A study of the factors influencing the location of wheat stored by farmers

Call number: LD2668 .T4 1951 P79Master of Scienc

Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.

CALM (clathrin assembly lymphoid myeloid leukemia protein) is a cargo-selective adaptor for the post-Golgi R-SNAREs VAMPs 2, 3, and 8, and it also regulates the size of clathrin-coated pits and vesicles at the plasma membrane. The present study has two objectives: to determine whether CALM can sort additional VAMPs, and to investigate whether VAMP sorting contributes to CALM-dependent vesicle size regulation. Using a flow cytometry-based endocytosis efficiency assay, we demonstrate that CALM is also able to sort VAMPs 4 and 7, even though they have sorting signals for other clathrin adaptors. CALM homologues are present in nearly every eukaryote, suggesting that the CALM family may have evolved as adaptors for retrieving all post-Golgi VAMPs from the plasma membrane. Using a knockdown/rescue system, we show that wild-type CALM restores normal VAMP sorting in CALM-depleted cells, but that two non-VAMP-binding mutants do not. However, when we assayed the effect of CALM depletion on coated pit morphology, using a fluorescence microscopy-based assay, we found that the two mutants were as effective as wild-type CALM. Thus, we can uncouple the sorting function of CALM from its structural role

The Ambivalent Role of Religion for Sustainable Development: A Review of the Empirical Evidence

Until recently, academia has largely neglected the impact of religion on sustainable development. However, empirical studies have shown that religion remains important in many societies and that its importance has been increasing since the beginning of the new millennium. This paper reviews the empirical quantitative literature on the effect of religion on development from the last decade. We start by disaggregating the concepts of religion and sustainable development into four religious and three developmental dimensions and proposing a framework to identify causal mechanisms. Numerous mechanisms are possible, and this complexity explains why only a few uncontested findings exist. Religion is ambivalent vis-à-vis development: although religious dimensions exert a positive influence on physical and mental health as well as on general well-being, scholars have found a negative relationship between religious dimensions and both income and gender equality. Studies agree that the dominance of one religious group together with parallel ethnic and religious cleavages increases the risk of conflict, while studies on the pro-peace effects of religious factors are largely missing. Methodological challenges relate to the availability of fine-grained data, especially for non-Western countries, and the use of concepts and definitions. Most importantly, the study of religion and development requires methods that allow for causal inference