The Mountain Pass Rare-Earth Deposits

Rare-earth minerals were discovered near Mountain Pass in northeastern San Bernardino County, Calif., in April 1949, and in the following year the Sulphide Queen carbonate body was found. This body is the world's greatest known concentration of rare-earth metals with a tonnage larger than the total of all rare earths used in the world prior to 1950. The rare earths in the Mountain Pass district are chiefly cerium, lanthanum, and neodymium. These elements occur principally in bastnaesite, a rare-earth fluocarbonate, heretofore reported from only about 10 localities in the world. The bastnaesite was discovered in samples from Mountain Pass obtained by H. E. Woodward and Clarence Watkins of Goodsprings, Nev., and its identity was established in laboratory studies by E . T. Schenk of the U. S. Bureau of Mines and D. F. Hewett of the U. S. Geological Survey. Subsequent prospecting by individuals and geologic investigations by the U. S. Geological Survey resulted in the discovery of bastnaesite in the Sulphide Queen carbonate body and numerous other deposits in a belt 6 miles long. Investigations by the U. S. Geological Survey since 1949 (Olson et al., in preparation) include detailed mapping of the site of the initial discovery-the Birthday claims-by L. C. Pray and W. N. Sharp; geologic mapping of the district by J. C. Olson; detailed mapping of the Sulphide Queen carbonate body and several smaller deposits by D. R. Shawe and W. N. Sharp; and laboratory mineralogic investigations by H. W. Jaffe

The Mountain Pass Rare-Earth Deposits

Rare-earth minerals were discovered near Mountain Pass in northeastern San Bernardino County, Calif., in April 1949, and in the following year the Sulphide Queen carbonate body was found. This body is the world's greatest known concentration of rare-earth metals with a tonnage larger than the total of all rare earths used in the world prior to 1950. The rare earths in the Mountain Pass district are chiefly cerium, lanthanum, and neodymium. These elements occur principally in bastnaesite, a rare-earth fluocarbonate, heretofore reported from only about 10 localities in the world. The bastnaesite was discovered in samples from Mountain Pass obtained by H. E. Woodward and Clarence Watkins of Goodsprings, Nev., and its identity was established in laboratory studies by E . T. Schenk of the U. S. Bureau of Mines and D. F. Hewett of the U. S. Geological Survey. Subsequent prospecting by individuals and geologic investigations by the U. S. Geological Survey resulted in the discovery of bastnaesite in the Sulphide Queen carbonate body and numerous other deposits in a belt 6 miles long. Investigations by the U. S. Geological Survey since 1949 (Olson et al., in preparation) include detailed mapping of the site of the initial discovery-the Birthday claims-by L. C. Pray and W. N. Sharp; geologic mapping of the district by J. C. Olson; detailed mapping of the Sulphide Queen carbonate body and several smaller deposits by D. R. Shawe and W. N. Sharp; and laboratory mineralogic investigations by H. W. Jaffe

Suicide in Eastern Europe, the Commonwealth of Independent States, and the Baltic Countries: Social and Public Health Determinants

While suicide is a major public health problem worldwide, the countries of the former Soviet Union, including the Baltic States and the Commonwealth of Independent States (CIS), have some of the highest rates in the world. High suicide rates across Eastern Europe have been correlated with the post-Soviet transitional period and the societal changes associated with that transition. Many scholars have speculated that the sudden collapse of the paternalistic Soviet system and the introduction of a market economy - and the psychosocial distress that ensued.contributed to the suicide mortality crisis that most of the former Soviet republics experienced in the 1990s. It is unclear whether the transitional period has ended or is still ongoing. While suicide mortality rates in many countries have declined since then, they remain alarmingly high. In some countries, such as Belarus, the rates have increased. From September 14 to 15, 2010, suicidologists and other scholars and professionals with expertise in suicide and suicide prevention gathered in Tallinn, Estonia, to discuss the evidence base for social and public health determinants of suicide in the Baltic States, the CIS, and Eastern Europe. The participants identified research and data gaps that, if filled, would strengthen the foundation for developing effective suicide prevention policies and programs. This report summarizes the presentations and discussions that took place during the conference

GMOs: Non-Health Issues

The controversy over genetically modified [GM] organisms is often framed in terms of possible hazards for human health. Articles in a previous volume of this *Encyclopedia* give a general overview of GM crops [@Mulvaney2014] and specifically examine human health [@Nordgard2014] and labeling [@Bruton2014] issues surrounding GM organisms. This article explores several other aspects of the controversy: environmental concerns, political and legal disputes, and the aim of "feeding the world" and promoting food security. Rather than discussing abstract, hypothetical GM organisms, this article explores the consequences of the GM organisms that have actually been deployed in the particular contexts that they have been deployed, on the belief that there is little point in discussing GM organisms in an idealized or context-independent way

The use of Pd catalysts on carbon-based structured materials for the catalytic hydrogenation of bromates in different types of water

[EN] The aim of this work is to study the activity of new Pd catalysts, supported on two different nano structured carbon materials, for bromate catalytic hydrogenation. The influence of the support has been studied, obtaining the best results with a palladium catalyst supported on carbon nanofibers (CNF) grown in sintered metal fibers (SMF). The results have shown the importance of the catalyst support in order to minimize the mass-transfer limitations ensuring an efficient catalyst use. In this way the most active catalysts are those with a mesoporous structure containing high dispersed Pd nanoparticles. The activity of this catalyst for bromate reduction has been tested in different types of water, namely, distilled water, natural water and industrial wastewater. It has been shown that the catalyst activity depends on the water matrix and bromate reduction rate depends on the hydrogen partial pressure. The potential use of the catalyst has been studied in a continuous reactor. It has been observed that the catalyst is active without any important deactivation at least during 100 h of reaction, but is necessary to avoid salt precipitation and plugging problems.The authors thank the European Union (European Community's Seventh Framework Programme FP7/2007-2013 under grant agreement no. 226347 Project) for financial support. A.E. Palomares also acknowledges the support from the Spanish Government through the project MAT2012-38567-C02-01.Palomares Gimeno, AE.; Franch Martí, C.; Yuranova, T.; Kiwi-Minsker, L.; Garcia Bordeje, JE.; Derrouiche, S. (2014). The use of Pd catalysts on carbon-based structured materials for the catalytic hydrogenation of bromates in different types of water. Applied Catalysis B: Environmental. 146:186-191. https://doi.org/10.1016/j.apcatb.2013.02.056S18619114

