New, nearby bright southern ultracool dwarfs

We report the discovery of twenty-one hitherto unknown bright southern ultracool dwarfs with spectral types in the range M7 to L5.5, together with new observations of a further three late M dwarfs previously confirmed. Three more objects are already identified in the literature as high proper motion stars;we derive their spectral types for the first time. All objects were selected from the 2MASS All Sky and SuperCOSMOS point source databases on the basis of their optical/near-infrared colours, $J$-band magnitudes and proper motions. Low resolution (R $\sim$ 1000) $JH$ spectroscopy with the ESO/NTT SOFI spectrograph has confirmed the ultracool nature of 24 targets, out of a total of 25 candidates observed. Spectral types are derived by direct comparison with template objects and compared to results from H$_2$O and FeH indices. We also report the discovery of one binary, as revealed by SOFI acquisition imaging; spectra were taken for both components. The spectral types of the two components are L2 and L4 and the distance $\sim$ 19 pc. Spectroscopic distances and transverse velocities are derived for the sample. Two $\sim$ L5 objects lie only $\sim$ 10 pc distant. Such nearby objects are excellent targets for further study to derive their parallaxes and to search for fainter, later companions with AO and/or methane imaging.Comment: 11 pages, 10 figures, accepted to MNRA

Widening participation in higher education: student quantitative skills and independent learning as impediments to progression

The UK government's widening participation strategy, and the concomitant development of a mass higher education system, has imposed a variety of pressures on higher education institutions. Not least of these is the changing nature of the student population, and the assumptions that can be made about its skills and knowledge base. It should not be surprising that this rapid expansion of the higher education system has resulted in declining student progression and retention rates. This paper takes a case study approach and attempts to identify the range of factors that might explain the variability of student performance on a first year undergraduate introductory statistics module. The paper concludes that there are no simple predictors of success or failure. However, there is evidence to suggest that any innovations in delivery need to take account of individual student development and that the presumption that students can rapidly become independent learners upon initial entry to higher education is an unrealistic one

Decoupling of epitaxial graphene via gold intercalation probed by dispersive Raman spectroscopy

Signatures of a superlattice structure composed of a quasi periodic arrangement of atomic gold clusters below an epitaxied graphene (EG) layer are examined using dispersive Raman spectroscopy. The gold-graphene system exhibits a laser excitation energy dependant red shift of the 2D mode as compared to pristine epitaxial graphene. The phonon dispersions in both the systems are mapped using the experimentally observed Raman signatures and a third-nearest neighbour tight binding electronic band structure model. Our results reveal that the observed excitation dependent Raman red shift in gold EG primarily arise from the modifications of the phonon dispersion in gold-graphene and shows that the extent of decoupling of graphene from the underlying SiC substrate can be monitored from the dispersive nature of the Raman 2D modes. The intercalated gold atoms restore the phonon band structure of epitaxial graphene towards free standing graphene

The Parallel Complexity of Growth Models

This paper investigates the parallel complexity of several non-equilibrium growth models. Invasion percolation, Eden growth, ballistic deposition and solid-on-solid growth are all seemingly highly sequential processes that yield self-similar or self-affine random clusters. Nonetheless, we present fast parallel randomized algorithms for generating these clusters. The running times of the algorithms scale as $O(\log^2 N)$, where $N$ is the system size, and the number of processors required scale as a polynomial in $N$. The algorithms are based on fast parallel procedures for finding minimum weight paths; they illuminate the close connection between growth models and self-avoiding paths in random environments. In addition to their potential practical value, our algorithms serve to classify these growth models as less complex than other growth models, such as diffusion-limited aggregation, for which fast parallel algorithms probably do not exist.Comment: 20 pages, latex, submitted to J. Stat. Phys., UNH-TR94-0

Small Changes in the Primary Structure of Transportan 10 Alter the Thermodynamics and Kinetics of its Interaction with Phospholipid Vesicles

