Radiation tests on commercial instrumentation amplifiers, analog switches & DAC's

A study of several commercial instrumentation amplifiers (INA110, INA111, INA114, INA116, INA118 & INA121) under neutron and vestigial gamma radiation was done. Some parameters (Gain, input offset voltage, input bias currents) were measured on-line and bandwidth, and slew rate were determined before and after radiation. The results of the testing of some voltage references REF102 and ADR290GR and the DG412 analog switch are shown. Finally, different digital-to-analog converters were tested under radiation

Sildenafil Citrate Liposomes for Pulmonary Delivery by Ultrasonic Nebulization

Technological advances in lipid vesicles facilitate optimization of their properties to achieve therapeutic goals and promote alternative drug administration routes. Sildenafil citrate (SC) is orally administered for the treatment of pulmonary hypertension, but local release would be advantageous in terms of efficacy and safety. In the present study, liposomes from egg phosphatidylcholine and cholesterol loaded with SC, with and without d-α-tocopheryl polyethylene glycol 1000 succinate (Vit E TPGS), were prepared by sonication of the components. A transmembrane pH gradient was applied for active loading of liposomes, and the size, zeta potential, and entrapment efficiency (EE%) were determined. The liposomes were lyophilized and then nebulized. The nebulized samples were collected and the EE% was determined. The transmembrane pH gradient produced a significant increase in the EE% (from 17.68 ± 4.25% to 89.77 ± 7.64%) and, after lyophilization, the EE% remained the same as that of the originals, but the size and zeta potential were modified. EE% of liposomes decreased upon nebulization, particularly for those with Vit E TPGS. Thus, the additives used for lyoprotection reduced the impact of nebulization. Additional studies are essential, but according to these results, SC-loaded liposomes can be considered as suitable and safe carriers for the local release of sildenafil in the pulmonary system

Instrumentation amplifiers and voltage controlled current sources for LHC cryogenic instrumentation

Instrumentation amplifiers and voltage controlled current sources have been designed by using single operational amplifiers (OPA124, TLE2071 and OPA627). Their performance has been evaluated in the laboratory and under neutron radiation. On line measurements of the offset voltages, offset currents, closed loop gain, CMRR and bias currents were performed on the amplifiers. The current sources were set to a constant value and the current was monitored on-line. The radiation tolerance of commercial voltage references has also been investigated. The radiation was performed out in ITN (Portugal) research nuclear reactor. In comparison to previous experimental campaigns the gamma radiation has been reduced by a factor 15 for a given neutron dose. This is achieved thanks to a recently constructed facility for neutron beam extractio

La gobernanza de los puertos atlánticos, siglos xiv-xx

La publicación de este volumen se inscribe en el estudio de las dinámicas portuarias atlánticas, bajo el foco de la larga duración, llevado a cabo por la red de investigación nacida en 2012 «La Gobernanza de los Puertos Atlánticos (siglos xiv-xxi)». Su contenido gira en torno a la temática de las políticas y estructuras portuarias y, en particular, al análisis sistemático de cuestiones estructurales sobre el gobierno de los puertos atlánticos. Las materias objeto de atención van desde el estatus jurídico de los puertos atlánticos, las políticas portuarias, las obras públicas, las instalaciones portuarias, a la gestión o las políticas económicas, todas ellas convertidas en elementos determinantes para la gobernanza de los puertos. Partiendo de una investigación plural, comparativa y cronológicamente transversal, se propone profundizar en un debate sobre cuestiones fundamentales que afectan a las políticas y estructuras portuarias, con particular incidencia sobre la articulación de los puertos atlánticos de la fachada europea, los puertos africanos y los de América Latina

Unfavourable results in the repair of the cleft lip

Introduction: Unfavorable results in unilateral and bilateral cleft lip repair are often easy to spot but not always easy to prevent as to treat. We have tried to deal with the more common problems and explain possible causes and the best possible management options from our experience. Unilateral cleft lip repair: Unfavorable results immediately after repair involve Dehiscence and Scaring. Delayed blemishes include vermillion notching, a short lip, deficiency in the height of the lateral vermillion on the cleft side, white roll malalignment, oro-vestibular fistula, the cleft lip nose deformity, a narrow nostril and a "high-riding" nostril. We analyze the causes of these blemishes and outline our views regarding the treatment of these. Bilateral cleft lip: Immediate problems again include dehiscence as also loss of prolabium or premaxilla. Delayed unfavorable results are central vermillion deficiency, a lip that is too tight, bilateral cleft lip nose deformity, problems with the premaxilla and maxillary growth disturbances. Here again we discuss the causation of these problems and our preferred methods of treatment. Conclusion: We have detailed the significant unfavorable results after unilateral and bilateral cleft lip surgery. The methods of treatment advocated have been layer from our own experience

Trypanosoma cruzi strains isolated from human, vector, and animal reservoir in the same endemic region in Mexico and typed as T. cruzi I, discrete typing unit 1 exhibit considerable biological diversity

In this study, three strains of Trypanosoma cruzi were isolated at the same time and in the same endemic region in Mexico from a human patient with chronic chagasic cardiomyopathy (RyC-H); vector (Triatoma barberi) (RyC-V); and rodent reservoir (Peromyscus peromyscus) (RyC-R). The three strains were characterized by multilocus enzyme electrophoresis, random amplified polymorphic DNA, and by pathological profiles in experimental animals (biodemes). Based on the analysis of genetic markers the three parasite strains were typed as belonging to T. cruzi I major group, discrete typing unit 1. The pathological profile of RyC-H and RyC-V strains indicated medium virulence and low mortality and, accordingly, the strains should be considered as belonging to biodeme Type III. On the other hand, the parasites from RyC-R strain induced more severe inflammatory processes and high mortality (> 40%) and were considered as belonging to biodeme Type II. The relationship between genotypes and biological characteristics in T. cruzi strains is still debated and not clearly understood. An expert committee recommended in 1999 that Biodeme Type III would correspond to T. cruzi I group, whereas Biodeme Type II, to T. cruzi II group. Our findings suggest that, at least for Mexican isolates, this correlation does not stand and that biological characteristics such as pathogenicity and virulence could be determined by factors different from those identified in the genotypic characterizatio