Narratives of the cornering: Place identity in coronel bay from the productive reconversion

El artículo analiza el proceso de construcción de identidad de lugar en la Bahía de Coronel en la Región del Bío-Bío en Chile en el contexto de industrialización reciente. Se adopta el concepto de zona de sacrificio para caracterizar la trayectoria de devastación socio-ambiental producida en el territorio. El estudio se focaliza en torno a tres referentes industriales implementados a partir de la reconversión productiva puesta en marcha en la década de 1990. Desde una perspectiva de historia ambiental híbrida y con un fuerte componente en el análisis de procesos contemporáneos, se utilizó un enfoque etnográfico que incluyó la realización de entrevistas y revisión de documentos, buscando poner en diálogo las fuentes cualitativas con un marco de procesos sociohistóricos más amplios. Se observó que las narrativas de identidad adoptan un carácter “residual” relacionado con el deterioro socio -ambiental y del bienestar de los residentes.The article analyzes the process of place identity construction in the Coronel Bay in the Bío-Bío Region in Chile in the context of recent industrialization processes. The concept of the sacrifice zone is adopted to characterize the trajectory of socio-environmental devastation taken place in the territory. The study focuses on three industrial milestones settled since the productive reconversion launched in the 1990s. From a perspective of hybrid environmental history and with a strong component in the analysis of contemporary processes, an ethnographic approach was taken. This included interviews and document review, seeking to establish a dialogue between the qualitative sources and a framework of broader socio-historical processes. An ethnographic approach is used by means of interviews and document review. It was observed that the identity narratives adopt a “residual” character related to the socio-environmental deterioration and the well-being of the residents.Fil: Bravo Ferretti, Cristóbal. Universidad del Bio Bio; ChileFil: Sandoval Díaz, José. Universidad del Bio Bio; ChileFil: Astudillo Pizarro, Francisco Segundo Cristian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Arquitectura Planeamiento y Diseño. Centro Universitario Rosario de Investigaciones Urbanas y Regionales; Argentin

The prognostic significance of tumor-infiltrating lymphocytes, PD-L1, BRCA mutation status and tumor mutational burden in early-stage high-grade serous ovarian carcinoma. A study by the Spanish Group for Ovarian Cancer Research (GEICO)

Early stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to determine the prognostic significance of CD8+ and CD4+ tumor-infiltrating lymphocytes (TILs), tumoral cell PD-L1 expression, BRCA mutational status and tumor mutation burden (TMB) in early-stage HGSOC. A retrospective study was performed on stage I and II HGSOC from the Molecular Reclassification of Early Stages of Ovarian Cancer (RECLAMO) cohort from the Spanish Group of Ovarian Cancer Research (GEICO). Centralized histological typing was performed based on morphological and immunohistochemical features. Intraepithelial (i) and stromal (s) CD8+ and CD4+ T cells and PD-L1 were evaluated on tissue microarrays by immunohistochemistry. BRCA1 and BRCA2 mutation status and TMB were analyzed in tumor DNA using next-generation sequencing. The study included 124 tumors. High iCD8+ (>20 TILs/core), low/intermediate CD4+ (35/core) were associated with favorable outcomes. Tumor cell PD-L1 expression (TPS ≥ 1) was present in only 8% of tumors. In total, 11 (16%) and 6 (9%) out of 69 HGSOC tested carried pathogenic or likely pathogenic BRCA1 or BRCA2 mutations, respectively. Median TMB of 40 tumors analyzed was 5.04 mutations/Mb and only 6 tumors had 10 or more mutations/Mb. BRCA status and TMB were not associated with TILs or prognosis. When compared with studies on advanced HGSOC, our results suggested that prognostic variables differed according to stage and that more studies focused on early stages of HGSOC are needed to better stratify these tumors: This work was supported by Instituto de Salud Carlos III (ISCIII) (grants PI19/01331, PI22/01892 and PMP22/00054); CIBERONC (grant CB16/12/00316); European Development Re gional Fund ‘A way to achieve Europe’ (FEDER), Spanish Group of Research in Ovarian Cancer (GEICO group); and by the Spanish Association Against Cancer Scientific Foundation (AECC)

Identifying priorities, targets, and actions for the long-term social and ecological management of invasive non-native species

Funding: The research and the workshop (December-2019; Centro Científico Tecnológico Patagonia Norte, San Carlos de Bariloche, Argentina) described in this manuscript were funded by the CONTAIN programme under the Latin American Biodiversity Programme as part of the Newton Fund (NE/S011641/1), with contributions from NERC, the Argentine National Scientific & Technical Research Council (CONICET,-2019-74-APN-DIR#CONICET), the Brazilian São Paulo Research Foundation (FAPESP 2018/14995-8), and the Chilean Agency for Research and Development (ANID; formerly CONICYT). Acknowledgments Thanks to the colleagues who replied to our informal questions about the usefulness of the methods and procedures described here. This informal survey of colleagues to obtain an initial critical evaluation was aligned with the policies relevant to the authors who contacted the participants. No one else had access to the responses and identities of the respondents. Servicio Agrícola y Ganadero, Gobierno de Chile, is one of the CONTAIN project partners, and it is represented by ER in this paper. However, the opinions and results presented in this document are entirely those of ER and may not represent SAG position on the topic. The Associate Editor and two reviewers provided feedback that helped improve a previous version of the manuscript. Open access via Springer compact agreementPeer reviewedPublisher PD

