8 research outputs found
Sclerostin: Current Knowledge and Future Perspectives
- Author
- A Eddleston
- A Moustafa
- AG Robling
- B Sevetson
- C Lin
- C. W. G. M. Löwik
- CA Kim
- CA O’Brien
- DG Winkler
- DL Ellies
- FS Buchem van
- G Silvestrini
- GG Loots
- H Clevers
- H Hamersma
- H Keller
- I Kramer
- J Pleiner-Duxneuner
- JA Robinson
- JC Gardner
- JE Wergedal
- JR Hens
- K Irie
- K Sawakami
- K Staehling-Hampton
- KE Poole
- LF Bonewald
- LM Boyden
- M Kansara
- M Semenov
- M. J. C. Moester
- ME Brunkow
- MK Sutherland
- MK Sutherland
- ML Knothe Tate
- MP Whyte
- MR Rickels
- N Kamiya
- N Kusu
- O Avsian-Kretchmer
- O Leupin
- P Beighton
- P Beighton
- P Beighton
- R. L. van Bezooijen
- RD Little
- RL Bezooijen van
- RL Bezooijen van
- RL Bezooijen van
- RL Bezooijen van
- RL Bezooijen van
- RL Bezooijen van
- S Epstein
- S Tatsumi
- S. E. Papapoulos
- SA Stein
- SC Hill
- SE Weidauer
- SM Pockwinse
- SR Goldring
- T Bellido
- V Veverka
- VK Yadav
- W Balemans
- W Balemans
- W Balemans
- W Balemans
- W Yao
- X Li
- X Li
- X Li
- Y Gong
- Y Han
- Y Ohyama
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
In recent years study of rare human bone disorders has led to the identification of important signaling pathways that regulate bone formation. Such diseases include the bone sclerosing dysplasias sclerosteosis and van Buchem disease, which are due to deficiency of sclerostin, a protein secreted by osteocytes that inhibits bone formation by osteoblasts. The restricted expression pattern of sclerostin in the skeleton and the exclusive bone phenotype of good quality of patients with sclerosteosis and van Buchem disease provide the basis for the design of therapeutics that stimulate bone formation. We review here current knowledge of the regulation of the expression and formation of sclerostin, its mechanism of action, and its potential as a bone-building treatment for patients with osteoporosis
The use of PTH in the treatment of osteoporosis
- Author
- Anastasilakis AD
- Anastasilakis AD
- Aspenberg P
- Black DM
- Bouxsein ML
- Burr DB
- Cosman F
- Cosman F
- Cosman F
- Dobnig H
- Eastell R
- File E
- Finkelstein JS
- Girotra M
- Glover SJ
- Graeff C
- Harper K
- Jilka RL
- Keel C
- Langdahl BL
- Lau AN
- Leder BZ
- Lindsay R
- Liu H
- Lunkdvist J
- Marcus R
- Migliaccio S
- Miller PD.
