Method Development and Validation of Cefixime by Using RP-HPLC in Pharmaceutical Formulations

Analytical method development and validation are ongoing and interconnected activities that are essential in research and development, quality control, and quality assurance departments. They involve the creation and testing of analytical procedures to assess equivalence and manage risks effectively. These procedures are crucial for establishing specific acceptance criteria for products and ensuring the reliability and consistency of results. Validations are essential in assessing whether an analytical procedure is appropriate and reliable for its intended purpose. Literature survey reveals that the analytical methods based on UV spectrometry, RP-HPLC and HPTLC for the determination of Cefixime individually and combination with others drugs . The methods were validated according to ICH guidelines in terms of accuracy, precision, lod, and other aspects of analytical validation. The developed analytical methods for cefixime have been designed to be straightforward, making them easy to perform. They have also demonstrated high sensitivity, enabling the detection and quantification of cefixime at low concentrations. This sensitivity is crucial for accurately determining the amount of cefixime present in bulk samples or tablet formulations

The Combine Effect of Suvarnaprashan with Speech-Language Therapy in Children with Delayed Speech and Language Disorder

Suvarnaprashan is ancient oral vaccination technique describe Ayurvedic texts. Delayed in acquiring language are most common symptoms of childhood developmental disability affecting around 5 to 10% of all children. The effectiveness of Suvarnaprashan in various developmental disabilities in children was reported earlier studies. However, its effectiveness for children with pure delayed speech and language disorder without any associated developmental difficulties was not studied previously. Hence, the study taken with aim of the combine outcome of Suvarnaprashan with speech-language therapy in children with delayed speech and language disorder. Total no. of 50 participants with early diagnosed delayed speech and language disorder with age range from 02 to 05 were included for this study. The participants were divided in two subgroups in which group A underwent for speech language therapy only and group B underwent for both speech-language therapy and Suvarnayaprashan sanskara. Children with delayed speech and language disorder showed significant improvement with Speech language therapy plus Suvarnayaprashan intervention compare to speech and language therapy alone. Suvarnaprashan can be utilized effectively as a therapeutic tool for children with delayed speech and language disorder. It is very simple, cost effective, infrastructure compatible, safe and prevention–centric approach. Hence, it should be adopted globally as immunization program also for preventive measure of delayed speech and language disorders and disability. The present study opened new dimensions and need of further research in different area of disability with large sample and long term follow up

Method Development and Validation of Lorazepam by Using RP-HPLC in Pharmaceutical Formulation

High pressure liquid chromatography (RP-HPLC) is a column chromatographic technique employing high pressure pump to pass both mobile phase and sample mixture through stationary phase column and perform efficient separation. A C-18 column with mobile phase containing Acetonitrile: methanol (80: 20) was used. The flow rate was 1.0ml/min. and were monitored at 210 nm. The retention time for Lorazepam was 1.3 min. The method was validated for linearity, accuracy, precision, limit of detection. The Mean percent recovery of Lorazepam from tablet formulation was found to be 94.80 %

Method Development and Validation of Latanoprost by using RP-HPLC in Pharmaceutical Formulations

Chromatography was performed with a mobile phase containing a methanol of assay (99.8%) with flow rate of 1ml/min. Quantitation was accomplished with an internal standard method. The procedure was validated for linearity (correlation coefficient = 0.990), accuracy and Limit of detection (LOD) intraday precision. To test validation of the Latanoprost three factors were considered as linearity, precision, LOD where mobile phase, flowrate and pressure are respectively selected as methanol, 1 ml/min, 1600 pascals

Laparoscopy Minimally Invasive Surgery for Pet Animals

Laparoscopy and minimally invasive surgery have become increasingly popular in veterinary medicine as they offer numerous benefits over traditional surgical techniques. This paper provides an overview of the basic principles of laparoscopy, the equipment and surgical instruments required, anesthesia and patient considerations, insufflation techniques, and specific laparoscopic procedures in veterinary medicine, such as biopsy, cystotomy, enterotomy, cryptorchidectomy, and gastropexy. Methods: Published peer-reviewed reports were used to write this short review paper. Results: The use of laparoscopy is enormously beneficial over open surgery. Published literature suggests using laparoscopy to reduce blood loss. Laparoscopy which is a minimally invasive surgery provide better visualization, less pain and scarring, faster recovery times, and fewer complications than traditional open surgery. Conclusion: The uses of laparoscopy in veterinary medicine are growing and continue to advance, offering new techniques and applications that will benefit both veterinarians and pet owners

A Two-Arm Parallel Double-Blind Randomised Controlled Trial of the Efficacy of Dashmoola Taila Nasya & Marma Chikitsa in Ardhavbhedaka (Migraine)

