Aircraft Leading Edge Strakes on Conventional NACA Wings

The prevention of stall on aircraft wings has been a great challenge over the history of airplanes. As the aircraft become more and more complex, it becomes harder to fit high lift devices and leading-edge devices onto high camber, supercritical airfoil aircraft wings. In the fighter jet class of aircraft the obstacle of stall is usually delayed by the implementation of leading-edge root extensions or strakes. Strakes create a tip vortice along the sharp leading edge that transitions over the surface of the wing preventing separation on both the upper and lower surface of the wing allowing the fighter jet to experience higher angles of attack. Implementation of a strake has been proven to be effective on thin, low aspect ratio wings since there is not an aggressive curve that vortice must overcome at the leading edge of the wing. In this study, using Computation Fluid Dynamics (CFD) via the Department of Defense’s new program HPCMP Create Genesis we are creating a series of geometry sets that will be run though the CFD flow simulation program to show what each iteration of strake does for a conventional NACA airfoil with camber and a much thicker cross section and if strakes aid in delaying onset of stall allowing aircraft, such as passenger planes, to safely operate at higher angles of attack. This information can be of great use as it can help prevent airline crashes that involve stall at take-off. POSTER PRESENTATION IGNITE AWAR

Post-translational modifications by sumo and ubiquitin-like proteins; role of sumoylation on sall proteins

206 p.Las modificaciones post-traduccional debidas a la conjugación de Ubiquitina y de proteínas similares a la Ubiquitina (UbLs) contribuyen a extender y diversificar la funcionalidad de los proteomas eucariotas. SUMO (Small Ubiquitin-related Modifier) se une de manera reversible a muchos substratos celulares para controlar su actividad y su localización, así como el reclutamiento de complejos proteicos que puedan reconocer la molécula de SUMO. La naturaleza dinámica de esta modificación y su escasa abundancia en las células hace que el estudio de la SUMOilación es a menudo difícil de encarar técnicamente. En este trabajo hemos desarrollado una nueva herramienta para aislar y analizar proteínas SUMOiladas en cultivo celulares y de manera específica de tejido en Drosophila. Tras la aplicación exitosa de la tecnología de bioSUMO en Drosophila, aplicamos la misma técnica a otras proteínas similares a Ubiquitina en mamíferos, utilizando para ello vectores multicistrónicos modulares desarrollados previamente en nuestro laboratorio. Presento en esta Tesis la batería de herramientas elaboradas que se puedan utilizar en células de mamífero y de Drosophila para aislar proteínas modificadas por diversas UbLs. En la segunda parte de esta Tesis, nos enfocamos en la investigación sobre la SUMOilacion de las proteínas SALL (Spalt-like). Estas proteínas son factores de trascripción del tipo dedos de zinc, conservadas desde C. elegans hasta mamíferos. Mutaciones en estos genes provocan enfermedades humanas hereditarias, tales como el Síndrome de Townes-Brocks y el Síndrome de Okihiro. Tanto el homólogo humano SALL1 como Salm en Drosophila están SUMOiladas in vitro. Aquí demostramos su SUMOilación en células e investigamos el papel de una posible E3 ligasa de SALL, utilizando células de mamífero y Drosophila como modelos.CICBiogun

The hyperbaric incident monitoring study (HIMS) : an international study of incidents occuring in hyperbaric medicine units

Analyses incidents which occured in hyperbaric medicine units, or as a consequence of hyperbaric oxygen exposure, with the aim of developing recommendations for safety improvement in hyperbaric medical practice. A review of the hyperbaric literature showed that ear barotrauma is the most frequently reported patient complication of hyperbaric treatment, with the second most frequently reported complication being oxygen toxicity. From the data, the study presents recommendations for quality improvement, research, policy and procedure development, education and equipment design modification.Thesis (M.Clin.Sc.) -- University of Adelaide, Dept. of Clinical Nursing, 2001

Environmental Burkholderia cenocepacia Strain Enhances Fitness by Serial Passages during Long-Term Chronic Airways Infection in Mice

Burkholderia cenocepacia is an important opportunistic pathogen in cystic fibrosis (CF) patients, and has also been isolated from natural environments. In previous work, we explored the virulence and pathogenic potential of environmental B. cenocepacia strains and demonstrated that they do not differ from clinical strains in some pathogenic traits. Here, we investigated the ability of the environmental B. cenocepacia Mex1 strain, isolated from the maize rhizosphere, to persist and increase its virulence after serial passages in a mouse model of chronic infection. B. cenocepacia Mex1 strain, belonging to the recA lineage IIIA, was embedded in agar beads and challenged into the lung of C57Bl/6 mice. The mice were sacrificed after 28 days from infection and their lungs were tested for bacterial loads. Agar beads containing the pool of B. cenocepacia colonies from the four sequential passages were used to infect the mice. The environmental B. cenocepacia strain showed a low incidence of chronic infection after the first passage; after the second, third and fourth passages in mice, its ability to establish chronic infection increased significantly and progressively up to 100%. Colonial morphology analysis and genetic profiling of the Mex1-derived clones recovered after the fourth passage from infected mice revealed that they were indistinguishable from the challenged strain both at phenotypic and genetic level. By testing the virulence of single clones in the Galleria mellonella infection model, we found that two Mex1-derived clones significantly increased their pathogenicity compared to the parental Mex1 strain and behaved similarly to the clinical and epidemic B. cenocepacia LMG16656(T). Our findings suggest that serial passages of the environmental B. cenocepacia Mex1 strain in mice resulted in an increased ability to determine chronic lung infection and the appearance of clonal variants with increased virulence in non-vertebrate hosts