- Neer RM
- Neuprez A
- Nádila Cecyn Pietszkowski Mañas
- Pleiner-Duxneuner J
- Recker RR
- Rubin MR
- Saag KG
- Subbiah V
- Trevisani VFM
- Verhaar HJ
- Victória Z. Cochenski Borba
- Watts NB
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Phase Ib trial combining capecitabine, erlotinib and bevacizumab in pancreatic adenocarcinoma - REBECA trial
- Author
- A Albuquerque de
- A Farkouh
- A Farkouh
- AH Ko
- AH Ko
- AS Chadha
- Azra Sahmanovic-Hrgovcic
- B Brennan
- C Twelves
- Christian Dittrich
- D Lambrechts
- D Su
- DD Hoff Von
- DR Budman
- E Borgen
- E Cutsem Van
- E Cutsem Van
- E Cutsem Van
- E Petit-Jean
- E Soeth
- ER Lepper
- F Ciardiello
- FC Bidard
- FC Bidard
- GA Manji
- H Friess
- H Ueno
- HA Burris 3rd
- HL Kindler
- HL Kindler
- HL Kindler
- J Tabernero
- Johannes Pleiner-Duxneuner
- K Han
- K Pantel
- K Tjensvoll
- Klaus Geissler
- L Han
- LC Pronk
- M Gil-Delgado
- M Korc
- M Reni
- MA Tempero
- Martin Czejka
- Martina Mittlböck
- MH Katz
- MH Kulke
- MJ Moore
- N Starling
- P Buchner
- P Piedbois
- P Rougier
- P Therasse
- Philipp Buchner
- R Königsberg
- Robert Königsberg
- RS Herbst
- SA Welch
- SB Dreyer
- SE Bates
- SG Louie
- T Conroy
- WW Ma
- XL Ma
- YD Jung
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
New PTH Signals Mediating Bone Anabolism
- Author
- A Iida-Klein
- A Moreau
- AB Abou-Samra
- AB Grey
- AG Robling
- AT Pearman
- AT Singh
- B Hekmatnejad
- B Lanske
- BN Bohinc
- C Li
- C Li
- C Niehrs
- C Santa Maria
- CA O’Brien
- D Gesty-Palmer
- D Yang
- DA Hanley
- F Elefteriou
- H Dobnig
- H Jouishomme
- H Jouishomme
- H Takasu
- H Yang
- I Kramer
- I Kramer
- I Kramer
- J Delgado-Calle
- J Pleiner-Duxneuner
- J Shirakawa
- JC Clohisy
- JF Whitfield
- JW Robinson
- JY Li
- L Qin
- L Revollo
- L Tascau
- LK McCauley
- LM Calvi
- M Parra
- M Pellicelli
- M Vinyoles
- M Wan
- MA Levine
- MN Wein
- MN Wein
- N Ogata
- NH Kulkarni
- NM Collette
- O Akhouayri
- O Leupin
- R Armamento-Villareal
- R Baron
- R Kedlaya
- RM Neer
- RS Kao
- RW Cheloha
- S Baertschi
- S Yu
- SJ Silverberg
- SL Ferrari
- SM Woo
- SP Acebron
- T Jafarov
- T Malinauskas
- T Meury
- T Qiu
- T Yoshizawa
- UT Iwaniec
- V Alonso
- V Saini
- WF Powell Jr
- WV Yotov
- X Yang
- XJ Yang
- Y Fei
- Y Rhee
- Y Tian
- Z Saidak
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies
- Author
- Aggarwal P.
- Amidon G. L.
- Anderson D. G.
- Anderson J.
- Aslan D.
- Attenello F. J.
- Beata Chertok
- Bellisle F.
- Bratlie K. M.
- Brown B.
- Brown L.
- Brown L. R.
- Carmena J. M.
- Casadio M.
- Chertok B.
- Choi H. S.
- Clynes M. E.
- De Jong S. E.
- De Micheli G.
- Disney D.
- Dromi S.
- Duckworth W. C.
- Farokhzad O. C.
- Farra R.
- Folkman J.
- Folkman J.
- Frenkel V.
- Gabizon A.
- Gabizon A. F.
- Geng Y.
- Golan D. E.
- Gold D. T.
- Greenspan S. L.
- Gu Z.
- Gualtieri P.
- Han S. L.
- Hobbs S. K.
- Hock J. M.
- Hohmann-Marriott M.
- Honda K.
- Hovorka R.
- Hu C. M.
- Irimia-Vladu M.
- Kelly J. Y.
- Kim D.
- Korin N.
- Kost J.
- Ku D. N.
- Langer R.
- Langer R.
- Langer R.
- Lauritzen T.
- Lee K.
- Leis A.
- Lin J.
- Lindsay R.
- Liu Y.
- Lukyanenko V.
- Maeda H.
- Maloney J. M.
- Manolio T. A.
- Marc D. Succi
- Marhefka J. N.
- Matthew J. Webber
- McEvoy G. K.
- McKillop A. M.
- McLennan D. N.
- Mebius R. E.
- Menna P.
- Merkel T. J.
- Moghimi S. M.
- Moghimi S. M.
- Muggeo M.
- Muller R. H.
- Muskovich M.
- Newcomb C. J.
- Northfelt D. W.
- Owens D. R.
- O’Brien M. E.
