First-generation college students\u27 family role transitions in college: a psychoeducational support group

The college student population continues to grow diverse in many ways, including the evolving cohorts of first-generation college students (FGCS). These students, whose student generational status is defined by having parents who have not enrolled in post-secondary education, enter college with a different background than their peers who have parents familiar with the college experience. This difference accounts for some challenges regularly faced by FGCS, including sensed tension within their family system and overall distress as they transition from their home-oriented to school-oriented roles. This student population lacks resources that aid understanding and management of new challenges within the family and coping with family-related stress. This dissertation project builds on empirical, theoretical, and applied literature about FGCS and their family, literature about the psychoeducational support group format, and original content to offer college mental health clinicians to facilitate a psychoeducational support group for FGCS on their campus. The recommendations outlined in the group handbook included in this dissertation provide college counseling center group facilitators a guide for helping familiarize FGCS members with changes that might occur in their family during the transition to college. This includes guidance on how to manage family-related stress that might arise, including preparation on how to convey expected role transitions to family members and negotiate changing roles. Additional considerations for using recommendations, project limitations, and directions for future research are also addressed

Cell-specific targeting of renal fibrosis

De focus van dit proefschrift ligt op het gunstige effect zien van celspecifieke getargete afgifte om transplantaatafstoting, ontsteking en fibrose te verbeteren in diermodellen van nierziekten. We bieden een nieuwe strategie van medicamentafgifte aan proximale tubuluscellen door gebruik van de megalinerecptor en aan myofibroblasten door antifibrotische cytokines naar PDGFβR te dirigeren. Deze strategieën vergroten het therapeutische potentieel van medicamenten door verhoogde doeltreffendheid en verminderde off-target bijwerkingen. We geloven dat celspecifieke afgifte van medicamenten een veelbelovende aanpak is om effectief renale fibrose te stoppen. Bovendien is het ex vivo-model dat we hier beschreven hebben een nieuwe methode om de pathofysiologie van het vroege proces en het eindstadium van fibrose te bestuderen, evenals om te screenen op de werkzaamheid van antifibrotische medicamenten ex vivo in een multicellulair en profibrotisch milieu. Belangrijke voordelen van het slice-model is dat de data van onze dierproef direct geëxtrapoleerd kunnen worden naar de humane situatie door het gebruik van (fibrotisch) humaan nierweefsel. Van belang is dat weefselslices een alternatief, of 3V-methode, vormen die inzicht verschaffen in mechanismen van ziekteprocessen en ontworpen zijn om dierexperimenten te vervangen, te verminderen en te verfijnen

Diagenetic factors controlling reservoir quality in the Faraghan Formation (Lower Permian), Darang Field, Southern Iran

The role of diagenesis in affecting (reduction or enhancement) reservoir quality in the Faraghan Formation in Darang #1 well was investigated. The Faraghan Formation is mainly composed of sandstone facies along with minor mudstone and siltstone and grades upward into mixed carbonate –siliciclastic facies and then to Dalan Formation carbonates. Depositional environment of this formation comprises various sub-environments of a delta setting in the lower part of the formation which grades upward into a shallow marine clastic environment in the upper part. The processes enhancing reservoir quality include dissolution of carbonate grains and cements and alteration of feldspar grains. Burial history diagram shows that after deposition during Lower Permain, the formation underwent a rapid burial up to 1000 meters below sea level in Upper Permian. Then a slight uplift (about 100 meters) and gradual burial followed up to Mid- Jurassic. Afterwards the formation experienced a series of rapid and moderate uplift from Mid-Jurassic to Tertiary when the formation uplifted to around 2500 meters above sea level. The suitable conditions resulting in dissolution took place in shallow buried sandstones. These conditions occurred two times during burial history: at the early stages of eodiagenesis and during telodiagenesis. The major processes deteriorating reservoir quality include compaction and cementation. Major cement types include carbonate cements (dolomite, siderite), clay cements (kaolinite, sericite, chlorite), silica cement and pyrite cement. The most abundant cement is the carbonate cement especially dolomite. The dolomite cement occurs as intergranular and poikilotopic forms. The most frequent clay cement is sericite which dominates in sitstones and lithicarenites. Silica cement, where present, fills all the pore spaces. The least frequent cement type is pyrite which is found in two forms of poikilotopic and framboidal. Where it is found in the form of poikilotopic cement, it massively fills the pore spaces and deteriorates the porosity and permeability of the sandstones

CenoDerm vs. fascia lata for the prevention of dorsal nasal irregularities in rhinoplasty

Introduction: Dorsal nasal irregularity is a complication of rhinoplasty surgery, mostly seen in patients with thin skin. Acellular dermis (CenoDerm) and homologous fascia lata covering the nasal bone cartilage structure have been used to achieve a smooth surface. In this study, we aimed to investigate clinical outcomes using these two materials. Materials and Methods: After a standard rhinoplasty procedure, a layer of the acellular dermis or homologous fascia lata was placed in the pocket of the dorsum. Patients were evaluated for clinical outcomes at 3, 6, and 12 months after the procedure. Results Forty-two of 68 patients completed the follow-up period. Patient satisfaction was higher in the homologous fascia lata group. Similarly, nasal dorsum inspection and palpation results were better in the homologous fascia lata group compared with the CenoDerm group but was significant in palpation (P=0.00). There was no complete absorption in the homologous fascia lata group 6 months after surgery (P= 0.04 vs. CenoDerm) but no significant difference was observed at 12 months. Conclusion: Homologous fascia lata is better than acellular dermis in preventing dorsal nasal irregularity after rhinoplasty in thin-skinned patients