ABSTRACT: The kinetics and thermodynamics of binding of transportan 10 (tp10) and four of its variants to phospholipid vesicles, and the kinetics of peptide-induced dye efflux, were compared. Tp10 is a 21-residue, amphipathic, cationic, cell-penetrating peptide similar to helical antimicrobial peptides. The tp10 variants examined include amidated and free peptides, and replacements of tyrosine by tryptophan. Carboxy-terminal amidation or substitution of tryptophan for tyrosine enhance binding and activity. The Gibbs energies of peptide binding to membranes determined experimentally and calculated from the interfacial hydrophobicity scale are in good agreement. The Gibbs energy for insertion into the bilayer core was calculated using hydrophobicity scales of residue transfer from water to octanol and to the membrane/ water interface. Peptide-induced efflux becomes faster as the Gibbs energies for binding and insertion of the tp10 variants decrease. If anionic lipids are included, binding and efflux rate increase, as expected because all tp10 variants are cationic and an electrostatic component is added. Whether the most important effect of peptide amidation is the change in charge or an enhancement of helical structure, however, still needs to be established. Nevertheless, it is clear that the changes in efflux rate reflect the differences in the thermodynamics of binding and insertion of the free and amidated peptide groups. We have recently reported a detailed investigation (1) o

The film business in the United States and Britain during the 1930s

Film was a most important product in the lives of the people during the 1930s. This paper sets out to analyse the underlying economic arrangements of the film industries of the U.S. and Britain during the decade in producing and diffusing this commodity-type to the population at large. In doing this, the paper finds a highly competitive industry that was built around showing films that audiences wanted to see, irrespective of the extent of vertical integration. It also examines the nature of the inter-relationship between the two industries and finds an asymmetry between the popularity of British films in the American market and that of American films in the British market. Our explanation for this is that the efforts of British firms on the American market were not sufficiently sustained to make a significant impact on American audiences

Spectroscopic signatures of youth in low-mass kinematic candidates of young moving groups

This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society ©: 2014 by the Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved.We present a study of age-related spectral signatures observed in 25 young low-mass objects that we have previously determined as possible kinematic members of five young moving groups: the Local Association (Pleiades moving group, age = 20–150 Myr), the Ursa Major group (Sirius supercluster, age = 300 Myr), the Hyades supercluster (age = 600 Myr), IC 2391 supercluster (age = 35–55 Myr) and the Castor moving group (age = 200 Myr). In this paper we characterize the spectral properties of observed high- or low-resolution spectra of our kinematic members by fitting theoretical spectral distributions. We study signatures of youth, such as lithium I 6708Å, Hα emission and other age-sensitive spectroscopic signatures in order to confirm the kinematic memberships through age constraints. We find that 21 (84 per cent) targets show spectroscopic signatures of youth in agreement with the age ranges of the moving group to which membership is implied. For two further objects, age-related constraints remain difficult to determine from our analysis. In addition, we confirm two moving group kinematic candidates as brown dwarfs.Peer reviewe

The long non-coding {RNA} {H19} suppresses carcinogenesis and chemoresistance in hepatocellular carcinoma

The long non-coding RNA (lncRNA) H19 represents a maternally expressed and epigenetically regulated imprinted gene product and is discussed to have either tumor-promoting or tumor-suppressive actions. Recently, H19 was shown to be regulated under inflammatory conditions. Therefore, aim of this study was to determine the function of H19 in hepatocellular carcinoma (HCC), an inflammation-associated type of tumor. In four different human HCC patient cohorts H19 was distinctly downregulated in tumor tissue compared to normal or non-tumorous adjacent tissue. We therefore determined the action of H19 in three different human hepatoma cell lines (HepG2, Plc/Prf5, and Huh7). Clonogenicity and proliferation assays showed that H19 overexpression could suppress tumor cell survival and proliferation after treatment with either sorafenib or doxorubicin, suggesting chemosensitizing actions of H19. Since HCC displays a highly chemoresistant tumor entity, cell lines resistant to doxorubicin or sorafenib were established. In all six chemoresistant cell lines H19 expression was significantly downregulated. The promoter methylation of the H19 gene was significantly different in chemoresistant cell lines compared to their sensitive counterparts. Chemoresistant cells were sensitized after H19 overexpression by either increasing the cytotoxic action of doxorubicin or decreasing cell proliferation upon sorafenib treatment. An H19 knockout mouse model (H19Δ3) showed increased tumor development and tumor cell proliferation after treatment with the carcinogen diethylnitrosamine (DEN) independent of the reciprocally imprinted insulin-like growth factor 2 (IGF2). In conclusion, H19 suppresses hepatocarcinogenesis, hepatoma cell growth, and HCC chemoresistance. Thus, mimicking H19 action might be a potential target to overcome chemoresistance in future HCC therapy