- O’Neal D. P.
- Panchagnula R.
- Panyam J.
- Perry J.
- Pissuwan D.
- Pleiner-Duxneuner J.
- Prescott J. H.
- Protzer U.
- Reginster J. Y.
- Richards Grayson A. C.
- Ricotti L.
- Robert Langer
- Rodriguez P. L.
- Rojanasakul Y.
- Rolland J. P.
- Rose S.
- Rubin M. R.
- Sanders J.
- Schmidt V.
- Schneider G.
- Simon D.
- Skousen J.
- Speth P. A.
- Stadler P.
- Stein P. D.
- Stone M. J.
- Swartz M. A.
- Tessadori J.
- Udhrain A.
- Ulijn R. V.
- Van Gemert A. G. M.
- Wagner J. G.
- Wang J.
- Wattendorf U.
- Westphal M.
- Westphal M.
- Williams D. F.
- Williams K. J.
- Yang D.
- Zhong C.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Treatment of post-menopausal osteoporosis: beyond bisphosphonates
- Author
- A Gambardella
- A Lipton
- A Peroni
- A Sikon
- AB Hodsman
- AD Anastasilakis
- AR Wijenayaka
- B Ettinger
- B Ettinger
- BD Gelb
- D Agnusdei
- D Diarra
- D Padhi
- DJ Heath
- DL Kendler
- DM Black
- DM Black
- DM Black
- DP McDonnell
- E Barrett-Connor
- E Seaman
- E Seeman
- E Shane
- EC Walker
- EF Eriksen
- EF Eriksen
- EN Toni De
- F Cosman
- F Otto
- F Vescini
- G Bachmann
- G Girasole
- G Hampson
- G Zaman
- GK Ellis
- H Keller
- H Minne
- HG Bone
- HM Frost
- J Pleiner-Duxneuner
- J Street
- J Tombran-Tink
- JA Cauley
- JB Lian
- JC Crockett
- JE Rossouw
- JI Aguirre
- JJ Body
- JL Vahle
- JN Tsai
- JP Brown
- JS Finkelstein
- JS Hwang
- JY Gauthier
- K Lippuner
- KD Harper
- KW Lyles
- L Pederson
- L Qin
- M Almeida
- M Kansara
- M Wan
- M Zaidi
- MB Humphrey
- MC Horowitz
- ML Brandi
- MN Dickler
- MR McClung
- MR Smith
- NE Lane
- P Chen
- P D’Amelio
- P Roschger
- PD Miller
- Q Rehman
- R Baron
- R Baron
- R Eastell
- R Lindsay
- R Lindsay
- R Pacifici
- R Pacifici
- R Prince
- R Rizzoli
- RB Kimble
- RH Giles
- RL Jilka
- RM Neer
- RR Recker
- S Adami
- S Boonen
- S Boonen
- S Khosla
- S Khosla
- S Kwan Tat
- SA Krum
- SC Manolagas
- SJ Rodda
- SR Cummings
- SR Cummings
- T Nakamura
- TD Rachner
- TL Aghaloo
- U Mayr-Wohlfart
- UH Lerner
- X Li
- X Li
- X Xiao-Juan
- Y Kawano
- YL Ma
- YL Ma
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Emerging Targets in Osteoporosis Disease Modification
- Author
- Adami S.
- Adams G. B.
- Adkison K. K.
- Allen J. G.
- Altmann E.
- Asagiri M.
- Bab I.
- Balan G.
- Baron R.
- Barrett D. G.
- Bilezikian J. P.
- Black W. C.
- Bodine P. V. N.
- Boyce B. F.
- Boyd M. J.
- Boyle W. J.
- Boys M. L.
- Bromme D.
- Buckbinder L.
- Böttiger D.
- Calvi L. M.
- Cameron K. O.
- Cameron K. O.
- Canalis E.
- Chagnovich D.
- Chang E. J.
- Chang Y.-T.
- Chapurlat R. D.
- Chen S.
- Clement-Lacroix P.
- Coleman P. J.
- Crane S. N.
- Cummings S. R.
- Cuong N. X.
- Dalgarno D.
