A case study of Dushta Vrana treated with Vrana Lepa w.s.r. to Sahasrayoga

The destruction/ break/ rupture/ discontinuity of body tissue/ part of body, is called Vrana.[1] Dushta Vrana is an issue that is frequently seen in surgical practice. The presence of Dushta Vrana (Non-healing ulcer) can harm the patient's state, causing various complications and even death. Slough, infection, and foreign bodies are all factors that might cause a wound to take longer to heal. In comparison to an infected wound, a healthy wound heals faster. As a result, it is critical to maintain the wound clean throughout its healing process. Every surgeon's main goal is to achieve good wound healing with little scarring and the least amount of pain. Acharya Sushruta has ornately explained six forms of Dushta Vrana[2], and Dushta Vrana treatment is comprised of a variety of medications, which are roughly classed as Vrana Shodhana and Vrana Ropana. Sushruta has mentioned regarding Shashti Upakrama (60 modalities of wound management) for Vrana Chikitsa.[3] In present study, Vranalepa is selected as topical application for Vrana Shodhana action. A case report of 34 year old man, who presented an open ulcer on the posterior aspect of the right thigh associated with pain, discharge, slough and foul smell has been presented here

AN INTEGRATED APPROACH IN TREATING NECK ABSCESS WITH NECROTISING FASCITIS – A CASE REPORT

Objective: Sushruta has explained various methods for Vrana Chikitsa. Virechana is vital to remove the vitiated Dosha from the body in turn normalize them and prevent recurrence of the abscess. Vrana Pichu is one of the best substitutes for wound healing and Jathyadi Taila has better Shodhana and Ropana effect. Case: A case of 70 year old man, who presented with complains of swelling in left anterio-lateral aspect of the neck since 4 days along with fever, pain and discolouration of the skin has been taken for the study. Methods: Initial I&D was done followed by a course of antibiotics. Then Deepana and Pachana. After Abhyantara and Bahya Snehana and Svedana, Virechana was administered. Vrana Pichu, with Jatyadi Taila was done every day. Results: The result of the current case study is based on the size of the wound. Conclusion: The combination of Virechana and Vrana Pichu can be used as a line of treatment for the management

Management of Recurrent Pilonidal Sinus through Ayurveda Care and Surgery - A Case Report

Introduction: Pilonidal disease refers to subcutaneous infection occurring in the upper half of the gluteal cleft having no communication in the anal canal. In Ayurveda it can be correlated to Shalyajanya Nadivrana which is described in detail by Acharya Sushrutha. It presents as an acute abscess or chronic wound associated with pus discharge and severe discomfort. In this case report we present 20 years old female patient who reported to the OPD of Shalya SDMCAH with the complains of pain associated with pus discharge at the natal cleft region since two weeks with a history of Z plasty surgery. Methods: The case was managed by surgical excision followed by Kshara Karma, Triphala Prakshalana and dressing with Jatyadi Taila. Internally the patient was administered with Triphala Guggulu and Gandhaka Rasayana. Discussion: Apamarga Kshara helps in removal of unhealthy granulation tissue and cellular debris by sclerosing properties thereby lowering the recurrence rate. Triphala Prakshalana and wound dressing by Jathyadhi Taila fastens the healing process by microcidal effect. Results: The initial complains of pain associated with pus discharge subsided within seven days, while complete healing of the tract was observed within two months. Conclusion:  The surgical approach in contemporary science includes excision with reconstructive flaps (z-plasty). However, the recurrence rate is more and there are increased chances of developing wound infection. Hence in this case excision of sinus followed by apamarga kshara pratisarana was incorporated which showed promising results along with complete healing of the tract

DESIGN AND IN VIVO EVALUATION OF METOPROLOL TARTRATE BILAYER FLOATING TABLETS IN HEALTHY HUMAN VOLUNTEERS

The aim of the present investigation was to prepare bilayer floating tablets of metoprolol tartrate using the combination of superdisintigrants, HPMC K grade polymers and natural polymers like xanthan gum and guar gum by direct compression method. Bilayer floating tablets were prepared using optimized immediate release layer and floating layer as sustained release layer. The physico-chemical characteristics of the prepared tablets were evaluated and found to be satisfactory. All the prepared batches showed in vitro buoyancy. It was observed that the tablets remained buoyant for more than 12 h.  Formulation F7 was selected as best formulation based on the in vitro characteristics and used in vivo radiographic studies by adding barium sulphate. These studies revealed that the tablets remained in the stomach for 210±5.4 min (n=3) in fasting human volunteers. Based on the in vivo performance in healthy subjects, the developed bilayer floating tablets showed superior bioavailability than the marketed tablets, the drug release was up to 12 h in controlled manner. The systemic availability of the best formulation was high after administration to obtain immediate action due to the immediate release layer, from sustained release layer the drug was released in controlled manner. It can be concluded that the best formulation F7 by choosing biphasic drug release pattern in a single dosage form could improve patient compliance and ensure better disease management

