417 research outputs found
Diagonally Neighbour Transitive Codes and Frequency Permutation Arrays
Constant composition codes have been proposed as suitable coding schemes to
solve the narrow band and impulse noise problems associated with powerline
communication. In particular, a certain class of constant composition codes
called frequency permutation arrays have been suggested as ideal, in some
sense, for these purposes. In this paper we characterise a family of neighbour
transitive codes in Hamming graphs in which frequency permutation arrays play a
central rode. We also classify all the permutation codes generated by groups in
this family
First CNGS events detected by LVD
The CERN Neutrino to Gran Sasso (CNGS) project aims to produce a high energy,
wide band beam at CERN and send it toward the INFN Gran Sasso
National Laboratory (LNGS), 732 km away. Its main goal is the observation of
the appearance, through neutrino flavour oscillation. The beam
started its operation in August 2006 for about 12 days: a total amount of
protons were delivered to the target. The LVD detector, installed
in hall A of the LNGS and mainly dedicated to the study of supernova neutrinos,
was fully operating during the whole CNGS running time. A total number of 569
events were detected in coincidence with the beam spill time. This is in good
agreement with the expected number of events from Montecarlo simulations.Comment: Accepted for publication by the European Physical Journal C ; 7
pages, 11 figure
On-line recognition of supernova neutrino bursts in the LVD detector
In this paper we show the capabilities of the Large Volume Detector (INFN
Gran Sasso National Laboratory) to identify a neutrino burst associated to a
supernova explosion, in the absence of an "external trigger", e.g., an optical
observation. We describe how the detector trigger and event selection have been
optimized for this purpose, and we detail the algorithm used for the on-line
burst recognition. The on-line sensitivity of the detector is defined and
discussed in terms of supernova distance and electron anti-neutrino intensity
at the source.Comment: Accepted for pubblication on Astroparticle Physics. 13 pages, 10
figure
The relative orientation of the TM3 and TM4 domains varies between α1 and α3 glycine receptors
Glycine receptors (GlyRs) are anion-conducting members of the pentameric ligand-gated ion channel family. We previously showed that the dramatic difference in glycine efficacies of α1 and α3 GlyRs is largely attributable to their nonconserved TM4 domains. Because mutation of individual nonconserved TM4 residues had little effect, we concluded that the efficacy difference was a distributed effect of all nonconserved TM4 residues. We therefore hypothesized that the TM4 domains of α1 and α3 GlyRs differ in structure, membrane orientation, and/or molecular dynamic properties. Here we employed voltage-clamp fluorometry to test whether their TM4 domains interact differently with their respective TM3 domains. We found a rhodamine fluorophore covalently attached to a homologous TM4 residue in each receptor interacts differentially with a conserved TM3 residue. We conclude that the α1 and α3 GlyR TM4 domains are orientated differently relative to their TM3 domains. This may underlie their differential ability to influence glycine efficacy
Pedestrian Road Traffic Injuries in Urban Peruvian Children and Adolescents: Case Control Analyses of Personal and Environmental Risk Factors
BACKGROUND: Child pedestrian road traffic injuries (RTIs) are an important cause of death and disability in poorer nations, however RTI prevention strategies in those countries largely draw upon studies conducted in wealthier countries. This research investigated personal and environmental risk factors for child pedestrian RTIs relevant to an urban, developing world setting. METHODS: This is a case control study of personal and environmental risk factors for child pedestrian RTIs in San Juan de Miraflores, Lima, Perú. The analysis of personal risk factors included 100 cases of serious pedestrian RTIs and 200 age and gender matched controls. Demographic, socioeconomic, and injury data were collected. The environmental risk factor study evaluated vehicle and pedestrian movement and infrastructure at the sites in which 40 of the above case RTIs occurred and 80 control sites. FINDINGS: After adjustment, factors associated with increased risk of child pedestrian RTIs included high vehicle volume (OR 7.88, 95%CI 1.97-31.52), absent lane demarcations (OR 6.59, 95% CI 1.65-26.26), high vehicle speed (OR 5.35, 95%CI 1.55-18.54), high street vendor density (OR 1.25, 95%CI 1.01-1.55), and more children living in the home (OR 1.25, 95%CI 1.00-1.56). Protective factors included more hours/day spent in school (OR 0.52, 95%CI 0.33-0.82) and years of family residence in the same home (OR 0.97, 95%CI 0.95-0.99). CONCLUSION: Reducing traffic volumes and speeds, limiting the number of street vendors on a given stretch of road, and improving lane demarcation should be evaluated as components of child pedestrian RTI interventions in poorer countries
Long-term outcomes of operable stage III NSCLC in the pre-immunotherapy era: results from a pooled analysis of the SAKK 16/96, SAKK 16/00, SAKK 16/01, and SAKK 16/08 trials.
BACKGROUND
Chemoradiotherapy with durvalumab consolidation has yielded excellent results in stage III non-small-cell lung cancer (NSCLC). Therefore, it is essential to identify patients who might benefit from a surgical approach.
MATERIAL AND METHODS
Data from 437 patients with operable stage III NSCLC enrolled in four consecutive Swiss Group for Clinical Cancer Research (SAKK) trials (16/96, 16/00, 16/01, 16/08) were pooled and outcomes were analyzed in 431 eligible patients. All patients were treated with three cycles of induction chemotherapy (cisplatin/docetaxel), followed in some patients by neoadjuvant radiotherapy (44 Gy, 22 fractions) (16/00, 16/01, 16/08) and cetuximab (16/08).
