Visuomotor Cerebellum in Human and Nonhuman Primates

In this paper, we will review the anatomical components of the visuomotor cerebellum in human and, where possible, in non-human primates and discuss their function in relation to those of extracerebellar visuomotor regions with which they are connected. The floccular lobe, the dorsal paraflocculus, the oculomotor vermis, the uvula–nodulus, and the ansiform lobule are more or less independent components of the visuomotor cerebellum that are involved in different corticocerebellar and/or brain stem olivocerebellar loops. The floccular lobe and the oculomotor vermis share different mossy fiber inputs from the brain stem; the dorsal paraflocculus and the ansiform lobule receive corticopontine mossy fibers from postrolandic visual areas and the frontal eye fields, respectively. Of the visuomotor functions of the cerebellum, the vestibulo-ocular reflex is controlled by the floccular lobe; saccadic eye movements are controlled by the oculomotor vermis and ansiform lobule, while control of smooth pursuit involves all these cerebellar visuomotor regions. Functional imaging studies in humans further emphasize cerebellar involvement in visual reflexive eye movements and are discussed

Circulating miRNA signatures of early pregnancy in cattle

BACKGROUND: Low fertility remains a leading cause of poor productivity in dairy cattle. In this context, there is significant interest in developing novel tools for accurate early diagnosis of pregnancy. MicroRNAs (miRNAs) are short RNA molecules which are critically involved in regulating gene expression during both health and disease. MiRNAs have been shown to regulate ovarian function, uterine receptivity, embryonic development and placental function. Circulating miRNAs can provide useful biomarkers of tissue function and disease; importantly, differential miRNA profiles have been linked to pregnancy and preeclampsia in humans. This study sought to establish the potential of circulating miRNAs as biomarkers of early pregnancy in cattle. RESULTS: We applied Illumina small-RNA sequencing to profile miRNAs in plasma samples collected from eight non-pregnant heifers on Days 0, 8 and 16 of the oestrous cycle and 11 heifers on Days 16 and 24 of pregnancy. We sequenced a total of 46 samples and generated 9.2 million miRNA reads per sample. There were no differences in miRNA read abundance between any of the pregnant and non-pregnant time-points (FDR > 0.1). As a complementary approach, we analysed sample pools (3–4 samples/pool) corresponding to Days 0, 8 and 16 of the oestrous cycle and Day 24 of pregnancy (n = 3 pools/group) using Qiagen PCR arrays. A total of 16 miRNAs were differentially expressed (FDR < 0.1) in plasma between pregnant and non-pregnant animals. RT-qPCR validation using the same plasma samples confirmed that miR-26a was differentially upregulated on Day 16 pregnant relative to non-pregnant heifers (1.7-fold; P = 0.043), whereas miR-1249 tended to be upregulated in Day 16 pregnant heifers (1.6-fold; P = 0.081). Further validation in an independent group of heifers confirmed an increase in plasma miR-26a levels during early pregnancy, which was significant only on Day 24 (2.0-fold; P = 0.027). CONCLUSIONS: Through genome-wide analyses we have successfully profiled plasma miRNA populations associated with early pregnancy in cattle. We have identified miR-26a as a potential circulating biomarker of early pregnancy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-016-2529-1) contains supplementary material, which is available to authorized users

Where less may be more: how the rare biosphere pulls ecosystems strings

Rare species are increasingly recognized as crucial, yet vulnerable components of Earth’s ecosystems. This is also true for microbial communities, which are typically composed of a high number of relatively rare species. Recent studies have demonstrated that rare species can have an over-proportional role in biogeochemical cycles and may be a hidden driver of microbiome function. In this review, we provide an ecological overview of the rare microbial biosphere, including causes of rarity and the impacts of rare species on ecosystem functioning. We discuss how rare species can have a preponderant role for local biodiversity and species turnover with rarity potentially bound to phylogenetically conserved features. Rare microbes may therefore be overlooked keystone species regulating the functioning of host-associated, terrestrial and aquatic environments. We conclude this review with recommendations to guide scientists interested in investigating this rapidly emerging research area

Rhabdomyolysis and acute renal failure in a child with parainfluenza type 1 infection

We present a rare case of para-influenza type 1 virus-induced rhabdomyolysis, complicated by acute renal failure (ARF). The child underwent continuous venovenous haemofiltration and has shown full clinical and biochemical recovery. ARF due to rhabdomyolysis in para-influenza type 1 infection in a child has, to the best of our knowledge, not been previously reported

Imaging the water content of rammed earth materials with induced polarization

International audienc

Complex conductivity of rammed earth

International audienceSearching for recyclable materials of construction, in the objective of building sobriety and resilience, is a major issue of our current societies. Mudbricks of compacted rammed earth represent an ancient construction material with many advantages associated with its availability, cost of production, potential reuse, and with a very low carbon footprint. Moisture content affects the mechanical resistance of such materials, which could become mechanically weak above a critical value. Therefore, non-intrusive characterization techniques able to image the water content distribution of these materials is highly in demand. We apply a recently developed theory of complex electrical conductivity (alias induced polarization) to characterize core samples of rammed earth materials in the laboratory. Complex conductivity describes both the ability of a porous material to conduct an electrical current (characterized by the in-phase conductivity) and its ability to store reversibly electrical charges (characterized by two interconnected properties namely the quadrature conductivity and the normalized chargeability). Samples of rammed earth and clayey soils with different pore water salinities, saturations, and compaction states are measured with the complex conductivity method in the frequency range 100 mHz–45 kHz. The in-phase and quadrature conductivities of the complex conductivity of rammed earth are connected to the water content offering therefore a new non-intrusive tomographic technique to study the water content distribution in walls made of rammed earth. The data are all consistent with the so-called dynamic Stern layer model of complex conductivity for clayey materials. This new approach provides a general method to image the change in the water content of walls made of rammed earth, a task that electrical conductivity imaging cannot perform as a stand-alone technique

An ARVA Sensor Simulator

Robot Operating System (ROS) framework supports different kind of sensors, typically used to develop robotic applications, such as vision and depth sensors, laser scanners and so on. In this chapter, we present a new ROS package designed to simulate ARVA transceiver sensors: arva_sim. ARVA is a French acronym which stands for Appareil de Recherche de Victims en Avalanche and represents the forefront technology adopted in Search &amp; Rescue operations to localize victims of avalanches buried under the snow. In order to simulate its behavior, this package provides two Gazebo plugins: the transmitter and receiver. The aim of this chapter is to describe the mathematical and theoretical background of the transceiver, discussing its implementation and integration with ROS. To demonstrate the accuracy of the proposed sensor model, we present a simulation scenario in which an Unmanned Aerial Vehicle (UAV) equipped with the transceiver sensor performs a basic S&amp;R pattern using the output of ARVA system. It is worth nothing that the proposed ROS package, arva_sim, represents the first simulation model of an ARVA transceiver system and can be useful for the developer to design, test and benchmark faster and smarter search strategies to speed up rescue missions in case of avalanches