Liquefaction potential of sand-gravel mixtures: experimental observations

Case histories from at least 27 earthquakes worldwide (including three from New Zealand: 1929 Mw7.6 Murchison earthquake; 2010 Mw 7.1 Darfield earthquake; and 2016 Mw 7.8 Kaikoura earthquake) have indicated that liquefaction can occur in gravelly soils (both in natural deposits and manmade reclamations) inducing large ground deformation and causing severe damage to civil infrastructures. However, the evaluation of the liquefaction potential and deformation characteristics of gravelly soils remains to be a major challenge in geotechnical earthquake engineering. Aimed at providing new and useful insights on this important topic, in this study, a series of undrained cyclic triaxial tests were conducted on selected sand-gravel mixtures (SGMs), which were attained by varying the proportion by weight of a fine sand (New Brighton sand), a coarse sand (washed river sand) and a rounded pea gravel. Reconstituted specimens (height = 130 mm and diameter = 61 mm) were prepared at two relative density states of 25% and 45% by wet tamping method. Fully saturated specimens were then isotopically consolidated at 100 kPa confining pressure and subjected to cyclic stress ratio (CSR) levels ranging between 0.15 and 0.45. In this paper, preliminary results are presented and discussed in terms of effects density state – i.e., relative density (Dr), and inter-granular void ratios – and gravel content ( ), on the liquefaction potential of SGMs. It is shown that while the liquefaction potential tends to increase with both increasing Dr and , it can be more uniquely described by the equivalent void ratio that accounts simultaneously for both the density state and gravel content effects

Infrared and upconversion spectroscopic studies of high Er3+content transparent YAG ceramic

In this article, we report the detailed spectroscopic studies of high Er3+content (50%) transparent YAG ceramic co-doped with nominal Cr3+ content (0.1 mol %). Various radiative and non-radiative spectroscopic properties such as radiative decay time, fluorescence branching ratio, emission/absorption cross sections, internal radiative quantum yields of the infrared and the upconverted emission bands are explored using standard experimental and theoretical methods and compared with YAG single crystal. Results show that although the non-radiative losses are high for 50% Er doped ceramic; several radiative spectral properties are almost in agreement with those for the single crystal YAG. Furthermore, because of the low dopant concentration of Cr3+, the sensitizing effect of Cr3+ was not observed. © 2011 Optical Society of America

Cytisine versus varenicline for smoking cessation for Māori (the indigenous people of New Zealand) and their extended family:Protocol for a randomized non‐inferiority trial

Background and aims Cytisine, a nicotinic acetylcholine receptor partial agonist (like varenicline) found in some plants, is a low-cost, effective smoking cessation medication that may appeal to Māori [the indigenous people of New Zealand (NZ)]. The RAUORA trial aims to determine the effectiveness, safety and cost-effectiveness of cytisine (Tabex®) versus varenicline (Champix®) for smoking cessation in Māori and the whānau (extended family) of Māori. Design Pragmatic, community-based, open-label randomized non-inferiority trial. Setting Lakes District Health Board region, NZ. Participants Daily smokers (n = 2140) who self-identify as Māori or whānau of Māori, and are: aged ≥ 18 years, motivated to quit smoking in the next 2 weeks, eligible for subsidized varenicline, able to provide verbal consent and have daily access to a mobile phone/internet. Recruitment uses multi-media advertising. Intervention and comparator Participants are randomized (1 : 1 ratio) to receive a prescription for 12 weeks of cytisine tablets [following the manufacturer’s dosing regimen for 25 days, then one 1.5-mg tablet every 6 hours (two per day) until 12 weeks] or varenicline tablets (following the manufacturer’s dosing regimen). Both groups receive brief stop-smoking advice from the prescribing doctor and withdrawal-orientated behavioural support via community-based stop-smoking counselling services (frequency, duration and mode of delivery tailored for participants) or a research assistant (six weekly 10–15- minute calls). Participants are advised to reduce their smoking over the first 4 days of treatment, with day 5 as their designated quit-date. Measurements The primary outcome is carbon monoxide-verified continuous abstinence at 6 months post-quit date. Secondary outcomes at 1, 3, 6 and 12 months post-quit date include: self-reported continuous abstinence, 7-day point prevalence abstinence, cigarettes per day, time to (re)lapse, adverse events, treatment adherence/compliance, treatment acceptability, nicotine withdrawal/urge to smoke and health-care utilization/health- related quality of life. Comments This trial compares cytisine and varenicline when used by the indigenous people of NZ and their extended family for smoking cessation

EQUIPT: protocol of a comparative effectiveness research study evaluating cross-context transferability of economic evidence on tobacco control

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.This article has been made available through the Brunel Open Access Publishing Fund.Tobacco smoking claims 700 000 lives every year in Europe and the cost of tobacco smoking in the EU is estimated between €98 and €130 billion annually; direct medical care costs and indirect costs such as workday losses each represent half of this amount. Policymakers all across Europe are in need of bespoke information on the economic and wider returns of investing in evidence-based tobacco control, including smoking cessation agendas. EQUIPT is designed to test the transferability of one such economic evidence base-the English Tobacco Return on Investment (ROI) tool-to other EU member states