- Dayam R.
- de Vries T. J.
- Dechantsreiter M. A.
- Delaisse J. M.
- Desmarais S.
- Diarra D.
- Doble B. W.
- Eastell R.
- Eastell R.
- Eddleston A.
- Engler T. A.
- Falgueyret J.-P.
- Fitzpatrick L. A.
- Frolik C. A.
- Fulciniti M.
- Fuller K.
- Gauthier J. Y.
- Gelb B. D.
- Gil-Henn H.
- Gilbert A. M.
- Glass D. A.
- Gopalsamy A.
- Gowen M.
- Graham S.
- Gramoun A.
- Grey A.
- Grisanti M.
- Han C.-Y. E.
- Han S.
- Hanus L.
- Heath D. J.
- Hennequin L. F.
- Hernandez F.
- Hoffman S. J.
- Hojo H.
- Huffman J. W.
- Huffman J. W.
- Hutchinson J. H.
- Idris A. I.
- Idris A. I.
- Ishikawa M.
- Ishikawa M.
- Ito M.
- Jilka R. L.
- Jilka R. L.
- Jones D. C.
- Karsenty G.
- Ke H. Z.
- Kearns A. E.
- Khosla S.
- Kiem P. V.
- Kim T.-S.
- Kingsley L. A.
- Klaus A.
- Klein P. S.
- Krishnan V.
- Kubota D.
- Kulkarni N. H.
- Kumar S.
- Kumar S.
- Lan R.
- Lee M. K.
- Leger S.
- Lewiecki E. M.
- Li C. S.
- Li M.
- Li X.
- Liao S.
- Lin R.-W.
- Liu F.
- Liu Z.-Y.
- Ma Y. L.
- MacAulay K.
- Macsai C. E.
- Manzoni L.
- Markt P.
- Marquis R. W.
- Marquis R. W.
- Marriott K.-S. C.
- Martinez A.
- Maruyama T.
- Maruyama T.
- Marzia M.
- Mathoo J. M. R.
- McClung M.
- McGrath M. E.
- Meissner R. S.
- Meyer A.
- Mohler M. L.
- Moore W. J.
- Morley A. D.
- Mukherjee S.
- Mundy G.
- Murphy M. G.
- Nagarajan S. R.
- Nakagawa K.
- Nemeth E. F.
- Ofek O.
- Ougolkov A. V.
- Padhi D.
- Page D.
- Palmer J. T.
- Palmer J. T.
- Pan L.
- Patel S.
- Pearsall R. S.
- Pelletier J. C.
- Peroni A.
- Pertwee R. G.
- Pleiner-Duxneuner J.
- Polakis P.
- Qiu S. X.
- Quibell M.
- Raboisson P.
- Raisz L. G.
- Ralston S. H.
- Reinholt F. P.
- Rickard D. J.
- Riggs B. L.
- Rinaldi-Carmona M.
- Robichaud J.
- Robichaud J.
- Robichaud J.
- Rodan S. B.
- Ruckle J.
- Saftig P.
- Schwan S.
- Scutt A.
- Seeman E.
- Setti E. L.
- Setti E. L.
- Setti E. L.
- Shakespeare W. C.
- Shcherbakova I.
- Shcherbakova I.
- Shi M.
- Shimazaki Y.
- Shinozuka T.
- Sinha S.
- Siu L. L.
- Smith M. R.
- Sophocleous A.
- Soriano P.
- Sun S.
- Tam J.
- Teno N.
- Teno N.
- Teno N.
- Toyoda H.
- Tung N. H.
- Twomey T.
- Vasiljeva O.
- Wang X.-L.
- Westover A. J.
- Whyte L. S.
- Widler L.
- Wilder R. L.
- Woodiel F. N.
- Wu X.
- Wu X.
- Xiong J. P.
- Xiong J.-P.
- Xu Y.
- Yadav V. K.
- Yadav V. K.
- Yamamoto M.
- Yamashita D. S.
- Yamashita M.
- Yang W.
- Yasothan U.
- Yoshida K.
- Zartman A. E.
- Zhao M.
- Zhao M.