Histological study of Acipenser persicus alimentary canal during early life stages

Histological study of alimentary canal of Persian sturgeon was conducted during early life from hatching to 56 days old by light microscope. Some hours after hatching, in anterior part, rudimentary eye and brain were visible, also in posterior part was completely filled with acidophil yolk. Mouth and anal were not clear. In 5-7 days after hatching all parts of the alimentary canal except stomach were roughly anatomically complete, as though in comparison with the hatching time the amount of acidophil yolk was less. At this stage, mouth was covered by stratified squamous epithelium in which several number of tast buds were visible and also rudimentary part of esophagus was squamous to pseudostratified columnar epithelium and in terminal part was columnar to ciliated pseudostratified columnar epithelium. In 8-9 days after hatching, the alimentary canal was structurally complete and two parts of stomach i.e. glandular stomach (cardia) and non-glandular stomach (pyloric) were more clear. The glandular stomach epithelium was simple columnar to ciliated pseudostratified columnar epithelium, while pyloric stomach had simple columnar to pseudostratified columnar epithelium. In 9 days after hatching, external food with a lot of yolk were visible in alimentary canal, which indicates endo-exogenous feeding. In I I-12 days after hatching a lot of external food i.e. daphnia were visible in alimentary canal .In 14 days after hatching pyloric caeca was appeared and in 40 days conical teeth was observed. In the primitive stages of life, the glycoprotein secretions belong to simple columnar cells (interior part of esophagus &some parts of intestine), while through age increase, these secretions belong to apical cells of simple columnar and also goblet cells. The beginning of active feeding of Persian sturgeon larvae was occurred in 9 to 11 days after hatching. Following the development, there was no special alternation except thickness increase of epithelium, muscular layer, connective tissue of lamina propria and increase of epithelial folds of intestine

CenoDerm vs. fascia lata for the prevention of dorsal nasal irregularities in rhinoplasty

Introduction: Dorsal nasal irregularity is a complication of rhinoplasty surgery, mostly seen in patients with thin skin. Acellular dermis (CenoDerm) and homologous fascia lata covering the nasal bone cartilage structure have been used to achieve a smooth surface. In this study, we aimed to investigate clinical outcomes using these two materials. Materials and Methods: After a standard rhinoplasty procedure, a layer of the acellular dermis or homologous fascia lata was placed in the pocket of the dorsum. Patients were evaluated for clinical outcomes at 3, 6, and 12 months after the procedure. Results Forty-two of 68 patients completed the follow-up period. Patient satisfaction was higher in the homologous fascia lata group. Similarly, nasal dorsum inspection and palpation results were better in the homologous fascia lata group compared with the CenoDerm group but was significant in palpation (P=0.00). There was no complete absorption in the homologous fascia lata group 6 months after surgery (P= 0.04 vs. CenoDerm) but no significant difference was observed at 12 months. Conclusion: Homologous fascia lata is better than acellular dermis in preventing dorsal nasal irregularity after rhinoplasty in thin-skinned patients

Evaluation of squamous cell carcinoma antigen 1 expression in oral squamous cell carcinoma (tumor cells and peritumoral T-lymphocytes) and verrucous carcinoma and comparison with normal oral mucosa

Background: Squamous cell carcinoma antigen (SCCA) is used as a prognostic marker for recurrence of squamous cell carcinoma in various sites, including head and neck. Studies suggest that its high serum levels are correlated to some clinical features, such as nodal metastasis. However, it is still unknown if high SCCA in patients with SCCA tissue expression in tumor cells are related to peripheral T-lymphocytes. Therefore, we did this study to evaluate SCCA expression in squamous cell carcinoma and verrucous carcinoma and to compare it with normal oral mucosa, also investigating the correlation between serum-based and tissue-based antigen levels. Methodology: In this study, the immunohistochemistry (IHC) technique was used to determine the SCCA1 expression pattern in 81 specimens divided into 3 groups, including oral squamous cell carcinoma, verrucous carcinoma, and normal oral mucosa. Serum-based and tissue-based antigen levels of 20 oral squamous cell carcinoma cases were compared by the western blot assay. SCCA expression was also evaluated and compared in both tumor cells and peripheral T-lymphocytes by the immunofluorescence assay. Results: Our results showed that the SCCA levels in SCC specimens were significantly lower than in verrucous carcinoma and normal and hyperplastic oral mucosa specimens. We found no correlation between the IHC expression of SCCA and serum levels. SCCA was well expressed in both tumor cells and peripheral T-lymphocytes. Conclusion: Decreasing SCCA in SCC specimens suggested that SCC tumor cells may affect more than the serum levels of SCCA in some patients. In addition, expression of SCCA in peripheral T-lymphocytes showed that both tumor cells and T-lymphocytes may cause serum SCCA.&nbsp