Brain Mass and Encephalization Quotients in the Domestic Industrial Pig (Sus scrofa)

open6siIn the present study we examined the brain of fetal, newborn, and adult pigs raised for meat production. The fresh and formalin-fixed weights of the brain have been recorded and used, together with body weight, to calculate the Encephalization Quotient (EQ). The weight of the cerebellum has been used to calculate the Cerebellar Quotient (CQ). The results have been discussed together with analogue data obtained in other terrestrial Cetartiodactyla (including the domestic bovine, sheep, goat, and camel), domesticated Carnivora, Proboscidata, and Primates. Our study, based on a relatively large experimental series, corrects former observations present in the literature based on smaller samples, and emphasizes that the domestic pig has a small brain relative to its body size (EQ = 0.38 for adults), possibly due to factors linked to the necessity of meat production and improved body weight. Comparison with other terrestrial Cetartiodactyla indicates a similar trend for all domesticated species.openMinervini, Serena; Accogli, Gianluca; Pirone, Andrea; Graïc, Jean-Marie; Cozzi, Bruno; Desantis, SalvatoreMinervini, Serena; Accogli, Gianluca; Pirone, Andrea; Graic, JEAN-MARIE; Cozzi, Bruno; Desantis, Salvator

Political Participation in Self-Managed Social Centres. Direct Social Action and Institutionalization in Bologna City

While regeneration is emerging as a paradigm capable of inspiring public policies and transforming lifestyles, the urban space remains a fertile ground in which collective initiatives based on activism and solidarity can emerge. The aim of this article is to describe some social and political practices in self-managed spaces and their relationship both with the wider background of the city and with local institu-tions. We argue that processes of institutionalization could affect practices of self-organization and political participation in different ways: these processes could mark the cooptation of conflicts into local administration strategies as well as open new forms of politicization around urban commons. We will present a case study, the evolution of the social centre Làbas in Bologna city, as a testing ground to explore and examine these practices and interactions. In the following paragraphs, we define the self-managed social centres, considering the processes of repression and institutionalization, and the development of new forms of political participation. Then we focus on the history of Bologna's social centres. Finally, we analyze the case study, briefly describing the process of institutionalization and the evolution of its practices

Circulating through the Pipeline. Algorithmic Subjectivities and Mobile Struggles

We are living within a transformation that has been variously labelled as industrial revolution 4.0, platform economy, digital capitalism. Nevertheless, this change is still mainly conceptualized through the vocabulary of factory system. In this article we aim to contribute to the development of an emerging framework on the 'new capitalism' without any nostalgia for the past by exploring some of its potential interpretative categories (pipeline, algorithmic subjectivities, mobile struggles), based in particular on its spatial configurations and on the production of living labour' subjectivities. Indeed, we are witnessing not simply a wave of technological innovation but a more general transformation of the forms of capitalist valorisation which rely on the role played by spaces and social cooperation. These changes do not affect only spatialities but also the subjective forms of living labour, including his/her practices of organization and struggle

Calibration of a granular matrix sensor for suction measurements in partially saturated pyroclastic soil

Field monitoring of soil moisture and matrix suction is a useful tool for the implementation of a reliable early warning system against rainfall-induced landslide occurrence. Several test fields have been set up in Campania region (southern Italy), frequently affected by flow-like landslides involving pyroclastic soil cover. In particular, at the Mount Faito test site (Lattari Mountains, southeast of Naples), field matric suctions were measured over two years by conventional jet-fill tensiometers and granular matrix sensors (Watermark, Irrometer®) at different depths. Granular matrix sensor is a resistive device that is more and more spread in agriculture applications and that may also be used for geotechnical purposes thanks to a suitable calibration. In order to gain the calibration curve of the Watermark sensor, two small tip tensiometers (STT) and one High Capacity Tensiometer (HCT) were installed at the same depth of the Watermark sensor in the partially saturated pyroclastic soil sampled at the topsoil of the Mount Faito test site. Tests were carried out in the laboratory by performing drying and wetting phases on undisturbed soil sample. By coupling resistance measurements by Watermark and matrix suction provided by the reference tensiometers, it was possible to derive the non-linear relationship between these two quantities. The soil retention curve was also determined thanks to the installation in the soil sample of a decagon probe previously calibrated in the same pyroclastic soil