The Root Of All Evil: Civic Genealogy From Brunetto To Dante

ABSTRACT THE ROOT OF ALL EVIL: CIVIC GENEALOGY FROM BRUNETTO TO DANTE Chelsea A. Pomponio Kevin Brownlee From the thirteenth century well into the Renaissance, the legend of Florence’s origins, which cast Fiesole as the antithesis of Florentine values, was continuously rewritten to reflect the changing nature of Tuscan society. Modern criticism has tended to dismiss the legend of Florence as a purely literary conceit that bore little relation to contemporary issues. Tracing the origins of the legend in the chronicles of the Duecento to its variants in the works of Brunetto Latini and Dante Alighieri, I contend that the legend was instead a highly adaptive mode of legitimation that proved crucial in the negotiation of medieval Florentine identity. My research reveals that the legend could be continually rewritten to serve the interests of collective and individual authorities. Versions of the legend were crafted to support both republican Guelfs and imperial Ghibellines; to curry favor with the Angevin rulers of Florence and to advance an ethnocentric policy against immigrants; to support the feudal system of privilege and to condemn elite misrule; to denounce the mercantile value of profit and to praise economic freedom. Consideration of the shifting social and political landscape of Florence further reveals a programmatic personalization of the legend over the course of the Trecento, as the boundaries between civic and familial history are increasingly obscured

Bloch oscillations and the lack of the decay of the false vacuum in a one-dimensional quantum spin chain

We consider the decay of the false vacuum, realised within a quantum quench into an anti-confining regime of the Ising spin chain with a magnetic field opposite to the initial magnetisation. Although the effective linear potential between the domain walls is repulsive, the time evolution of correlations still shows a suppression of the light cone and a reduction of vacuum decay. The suppressed decay is a lattice effect, and can be assigned to emergent Bloch oscillations.Comment: 12 pages, 6 figures, pdflatex file. v2: 14 pages, new material and references added, improved discussion, main results and conclusions unchange

Rituximab for eosinophilic granulomatosis with polyangiitis: a systematic review of observational studies

Objective To analyse the available evidence about the use of rituximab (RTX) and other biologic agents in eosinophilic granulomatosis with polyangiitis (EGPA) patients and to provide useful findings to inform the design of future, reliable clinical trials. Methods A systematic review was performed. A systematic search was conducted in PubMed/MEDLINE, Scopus, Web of Science and the Cochrane library databases on RTX, and an extensive literature search was conducted on other biologic agents. Results Forty-five papers pertinent to our questions were found: 16 retrospective cohort studies, 8 case series, 3 prospective cohort studies and 18 single case reports, for a total of 368 EGPA patients. More than 80% of evaluable patients achieved complete or partial remission with a tendency towards a higher rate of complete response in the pANCA-positive subgroup. Conclusion Although the majority of the evaluable EGPA patients treated with RTX appears to achieve complete remission, we strongly believe that a number of sources of heterogeneity impair a clear interpretation of results and limit their transferability in clinical practice. Differences in design, enrolment criteria, outcome definition and measurement make a comparison among data obtained from studies on RTX and other biologic agents unreliable

Analysis of Amphetamine and Congeners in Illicit Samples by Liquid Chromatography and Capillary Electrophoresis

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Ground state solutions to the nonlinear Schrodinger-Maxwell equations

We prove the existence of ground state solutions for the nonlinear Schrodinger-Maxwell equations.Comment: 27 page

Positive Least Energy Solutions and Phase Separation for Coupled Schrodinger Equations with Critical Exponent: Higher Dimensional Case

We study the following nonlinear Schr\"{o}dinger system which is related to Bose-Einstein condensate: {displaymath} {cases}-\Delta u +\la_1 u = \mu_1 u^{2^\ast-1}+\beta u^{\frac{2^\ast}{2}-1}v^{\frac{2^\ast}{2}}, \quad x\in \Omega, -\Delta v +\la_2 v =\mu_2 v^{2^\ast-1}+\beta v^{\frac{2^\ast}{2}-1} u^{\frac{2^\ast}{2}}, \quad x\in \om, u\ge 0, v\ge 0 \,\,\hbox{in \om},\quad u=v=0 \,\,\hbox{on \partial\om}.{cases}{displaymath} Here \om\subset \R^N is a smooth bounded domain, $2^\ast:=\frac{2N}{N-2}$ is the Sobolev critical exponent, -\la_1(\om)0 and $\beta\neq 0$, where \lambda_1(\om) is the first eigenvalue of $-\Delta$ with the Dirichlet boundary condition. When \bb=0, this is just the well-known Brezis-Nirenberg problem. The special case N=4 was studied by the authors in (Arch. Ration. Mech. Anal. 205: 515-551, 2012). In this paper we consider {\it the higher dimensional case $N\ge 5$}. It is interesting that we can prove the existence of a positive least energy solution (u_\bb, v_\bb) {\it for any $\beta\neq 0$} (which can not hold in the special case N=4). We also study the limit behavior of (u_\bb, v_\bb) as $\beta\to -\infty$ and phase separation is expected. In particular, u_\bb-v_\bb will converge to {\it sign-changing solutions} of the Brezis-Nirenberg problem, provided $N\ge 6$. In case \la_1=\la_2, the classification of the least energy solutions is also studied. It turns out that some quite different phenomena appear comparing to the special case N=4.Comment: 48 pages. This is a revised version of arXiv:1209.2522v1 [math.AP

On the Schrodinger-Maxwell equations under the effect of a general nonlinear term

In this paper we prove the existence of a nontrivial solution to the nonlinear Schrodinger-Maxwell equations in $\R^3,$ assuming on the nonlinearity the general hypotheses introduced by Berestycki & Lions.Comment: 18 page

Low-dose oral imatinib in the treatment of systemic sclerosis interstitial lung disease unresponsive to cyclophosphamide: a phase II pilot study.

NTRODUCTION: Pulmonary involvement represents a major cause of death of systemic sclerosis (SSc) patients. Recent data suggest that tyrosine kinase inhibitors, such as imatinib, may be a therapeutic option for SSc patients. However, preliminary published clinical trials were inconclusive about imatinib efficacy and showed side effects. The purpose of this study was to verify efficacy and tolerability of low-dose imatinib on interstitial lung disease in a cohort of SSc patients unresponsive to cyclophosphamide therapy. METHODS: Thirty consecutive SSc patients with active pulmonary involvement, unresponsive to cyclophosphamide, were treated with imatinib 200 mg/day for 6 months followed by a 6-month follow-up. A "good response" was defined as an increase of forced vital capacity (FVC) by more of 15% and/or increase of diffusing capacity of carbon monoxide (DLCO) >15% and PaO2 > 90% of initial value and high-resolution computed tomography (HRCT)-scan pattern unchanged or improved. RESULTS: Twenty-six patients completed the study. Three patients died and one patient was lost to follow-up. Four patients (15.32%) had a good response, 7 worsened and 15 had a stabilized lung disease. Overall, 19 (73.07%) patients had an improved or stabilized lung disease. After a 6-month follow-up, 12 (54.5%) of the 22 patients showed an improved or stabilized lung disease. CONCLUSIONS: Lung function was stabilized in a large proportion of patients unresponsive to cyclophosphamide therapy and a beneficial outcome emerged from the analysis of HRCT lung scans. There was no significant improvement of skin involvement, and the low dose was well tolerated. These data provide useful suggestions to design future randomized clinical trials for SSc therapeutics