46 research outputs found

    First measurement of the BSB_S meson mass

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    If simplified, every information retrieval problem can be solved when the information need implied by its expression has been identified. We are interested in the criteria used in realising a good information retrieval problem expression. We have listed these criteria through some principles and maxims which first characterized the communication between two persons are applied. We choose to use the gricean maxims because they are the most favoured for this type of situation. Secondly, we have tried to identify some others principles that can be used to realise a good information retrieval problem expression. The principles by Grice can not resolve all forms of error associated with this particular form of communication. In our work, we defined three other principles namely: adhesion principle, reformulation principle, memorization principle. We give some examples of situations where the principles we have formulated are not applicable and the consequences. We present the possible applications of our new model: MIRABEL, which can help in the description of information retrieval problem from. It also compels its user to use essential good expression principle implicitly

    Final results from the PERUSE study of first-line pertuzumab plus trastuzumab plus a taxane for HER2-positive locally recurrent or metastatic breast cancer, with a multivariable approach to guide prognostication

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    Background: The phase III CLinical Evaluation Of Pertuzumab And TRAstuzumab (CLEOPATRA) trial established the combination of pertuzumab, trastuzumab and docetaxel as standard first-line therapy for human epidermal growth factor receptor 2 (HER2)-positive locally recurrent/metastatic breast cancer (LR/mBC). The multicentre single-arm PERtUzumab global SafEty (PERUSE) study assessed the safety and efficacy of pertuzumab and trastuzumab combined with investigator-selected taxane in this setting. Patients and methods: Eligible patients with inoperable HER2-positive LR/mBC and no prior systemic therapy for LR/mBC (except endocrine therapy) received docetaxel, paclitaxel or nab-paclitaxel with trastuzumab and pertuzumab until disease progression or unacceptable toxicity. The primary endpoint was safety. Secondary endpoints included progression-free survival (PFS) and overall survival (OS). Prespecified subgroup analyses included subgroups according to taxane, hormone receptor (HR) status and prior trastuzumab. Exploratory univariable analyses identified potential prognostic factors; those that remained significant in multivariable analysis were used to analyse PFS and OS in subgroups with all, some or none of these factors. Results: Of 1436 treated patients, 588 (41%) initially received paclitaxel and 918 (64%) had HR-positive disease. The most common grade 653 adverse events were neutropenia (10%, mainly with docetaxel) and diarrhoea (8%). At the final analysis (median follow-up: 5.7 years), median PFS was 20.7 [95% confidence interval (CI) 18.9-23.1] months overall and was similar irrespective of HR status or taxane. Median OS was 65.3 (95% CI 60.9-70.9) months overall. OS was similar regardless of taxane backbone but was more favourable in patients with HR-positive than HR-negative LR/mBC. In exploratory analyses, trastuzumab-pretreated patients with visceral disease had the shortest median PFS (13.1 months) and OS (46.3 months). Conclusions: Mature results from PERUSE show a safety and efficacy profile consistent with results from CLEOPATRA and median OS exceeding 5 years. Results suggest that paclitaxel is a valid alternative to docetaxel as backbone chemotherapy. Exploratory analyses suggest risk factors that could guide future trial design

    Final results from the PERUSE study of first-line pertuzumab plus trastuzumab plus a taxane for HER2-positive locally recurrent or metastatic breast cancer, with a multivariable approach to guide prognostication

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    Search for particles with unexpected mass and charge in Z decays

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    Update of electroweak parameters from Z decays

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    Measurement of the Mass of the Z-Boson and the Energy Calibration of Lep

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    Contains fulltext : 26847___.PDF (publisher's version ) (Open Access

    Electroweak parameters of the z0 resonance and the standard model

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    Contains fulltext : 124399.pdf (publisher's version ) (Open Access

    Electroweak parameters of the Z0^0 resonance and the standard model

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    Media temporalities of the elderly : evolutions in stability This article shows the context of analysis and the first results of a research on media temporalities of the elderly. Several works have finely analysed the diversity of the media practices and studied meanings of media uses. I wish to continue these analyses by insisting on the evolutionary and dynamic aspect of the practices and temporalities of users having expanded, enhanced, so called "interactive" radio and especially television programming. A priori, the elderly, upon retirement, have a "full-time free time". Their media practices seem strongly influenced by their first experiments ; the appropriation of the various peripheral accessories which gradually came with the media, to the latest digital ones, seems to reinforce their habits of watching television. Their representations and relations with times and media are very far away from the image of television like omnipresent media or "devourer of time". Rather, their media practices are to be understood like a temporality of the occupation, according to the expression of Gerard Derèze, characterized by interest and utility. A particular glance at the users who do not carry out a systematic selection of the programs, accepting the unforeseen, highlights an approach of media and time that allow "useful encounter" which I would qualify in a first stage by : "chance and encounter" and "random and the following". The few points presented here make me assume that the global relation of the autonomous elderly persons to the media can evolve when confronted to their new temporal framework and the new program offer, whereas their representations and use of the media remain quite stable

    Electroweak parameters of the Z0^0 resonance and the standard model

    No full text
    Media temporalities of the elderly : evolutions in stability This article shows the context of analysis and the first results of a research on media temporalities of the elderly. Several works have finely analysed the diversity of the media practices and studied meanings of media uses. I wish to continue these analyses by insisting on the evolutionary and dynamic aspect of the practices and temporalities of users having expanded, enhanced, so called "interactive" radio and especially television programming. A priori, the elderly, upon retirement, have a "full-time free time". Their media practices seem strongly influenced by their first experiments ; the appropriation of the various peripheral accessories which gradually came with the media, to the latest digital ones, seems to reinforce their habits of watching television. Their representations and relations with times and media are very far away from the image of television like omnipresent media or "devourer of time". Rather, their media practices are to be understood like a temporality of the occupation, according to the expression of Gerard Derèze, characterized by interest and utility. A particular glance at the users who do not carry out a systematic selection of the programs, accepting the unforeseen, highlights an approach of media and time that allow "useful encounter" which I would qualify in a first stage by : "chance and encounter" and "random and the following". The few points presented here make me assume that the global relation of the autonomous elderly persons to the media can evolve when confronted to their new temporal framework and the new program offer, whereas their representations and use of the media remain quite stable
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