The Subprime Remediation: Efforts in Reducing the Effects of Predatory Lending during the Great Recession

During the subprime mortgage crisis of the early 2000’s, predatory mortgage lending practices were the leading cause for the housing bubble burst. A surge in unequivocal risk in the favor of mortgage lenders stripped the consumer of their financial abilities as a result of de-regulated lending packages and the packaging of such loans in the secondary market. As the crisis unfolded, policymakers and financial regulators implemented measures to address the issues and prevent a similar catastrophe from occurring in the future. Bank bailouts and other forms of reparations were dispersed over the span of nearly five years to recover from the global incident

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.

The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate

Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes

Background The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes. Aim To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave. Methods A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records. Findings In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home. Conclusion The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Diario de Córdoba de comercio, industria, administración, noticias y avisos: Año XXXVII Número 11141 - 07 Noviembre 1886

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 200

Mathematical Literacy and the Secondary Student

Public education is a continually evolving field, with new research, policies, and practices explored by professionals who are driven to provide America’s youth with high-quality education. The years since 2000 have been ripe with literature regarding the importance of content-area reading, and more recently, disciplinary literacy in adolescent classrooms. Students who are literate in a particular discipline, such as math, view themselves as fluent in the language of mathematics, comfortable with reading, discussing, and practicing complex mathematical concepts while using appropriate vocabulary (Buehl 2017). As seasoned professionals and novice educators consider the role of disciplinary literacy in their own classrooms, it is necessary to ponder the practices that are implemented within classrooms. Do they align with current research on the matter? What role do motivation and culture play in the process of becoming mathematically literate? How does adolescent development influence classroom literacy practices? These are the central questions that have guided the construction of this research study, which will seek to examine the phenomena that occur within a classroom as teachers implement practices which promote and teach mathematical literacy. The exploratory nature of this study dictates that no judgement on the effectiveness of observed and discussed instructional strategies is considered, rather, a comparison of the latter with those strategies recommended by current educational researchers and literature. Interviews and classroom observations will work in tandem with a review of the current publications that address the areas of motivation, mathematical literacy, and culture in the context of adolescent development

Mathematical Literacy and the Secondary Student

Public education is a continually evolving field, with new research, policies, and practices explored by professionals who are driven to provide America’s youth with high-quality education. The years since 2000 have been ripe with literature regarding the importance of content-area reading, and more recently, disciplinary literacy in adolescent classrooms. Students who are literate in a particular discipline, such as math, view themselves as fluent in the language of mathematics, comfortable with reading, discussing, and practicing complex mathematical concepts while using appropriate vocabulary (Buehl 2017). As seasoned professionals and novice educators consider the role of disciplinary literacy in their own classrooms, it is necessary to ponder the practices that are implemented within classrooms. Do they align with current research on the matter? What role do motivation and culture play in the process of becoming mathematically literate? How does adolescent development influence classroom literacy practices? These are the central questions that have guided the construction of this research study, which will seek to examine the phenomena that occur within a classroom as teachers implement practices which promote and teach mathematical literacy. The exploratory nature of this study dictates that no judgement on the effectiveness of observed and discussed instructional strategies is considered, rather, a comparison of the latter with those strategies recommended by current educational researchers and literature. Interviews and classroom observations will work in tandem with a review of the current publications that address the areas of motivation, mathematical literacy, and culture in the context of adolescent development

A high-frequency divider in 0.18 µm SiGe BiCMOS technology

High speed frequency dividers are critical parts of frequency synthesisers in wireless systems. These dividers allow the output frequency from a voltage controlled oscillator to be compared with a much lower external reference frequency that is commonly used in these synthesisers. Common trade-offs in high frequency dividers are speed of division, power consumption, real estate area, and output signal dynamic range. In this paper we demonstrate the design of a high frequency, low power divider in 0.18 µm SiGe BiCMOS technology. Three dividers are presented, which are a regenerative divider, a master-slave divider, and a combination of regenerative and master-slave dividers to perform a divide-by-8 chain. The dividers are used as part of a 60 GHz frequency synthesizer. The simulation results are in agreement with measured performance of the regenerative divider. At 48 GHz the divider consumes 18 mW from a 1.8 V supply voltage. The master-slave divider operates up to 36 GHz from a very low supply voltage, 1.8 V. The divide-by-8 operates successfully from 40 GHz to 50 GHz.9 page(s