Shirah is considered as Uttamanga i.e., supreme, important, and major part of the body. Thus, it is necessary to maintain the health of Shirah. Almost all our ancient Acharyas have mentioned the Shirorogas of which Sirah-Shoola (headache) is the leading symptom. Ardhavbhedaka is one of the Shiro-Roga which can be correlated with migraine. It indicates the pain or headache in half of the head i.e. in the right or left half of the head. Several Aushadha have been enumerated by the Acharyas for the management of Ardhavbhedaka. Doshika predominance in Ardhavbhedaka disease, Dashmoola taila was selected as Nasya Yoga. This Yoga pacifies Tri-doshas, and helps to counteract the symptoms of Ardhavbhedaka. A lot of research work has been conducted to evaluate the effect of Nasya Karma on migraine. But this research conducted on the treatment of migraine with Dashmoola taila Nasya and Marma Chikitsa, as adjuvant therapy. Hence, intending to identify and establish, an alternative, safer, effective and long-lasting treatment modality, the study entitled “Evaluation of Dashmoola Taila Nasya and Marma Chikitsa in Ardhavbhedaka (migraine)” was conducted in 40 patients. They were selected based on standard inclusion and exclusion criteria and randomly allocated to two different treatment groups; Group- A (Dashmoola Taila Nasya with Marma Chikitsa) and Group- B (Dashmoola Taila Nasya)

Analysis of Prakriti in Ayurvedic Classical Texts

Prakriti is an integral part of Ayurveda, which is an eternal science based on absolute principles. It is essential for the selection and formation of all factors for which a person will interact from conception to death, such as lifestyle, diet, etc. It represents the character of the body in relation to the Dosha and is determined at the moment of conception based on the predominant Dosha. This character does not change throughout a person's lifetime and is responsible for their physical and mental attributes. Tridosha says there are seven types of Prakriti. People with certain Prakriti have different bodies in terms of how they work, how they act, how they react to things in their environment, how likely they are to get diseases, and so on. Prakriti identifies how an individual reacts to environmental conditions, lifestyle changes, and drugs, and how susceptible they are to different diseases. It's one of the first ideas in preventive and personalized (or genomic) medicine. To figure out how susceptible an individual is to different diseases, what drugs to use, how much to take, how the drug reacts to the body, how the disease will progress, and how to prevent it, first Prakriti is done, then Vikriti is done. Prakriti focuses on uniqueness and plays a big role in preventing and curing diseases, as well as keeping you healthy throughout your life. Analysis of the concept of Prakriti is made to find out through this paper

A Single Case Study on the Management of Vipadika

Kushtha is an encompassing phrase that refers to all skin conditions mentioned in Ayurvedic writings. One of the illnesses covered under the category of Kshudra Kushtha is Vipadika. It is distinguished by Teevra vedana (with excruciating agony) and Pani-pada Sphutan (fissure in the palms and soles). The individual is impacted as a result of erratic eating habits, stressed lifestyle. Its manifestation is mostly caused by vitiation of Vata, Kapha, and Pitta/Rakta. In this case, the patient has been complaining for six months about discomfort and bleeding along with the dryness, scaling, itching, and cracking of both hands. Vipadika patients experience higher negative effects on their personal and social lives because they have severe difficulties with daily tasks, mobility issues, and self-care challenges

Study of Trataka Yoga Kriya on Health in Trisutra Ayurveda

We have come a long way in almost every field of life. Things that were once thought to be impossible for us are now possible for us. Scientists and researchers have changed the way we live. But pollution of air and water, body and mind are also a result of science. With the progress of civilization, mankind is getting weaker every day. Industrialization, diet, exercise, and the nature of work sitting for hours in front of the computer, always in the car, and lack of exercise have led to many diseases such as diabetes, heart disease, obesity, etc. Routine health issues like constipation, stomach issues, gas, eye burning, sinus issues, headaches, and so on, need to be treated in a way that works for them. You can't just take medicines for these things every day. You need to give your body some physical training to show it how effective it is. This is done through the practice of something called 'Shatkarma', which can bring good results if you do it forever. It's all about body cleansing, and the six purification techniques are really important for both physical and mental health. These simple techniques are also really useful for treating internal disorders, which is what this paper is all about

An Overview of Patients Visited at Department of Stri-Roga and Prasuti Tantra at District Ayurveda Health Center Kathmandu

District Ayurveda Health Center, located in Sinamangal, deals with different branches such as Stri Prasuti, Kayachikitsa, Panchakarma, Physiotherapy, Acupuncture, and Acupressure. The majority of the patients who visited DAHC were females. In this retrospective analysis, Gynec patients who underwent treatment from Shrawan 2079 to Ashad 2080 were studied. Objective: The major objective of this study was to determine the treated disease pattern and the frequency of gynec patients who benefited from treatments and services provided in the OPD of DAHC. Material and methods: The study was analytically retrospective in nature, where an analysis of registered patient case records of Stri roga and Prasuti roga from the OPD of DAHC during the period 079-080 B.S. was conducted. Result: Despite a good number of patients visiting the OPD of DAHC and patients with different gynecological diseases being treated with Ayurvedic medications, Sthanika chikitsa (local in situ procedures), Beejasanskara (pre-conceptional care), Garbhasansakara (antenatal care), and Sutika (post-natal care), there is a lack of good publicity and awareness in the general population about the wide range of treatments available for various diseases at DAHC. The follow-up cases were also good. Conclusion: The study showed that DAHC provided services for various gynecological diseases, Sthanika chikitsa (local in situ procedures), Beejasanskara (pre-conceptional care), Garbhasansakara (antenatal care), and Sutika (post-natal care) facilities, benefiting females. Hence, improving the services and conducting awareness programs can provide better Ayurvedic health services to many needy people at the district level