FORMULATION AND EVALUATION OF PARACETAMOL SUSPENSION BY USING NATURAL SUSPENDING AGENT EXTRACTED FROM BANANA PEELS

The present work was aimed to formulate and evaluate a new, cheap and effective natural suspending agent that can be used as an effective alternative for traditional suspending agent. The study procedure involved extraction of suspending agent from the Musa paradisica (Banana) fruit peels, determination of swelling index, phytochemical testing, Micromeritic properties of mucilage like Bulk density, Tapped density, Carr’s index, Hausner’s ratio, Angle of repose, Calibration of paracetamol, preparation of paracetamol suspensions and evaluated for pH determination, determination of sedimentation volume, redispersibility, determination of flow rate, measurement of viscosity, effect of temperature, drug content, particle size determination and In-vitro dissolution studies. The study showed that the extraction of suspending agent from banana fruit peels. The swelling index was found to be 40%. The photochemical test showed contains carbohydrates. As the concentration of suspending agent increases therefore viscosity of suspension increases which ultimately reduces the sedimentation of suspension

A COMMUNITY BASED CROSS-SECTIONAL STUDY: INCREASING PREVALENCE OF TYPE 2 DIABETES AMONG RURAL ADULT POPULATION OF KARNATAKA, INDIA

A community based cross-sectional study in the age group 25 years and above conducted at the field area of primary health centre Chakenahalli, Hassan district, Karnataka, India. The population was similar in characteristics regarding occupation, socio-economic status and food habits. Total of 626 subjects were included by multi-stage sampling. Information collected by the interviewers through face to face interview, after informed consent. The individuals were assessed on anthropometric parameters and screening was done by Random Blood Glucose (RBG) with a standardized technique; diagnosis of type 2 diabetes done by WHO criteria. Prevalence of diabetes was found in 11.3% males and 15% females, altogether the total prevalence was 13.09% with 8.79% self reported cases of diabetes . Hypertension was associated with 25.6% diabetic subjects. It was also observed that 28.1% of study population had BMI ≥ 25

DESIGN AND IN VIVO EVALUATION OF METOPROLOL TARTRATE BILAYER FLOATING TABLETS IN HEALTHY HUMAN VOLUNTEERS

The aim of the present investigation was to prepare bilayer floating tablets of metoprolol tartrate using the combination of superdisintigrants, HPMC K grade polymers and natural polymers like xanthan gum and guar gum by direct compression method. Bilayer floating tablets were prepared using optimized immediate release layer and floating layer as sustained release layer. The physico-chemical characteristics of the prepared tablets were evaluated and found to be satisfactory. All the prepared batches showed in vitro buoyancy. It was observed that the tablets remained buoyant for more than 12 h.  Formulation F7 was selected as best formulation based on the in vitro characteristics and used in vivo radiographic studies by adding barium sulphate. These studies revealed that the tablets remained in the stomach for 210±5.4 min (n=3) in fasting human volunteers. Based on the in vivo performance in healthy subjects, the developed bilayer floating tablets showed superior bioavailability than the marketed tablets, the drug release was up to 12 h in controlled manner. The systemic availability of the best formulation was high after administration to obtain immediate action due to the immediate release layer, from sustained release layer the drug was released in controlled manner. It can be concluded that the best formulation F7 by choosing biphasic drug release pattern in a single dosage form could improve patient compliance and ensure better disease management

PHARMACOGNOSTIC EVALUATION OF GOMPHRENA SERRATA ROOT

Objectives: Gomphrena serrata (Amaranthaceae) has been utilized for many ailments in the conventional system ethnomedicinally; most significantly against bronchial asthma, diarrhea, hay fever, pains, tonic, carminative, diabetes, dermatitis, and piles. The key challenge experienced in the standardization of herbal drugs is the correct identification of the plant source. Thus, setting up quality control parameters by means of pharmacognostic and phytochemical analysis which assures the purity, safety, and efficiency of G. serrata is necessary. The current research was conducted to assess the pharmacognostic characteristics including macroscopic, microscopic, phytochemical and physicochemical parameters of the root of G. serrata. Methods:  Micro, as well as macroscopic characteristics was investigated. Physicochemical parameters had been done by implementing WHO suggested parameters; preliminary phytochemical and fluorescent evaluation of root was executed for appropriate identification and standardization. Results:  The color, shape, size, odor, and surface characteristics were reported from the root and powdered root material of G. serrata.  Light microscope images of cross section and powdered root revealed the presence of lignified xylem fibers, xylem vessels, cork cells and parenchyma cells. Phytochemical testing confirmed the presence of alkaloids, carbohydrates, saponins, tannins, proteins, amino acids, phytosterols and flavonoids. Physicochemical parameters such as moisture content, ash value, extractive value and fluorescent behavior of root powder have also been established Conclusion: The current research is useful in order to supplement the information with regard to its standardization, identification and in carrying out further investigation in Ayurvedic system of medicine.            Peer Review History: Received 24 July 2017;   Revised 22 August; Accepted 28 August, Available online 15 September 2017 Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:        Reviewer's Comments: Average Peer review marks at initial stage: 4.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, [email protected] Dr. Mohamed Said Fathy Al-Refaey, University of Sadat City, Menofia, Egypt, [email protected] Similar Articles: PURIFICATION AND BIOLOGICAL ACTIVITIES OF COMBINATION OF HEMI-SYNTHESIZED THIOSEMICARBAZONES OF MITRACARPUS SCABER ZUC