The Management of Second Generation Thyrosine Kinase Inhibitors Treatment: Case Report

The current management of chronic myeloid leukemia (CML) is dependent upon chronic thyrosine kinase inhibition (TKI). Several drugs have been developed for tyrosine kinases during the last decade. Imatinib mesylate (IM) is the first molecular targeting TKI. IM is the current 'standard- of -care' in CML patients to obtain cytogenetic remission. Patients refractory to IM can be treated with second generation TKI including dasatinib. The aim of this case report is to assess the efficacy of dasatinib treatment in the basis of IM failure

Imaging of liposomes by scanning tunneling microscopy

In this study, unilamellar and multilamellar liposomes consisting of dipalmitoylphosphatidylcholine, cholesterol and dicetylphosphate were prepared. Scanning tunneling microscopy images of these liposomes on highly oriented pyrolytic graphite surfaces were obtained. It was observed that scanning tunnelling microscopy can be succesfully used for high-resolution, three-dimensional structure analysis of liposomes under very mild conditions

Gold-nanoisland-decorated titanium nanorod arrays fabricated by thermal dewetting approach

Ozden, Dilek Sura/0000-0001-6326-1150; yilmaz, mehmet/0000-0003-2687-9167WOS: 000488629800003Solid-state dewetting is a simple and versatile technique for fabricating plasmonic-nanostructure-decorated platforms. However, understanding of the optical properties of these platforms and the effect of the three-dimensional (3D) morphology of the underlying substrate on the dewetting of metallic thin films is still needed for developing effective platforms for further applications. Herein, the authors report gold (Au)-nanoisland-decorated 3D titanium dioxide (TiO2) nanorod (TiNR) arrays fabricated through the thermal dewetting approach. It is demonstrated that the plasmonic behavior of the fabricated platforms can be manipulated by controlling both the initial gold film thickness and annealing temperature. Furthermore, the fabricated platforms exhibited Raman signal enhancement of up to similar to 10(2) for the probe molecule methylene blue. The surface characteristics of the fabricated platforms were evaluated for biological interactions. For this purpose, osteogenic cells (Saos-2) were seeded on the samples. It was found that the cell behavior was improved on the anisotropic micro-nano pattern of TiNRs and gold-coated TiNR films because of features such as topography and surface chemistry. The authors' results clearly offer simple but important guidance for the creation of surface-enhanced Raman spectroscopy platforms and tissue-integration devices as biomaterials for real-life applications.Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113O864]; Turkish Academy of SciencesTurkish Academy of SciencesThe authors thank Dr Gokhan Demirel for the helpful discussions and support with equipments and protocols. This work was partially supported by the Scientific and Technological Research Council of Turkey (Project/Grand Number: 113O864) and E. P. also acknowledges support from Turkish Academy of Sciences

Chronic myeloid leukaemia associated with extreme thrombocytosis

Extreme thrombocytosis is considered when platelet count is above the 1000000/μl. Although secondary thrombocytosis is much more frequent than primary thrombocytosis, autonomous thrombocytosis should also be kept in mind. In the literature, extreme thrombocytosis in chronic myeloid leukaemia (CML) is rare. Cases presenting with thrombocytosis and megakaryocyte hyperplasia in bone marrow analysis, are reported in the context of an essential thrombocythaemia (ET). We present a case with a platelet count of 9387000/μl. It was diagnosed as CML, but presentation doesn't resemble typical CML. Copyright © Hellenic Society of Haematology

The Effect of the Acute Submaximal Exercise on Thrombin Activatable Fibrinolysis Inhibitor Levels in Young Sedentary Males

Depending on type, duration, and intensity of the exercise, changes occur in hemostasis. In this study, we evaluated the changes in the parameters of coagulation and fibrinolytic systems that happened after the submaximal aerobic exercises by bicycle ergomater. Twelve healthy male participants whose ages were between 21 and 28 have been included. The venous samples have been drawn before the exercise as well as at the 0th, 15th, and 60th minutes after the submaximal exercise. The values of prothrombin time (PT), active partial thromboplastin time (aPTT), D-dimer, fibrinogen, plasminogen activator inhibitor 1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI) have been measured. Plasminogen activator inhibitor 1 values have shown an insignificant increase after exercise (P = .328), whereas, it has decreased significantly during the resting period (P = .033) Postexercise 15th and 60th minutes TAFI values have decreased significantly comparing to basal and postexercise (0th minute) values (P = .001). Fibrinolytic system activation is observed after acute submaximal aerobic exercise of sedentary healthy participants

The correlation between T regulatory cells and autologous peripheral blood stem cell transplantation in multiple myeloma

Objective: Multiple myeloma (MM) is characterized by malignant proliferation of plasmocytes and their precursors. T regulatory cells (Tregs) have a role in immunosuppression and control of autoimmunity, and are currently an important topic in the study of immune response to tumor cells. The correlation between Tregs and autologous peripheral blood stem cell transplantation (APBSCT) in MM has not been studied. The aim of this study was to compare CD4+CD25+FOXP3+ Treg, CD200, and PD-1 levels in MM patients that did and did not undergo APBSCT

Ischemic stroke after recombinant factor VIIa treatment in acquired hemophilia A patient

Acquired hemophilia is a rare, life-threatening coagulopathy in adults caused by the development of autoantibodies against factor VIII. Bypass agents such as recombinant factor VIIa (rFVIIa) are usually preferred for bleeding control; however, thromboembolic complications may occur. We report here a case that presented with extensive cutaneous and mucosal bleedings due to factor VIII inhibitors and was treated successfully with rFVIIa and steroid therapy, but was complicated with a life-threatening thromboembolic attack during follow-up. Blood Coagul Fibrinolysis 23:69-70 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins

The Effect of Fc gamma RIIIA Gene Polymorphism on the Treatment of Diffuse Large B-cell Non-Hodgkin Lymphoma: A Multicenter Prospective Observational Study

Objective: The curative treatment approach for diffuse large B-cell lymphoma (DLBCL) is controversial even in the rituximab (R) era. The aim of this study was to examine the Fc gamma RIIIA gene polymorphism distribution of DLBCL patients who had been treated with R-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy. Furthermore, we investigated the impact of Fc gamma RIIIA gene polymorphism on the overall response rate (ORR) and overall survival (OS). Materials and Methods: Patients from 3 centers in the Aegean region of Turkey who had newly diagnosed CD20-positive DLBCL were enrolled in the study. The single nucleotide polymorphisms of the Fc gamma RIIIA gene were analyzed by real time-PCR. The response to treatment was determined in the middle and at the end of the protocol. During 2 years of follow-up, the patients were clinically and radiologically evaluated for disease status every 3 months. Results: Thirty-six patients were included in the study and the distributions of F/F, V/F, and V/V types of alleles of Fc gamma RIIIA were 25%, 50%, and 25%, respectively. Twenty-seven patients were considered as evaluable according to ORR and OS. The patients' ORR was 87.5%, 100%, and 50% in the F/F, V/F, and V/V allele groups, respectively. We did not establish any statistically significant differences among the 3 alleles groups in respect to ORR (p=0.93). The OS within 2 years in the F/F, V/F, and V/V allele groups was 62.5%, 100%, and 100%, respectively. The OS in the F/F allele group was found to be lower than in the other 2 allele groups (p=0.01). Conclusion: The distribution of gene polymorphisms in our study group was similar to those of previous studies. While ORR was similar between the groups, our results highlight a lower OS in F/F patients compared to other allele groups of Fc gamma RIIIA