Atherosclerosis and calcium signalling in endothelial cells

The link between atherosclerosis and regions of disturbed flow and low wall shear stress is now firmly established, but the causal mechanisms underlying the link are not yet understood. It is now recognised that the endothelium is not simply a passive barrier between the blood and the vessel wall, but plays an active role in maintaining vascular homeostasis and participates in the onset of atherosclerosis. Calcium signalling is one of the principal intracellular signalling mechanisms by which endothelial cells (EC) respond to external stimuli, such as fluid shear stress and ligand binding. Previous studies have separately modelled mass transport of chemical species in the bloodstream and calcium dynamics in EC via the inositol triphosphate (IP₃) signalling pathway. In this study, we integrate these two important components to provide an inclusive model for the calcium response of the endothelium in an arbitrary vessel geometry. This enables the combined effects of fluid flow and biochemical stimulation on EC to be investigated. Model results show that low endothelial calcium levels in the area of disturbed flow at an arterial widening may be one contributing factor to the onset of vascular disease

FADI: a fault-tolerant environment for open distributed computing

FADI is a complete programming environment that serves the reliable execution of distributed application programs. FADI encompasses all aspects of modern fault-tolerant distributed computing. The built-in user-transparent error detection mechanism covers processor node crashes and hardware transient failures. The mechanism also integrates user-assisted error checks into the system failure model. The nucleus non-blocking checkpointing mechanism combined with a novel selective message logging technique delivers an efficient, low-overhead backup and recovery mechanism for distributed processes. FADI also provides means for remote automatic process allocation on the distributed system nodes

A mantle melting profile across the Basin and Range, SW USA

This is the published version. Copyright 2002 American Geophysical Union. All Rights Reserved.The major and trace element composition of late Cenozoic basalts (0–10 Ma) across the Basin and Range province (B&R) preserve a clear signal of mantle melting depth variations. FeO, Fe8.0, and Tb/Yb increase, whereas Si8.0 and Al8.0 decrease, from west to east across the B&R along a profile at 36°–37°N. These variations are qualitatively consistent with shallower melting beneath the Western Great Basin (WGB) than in the central B&R. In order to quantify the depth range and percent of decompression melting, we invert primary Na2O and FeO contents of basalts using a melting model based on the partitioning of FeO and MgO in olivine and Na2O in clinopyroxene. An independent inversion, using the rare earth elements (REE), corroborates the melting depths obtained from the major element model and places most of the melting beneath the central B&R in the garnet-peridotite stability field. We find that the shape of the melting region across the B&R closely mimics the shape of the mantle lithosphere, as inferred from geological and geophysical observations. Melting across the study area occurs largely within the asthenosphere and generally stops at the base of the mantle lithosphere. In the WGB, melting paths are shallow, from 75 to 50 km, and in some cases extend almost to the base of the crust. These melting paths are consistent with adiabatic melting in normal-temperature asthenosphere, beneath an extensively thinned (or absent) mantle lithosphere. Shallow melting is consistent with geobarometry and isotopic compositions of local mantle xenoliths. Lithospheric thinning was caused by thermal erosion during Mesozoic subduction and/or simple shear or foundering during Cenozoic extension. In contrast, melting beneath the central B&R occurs beneath thick mantle lithosphere and requires mantle potential temperatures 200°C hotter than normal (melting paths from 140 to 100 km). The excess temperature beneath the central B&R is consistent with active upwelling of hot mantle in this region

Volcanic activity and gas emissions along the South Sandwich Arc

The South Sandwich Volcanic Arc is one of the most remote and enigmatic arcs on Earth. Sporadic observations from rare cloud-free satellite images—and even rarer in situ reports—provide glimpses into a dynamic arc system characterised by persistent gas emissions and frequent eruptive activity. Our understanding of the state of volcanic activity along this arc is incomplete compared to arcs globally. To fill this gap, we present here detailed geological and volcanological observations made during an expedition to the South Sandwich Islands in January 2020. We report the first in situ measurements of gas chemistry, emission rate and carbon isotope composition from along the arc. We show that Mt. Michael on Saunders Island is a persistent source of gas emissions, releasing 145 ± 59 t day−1 SO2 in a plume characterised by a CO2/SO2 molar ratio of 1.8 ± 0.2. Combining this CO2/SO2 ratio with our independent SO2 emission rate measured near simultaneously, we derive a CO2 flux of 179 ± 76 t day−1. Outgassing from low temperature (90–100 °C) fumaroles is pervasive at the active centres of Candlemas and Bellingshausen, with measured gas compositions indicative of interaction between magmatic fluids and hydrothermal systems. Carbon isotope measurements of dilute plume and fumarole gases from along the arc indicate a magmatic δ13C of − 4.5 ± 2.0‰. Interpreted most simply, this result suggests a carbon source dominated by mantle-derived carbon. However, based on a carbon mass balance from sediment core ODP 701, we show that mixing between depleted upper mantle and a subduction component composed of sediment and altered crust is also permissible. We conclude that, although remote, the South Sandwich Volcanic Arc is an ideal tectonic setting in which to explore geochemical processes in a young, developing arc

