Maize in India: Production Systems, Constraints, and Research Priorities

Crop Production/Industries, Research and Development/Tech Change/Emerging Technologies,

Automated fundus image quality assessment and segmentation of optic disc using convolutional neural networks

An automated fundus image analysis is used as a tool for the diagnosis of common retinal diseases. A good quality fundus image results in better diagnosis and hence discarding the degraded fundus images at the time of screening itself provides an opportunity to retake the adequate fundus photographs, which save both time and resources. In this paper, we propose a novel fundus image quality assessment (IQA) model using the convolutional neural network (CNN) based on the quality of optic disc (OD) visibility. We localize the OD by transfer learning with Inception v-3 model. Precise segmentation of OD is done using the GrabCut algorithm. Contour operations are applied to the segmented OD to approximate it to the nearest circle for finding its center and diameter. For training the model, we are using the publicly available fundus databases and a private hospital database. We have attained excellent classification accuracy for fundus IQA on DRIVE, CHASE-DB, and HRF databases. For the OD segmentation, we have experimented our method on DRINS-DB, DRISHTI-GS, and RIM-ONE v.3 databases and compared the results with existing state-of-the-art methods. Our proposed method outperforms existing methods for OD segmentation on Jaccard index and F-score metrics

Generalizing Greenwald-Khanna Streaming Quantile Summaries for Weighted Inputs

Estimating quantiles, like the median or percentiles, is a fundamental task in data mining and data science. A (streaming) quantile summary is a data structure that can process a set S of n elements in a streaming fashion and at the end, for any phi in (0,1], return a phi-quantile of S up to an eps error, i.e., return a phi'-quantile with phi'=phi +- eps. We are particularly interested in comparison-based summaries that only compare elements of the universe under a total ordering and are otherwise completely oblivious of the universe. The best known deterministic quantile summary is the 20-year old Greenwald-Khanna (GK) summary that uses O((1/eps) log(eps n)) space [SIGMOD'01]. This bound was recently proved to be optimal for all deterministic comparison-based summaries by Cormode and Vesle\'y [PODS'20]. In this paper, we study weighted quantiles, a generalization of the quantiles problem, where each element arrives with a positive integer weight which denotes the number of copies of that element being inserted. The only known method of handling weighted inputs via GK summaries is the naive approach of breaking each weighted element into multiple unweighted items and feeding them one by one to the summary, which results in a prohibitively large update time (proportional to the maximum weight of input elements). We give the first non-trivial extension of GK summaries for weighted inputs and show that it takes O((1/eps) log(eps n)) space and O(log(1/eps)+ log log(eps n)) update time per element to process a stream of length n (under some quite mild assumptions on the range of weights and eps). En route to this, we also simplify the original GK summaries for unweighted quantiles.Comment: 33 pages, 7 figures, International Conference on Database Theory 202

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翻訳・解

Innovative Method for the Estimation of Closure Velocity between RAT Driven Drogue and IFR Probe Air to Air refueling Flight Trials

Air-to-air refueling for a fighter platform is a force multiplier in terms of increasing its combat radius and payload carrying ability. Adapting for such a facility especially for an aircraft under design and development is a challenging task. It requires rigorous ground and flight testing to meet the certification standards. One of important flight test parameter that needs to be validated for structural impact load calculations and certification needs is the closure velocity. The air-to-air refueller was equipped with a Ram-air-turbine powered drogue and chute system. An innovative methodology of estimating the closure velocity between the drogue of the mother aircraft and the in-flight refueling probe of the receiving aircraft was evolved. The method was employed and validated during the air-to-air refueling trials of a prototype fighter platform. The intention of this paper is to explain the methodology employed and deliberate the results obtained with respect to the air-to-air refueling certification

Iron Dynamics Shape Host-Pathogen Interactions

Hosts and their pathogens often compete for trace metal elements that are essential to each of their survival. Iron is one of these trace metal elements and consequently, iron dynamics are central in host-pathogen interactions. Here we review how competition for iron during infection influences host-pathogen interactions and shapes disease outcomes. Hosts have developed diverse mechanisms to limit nutrient availability to the pathogen, also known as nutritional immunity. In response to infection, vertebrate, invertebrate, and plant hosts generate a hypoferremic environment using a variety of iron-binding proteins and chelators, alongside iron transporters, to limit pathogen replication. To counter nutritional immunity responses, pathogens use TonB-dependent (e.g., siderophores) and TonB-independent mechanisms to scavenge ferric and ferrous iron. Pathogens also compete with the host-associated microbiota to access iron. Competition between microbes for iron can either hinder or facilitate pathogen establishment and proliferation within hosts. Iron dynamics are an exciting new avenue for therapeutic interventions that may be employed against a broad range of pathogens

