La percepción cinematográfica en la prosa de Azorín: un paseo por París

En el marco del homenaje dedicado a nuestro compañero y amigo Francisco Ramón-Trives hemos elegido este autor por ser alicantino, como él, y esta obra porque en París fue donde cultivó el amor a las letras francesas y allí conoció a Matilde, su Amor

Galaxy clusters with the square kilometer array

We review some science cases for galaxy clusters and the impact that the future SKA data will have in those analyses. We first describe how the search for galaxy clusters through radio-sources will be significantly improved through the detection of much fainter radiosources in a big volume. Secondly, we bring out the benefits of using very sensitive radio data to study the thermal and non-thermal component of clusters and disentangle the main processes happening in the physics of their plasma. Moreover, we discuss the possibility of using the high frequencies of the SKA to separate the thermal Sunyaev-Zeldovich (SZ) effect from the radio halo emission and use the former as a mass proxy for galaxy clusters. Finally, we investigate how the very high sensitivity and spatial resolution of SKA will result into a great improvement in the lensing treatment, underlining the lensing distribution of the 21-cm intensity from the reionization period. As a whole, SKA will become an impressive window covering a significant wider range in redshift to look at an unknown radio universe and set constraints on different mechanisms happening in clusters.This work has been supported by a grant funded by the “Consorzio per la Fisica di Trieste”. SP also acknowledges support by the PRIN-INAF09 project “Towards an Italian Network for Computational Cosmology”, by the PRIN-MIUR09 “Tracing the growth of structures in the Universe”, and by the PD51 INFN grant. Partial support is also provided by Spanish Ministerio de Ciencia e Innovación (AYA2010-21322-C03-02). JD acknowledges support from the Spanish Ministry of Economy and Competitiveness (MINECO) through grants AYA2010-21766-C03-02, AYA2012-30789, and the Consolider-Ingenio project CSD2010-00064 (EPI: Exploring the Physics of Inflation). YA is financially supported by the Spanish Ramón y Cajal programme (RyC-2011-09461) and grant AYA2013-47742-C4-3-P (MINECO), as well as the ‘Study of Emission-Line Galaxies with Integral-Field Spectroscopy’ (SELGIFS) exchange programme, funded by the EU through the IRSES scheme (FP7-PEOPLE-2013-IRSES-612701). BA acknowledges financial support for a postdoctoral fellowship from the Observatory of Paris.Peer reviewe

Non-Melanocytic Benign Skin Tumors in Children

Background: Dermatologists often attend children with benign skin tumors and cysts. The decision to perform dermatologic surgery in children may be difficult to make, especially in cases of benign tumors. Objective: The objective of this study was to determine the nature of non-melanocytic benign skin tumors amenable to dermatologic surgery in children. Methods: Histopathologic studies of skin tumors in children treated by our department between January 2004 and December 2005 were studied. Malignant and melanocytic tumors were excluded. Age, sex, type of tumor, diagnostic category, site, size, reason for removal, type of anesthesia, and any other associated disorders were recorded. Results: The records revealed that 121 patients presented 129 non-melanocytic benign skin tumors (73 in boys and 56 in girls). A total of 27 different anatomopathologic diagnoses were found. The most frequent was pilomatrixoma with 27 cases (20.9%), followed by infundibular cyst with 14 (10.9%), and molluscum contagiosum with 13 (10.1%). Tumors were located on the head and neck (45.7%), trunk (34.1%), and limbs (20.1%). The most frequently affected age group was children aged 11-14 years, which included 50 patients (38.8%). The main type of anesthesia used was local in 54.6% of the cases, sedation plus local anesthesia in 39.7%, and general anesthesia in 5.7%. The reasons that led to removal of the tumors were: increase in the size of the tumor (49%); various types of discomfort, such as severe itching or pain (30%); parental concern (4%); diagnostic uncertainty (16%); and esthetic reasons (1%). Conclusion: There is a wide diversity of non-melanocytic benign skin tumors in children, some of which require surgical treatment. Pilomatrixomas appear to be the most frequent benign tumors; there are also high frequencies of infundibular cysts, pyogenic granulomas, and viral tumors. Most can be removed under local anesthesia, with or without sedatio

Los corticoides epidurales en el tratamiento del síndrome del canal lumbar estrecho

Se presenta una serie de 67 pacientes diagnosticados de síndrome del canal lumbar estrecho, tratados todos ellos con infíltraciones epidurales de corticosteroides, asociadas a un programa de rehabilitación realizado a continuación de las inyecciones. Tras el análisis de los datos se ha observado un porcentaje de buenos resultados cercano al 80%. Asimismo, el estudio ha puesto en evidencia la influencia clara del factor rehabilitación en la calidad del resultado final de los pacientes.The authors present a study on 67 patients with degenerative lumbar spinal stenosis. The treatment consisted in epidural injections with corticosteroids and a program of physical therapy. There was 80% of good results. A clear influence of the physical therapy program on the quality of the final result, has been proved

OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients

Screening for opioid use disorder should be considered in chronic non-cancer pain (CNCP) patients with long-term use of opioids. The aim of our study was to assess the effectiveness of an individualized treatment plan (ITP) for prescription opioid dependence that included screening of pharmacogenetic markers. An observational prospective study was performed using prescription opioid-dependent CNCP outpatients (n = 88). Patients were divided into nonresponders, responders, or high responders according to their response to the ITP. Genotyping of OPRM1 (A118G), OPRD1 (T921C), COMT (G472A), ABCB1 (C3435T), and ARRB2 (C8622T) was performed by real-time PCR. Our ITP achieved a significant reduction of the morphine equivalent daily dose (MEDD) in 64% of responders, including 33% of high responders. Nonopioid medication or buprenorphine use was significantly higher at final versus basal visit. 118-AA OPRM1 patients required significantly lower MEDD at basal and final visits. Our ITP showed effectiveness and security in reducing MEDD in opioid-dependent patients, with good conversion to buprenorphine that was more pronounced in 118-AA OPRM1 patients

Los corticoides epidurales en el tratamiento de la hernia discal

Se presenta una serie de 233 pacientes diagnosticados de hernia discal lumbar y tratados mediante infiltraciones epidurales de corticoides, asociadas a un programa de rehabilitación realizado a continuación de las inyecciones. Los resultados con dicho tratamiento fueron satisfactorios en un 75% de los casos. Se observó una mejor evolución en pacientes varones, en pacientes cuya profesión conlleva esfuerzo físico, en hernias discales L5-S1, y en aquellos que han seguido un programa de rehabilitación tras las infiltraciones.An study on 233 patients with lumbar disc herniation, treated by means of epidural injections of steroids, added to a physical therapy programme is presented. The results obtained were fully satisfactory in 75% of the cases. Better results were observed in male patients, in patients subject to heavy physical activity in their laboral life, in disc herniations at L5-S1 level, and finally in those patients following a physical therapy programme after injections

Design and validation of an instrument for the detection of school difficulties in Primary Education

En la actualidad se sigue encontrando un porcentaje bastante elevado de aprendices con dificultades de aprendizaje que limitan su progreso académico. Se sabe como consecuencia de las investigaciones efectuadas en los últimos años que estas complicaciones no aparecen de manera espontánea en un momento determinado, sino que tienen su origen en los primeros niveles educativos y que tienden a incrementarse a medida que se avanza a lo largo de la escolaridad. Una explicación de este hecho se debe a que no siempre las carencias escolares se detectan a tiempo, lo que impide la toma de medidas que den respuesta a tales necesidades. Investigaciones recientes han evidenciado que la intervención educativa más eficaz es aquella que comienza en los primeros cursos, sin embargo, no se dispone de muchos recursos destinados a los docentes que les facilite la identificación temprana de los problemas de aprendizaje. Con la finalidad de dar respuesta a esta necesidad se elaboró el presente trabajo que tiene como objetivo favorecer la detección de las dificultades de aprendizaje en los primeros niveles de la escolaridad formal mediante la elaboración y validación de un instrumento que permita la puesta en práctica de medidas de detección e intervención educativa. Los resultados obtenidos evidencian que la herramienta diseñada constituye un recurso educativo de gran eficacia que ofrece a los docentes información relevante acerca del dominio de las habilidades, conocimientos y competencias que poseen los estudiantes, lo que brinda la posibilidad de adecuar el proceso de enseñanza a las características de aprendizaje de los escolares.At present, despite the numerous works that have been carried out on the learning problems that students encounter throughout their training, a fairly high percentage of apprentices with learning difficulties that limit their academic progress continue to be found. It is known as a consequence of the investigations carried out in recent years that these complications do not appear spontaneously at a certain moment, but rather have their origin in the first educational levels and that they tend to increase as progress is made throughout the education. scholarship. One explanation for this fact is due to the fact that school deficiencies are not always detected on time, which prevents the taking of measures that respond to such needs. Recent research has shown that the most effective educational intervention is the one that begins in the first grades; however, there are not many resources available for teachers to facilitate early identification of learning problems. In order to respond to this need, the present work was developed, which aims to favor the detection of learning difficulties in the first levels of formal schooling through the development and validation of an instrument that allows the implementation of measures detection and educational intervention. The results obtained show that the designed tool constitutes a highly effective educational resource that offers teachers relevant information about the mastery of skills, knowledge and competencies that students possess, which offers the possibility of adapting the teaching process to the needs of the students

Oxycodone/naloxone versus tapentadol in real‑world chronic non‑cancer pain management: an observational and pharmacogenetic study