Continual Professional Development (CPD): Improving Quality of Nursing Care in Nepal

The notion that health professionals should be accountable to people and the society they serve is not a new concept (1). Globally, health professionals are being nudged to demonstrate their commitment with continuing professional development (CPD) in order to maintain competence in light of evidence-based practice and ever changing technology in health service provision. CPD provides an important strategy to improve the knowledge and skills of health practitioners as well as the quality of service (2). The World Health Organization also stresses the need to capacity enhancement of nurses and midwives through education, training and career development in Southeast Asia (3). The member states in the Region have agreed on a Decade for Strengthening Human Resources for Health in South-East Asia, 2015–2024, and country action plans have been developed to strengthen physicians, nurses and midwives with the focus on transforming education and retention (4). This editorial highlights the importance of CPD and existing lack of such provision in the field of nursing in Nepal

Investigation into the multiple recent sinkholes in Pokhara, Nepal

Since November 2013, numerous sinkholes have been forming in the Armala area of Pokhara Valley, Central Nepal, posing serious threat to local residents. In order to provide countermeasures for reducing sinkhole risk, detailed investigations into the cause and the formation mechanism of the sinkholes are crucial. Preliminary surveys were conducted in June 2014 and November 2014. Comparison of photos, taken in the two surveys, clearly indicates not only the formation of new sinkholes, but also the re-activation of filled sinkholes. By means of dynamic cone penetration tests and surface wave investigations, qualitative characterization of the soil profile was attained, and shallow weak soil layers which are believed to be the location for future sinkholes could be identified. On the basis of the preliminary field investigation, possible sinkhole formation mechanisms are considered. A risk of sinkhole does not seem to disappear as white turbid water continuously springs. It indicates that the internal erosion of white clayey silt layer is still in progress. In August 2015, a boring was carried out beside one of the largest sinkholes. The overall structure of ground layers was first revealed and a 2.5m high cavity at 7.5-10m deep from the ground surface was found within a thick white clayey silt layer. Further ground investigations including surface wave exploration were conducted in December 2015 and the results are reported

What is the evidence on policies, interventions and tools for establishing and/or strengthening national health research systems and their effectiveness?

High-quality research is important for improving population health and well-being and for achieving the health-related Sustainable Development Goals. The challenges facing individuals, organizations and countries in securing research funding and building research capacity, and then using these resources effectively, have led to renewed interest in adopting a systems approach to national health research systems strengthening. This report found that health research strategies play a key role in combining the diverse interventions to strengthen specific health research system functions into an overall system. Good practices in research systems strengthening were identified as health ministry involvement in and sustained political commitment to the comprehensive research strategy, and, where appropriate, integration of the health research system into the wider health system. Policy considerations include actions to ensure a contextual analysis to inform a comprehensive strategy; stakeholder engagement, including in priority-setting; monitoring and evaluation tools focused on system objectives; and partnerships

The demand for sports and exercise: Results from an illustrative survey

Funding from the Department of Health policy research programme was used in this study.There is a paucity of empirical evidence on the extent to which price and perceived benefits affect the level of participation in sports and exercise. Using an illustrative sample of 60 adults at Brunel University, West London, we investigate the determinants of demand for sports and exercise. The data were collected through face-to-face interviews that covered indicators of sports and exercise behaviour; money/time price and perceived benefits of participation; and socio- economic/demographic details. Count, linear and probit regression models were fitted as appropriate. Seventy eight per cent of the sample participated in sports and exercise and spent an average of £27 per month and an average of 20 min travelling per occasion of sports and exercise. The demand for sport and exercise was negatively associated with time (travel or access time) and ‘variable’ price and positively correlated with ‘fixed’ price. Demand was price inelastic, except in the case of meeting the UK government’s recommended level of participation, which is time price elastic (elasticity = −2.2). The implications of data from a larger nationally representative sample as well as the role of economic incentives in influencing uptake of sports and exercise are discussed.This article is available through the Brunel Open Access Publishing Fund

Water scarcity hotspots travel downstream due to human interventions in the 20th and 21st century

Water scarcity is rapidly increasing in many regions. In a novel, multi-model assessment, we examine how human interventions (HI: land use and land cover change, man-made reservoirs and human water use) affected monthly river water availability and water scarcity over the period 1971-2010. Here we show that HI drastically change the critical dimensions of water scarcity, aggravating water scarcity for 8.8% (7.4-16.5%) of the global population but alleviating it for another 8.3% (6.4-15.8%). Positive impacts of HI mostly occur upstream, whereas HI aggravate water scarcity downstream; HI cause water scarcity to travel downstream. Attribution of water scarcity changes to HI components is complex and varies among the hydrological models. Seasonal variation in impacts and dominant HI components is also substantial. A thorough consideration of the spatially and temporally varying interactions among HI components and of uncertainties is therefore crucial for the success of water scarcity adaptation by HI