Distribución temporal y espacial de Paranortes cordicollis y Pachymorphus striatulus (Coleoptera, Carabide) en dos ambientes edáficos de la Laguna Nahuel Rucá, Buenos Aires, Argentina

Fil: Porrini, Darío P.. CONICETFil: Castro, Adela V.. CONICETFil: Cicchino, Armando Conrado. División Entomología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; Argentin

Dominancia estacional de las Carabidae edáficas (Insecta, Coleoptera) en dos ambientes de la Reserva Integral Laguna de los Padres, Partido de General Pueyrredón, provincia de Buenos Aires

Fil: Cicchino, Armando Conrado. División Entomología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Castro, Adela V.. CONICETFil: Porrini, Darío P.. CONICE

Distribución temporal y espacial de Loxandrus simplex y Loxandrus planicollis (Coleoptera, Carabide) en la Laguna Nahuel Rucá

Fil: Castro, Adela V.. CONICETFil: Porrini, Darío P.. CONICETFil: Cicchino, Armando Conrado. División Entomología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; Argentin

Rasgos biológicos y fenología estacional de Bradycellus viduus (Dejean, 1829) (Insecta, Coleoptera, Harpalini) en el sudeste de la provincia de Buenos Aires, Argentina

Fil: Cicchino, Armando Conrado. División Entomología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Castro, Adela V.. CONICETFil: Porrini, Darío P.. CONICE

Riqueza específica y estructura de dominancia del ensamble de carábidos edáficos (Coleoptera, Carabidae) del saucedal (Salix humboldtiana) de Laguna de los Padres (Buenos Aires, Argentina) durante el período invernal

Fil: Porrini, Darío P.. CONICETFil: Castro, Adela V.. CONICETFil: Cicchino, Armando Conrado. División Entomología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; Argentin

Riqueza específica de las Carabidae (Insecta, Coleoptera) de los suelos de la Reserva Integral Laguna de los Padres, Partido de General Pueyrredón, provincia de Buenos Aires : Resultados de diez años de muestreos (1999-2009)

Fil: Cicchino, Armando Conrado. División Entomología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Porrini, Darío P.. CONICETFil: Castro, Adela V.. CONICE

Diversidad de escarabajos de la familia Carabidae en un ambiente peridomiciliario del talar de Laguna Nahuel Rucá, Mar Chiquita

Fil: Castro, Adela V.. Laboratorio de Artrópodos. Departamento de Biología. Facultad de Ciencias Exactas y Naturales. Universidad Nacional de Mar del Plata; ArgentinaFil: Porrini, Darío P.. Laboratorio de Artrópodos. Departamento de Biología. Facultad de Ciencias Exactas y Naturales. Universidad Nacional de Mar del Plata; ArgentinaFil: Cicchino, Armando Conrado. División Entomología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; Argentin

Intra and inter-day repeatability of peripheral arterial function: suitability and potential limitations

The present study aimed to investigate the inter- and intraday repeatability of reactive hyperemia index (RHI) measured by Endo-PAT in healthy volunteers. Interday RHI repeatability was tested in two consecutive days in a group of thirty-one male subjects. Intraday repeatability was investigated at baseline and after 2 and 4 h in a group of sixteen volunteers. Data were evaluated by analysis of variance. Bland-Altman plot, coefficient of variation (CV), coefficient of repeatability (CR) and intraclass correlation coefficient (ICC) were measured. While interday RHI repeatability was found to be reliable (CV: 6.0%; CR: 0.51; ICC: 0.77), multiple evaluations within the same day significantly (p<0.001) affected RHI (repeatability of the measurement - CV: 18.8%; CR: 1.26; ICC: 0.48). In particular, a significant increase in RHI occurred at 4 h compared to 2 h (+16.8%; p<0.05) and to baseline (+30.1%; p<0.05). In conclusion, RHI showed good interday but poor intraday repeatability. Multiple evaluations increased RHI especially in subjects with endothelial dysfunction who improved or reversed their impairment. These results show the potential limitations of multiple Endo-PAT measurements within the same day and the importance of standardizing the protocols before RHI evaluations

Age-Dependent Neuropsychiatric Symptoms in the NF-κB/c-Rel Knockout Mouse Model of Parkinson’s Disease

Non-motor symptoms are frequently observed in Parkinson’s disease (PD) and precede the onset of motor deficits by years. Among them, neuropsychiatric symptoms, including anxiety, depression, and apathy, are increasingly considered as a major challenge for patients with PD and their caregivers. We recently reported that mice lacking the nuclear factor-κB (NF-κB)/c-Rel protein (c-rel–/– mice) develop an age-dependent PD-like pathology and phenotype characterized by the onset of non-motor symptoms, including constipation and hyposmia, starting at 2 months of age, and motor deficits at 18 months. To assess whether c-rel–/– mice also suffer from neuropsychiatric symptoms, in this study we tested different cohorts of wild-type (wt) and c-rel–/– mice at 3, 6, 12, and 18–20 months with different behavioral tests. Mice lacking c-Rel displayed anxiety and depressive-like behavior starting in the premotor phase at 12 months, as indicated by the analysis with the open field (OF) test and the forced swim test with water wheel (FST), respectively. A deficit in the goal-oriented nesting building test was detected at 18–20 months, suggesting apathetic behavior. Taken together, these results indicate that c-rel–/– mice recapitulate the onset and the progression of PD-related neuropsychiatric symptoms. Therefore, this animal model may represent a valuable tool to study the prodromal stage of PD and for testing new therapeutic strategies to alleviate neuropsychiatric symptoms

Effect of short-term hazelnut consumption on DNA damage and oxidized LDL in children and adolescents with primary hyperlipidemia : a randomized controlled trial

Children with primary hyperlipidemia are prone to develop premature atherosclerosis, possibly associated with increased oxidative stress. Nutritional therapy is the primary strategy in the treatment of hyperlipidemia and associated conditions. Dietary interventions with bioactive-rich foods, such as nuts, may contribute to the modulation of both lipid profile and the oxidative/antioxidant status. Our study aimed to assess the impact of a dietary intervention with hazelnuts on selected oxidative stress markers in children and adolescents with primary hyperlipidemia. A single-blind, 8-week, randomized, controlled, three-arm, parallel-group study was performed. Children and adolescents diagnosed with primary hyperlipidemia (n=60) received dietary guidelines and were randomized into three groups: group 1 received hazelnuts with skin (HZN+S), and group 2 hazelnuts without skin (HZN-S), at equivalent doses (15-30 g/day, based on body weight); group 3 (controls) received only dietary recommendations (no nuts). At baseline and after 8 weeks, plasma oxidized low-density lipoprotein (ox-LDL) concentrations, oxidative levels of DNA damage in PBMCs and potential correlation with changes in serum lipids were examined. A reduction of endogenous DNA damage by 18.9%\ub151.3% (P=.002) and 23.1%\ub147.9% (P=.007) was observed after HZN+S and HZN-S, respectively. Oxidatively induced DNA strand breaks decreased by 16.0%\ub138.2% (P=.02) following HZN+S treatment. Ox-LDL levels did not change after HZN+S intervention but positively correlated with total cholesterol and LDL cholesterol. A short-term hazelnut intervention improves cell DNA protection and resistance against oxidative stress but not ox-LDL in hyperlipidemic pediatric patients. The trial was registered at ISRCTN.com, ID no. ISRCTN12261900