by inhibition of its promoter activation. DNA damage induced by bleomycin dissociates MDM2 from the p53/HERC2/NEURL4 complex and increases the phosphorylation and acetylation of oligomeric p53 bound to HERC2 and NEURL4. Moreover, the MDM2 promoter, which contains p53‐response elements, competes with HERC2 for binding of oligomeric, phosphorylated and acetylated p53. We integrate these findings in a model showing the pivotal role of HERC2 in p53‐MDM2 loop regulation. Altogether, these new insights in p53 pathway regulation are of great interest in cancer and may provide new therapeutic targets

Diagnostic value of different anti-citrullinated peptides antibodies in rheumatoid arthritis

Póster presentat al 6th European Workshop on Immune-Mediated Inflammatory Diseases, celebrat a Niça (França) el 201