Morphometric analyses of the visual pathways in macular degeneration

Introduction. Macular degeneration (MD) causes central visual field loss. When field defects occur in both eyes and overlap, parts of the visual pathways are no longer stimulated. Previous reports have shown that this affects the grey matter of the primary visual cortex, but possible effects on the preceding visual pathway structures have not been fully established. Method. In this multicentre study, we used high-resolution anatomical magnetic resonance imaging and voxel-based morphometry to investigate the visual pathway structures up to the primary visual cortex of patients with age-related macular degeneration (AMD) and juvenile macular degeneration (JMD). Results. Compared to age-matched healthy controls, in patients with JMD we found volumetric reductions in the optic nerves, the chiasm, the lateral geniculate bodies, the optic radiations and the visual cortex. In patients with AMD we found volumetric reductions in the lateral geniculate bodies, the optic radiations and the visual cortex. An unexpected finding was that AMD, but not JMD, was associated with a reduction in frontal white matter volume. Conclusion. MD is associated with degeneration of structures along the visual pathways. A reduction in frontal white matter volume only present in the AMD patients may constitute a neural correlate of previously reported association between AMD and mild cognitive impairment. Keywords: macular degeneration - visual pathway - visual field - voxel-based morphometryComment: appears in Cortex (2013

Central American Subduction System

Workshop to Integrate Subduction Factory and Seismogenic Zone Studies in Central America, Heredia, Costa Rica, 18–22 June 2007 The driving force for great earthquakes and the cycling of water and climate-influencing volatiles (carbon dioxide, sulfur, halogens) across the convergent margin of Central America have been a focus of international efforts for over 8 years, as part of the MARGINS program of the U.S. National Science Foundation, the Collaborative Research Center (SFB 574) of the German Science Foundation, and the Central American science community. Over 120 scientists and students from 10 countries met in Costa Rica to synthesize this intense effort spanning from land to marine geological and geophysical studies

Reduced model for H-mode sustainment in unfavorable ∇B\mathbf{ \nabla B} drift configuration in ASDEX Upgrade

A recently developed reduced model of H-mode sustainment based on interchange-drift-Alfv\'en turbulence description in the vicinity of the separatrix matching experimental observations in ASDEX Upgrade has been extended to experiments with the unfavorable $\nabla B$ drift. The combination with the theory of the magnetic-shear-induced Reynolds stress offers a possibility to quantitatively explain the phenomena. The extension of the Reynolds stress estimate in the reduced model via the magnetic shear contribution is able to reproduce the strong asymmetry in the access conditions depending on the ion $\nabla B$ drift orientation in agreement with experimental observations. The Reynolds stress profile asymmetry predicted by the magnetic shear model is further extended by comparison with GRILLIX and GENE-X simulations matched with comparable experiments in realistic X-point geometry. The predictions of the radial electric field well depth and its difference between the favorable and unfavorable configurations at the same heating power from the extended model also show consistency with experimental measurements.Comment: Submitted to Nuclear Fusio

Magma decompression rates during explosive eruptions of Kīlauea volcano, Hawai'i, recorded by melt embayments

The decompression rate of magma as it ascends during volcanic eruptions is an important but poorly constrained parameter that controls many of the processes that influence eruptive behaviour. In this study we quantify decompression rates for basaltic magmas using volatile diffusion in olivine-hosted melt tubes (embayments) for three contrasting eruptions of Kīlauea volcano, Hawai'i. Incomplete exsolution of H₂O, CO₂ and S from the embayment melts during eruptive ascent creates diffusion profiles that can be measured using microanalytical techniques, and then modelled to infer the average decompression rate. We obtain average rates of ~0.05-0.45 MPa s-1 for eruptions ranging from Hawaiian style fountains to basaltic subplinian, with the more intense eruptions having higher rates. The ascent timescales for these magmas vary from around ~5 to ~36 minutes from depths of ~2 to ~4 km respectively. Decompression-exsolution models based on the embayment data also allow for an estimate of the mass fraction of pre-existing exsolved volatiles within the magma body. In the eruptions studied this varies from 0.1-3.2 wt%, but does not appear to be the key control on eruptive intensity. Our results do not support a direct link between the concentration of pre-eruptive volatiles and eruptive intensity; rather they suggest that for these eruptions decompression rates are proportional to independent estimates of mass discharge rate. Although the intensity of eruptions is defined by the discharge rate, based on the currently available dataset of embayment analyses it does not appear to scale linearly with average decompression rate. This study demonstrates the utility of the embayment method for providing quantitative constraints on magma ascent during explosive basaltic eruptions