Determining North Atlantic meridional transport variability from pressure on the western boundary: a model investigation.

In this paper we investigate the possibility of determining North Atlantic meridional transport variability using pressure on the western boundary, focusing on the 42degN latitude of the Halifax WAVE array. We start by reviewing the theoretical foundations of this approach. Next we present results from a model analysis, both statistical and dynamic, that demonstrate the feasibility of the approach. We consider how well we can quantify the meridional transport variability at 42degN given complete knowledge of bottom pressure across the basin, and to what degree this quantification is degraded by first ignoring the effect of intervening topography, and then by using only bottom pressure on the western boundary. We find that for periods of greater than one year we can recover more than 90% of the variability of the main overturning cell at 42degN using only the western boundary pressure, provided we remove the depth-average boundary pressure signal. This signal arises from a basin mode of bottom pressure variability, which has power at all timescales, but that does not in truth have a meridional transport signal associated with it, and from the geostrophic depth-independent compensation of the Ekman transport. An additional benefit of the removal of the depth-average pressure is that this high-frequency Ekman signal, which is essentially noise as far as monitoring the MOC for climatically important changes is concerned, is clearly separated from other modes

Developmental depression-to-facilitation shift controls excitation-inhibition balance

Changes in the short-term dynamics of excitatory synapses over development have been observed throughout cortex, but their purpose and consequences remain unclear. Here, we propose that developmental changes in synaptic dynamics buffer the effect of slow inhibitory long-term plasticity, allowing for continuously stable neural activity. Using computational modeling we demonstrate that early in development excitatory short-term depression quickly stabilises neural activity, even in the face of strong, unbalanced excitation. We introduce a model of the commonly observed developmental shift from depression to facilitation and show that neural activity remains stable throughout development, while inhibitory synaptic plasticity slowly balances excitation, consistent with experimental observations. Our model predicts changes in the input responses from phasic to phasic-and-tonic and more precise spike timings. We also observe a gradual emergence of short-lasting memory traces governed by short-term plasticity development. We conclude that the developmental depression-to-facilitation shift may control excitation-inhibition balance throughout development with important functional consequences

Drug resistance and treatment failure in leishmaniasis: A 21st century challenge

Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently needed on a global basis because treatment failure is an increasing problem. Drug resistance is a fundamental determinant of treatment failure, although other factors also contribute to this phenomenon, including the global HIV/AIDS epidemic with its accompanying impact on the immune system. Pentavalent antimonials have been used successfully worldwide for the treatment of leishmaniasis since the first half of the 20th century, but the last 10 to 20 years have witnessed an increase in clinical resistance, e.g., in North Bihar in India. In this review, we discuss the meaning of “resistance” related to leishmaniasis and discuss its molecular epidemiology, particularly for Leishmania donovani that causes visceral leishmaniasis. We also discuss how resistance can affect drug combination therapies. Molecular mechanisms known to contribute to resistance to antimonials, amphotericin B, and miltefosine are also outlined

Path Integral Approach to Strongly Nonlinear Composite

We study strongly nonlinear disordered media using a functional method. We solve exactly the problem of a nonlinear impurity in a linear host and we obtain a Bruggeman-like formula for the effective nonlinear susceptibility. This formula reduces to the usual Bruggeman effective medium approximation in the linear case and has the following features: (i) It reproduces the weak contrast expansion to the second order and (ii) the effective medium exponent near the percolation threshold are $s=1$, $t=1+\kappa$, where $\kappa$ is the nonlinearity exponent. Finally, we give analytical expressions for previously numerically calculated quantities.Comment: 4 pages, 1 figure, to appear in Phys. Rev.

Deep currents and the eastward salinity tongue in the equatorial Atlantic: Results from an eddy-resolving, primitive equation model

The high-resolution model of the wind-driven and thermohaline circulation in the Atlantic Ocean developed in recent years as a “community modeling effort” for the World Ocean Circulation Experiment is examined for the temporal and spatial structure of the deep equatorial current field and its effect on the spreading of North Atlantic Deep Water (NADW). Under seasonally varying wind forcing, the model reveals a system of basin-wide zonal currents of O(5 cm s−1), alternating east-west, and oscillating at an annual period. The current fluctuations are induced by the seasonal cycle of the wind stress in the equatorial Atlantic and show characteristics of long equatorial Rossby waves with westward phase propagation of about 15 cm s−1. The mean flow in the deep western tropical Atlantic is governed by a deep western boundary current (DWBC) with core velocities of more than 10 cm s−1. Only a small fraction of the DWBC branches off at the equator, with correspondingly low mean eastward currents of only about 1 cm s−1. Despite this weak advection along the equator, a well-developed salinity tongue is observed in the model, which is reminiscent of observed property distributions at the upper NADW level. The model evaluation indicates the salinity pattern to be a result of a balance between mean zonal advection and meridional diffusion of salt. The presence of the zonal current oscillations appears to have no significance for the existence of the salinity tongue

A Polymerase-chain-reaction Assay for the Specific Identification of Transcripts Encoded by Individual Carcinoembryonic Antigen (CEA)-gene-family Members