NMR investigations of the interaction between the azo-dye sunset yellow and Fluorophenol

The interaction of small molecules with larger noncovalent assemblies is important across a wide range of disciplines. Here, we apply two complementary NMR spectroscopic methods to investigate the interaction of various fluorophenol isomers with sunset yellow. This latter molecule is known to form noncovalent aggregates in isotropic solution, and form liquid crystals at high concentrations. We utilize the unique fluorine-19 nucleus of the fluorophenol as a reporter of the interactions via changes in both the observed chemical shift and diffusion coefficients. The data are interpreted in terms of the indefinite self-association model and simple modifications for the incorporation of a second species into an assembly. A change in association mode is tentatively assigned whereby the fluorophenol binds end-on with the sunset yellow aggregates at low concentration and inserts into the stacks at higher concentrations

Sequence Analysis of Novel Staphylococcus aureus Lineages from Wild and Captive Macaques

Staphylococcus aureus is a widespread and common opportunistic bacterium that can colonise or infect humans as well as a wide range of animals. There are a few studies of both methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) isolated from monkeys, apes, and lemurs, indicating a presence of a number of poorly or unknown lineages of the pathogen. In order to obtain insight into staphylococcal diversity, we sequenced strains from wild and captive individuals of three macaque species (Macaca mulatta, M. assamensis, and M. sylvanus) using Nanopore and Illumina technologies. These strains were previously identified by microarray as poorly or unknown strains. Isolates of novel lineages ST4168, ST7687, ST7688, ST7689, ST7690, ST7691, ST7692, ST7693, ST7694, ST7695, ST7745, ST7746, ST7747, ST7748, ST7749, ST7750, ST7751, ST7752, ST7753, and ST7754 were sequenced and characterised for the first time. In addition, isolates belonging to ST2990, a lineage also observed in humans, and ST3268, a MRSA strain already known from macaques, were also included into the study. Mobile genetic elements, genomic islands, and carriage of prophages were analysed. There was no evidence for novel host-specific virulence factors. However, a conspicuously high rate of carriage of a pathogenicity island harbouring edinB and etD2/etE as well as a higher number of repeat units within the gene sasG (encoding an adhesion factor) than in human isolates were observed. None of the strains harboured the genes encoding Panton–Valentine leukocidin. In conclusion, wildlife including macaques may harbour an unappreciated diversity of S. aureus lineages that may be of clinical relevance for humans, livestock, or for wildlife conservation, given the declining state of many wildlife populations

Sequence Analysis of Novel Staphylococcus aureus Lineages from Wild and Captive Macaques

Staphylococcus aureus is a widespread and common opportunistic bacterium that can colonise or infect humans as well as a wide range of animals. There are a few studies of both methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) isolated from monkeys, apes, and lemurs, indicating a presence of a number of poorly or unknown lineages of the pathogen. In order to obtain insight into staphylococcal diversity, we sequenced strains from wild and captive individuals of three macaque species (Macaca mulatta, M. assamensis, and M. sylvanus) using Nanopore and Illumina technologies. These strains were previously identified by microarray as poorly or unknown strains. Isolates of novel lineages ST4168, ST7687, ST7688, ST7689, ST7690, ST7691, ST7692, ST7693, ST7694, ST7695, ST7745, ST7746, ST7747, ST7748, ST7749, ST7750, ST7751, ST7752, ST7753, and ST7754 were sequenced and characterised for the first time. In addition, isolates belonging to ST2990, a lineage also observed in humans, and ST3268, a MRSA strain already known from macaques, were also included into the study. Mobile genetic elements, genomic islands, and carriage of prophages were analysed. There was no evidence for novel host-specific virulence factors. However, a conspicuously high rate of carriage of a pathogenicity island harbouring edinB and etD2/etE as well as a higher number of repeat units within the gene sasG (encoding an adhesion factor) than in human isolates were observed. None of the strains harboured the genes encoding Panton–Valentine leukocidin. In conclusion, wildlife including macaques may harbour an unappreciated diversity of S. aureus lineages that may be of clinical relevance for humans, livestock, or for wildlife conservation, given the declining state of many wildlife populations