De la recherche en collaboration à la recherche communautaire. Un guide méthodologique (From collaborative research to community-based research. A methodological toolkit)

Paris, ANRS/Coalition Plus (coll. Sciences sociales et sida)Intitulé " De la recherche en collaboration à la recherche communautaire. Un guide méthodologique " et édité dans la collection " Sciences sociales et sida " de l'ANRS, cet ouvrage alimente de manière inédite le partage d'expériences et la réflexion sur la fabrication de la recherche dans ses aspects les plus concrets. Guide méthodologique innovant de par son ancrage dans le domaine de la recherche communautaire - recherche guidée par les besoins des communautés, répondant à des problématiques de terrain et effectuée dans l'action, avec les principes de participation et de collaboration communautaires -, il constitue un précieux outil pour tous ceux qui s'engagent dans des recherches en collaboration et éveillera l'intérêt de ceux qui ne s'y sont pas encore essayés, qu'ils soient chercheurs, cliniciens ou acteurs de terrain

Holographic neutrino transport in dense strongly-coupled matter

A (toy) model for cold and luke-warm strongly-coupled nuclear matter at finite baryon density and isospin chemical potential is used to study neutrino transport. The complete charged current two-point correlators are computed in the strongly-coupled medium and their impact on neutrino transport is analyzed. The full result is compared with various approximations for the current correlators and the distributions, including the degenerate approximation, the hydrodynamic approximation as well as the diffusive approximation and we comment on their successes. Further improvements are discussed.Comment: 69 pages + Appendix; 27 figure

Questioning the “Ease” in disease: Was living with HIV a burden or boost during the first wave of Covid-19 in France? A qualitative study (COVIDHIV)

Introduction Clinical research has focused on risk factors and treatment for severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), particularly in people with a comorbidity including the human immunodeficiency virus (HIV), but little attention has been paid to the care pathway. This article aims to show how living with HIV may have been a biopsychosocial burden or boost in care pathways for Covid-19. Method People living with HIV (PLHIV) from 9 clinical centers were invited to participate in this qualitative study. The sampling was purposive with a maximum variation in their sociodemographic profiles. Semi-structured interviews were conducted until data saturation, then coded for thematic analysis, using an inductive general approach. Results We interviewed 34 PLHIV of which 20 had SARS-COV-2 once. They were 24 males, 26 born in France; median age: 55. Twenty had a CD4 number above 500, and all were on antiretroviral therapy (ART). HIV appeared as a burden when Covid-19 symptoms reminded HIV seroconversion, fear of contamination, and triggered questions about ART effectiveness. HIV was not considered relevant when diagnosing Covid-19, caused fear of disclosure when participants sought SARS-COV-2 testing, and its care in hospitals was disrupted by the pandemic. ART-pill fatigue caused avoidance for Covid-19 treatment. As a boost, living with HIV led participants to observe symptoms, to get advice from healthcare professionals, and screening access through them. Some participants could accept the result of screening or a clinical diagnosis out of resilience. Some could consider ART or another drug prescribed by their HIV specialist help them to recover from Covid-19. Conclusion Living with HIV could function as a burden and/or a boost in the care pathways for Covid-19, according to patients’ relationship to their HIV history, comorbidities and representation of ART. Covid-19 in PLHIV needs further qualitative study to gain a more comprehensive assessment of the pandemic’s consequences on their lives and coping strategies

Beneficial effects of physical activity in an HIV-infected woman with lipodystrophy: a case report

<p>Abstract</p> <p>Introduction</p> <p>Lipodystrophy is common in patients infected with human immunodeficiency virus receiving highly active antiretroviral therapy, and presents with morphologic changes and metabolic alterations that are associated with depressive behavior and reduced quality of life. We examined the effects of exercise training on morphological changes, lipid profile and quality of life in a woman with human immunodeficiency virus presenting with lipodystrophy.</p> <p>Case presentation</p> <p>A 31-year-old Latin-American Caucasian woman infected with human immunodeficiency virus participated in a 12-week progressive resistance exercise training program with an aerobic component. Her weight, height, skinfold thickness, body circumferences, femur and humerus diameter, blood lipid profile, maximal oxygen uptake volume, exercise duration, strength and quality of life were assessed pre-exercise and post-exercise training. After 12 weeks, she exhibited reductions in her total subcutaneous fat (18.5%), central subcutaneous fat (21.0%), peripheral subcutaneous fat (10.7%), waist circumference (WC) (4.5%), triglycerides (9.9%), total cholesterol (12.0%) and low-density lipoprotein cholesterol (8.6%). She had increased body mass (4.6%), body mass index (4.37%), humerus and femur diameter (3.0% and 2.3%, respectively), high-density lipoprotein cholesterol (16.7%), maximal oxygen uptake volume (33.3%), exercise duration (37.5%) and strength (65.5%). Quality of life measures improved mainly for psychological and physical measures, independence and social relationships.</p> <p>Conclusions</p> <p>These findings suggest that supervised progressive resistance exercise training is a safe and effective treatment for evolving morphologic and metabolic disorders in adults infected with HIV receiving highly active antiretroviral therapy, and improves their quality of life.</p