Survey Data on the Impact of COVID-19 on Parental Engagement Across 23 Countries

This data article describes the dataset of the International COVID-19 Impact on Parental Engagement Study (ICIPES). ICIPES is a collaborative effort of more than 20 institutions to investigate the ways in which, parents and caregivers built capacity engaged with children's learning during the period of social distancing arising from global COVID-19 pandemic. A series of data were collected using an online survey conducted in 23 countries and had a total sample of 4,658 parents/caregivers. The description of the data contained in this article is divided into two main parts. The first part is a descriptive analysis of all the items included in the survey and was performed using tables and figures. The second part refers to the construction of scales. Three scales were constructed and included in the dataset: ‘parental acceptance and confidence in the use of technology’, ‘parental engagement in children's learning’ and ‘socioeconomic status’. The scales were created using Confirmatory Factor Analysis (CFA) and Multi-Group Confirmatory Analysis (MG-CFA) and were adopted to evaluate their cross-cultural comparability (i.e., measurement invariance) across countries and within sub-groups. This dataset will be relevant for researchers in different fields, particularly for those interested in international comparative education

Survey data on the impact of COVID-19 on parental engagement across 23 countries

This data article describes the dataset of the International COVID-19 Impact on Parental Engagement Study (ICIPES). ICIPES is a collaborative effort of more than 20 institutions to investigate the ways in which, parents and caregivers built capacity engaged with children's learning during the period of social distancing arising from global COVID-19 pandemic. A series of data were collected using an online survey conducted in 23 countries and had a total sample of 4,658 parents/caregivers. The description of the data contained in this article is divided into two main parts. The first part is a descriptive analysis of all the items included in the survey and was performed using tables and figures. The second part refers to the construction of scales. Three scales were constructed and included in the dataset: 'parental acceptance and confidence in the use of technology', 'parental engagement in children's learning' and 'socioeconomic status'. The scales were created using Confirmatory Factor Analysis (CFA) and Multi-Group Confirmatory Analysis (MG-CFA) and were adopted to evaluate their cross-cultural comparability (i.e., measurement invariance) across countries and within sub-groups. This dataset will be relevant for researchers in different fields, particularly for those interested in international comparative education

Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac disease

[Background] Gluten-free diet (GFD) is the only treatment for patients with coeliac disease (CD) and its compliance should be monitored to avoid cumulative damage.[Aims] To analyse gluten exposures of coeliac patients on GFD for at least 24 months using different monitoring tools and its impact on duodenal histology at 12-month follow-up and evaluate the interval of determination of urinary gluten immunogenic peptides (u-GIP) for the monitoring of GFD adherence.[Methods] Ninety-four patients with CD on a GFD for at least 24 months were prospectively included. Symptoms, serology, CDAT questionnaire, and u-GIP (three samples/visit) were analysed at inclusion, 3, 6, and 12 months. Duodenal biopsy was performed at inclusion and 12 months.[Results] At inclusion, 25.8% presented duodenal mucosal damage; at 12 months, this percentage reduced by half. This histological improvement was indicated by a reduction in u-GIP but did not correlate with the remaining tools. The determination of u-GIP detected a higher number of transgressions than serology, regardless of histological evolution type. The presence of >4 u-GIP-positive samples out of 12 collected during 12 months predicted histological lesion with a specificity of 93%. Most patients (94%) with negative u-GIP in ≥2 follow-up visits showed the absence of histological lesions (p < 0.05).[Conclusion] This study suggests that the frequency of recurrent gluten exposures, according to serial determination of u-GIP, could be related to the persistence of villous atrophy and that a more regular follow-up every 6 months, instead of annually, provides more useful data about the adequate adherence to GFD and mucosal healing.This study was funded in part by Fundación Progreso y Salud, Consejería de Salud, Junta de Andalucía (PI-0427-2017 and PI-0053-2018).Peer reviewe

Memorial ajustado, hecho de orden del Consejo, con citacion, y assistencia de las partes, del pleyto, que siguen don Antonio Maria Pantoja, y Pizarro, Conde de Torrejon ... D. Joseph Godoy ... doña Juana Pizarro ... y don Francisco Monroy ... sobre la tenuta, y possession del mayorazgo, que ... fundaron ... don Christoval Pizarro, y doña Beatriz de Carvajal... [Joseph Francisco de Roxas]

Lugar y fecha de imp. tomado del texto, fechado en Granada, 1756Inic. grab.No recogido en LopHue.Enc. Perg.Sign.: [ ]1, A-F2, G

Copia del nombramiento de beca en el Colegio Mayor del Rosario a favor de Nicolás Neira

Copia del nombramiento como colegial formal en el Colegio Mayor del Rosario a favor de Nicolás Neyra por parte del virrey de la Nueva Granada. Se le concedió una de las becas creadas desde la fundación del Colegio

Nombramiento de beca en el Colegio Mayor del Rosario a favor de Carlos Manuel de Olarte

Solicitud y concesión de una de las becas formales en el Colegio Mayor del Rosario a Carlos Manuel de Olarte, natural de la ciudad de Vélez. El nombramiento en la beca fue hecho por el virrey de la Nueva Granada y luego ratificado por el rector del Colegio Mayor