Tapentadol (TAP) and oxycodone/naloxone (OXN) potentially offer an improved opioid tolerability. However, real-world studies in chronic non-cancer pain (CNCP) remain scarce. Our aim was to compare effectiveness and security in daily pain practice, together with the influence of pharmacogenetic markers. An observational study was developed with ambulatory test cases under TAP (n = 194) or OXN (n = 175) prescription with controls (prescribed with other opioids (control), n = 216) CNCP patients. Pain intensity and relief, quality of life, morphine equivalent daily doses (MEDD), concomitant analgesic drugs, adverse events (AEs), hospital frequentation and genetic variants of OPRM1 (rs1799971, A118G) and COMT (rs4680, G472A) genes, were analysed. Test CNCP cases evidenced a significantly higher pain relief predictable due to pain intensity and quality of life (R2 = 0.3), in front of controls. Here, OXN achieved the greatest pain relief under a 28% higher MEDD, 8-13% higher use of pregabalin and duloxetine, and 23% more prescription change due to pain, compared to TAP. Whilst, TAP yielded a better tolerability due the lower number of 4 [0-6] AEs/patient, in front of OXN. Furthermore, OXN COMT-AA homozygotes evidenced higher rates of erythema and vomiting, especially in females. CNCP real-world patients achieved higher pain relief than other traditional opioids with a better tolerability for TAP. Further research is necessary to clarify the potential influence of COMT and sex on OXN side-effects

El síndrome facetar lumbar: Tratamiento mediante infiltraciones facetarias con fenol

Se presenta una serie de 125 pacientes afectos de cuadro de lumbociatalgia atípica, diagnosticados de síndrome facetario y tratados con infiltraciones de solución fenolada en las articulaciones interapofisarias posteriores afectadas, seguidas de un programa de rehabilitación protocolizado tras las infiltraciones. A propósito de los mismos y tras una análisis estadístico de los datos obtenidos del estudio, se establecen algunos criterios para el tratamiento de pacientes aquejados de este tipo de patología.The authors present a series of 125 patients afflicted with an atypical sciatic low-back pain, who were diagnosed of "facet joint syndrome" and treated with injections of phenol solution in the affected lumbar zygapophysial joints. The patients followed a protocolized rehabilitation program. After an statistical analysis of the data obtained from the study, some criteria are stabilized for the treatment of patients suffering this pathology

Impaired Antibody-Dependent Cellular Cytotoxicity in a Spanish Cohort of Patients With COVID-19 Admitted to the ICU

SARS-CoV-2 infection causes COVID-19, ranging from mild to critical disease in symptomatic subjects. It is essential to better understand the immunologic responses occurring in patients with the most severe outcomes. In this study, parameters related to the humoral immune response elicited against SARS-CoV-2 were analysed in 61 patients with different presentations of COVID-19 who were recruited in Hospitals and Primary Healthcare Centres in Madrid, Spain, during the first pandemic peak between April and June 2020. Subjects were allocated as mild patients without hospitalization, severe patients hospitalized or critical patients requiring ICU assistance. Critical patients showed significantly enhanced levels of B cells with memory and plasmablast phenotypes, as well as higher levels of antibodies against SARS-CoV-2 with neutralization ability, which were particularly increased in male gender. Despite all this, antibody-dependent cell-mediated cytotoxicity was defective in these individuals. Besides, patients with critical COVID-19 also showed increased IgG levels against herpesvirus such as CMV, EBV, HSV-1 and VZV, as well as detectable CMV and EBV viremia in plasma. Altogether, these results suggest an enhanced but ineffectual immune response in patients with critical COVID-19 that allowed latent herpesvirus reactivation. These findings should be considered during the clinical management of these patients due to the potential contribution to the most severe disease during SARS-CoV-2 infection.This work was supported by the Coordinated Research Activities at the Centro Nacional de Microbiología (CNM, Instituto de Salud Carlos III) (COV20_00679) to promote an integrated response against SARS-CoV-2 in Spain (Spanish Ministry of Science and Innovation) that is coordinated by Dr Inmaculada Casas (WHO National Influenza Center of the CNM) and a generous donation provided by Chiesi España, S.A.U. (Barcelona, Spain). The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication. This work was also supported by the Spanish Ministry of Economy and Competitiveness (PID2019 110275RB-I00); the Spanish AIDS Research Network RD16CIII/0002/0001 that is included in Acción Estratégica en Salud, Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica 2016-2020, Instituto de Salud Carlos III, European Region Development Fund (ERDF); Miguel Servet - AESI, MPY 341/21. The work of ML-H and SR is financed by NIH grant R01AI143567. The work of MT is supported by Instituto de Salud Carlos III (COV20_00679). The work of LV is supported by a predoctoral grant from Instituto de Salud Carlos III (FIS PI16CIII/00034-ISCIII-FEDER).S