Carcinoembryonic antigen (CEA) is a tumor marker that belongs to a family of closely related molecules with variable expression patterns. We have developed sets of oligonucleotide primers for the specific amplification of transcripts from individual CEA-family members using the reverse transcriptase/ polymerase chain reaction (RT/PCR). Specific primer sets were designed for CEA, non-specific cross-reacting antigen (NCA), biliary glycoprotein (BGP), carcinoembryonic antigen gene-family members 1, 6 and 7 (CGMI, CGM6 and CGM7), and one set for all pregnancy-specific glycoprotein (PSG) transcripts. Primers were first tested for their specificity against individual cDNA clones and product-hybridization with internal, transcript-specific oligonucleotides. Total RNA from 12 brain and 63 gynecological tumors were then tested for expression of CEA-related transcripts. None were found in tumors located in the brain, including various mesenchymal and neuro-epithelial tumors. CEA and NCA transcripts were, however, present in an adenocarcinoma located in the nasal sinuses. In ovarian mucinous adenocarcinomas, we always found co-expression of CEA and NCA transcripts, and occasionally BGP mRNA. CEA-related transcripts were also found in some serous, endometrioid and clear-cell ovarian carcinomas. CEA, NCA and BGP transcripts were present in endometrial carcinomas of the uterus and cervical carcinomas, whereas uterine leiomyomas were completely negative. No transcripts were found from CGM 1, CGM6, CGM7 or from PSG genes in any of the tumors tested. The PCR data were compared with immunohistochemical investigations of ovarian tumors at the protein level using CEA (26/3/13)-, NCA-50/90 (9A6FR) and NCA-95 (80H3)-specific monoclonal antibodies

Um aplicativo iPhone para a rastreabilidade da ferrugem asiática da soja no Brasil.

RESUMO: A soja é, no Brasil, um dos principais itens da produção agrícola, sendo o país o segundo maior produtor mundial deste grão. Devido ao grande crescimento da produção nas últimas décadas, a soja, tornou-se o foco dos principais órgãos relacionados ao agro-negócio brasileiro. Com a introdução da ferrugem asiática da soja no Brasil, um melhor gerenciamento no combate a essa doença se tornou necessária, sendo assim, criado em setembro de 2004, o Consórcio Antiferrugem surgiu com a finalidade de trazer soluções de manejo e controle da dispersão desta doença no Brasil. Este artigo descreve o desenvolvimento de um aplicativo iPhone, criado para dar suporte ao sistema Web do Consórcio Antiferrugem, como uma ferramenta móvel auxiliando o monitoramento da dispersão e a rastreabilidade da ferrugem asiática da soja no Brasil. ABSTRACT: Soybean is one of the major items of agricultural production in Brazil, being the country the second largest producer of this grain. Due to the large increase in production in recent decades, soybean has become the focus of the main organs related to brazilian agribusiness. With the introduction of Asian soybean rust in Brazil, a better management of this disease became necessary, therefore, created in September 2004, the Consortium Antirust emerged with the purpose to bringing solutions to help manage and control the spread of this disease in Brazil. This article describes the development of an iPhone application, designed to support the Antirust Consortium Web System as a mobile tool to assist on monitoring and tracking the dispersion of soybean rust in Brazil.Trabalho apresentado no III Simpósio de Computação Aplicada, Passo Fundo, 2011

Probabilistic models of information retrieval based on measuring the divergence from randomness

We introduce and create a framework for deriving probabilistic models of Information Retrieval. The models are nonparametric models of IR obtained in the language model approach. We derive term-weighting models by measuring the divergence of the actual term distribution from that obtained under a random process. Among the random processes we study the binomial distribution and Bose--Einstein statistics. We define two types of term frequency normalization for tuning term weights in the document--query matching process. The first normalization assumes that documents have the same length and measures the information gain with the observed term once it has been accepted as a good descriptor of the observed document. The second normalization is related to the document length and to other statistics. These two normalization methods are applied to the basic models in succession to obtain weighting formulae. Results show that our framework produces different nonparametric models forming baseline alternatives to the standard tf-idf model

A catalogue of dosemeters and dosimetric services within Europe—an update

The catalogue of dosemeters and dosimetric services within the European Union (EU) Member States and Switzerland that was issued by EURADOS in the year 2000 has been updated and extended with information on dosimetric services in the new EU Member States and Bulgaria, Croatia, Romania, Serbia and Montenegro, and Ukraine. The total number of dosimetric services in these European countries is now estimated to be about 200. The present catalogue is based on information collected from 90 European dosimetric services, among which 34 questionnaires from 32 services were obtained over the years 2001-2004 for the first time. This article assesses and updates the present use of personal dosemeters and the extent to which occupationally exposed persons in Europe are monitored with dosemeters able to measure the operational quantity—personal dose equivalent, HP(d). The perspective of joining EU by the new countries accelerated the implementation of the EU Basic Safety Standard Directive to their national regulations. As a result, all newly investigated services reported their ability to measure HP(d). The catalogue provides information on the dosemeters, dose calculation and background subtraction algorithms, calibration methods, energy and angular response, and performanc

Reentrant behaviour in Landau Fermi liquids with spin-split Pomeranchuk instabilities

We study the effects of spin-antisymmetric interactions on the stability of a Landau-Fermi liquid on the square lattice, using the generalized Pomeranchuk method for two-dimensional lattice systems. In particular, we analyze interactions that could induce instabilities of the so called spin-split type, that is when spin-up and spin-down Fermi surfaces are displaced with respect to each other. The phase space is studied as a function of the strength of the interaction $V$, the electron chemical potential $\mu$ and an external magnetic field $h$. We find that such interactions produce in general an enhancement of the instability region of the Landau-Fermi liquid. More interestingly, in certain regions of the $V$-$\mu$ phase space, we find a reentrant behaviour as a function of the magnetic field $h$, similar to that found in recent experiments, e.g. in URu$_2$Si$_2$ and Sr$_3$Ru$_2$O$_7$.Comment: 5 pages, 3 figure