RESULTS
With a median follow-up time of 9.3 years (range 8.5-10.3 years), 5- and 10-year overall survival (OS) rates were 37% and 25%, respectively. Overall, 342 patients (79%) underwent tumor resection, with a complete resection (R0) rate of 80%. Patients (n = 272, 63%) with R0 had significantly longer OS compared to patients who had surgery but incomplete resection (64.8 versus 19.2 months, P < 0.001). OS for patients who achieved pathological complete remission (pCR) (n = 66, 15%) was significantly better compared to resected patients without pCR (86.5 versus 37.0 months, P = 0.003). For patients with pCR, the 5- and 10-year event-free survival and OS rates were 45.7% [95% confidence interval (CI) 32.8% to 57.7%] and 28.1% (95% CI 15.2% to 42.6%), and 58.2% (95% CI 45.2% to 69.2%) and 45.0% (95% CI 31.5% to 57.6%), respectively.
CONCLUSION
We report favorable long-term outcomes in patients with operable stage III NSCLC treated with neoadjuvant chemotherapy with cisplatin and docetaxel ± neoadjuvant sequential radiotherapy from four prospective SAKK trials. Almost two-third of the patients underwent complete resection after neoadjuvant therapy. We confirm R0 resection and pCR as important predictors of outcome
Corrigendum to 'Long-term outcomes of operable stage III NSCLC in the pre-immunotherapy era: results from a pooled analysis of the SAKK 16/96, SAKK 16/00, SAKK 16/01, and SAKK 16/08 trials': [ESMO Open Volume 7, Issue 2, (2022), 100455].
BACKGROUND: Chemoradiotherapy with durvalumab consolidation has yielded excellent results in stage III non-small-cell lung cancer (NSCLC). Therefore, it is essential to identify patients who might benefit from a surgical approach. MATERIAL AND METHODS: Data from 437 patients with operable stage III NSCLC enrolled in four consecutive Swiss Group for Clinical Cancer Research (SAKK) trials (16/96, 16/00, 16/01, 16/08) were pooled and outcomes were analyzed in 431 eligible patients. All patients were treated with three cycles of induction chemotherapy (cisplatin/docetaxel), followed in some patients by neoadjuvant radiotherapy (44 Gy, 22 fractions) (16/00, 16/01, 16/08) and cetuximab (16/08). RESULTS: With a median follow-up time of 9.3 years (range 8.5-10.3 years), 5- and 10-year overall survival (OS) rates were 37% and 25%, respectively. Overall, 342 patients (79%) underwent tumor resection, with a complete resection (R0) rate of 80%. Patients (n = 272, 63%) with R0 had significantly longer OS compared to patients who had surgery but incomplete resection (64.8 versus 19.2 months, P < 0.001). OS for patients who achieved pathological complete remission (pCR) (n = 66, 15%) was significantly better compared to resected patients without pCR (86.5 versus 37.0 months, P = 0.003). For patients with pCR, the 5- and 10-year event-free survival and OS rates were 45.7% [95% confidence interval (CI) 32.8% to 57.7%] and 28.1% (95% CI 15.2% to 42.6%), and 58.2% (95% CI 45.2% to 69.2%) and 45.0% (95% CI 31.5% to 57.6%), respectively. CONCLUSION: We report favorable long-term outcomes in patients with operable stage III NSCLC treated with neoadjuvant chemotherapy with cisplatin and docetaxel ± neoadjuvant sequential radiotherapy from four prospective SAKK trials. Almost two-third of the patients underwent complete resection after neoadjuvant therapy. We confirm R0 resection and pCR as important predictors of outcome
Search for low energy neutrinos in correlation with the 8 events observed by the EXPLORER and NAUTILUS detectors in 2001
We report on a search for low-energy neutrino (antineutrino) bursts in
correlation with the 8 time coincident events observed by the gravitational
waves detectors EXPLORER and NAUTILUS (GWD) during the year 2001. The search,
conducted with the LVD detector (INFN Gran Sasso National Laboratory, Italy),
has considered several neutrino reactions, corresponding to different neutrino
species, and a wide range of time intervals around the (GWD) observed events.
No evidence for statistically significant correlated signals in LVD has been
found. Assuming two different origins for neutrino emission, the cooling of a
neutron star from a core-collapse supernova or from coalescing neutron stars
and the accretion of shocked matter, and taking into account neutrino
oscillations, we derive limits to the total energy emitted in neutrinos and to
the amount of accreting mass, respectively.Comment: Accepted for publication in Astronomy and Astrophysic
Study of single muons with the Large Volume Detector at Gran Sasso Laboratory
The present study is based on the sample of about 3 mln single muons observed
by LVD at underground Gran Sasso Laboratory during 36500 live hours from June
1992 to February 1998. We have measured the muon intensity at slant depths from
3 km w.e. to 20 km w.e. Most events are high energy downward muons produced by
meson decay in the atmosphere. The analysis of these muons has revealed the
power index of pion and kaon spectrum: 2.76 \pm 0.05. The reminders are
horizontal muons produced by the neutrino interactions in the rock surrounding
LVD. The value of this flux is obtained. The results are compared with Monte
Carlo simulations and the world data.Comment: 13 pages, 2 figures, accepted for publication in "Physics of Atomic
Nuclei
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