Система спутникового мониторинга территории Красноярского края на основе использования малых космических аппаратов

The satellite monitoring system for the Krasnoyarsk Territory area is proposed. The main feature of proposed system is its implementation at three levels: space, low altitude and ground levels. Each level assumes the use of data compatible spectrophotometric equipment for subsequent integrated interpretation. The development of ground system for control, data acquisition, processing and distribution is assumedПредлагается система спутникового мониторинга территории Красноярского края. Основной особенностью этой системы является реализация ее на трех уровнях: космическом, маловысотном и наземном. На каждом из уровней предполагается использование информационно совместимой спектрофотометрической аппаратуры для дальнейшей комплексной интерпретации. Предполагается разработка наземной системы управления, сбора, обработки и распространения информаци

Improving Aircraft Fuel Efficiency by Using the Adaptive Wing and Winglets

Improving the aircraft's fuel efficiency is one of the main requirements for prospective and modernized aircraft. This paper reports the assessment of change in aerodynamic quality resulting in the improved fuel efficiency of a long-range aircraft when using promising means to enhance aerodynamic quality. These means include the abandonment of the mechanization of wing edges and conventional controls through the use of an adaptive wing, the artificial laminarization of the flow around the elements of a glider, the application of winglets. The abandonment of conventional wing controls and wing mechanization is predetermined by the need to ensure a seamless surface of the glider elements to prevent the premature turbulization of the flow that consequently leads to a decrease in the profile drag of an aircraft. The use of winglets is aimed at reducing inductive drag. Determining a change in the aircraft's fuel efficiency would make it possible to estimate a change in the operating costs during its life cycle.The study employed the known modular software complex «Integration 2.1». The engineering and navigational calculation was performed for a typical flight profile of a long-range aircraft. The possibility of reducing fuel consumption by up to 20 % has been shown. The largest impact on the decrease in fuel consumption is exerted by the flow laminarization on the surface of the glider elements; the reduction in fuel consumption was 17.1 %. The abandonment of mechanization and ailerons decreases fuel consumption by 3.9 %, while the abandonment of ailerons, slats, and flaps reduces fuel consumption by 0.4, 1.5, and 0.4 %, respectively. The use of spiroid winglets made it possible to reduce fuel consumption by 1.95

Система спутникового мониторинга территории Красноярского края на основе использования малых космических аппаратов

The satellite monitoring system for the Krasnoyarsk Territory area is proposed. The main feature of proposed system is its implementation at three levels: space, low altitude and ground levels. Each level assumes the use of data compatible spectrophotometric equipment for subsequent integrated interpretation. The development of ground system for control, data acquisition, processing and distribution is assumedПредлагается система спутникового мониторинга территории Красноярского края. Основной особенностью этой системы является реализация ее на трех уровнях: космическом, маловысотном и наземном. На каждом из уровней предполагается использование информационно совместимой спектрофотометрической аппаратуры для дальнейшей комплексной интерпретации. Предполагается разработка наземной системы управления, сбора, обработки и распространения информаци

Shapley Value as a Quality Control for Mass Spectra of Human Glioblastoma Tissues

The automatic processing of high-dimensional mass spectrometry data is required for the clinical implementation of ambient ionization molecular profiling methods. However, complex algorithms required for the analysis of peak-rich spectra are sensitive to the quality of the input data. Therefore, an objective and quantitative indicator, insensitive to the conditions of the experiment, is currently in high demand for the automated treatment of mass spectrometric data. In this work, we demonstrate the utility of the Shapley value as an indicator of the quality of the individual mass spectrum in the classification task for human brain tumor tissue discrimination. The Shapley values are calculated on the training set of glioblastoma and nontumor pathological tissues spectra and used as feedback to create a random forest regression model to estimate the contributions for all spectra of each specimen. As a result, it is shown that the implementation of Shapley values significantly accelerates the data analysis of negative mode mass spectrometry data alongside simultaneous improving the regression models’ accuracy

Molecular Mapping of Sorbent Selectivities with Respect to Isolation of Arctic Dissolved Organic Matter as Measured by Fourier Transform Mass Spectrometry

The objectives of this study were to identify molecular features characteristic to arctic DOM from the Kolyma River basin and to elucidate structural imprints induced by a choice of the sorption technique. To achieve this goal, DOM was isolated from the Kolyma River basin with a use of three nonionic sorbents: Amberlite XAD-8 resin, PPL- and C18 - SPE cartridges, and one anion exchanging resin–diethylaminoethyl (DEAE) -cellulose. The structural studies were conducted with a use of electrospray ionization Fourier Transform Ion Cyclotron Resonance (ESI FT-ICR) mass spectrometry and liquid state ¹H NMR spectroscopy. The DOM isolates obtained with a use of PPL and C18 cartridges were characterized with higher content of aliphatic compounds as compared to XAD-8 and DEAE-isolates. In total, for all arctic DOM isolates we observed predominance of hydrogen saturated compounds with high H/C values of identified formulas from FT-ICR MS data. ¹H NMR spectroscopy studies have confirmed this trend and revealed high contribution of alkyl-chain protons into the spectral density of the arctic DOM reaching 43% for PPL isolates

“Silicon-On-Insulator”-Based Biosensor for the Detection of MicroRNA Markers of Ovarian Cancer

Ovarian cancer is a gynecological cancer characterized by a high mortality rate and tumor heterogeneity. Its early detection and primary prophylaxis are difficult to perform. Detecting biomarkers for ovarian cancer plays a pivotal role in therapy effectiveness and affects patients’ survival. This study demonstrates the detection of microRNAs (miRNAs), which were reported to be associated with ovarian cancer tumorigenesis, with a nanowire biosensor based on silicon-on-insulator structures (SOI-NW biosensor). The advantages of the method proposed for miRNA detection using the SOI-NW biosensor are as follows: (1) no need for additional labeling or amplification reaction during sample preparation, and (2) real-time detection of target biomolecules. The detecting component of the biosensor is a chip with an array of 3 µm wide, 10 µm long silicon nanowires on its surface. The SOI-NW chip was fabricated using the “top-down” method, which is compatible with large-scale CMOS technology. Oligonucleotide probes (oDNA probes) carrying sequences complementary to the target miRNAs were covalently immobilized on the nanowire surface to ensure high-sensitivity biospecific sensing of the target biomolecules. The study involved two experimental series. Detection of model DNA oligonucleotides being synthetic analogs of the target miRNAs was carried out to assess the method’s sensitivity. The lowest concentration of the target oligonucleotides detectable in buffer solution was 1.1 × 10−16 M. In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed. The results of our present study represent a step towards the development of novel highly sensitive diagnostic systems for the early revelation of ovarian cancer in women

Shower development of particles with momenta from 1 to 10 GeV in the CALICE Scintillator-Tungsten HCAL

28 pages, 23 figures, 3 tablesLepton colliders are considered as options to complement and to extend the physics programme at the Large Hadron Collider. The Compact Linear Collider (CLIC) is an $e^+e^-$ collider under development aiming at centre-of-mass energies of up to 3 TeV. For experiments at CLIC, a hadron sampling calorimeter with tungsten absorber is proposed. Such a calorimeter provides sufficient depth to contain high-energy showers, while allowing a compact size for the surrounding solenoid. A fine-grained calorimeter prototype with tungsten absorber plates and scintillator tiles read out by silicon photomultipliers was built and exposed to particle beams at CERN. Results obtained with electrons, pions and protons of momenta up to 10 GeV are presented in terms of energy resolution and shower shape studies. The results are compared with several GEANT4 simulation models in order to assess the reliability of the Monte Carlo predictions relevant for a future experiment at CLIC