Physical and emotional health outcomes after 12 months of public-sector antiretroviral treatment in the Free State Province of South Africa: a longitudinal study using structural equation modelling

<p>Abstract</p> <p>Background</p> <p>African and Asian cohort studies have demonstrated the clinical efficacy of antiretroviral treatment (ART) in resource-limited settings. However, reports of the long-term changes in the physical and emotional quality of life (QoL) of patients on ART in these settings are still scarce. In this study, we assessed the physical and emotional QoL after six and 12 months of ART of a sample of 268 patients enrolled in South Africa's public-sector ART programme. The study also tested the impact of the adverse effects of medication on patients' physical and emotional QoL.</p> <p>Methods</p> <p>A stratified random sample of 268 patients undergoing ART was interviewed at baseline (< 6 months ART) and follow-up (< 12 months ART). A model of the relationships between the duration of ART, the adverse effects of medication, and physical and emotional QoL (measured using EUROQOL-5D) was tested using structural equation modelling.</p> <p>Results</p> <p>The improved physical and emotional QoL shown at baseline was sustained over the 12-month study period, because treatment duration was not significantly associated with changes in the patients' QoL. Physical QoL significantly and positively influenced the patients' emotional QoL (subjective well-being [SWB]) (β = 0.33, <it>P </it>< 0.01). Longitudinal data showed that patients reported significantly fewer adverse effects at follow-up than at baseline (β = -0.38, <it>P </it>< 0.001) and that these adverse effects negatively influenced physical (β = -0.27, <it>P </it>< 0.01) and emotional QoL (β = -0.15, <it>P </it>< 0.05).</p> <p>Conclusion</p> <p>This study provides evidence that the South African public-sector ART programme is effective in delivering sustained improvement in patient well-being. However, the results should encourage clinicians and lay health workers to be vigilant regarding the adverse effects of treatment, because they can seriously affect physical and emotional QoL.</p

De la recherche en collaboration à la recherche communautaire. Un guide méthodologique (From collaborative research to community-based research. A methodological toolkit)

Paris, ANRS/Coalition Plus (coll. Sciences sociales et sida)Intitulé " De la recherche en collaboration à la recherche communautaire. Un guide méthodologique " et édité dans la collection " Sciences sociales et sida " de l'ANRS, cet ouvrage alimente de manière inédite le partage d'expériences et la réflexion sur la fabrication de la recherche dans ses aspects les plus concrets. Guide méthodologique innovant de par son ancrage dans le domaine de la recherche communautaire - recherche guidée par les besoins des communautés, répondant à des problématiques de terrain et effectuée dans l'action, avec les principes de participation et de collaboration communautaires -, il constitue un précieux outil pour tous ceux qui s'engagent dans des recherches en collaboration et éveillera l'intérêt de ceux qui ne s'y sont pas encore essayés, qu'ils soient chercheurs, cliniciens ou acteurs de terrain

Tachyon-dependent Chern-Simons terms and the V-QCD Baryon

The structure of the five-dimensional Tachyon-Chern-Simons action and its relevance to single-baryon states in the context of the V-QCD models for holographic QCD with backreacting flavor are analyzed. The most general form of the Tachyon-Chern-Simons 5-form, compatible with symmetries and flavor anomalies is determined. It is the sum of a non-trivial gauge-invariant 5-dimensional form and a non-invariant closed 5-form that reproduces the flavor anomalies. Single-baryon solutions of the gravity theory, arising from the DBI plus Tachyon-Chern-Simons actions are considered. The baryon is realised as a bulk axial instanton. The baryon ansatz and the field equations are derived and the boundary conditions are determined, which ensure that the solution has finite boundary energy and unit baryon charge. The boundary baryon number, which is computed from the universal (closed) part of the Tachyon-Chern-Simons action, is shown to coincide with the bulk axial instanton number