- Zhou Y.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review
- Author
- Abu-Id
- Adornato
- Agrillo
- Agrillo
- Alons
- Alsehimy
- American Association of Oral and Maxillofacial Surgeons
- Anavi-Lev
- Angiero
- Arantes
- Arora
- Atalay
- Babior
- Badros
- Badros
- Bagan
- Bagan
- Bamias
- Baqain
- Bashutski
- Basso
- Bedogni
- Bedogni
- Bedogni
- Beninati
- Berenson
- Bilezikian
- Blus
- Bocanegra-Perez
- Bocci
- Bocci
- Boonyapakorn
- Boykin
- Brozoski
- Burr
- Cafro
- Carlson
- Cavanna
- Cella
- Chen
- Chiu
- Chuah
- Cicciu
- Conte-Neto
- Coviello
- Csonka
- Curi
- Curi
- Dannemann
- Dannemann
- Dimitrakopoulos
- Dimopoulos
- Dimopoulos
- Dunstan
- Eckert
- Elad
- Epstein
- Estilo
- Ettinger
- Favia
- Ferlito
- Filleul
- Fleisch
- Fleisher
- Fortuna
- Freiberger
- Freiberger
- Freiberger
- Gibbs
- Gomez Font
- Graziani
- Green
- Greenberg
- Griz
- Gronqvist
- Hadji
- Hanasono
- Hansen
- Harper
- Hellstein
- Hernandez
- Hoefert
- Hoff
- Hoff
- Hoff
- Hollick
- Holzinger
- Hong
- Ibrahim
- J. Kühnisch
- Jabbour
- Jacobsen
- Jin
- Johnson
- Junquera
- Khamaisi
- Khosla
- Kim
- Kim
- King
- Kos
- Kulikov
- Kwon
- Lazarovici
- Lazarovici
- Lee
- Lemound
- Lerman
- Lindsay
- Lipton
- Lo
- Longobardi
- Lopez-Vidriero
- Lugassy
- M. Ehrenfeld
- M. Tröltzsch
- Ma
- Magopoulos
- Maines
- Malden
- Manfredi
- Markenson
- Martins
- Marunick
- Marx
- Marx
- Marx
- Marx
- Maurer
- Mavrokokki
- McClung
- Mehanna
- Mehrotra
- Melo
- Mercer
- Migliorati
- Migliorati
- Migliorati
- Migliorati
- Millesi
- Milner
- Misawa
- Mitsimponas
- Moher
- Montebugnoli
- Moretti
- Mortensen
- Mozzati
- Mücke
- Narvaez
- Nase
- Nicolatou-Galitis
- Nocini
- Nomura
- Ohbayashi
- Olutayo
- Otto
- O’Ryan
- O’Ryan
- Park
- Patel
- Pautke
- Pautke
- Pautke
- Petrucci
- Pichardo
- Pires
- Plachokova
- Pleiner-Duxneuner
- Pozzi
- Purcell
- Quattrocchi
- R. Fliefel
- Reid
- Reth
- Ripamonti
- Ripamonti
- Rogers
- Rogers
- Romeo
- Rosenberg
- Rubin
- Rugani
- Rugani
- Ruggiero
- Ruggiero
- Ruggiero
- Ruggiero
- Ruggiero
- Ruggiero
- Ruggiero
- Ruggiero
- Russell
- S. Otto
- Saad
- Saad
- Saussez
- Schiffrin
- Schubert
- Scoletta
- Scoletta
- Sedghizadeh
- Semba
- Seth
- Shin
- Silverman
- Stanton
- Stockmann
- Stübinger
- Then
- Thumbigere-Math
- Thumbigere-Math
- Urade
- Vahtsevanos
- Van den Wyngaert
- Van Poznak
- Vannucchi
- Vescovi
- Vescovi
- Vescovi
- Vescovi
- Vescovi
- Vescovi
- Vescovi
- Vescovi
- Vincenzi
- Vogel
- Voss
- Wang
- Watters
- Wilde
- Williamson
- Woo
- Wood
- Wutzl
- Wutzl
- Wysowski
- Yarom
- Ziebart
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study