The three main monotheistic religions and gm food technology: an overview of perspectives

Abstract Background Public acceptance of genetically modified crops is partly rooted in religious views. However, the views of different religions and their potential influence on consumers' decisions have not been systematically examined and summarized in a brief overview. We review the positions of the Judaism, Islam and Christianity – the three major monotheistic religions to which more than 55% of humanity adheres to – on the controversies aroused by GM technology. Discussion The article establishes that there is no overarching consensus within the three religions. Overall, however, it appears that mainstream theology in all three religions increasingly tends towards acceptance of GM technology per se, on performing GM research, and on consumption of GM foods. These more liberal approaches, however, are predicated on there being rigorous scientific, ethical and regulatory scrutiny of research and development of such products, and that these products are properly labeled. Summary We conclude that there are several other interests competing with the influence exerted on consumers by religion. These include the media, environmental activists, scientists and the food industry, all of which function as sources of information and shapers of perception for consumers

Effects of partner proteins on BCA2 RING ligase activity

Abstract Background BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2. Methods Here, additional BCA2 binding proteins were found using yeast two-hybrid and bacterial-II-hybrid screening techniques with Human breast and HeLa cDNA libraries. Co-expression of these proteins was analyzed through IHC of TMAs. Investigation of the molecular interactions and effects were examined through a series of in vivo and in vitro assays. Results Ten unique BCA2 interacting proteins were identified, two of which were hHR23a and 14-3-3sigma. Both hHR23a and 14-3-3sigma are co-expressed with BCA2 in breast cancer cell lines and patient breast tumors (n = 105). hHR23a and BCA2 expression was significantly correlated (P = \u3c 0.0001 and P = 0.0113) in both nucleus and cytoplasm. BCA2 expression showed a statistically significant correlation with tumor grade. High cytoplasmic hHR23a trended towards negative nodal status. Binding to BCA2 by hHR23a and 14-3-3sigma was confirmed in vitro using tagged partner proteins and BCA2. hHR23a and 14-3-3sigma effect the autoubiquitination and auto-degradation activity of BCA2. Ubiquitination of hHR23a-bound BCA2 was found to be dramatically lower than that of free BCA2, suggesting that hHR23a promotes the stabilization of BCA2 by inactivating its autoubiquitination activity, without degradation of hHR23a. On the other hand, phosphorylated BCA2 protein is stabilized by interaction with 14-3-3sigma both with and without proteasome inhibitor MG-132 suggesting that BCA2 is regulated by multiple degradation pathways. Conclusions The interaction between BCA2 and hHR23a in breast cancer cells stabilizes BCA2. High expression of BCA2 is correlated with grade in breast cancer, suggesting regulation of this E3 ligase is important to cancer progression

Structural Basis for Specific Binding of Human MPP8 Chromodomain to Histone H3 Methylated at Lysine 9

. MPP8 binding to methylated H3K9 is suggested to recruit the H3K9 methyltransferases GLP and ESET, and DNA methyltransferase 3A to the promoter of the E-cadherin gene, mediating the E-cadherin gene silencing and promote tumor cell motility and invasion. MPP8 contains a chromodomain in its N-terminus, which is used to bind the methylated H3K9. HP1, a chromodomain containing protein that binds to methylated H3K9 as well. The structure also reveals that the human MPP8 chromodomain forms homodimer, which is mediated via an unexpected domain swapping interaction through two β strands from the two protomer subunits.Our findings reveal the molecular mechanism of selective binding of human MPP8 chromodomain to methylated histone H3K9. The observation of human MPP8 chromodomain in both solution and crystal lattice may provide clues to study MPP8-mediated gene regulation furthermore

Deciphering the Code for Retroviral Integration Target Site Selection

Upon cell invasion, retroviruses generate a DNA copy of their RNA genome and integrate retroviral cDNA within host chromosomal DNA. Integration occurs throughout the host cell genome, but target site selection is not random. Each subgroup of retrovirus is distinguished from the others by attraction to particular features on chromosomes. Despite extensive efforts to identify host factors that interact with retrovirion components or chromosome features predictive of integration, little is known about how integration sites are selected. We attempted to identify markers predictive of retroviral integration by exploiting Precision-Recall methods for extracting information from highly skewed datasets to derive robust and discriminating measures of association. ChIPSeq datasets for more than 60 factors were compared with 14 retroviral integration datasets. When compared with MLV, PERV or XMRV integration sites, strong association was observed with STAT1, acetylation of H3 and H4 at several positions, and methylation of H2AZ, H3K4, and K9. By combining peaks from ChIPSeq datasets, a supermarker was identified that localized within 2 kB of 75% of MLV proviruses and detected differences in integration preferences among different cell types. The supermarker predicted the likelihood of integration within specific chromosomal regions in a cell-type specific manner, yielding probabilities for integration into proto-oncogene LMO2 identical to experimentally determined values. The supermarker thus identifies chromosomal features highly favored for retroviral integration, provides clues to the mechanism by which retrovirus integration sites are selected, and offers a tool for predicting cell-type specific proto-oncogene activation by retroviruses