Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP

Gezonder rendementsdenken : duurzaam waarderen van vastgoed

Rendementsdenken is vanzelfsprekend bij vastgoedontwikkeling. Wat betekent dit voor de kansen voor duurzaamheid? Duurzaamheid kan als aspect heel goed worden meegenomen in rendementsrekenmodellen, zo blijkt

De toekomst en duurzaam bouwen: XX kritisch bekeken

No abstract

De glasbak

Geen samenvatting

De aaibaarheid van beton (voorwoord)

No abstract

Een stap verder, Duurzame Architectuur

Het gaat de goede kant uit. Ook de installatiebranche ontdekt dat gebouwen niet voor eeuwig en onveranderd blijven staan. Afgelopen maand zijn we op de TU/e benaderd voor samenwerking, om de kennis die we hebben op het gebied van veranderbaar bouwen te delen met de branche

Kinderkunsthaus In Rotterdam : Children's Hall of Art in Rotterdam

No abstract

Sustainable lifepans of building systems in urban coastal tropical settlements : a literature review assessment methods

Many coastal settlements in humid tropical developing countries face the burdens of risks due to their location as well as due to a rather low quality of housing that does not meet the requirements of sustainability. The main aim of the paper is to investigate and identify the existing methodologies for the determination and adaptation of the performance for low cost housing in urban coastal tropical settlements towards improved sustainability. For this purpose a literature study was carried out whereby the existing methodologies are assessed by particularly investigating whether and how the sustainability requirements posed at present by the inhabitants as well as the possibility of future changes of these requirements during the lifespan of the houses are taken into account. Another aspect that was included is whether and how the local context such as that of urban coastal tropical settlements are taken into account in the assessment methodologies. This paper describes the literature review results on the assessment method and methodologies that have been used in previous research. The paper’s relevance is to provide proposals and recommendations for the development of methodological approaches to analyze building systems and research instruments that can be used for the assessment of context-dependent sustainability and lifespan performance of building systems. The methodology and research tools that will be developed are to be applied in a survey amongst low cost housing projects in urban tropical coastal settlements at Java, Indonesia. Once the performance of existing technologies as well as the features of the context in which they are applied is known, it will be possible to adapt or develop technologies that better respond to the contextual requirements. By means of applying the developed methodology and research tools in the survey also their usefulness will be validated for the purpose of increasing the insight and understanding of the sustainability and lifespan performance of building systems, particularly of those building systems that can be applied in low cost housing in urban coastal tropical settlements in developing countries. Key words: sustainability and lifespan, building systems, urban coastal tropical settlements, developing countries

The need for post-occupancy evaluation of public apartment buildings in Ghana

\u3cp\u3ePurpose: The purpose of this paper is to examine and show why post-occupancy evaluation (POE) of public apartment buildings in Ghana as a product of design is important. Design/methodology/approach: By design the paper is descriptive. It uses a literature review as a method to summarize, synthesize and show the gaps in the existing knowledge on public apartment buildings in general and Ghana in particular. These arguments are brought together in a conceptual framework for approaching POE studies. Findings: This paper finds that gaps exist in the existing POE research knowledge regarding public apartment buildings in Ghana not only as residential settings but also as designed artifacts intended for use. Research limitations/implications: There is a need for scientific research which focus on the design and use of public apartment buildings in Ghana to provide empirical basis for design, policy and research decision-making. Social implications: This paper shows that occupants’ feedback information is important, as it can benefits government, designers and builders, building regulators and managers, as well as end users. Originality/value: The paper contributes a conceptual framework based on which POE studies can be designed.\u3c/p\u3