Influence of rest on players’ performance and physiological responses during basketball play

Pre-match warm-ups are standard in many sports but the focus has excluded the substitute players. The aim of this research was to investigate the result of inactivity on physiological and performance responses in substitute basketball players during competition. Two basketball players from the second tier of the State League of Queensland, Australia volunteered for this study and were assessed for performance (countermovement jump—CMJ) and physiological (core temperature via ingestible pill; skin temperature at the arm, chest, calf and thigh; heart rate—HR) responses prior to and following a 20-min warm-up, and during the first half of a competitive basketball match (2 × 20-min real time quarters). Warm up resulted in increases in CMJ (~7%), HR (~100 bpm) and core (~0.8 °C) and skin (~1.0 °C) temperatures. Following the warm up and during inactivity, substitute players exhibited a decrease in all responses including CMJ (~13%), HR (~100 bpm), and core (~0.5 °C) and skin (~2.0 °C) temperatures. Rest resulted in reductions in key performance and physiological responses during a competitive match that poses a risk for match strategies. Coaches should consider implementing a warm up to enhance core/skin temperature for substitute players immediately before they engage with competition to optimise player performance

A Novel CCR5 Mutation Common in Sooty Mangabeys Reveals SIVsmm Infection of CCR5-Null Natural Hosts and Efficient Alternative Coreceptor Use In Vivo

In contrast to HIV infection in humans and SIV in macaques, SIV infection of natural hosts including sooty mangabeys (SM) is non-pathogenic despite robust virus replication. We identified a novel SM CCR5 allele containing a two base pair deletion (Δ2) encoding a truncated molecule that is not expressed on the cell surface and does not support SIV entry in vitro. The allele was present at a 26% frequency in a large SM colony, along with 3% for a CCR5Δ24 deletion allele that also abrogates surface expression. Overall, 8% of animals were homozygous for defective CCR5 alleles and 41% were heterozygous. The mutant allele was also present in wild SM in West Africa. CD8+ and CD4+ T cells displayed a gradient of CCR5 expression across genotype groups, which was highly significant for CD8+ cells. Remarkably, the prevalence of natural SIVsmm infection was not significantly different in animals lacking functional CCR5 compared to heterozygous and homozygous wild-type animals. Furthermore, animals lacking functional CCR5 had robust plasma viral loads, which were only modestly lower than wild-type animals. SIVsmm primary isolates infected both homozygous mutant and wild-type PBMC in a CCR5-independent manner in vitro, and Envs from both CCR5-null and wild-type infected animals used CXCR6, GPR15 and GPR1 in addition to CCR5 in transfected cells. These data clearly indicate that SIVsmm relies on CCR5-independent entry pathways in SM that are homozygous for defective CCR5 alleles and, while the extent of alternative coreceptor use in SM with CCR5 wild type alleles is uncertain, strongly suggest that SIVsmm tropism and host cell targeting in vivo is defined by the distribution and use of alternative entry pathways in addition to CCR5. SIVsmm entry through alternative pathways in vivo raises the possibility of novel CCR5-negative target cells that may be more expendable than CCR5+ cells and enable the virus to replicate efficiently without causing disease in the face of extremely restricted CCR5 expression seen in SM and several other natural host species

Biomechanical comparison between traditional hula-hooping and Nintendo Wii hula-hooping

Introduction: The use of gaming consoles for exercise training and rehabilitation has been gaining popularity however, research comparing exercises performed with gaming consoles vs. traditional methods are lacking. Therefore, the aim of this study was to compare the muscle activity and lower limb joint movement during Nintendo Wii Hula-Hooping and traditional Hula-Hooping. Methods: Participants (N = 14) performed Nintendo Wii Hula-Hooping and traditional Hula-Hopping while lower limb joint kinematics and core (erector spinae, external oblique and rectus abdominis) muscle activities were recorded via optical infrared cameras and surface electromyography respectively. Results: Nintendo Wii Hula-Hooping pelvis (obliquity, tilt and rotation) and hip (sagittal plane) range of movement were significantly (P < .05) greater than during traditional Hula-Hooping. Traditional Hula-Hooping displayed significantly (P < .05) more external oblique, rectus abdominis and erector spine muscle activation than the Nintendo Wii Hula-Hooping. Conclusion: Although differences between Nintendo Wii Hula-Hooping and traditional Hula-Hooping conditions exist, the use of these methods may be more dependent on the exercise therapy program that has been designed for the client and the capacity of the client