Strategic insights : navigating business intelligence implementation : phases, tasks, and risks : a case study on an international manufacturing company

PURPOSE: This article aims to present a comprehensive case study of implementing a business intelligence system in the manufacturing company. Therefore, a comprehensive understanding of key implementation aspects and associated risks is vital for meticulous planning before investing in information systems.DESIGN/METHODOLOGY/APPROACH: Through qualitative research, the study will identify the main implementation phases, assign key tasks, and highlight the potential risks encountered during the process. By examining the case study, readers can gain insights into the effective implementation of a business intelligence system in manufacturing company, enabling them to better navigate similar ventures a significant input for researchers to create an implementation model.FINDINGS: Having accurate and timely information is a crucial asset for businesses, influencing their competitive advantage. Information is essential for decision-making, enabling organizations to identify opportunities, threats, strengths, weaknesses, and changes. Business Intelligence (BI) solutions cater to these needs by automatically transforming data into actionable information. However, due to the wide array of tools available in the market, the implementation process of BI can be complex.PRACTICAL IMPLICATIONS: The findings from this article's case study can serve as a foundation for proposing an implementation model for business intelligence systems.ORIGINALITY/VALUE: By analyzing the challenges, key phases, and risks identified in the case study, future research can develop a structured framework or model that outlines the necessary steps, considerations, and best practices for implementing BI systems specifically tailored to manufacturing industries.peer-reviewe

Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain

Background Treatment of neuropathic pain is still challenging. Recent studies have suggested that dorsal root ganglia (DRG), which carry sensory neural signals from the peripheral nervous system to the central nervous system, are important for pathological nociception. A proper understanding of the significance and function of DRG and their role in pharmacotherapy can help to improve the treatment of neuropathic pain. Metamizole, also known as sulpyrine or dipyrone, is a non-opioid analgesic commonly used in clinical practice, but it is not used for neuropathic pain treatment. Methods Chronic constriction injury (CCI) of the sciatic nerve was induced in Wistar rats. Metamizole was administered intraperitoneally (ip) preemptively at 16 and 1 h before CCI and then twice a day for 7 days. To evaluate tactile and thermal hypersensitivity, von Frey and cold plate tests were conducted, respectively. Results Our behavioral results provide evidence that repeated intraperitoneal administration of metamizole diminishes the development of neuropathic pain symptoms in rats. Simultaneously, our findings provide evidence that metamizole diminishes the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury. These assays indicate, for the first time, that metamizole exerts antinociceptive effects on nerve injury-induced neuropathic pain at the DRG level. Conclusions Finally, we indicate that metamizole-induced analgesia in neuropathy is associated with silencing of a broad spectrum of cytokines in DRG. Our results also suggest that metamizole is likely to be an effective medication for neuropathic pain

Anthropometry and body composition of adolescents in Cracow, Poland

The aim of the present study was to determine the level of adiposity and obesity in Polish adolescents and compare the results with earlier studies conducted in this population as well as those carried out in other populations.The study group consisted of 456 boys and 514 girls aged 14-18 years living in Cracow chosen from randomly selected secondary schools. Weight, height, waist, and hip circumference (WC, HC) as well as triceps, biceps, subscapular, and suprailiac skinfold thickness (SFT) were measured. Body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), subscapular/triceps skinfold ratio (STR), and percentage body fat were computed. The prevalence of overweight and obesity based on Polish children growth reference were calculated and age-dependent and gender-specific smoothed percentile curves for BMI and ROC curves were generated.Weight, height, WC, HC (up 16yr), WHtR (up 15yr), and WHR were considerably higher in males than females. Weight, height, and HC increased with age; WHtR remained the same. The prevalence of overweight and obesity were 10.2% (boys 10.3%; girls 10.1%) and 4.2% (boys 5.3%; girls 3.3%). ROC analysis revealed that WHtR was the best tool for detection of obesity (AUC of 0.982±0.007) in males, whereas the sum of four SFTs (AUC: 0.968±0.011) and WHtR (AUC: 0.963±0.012) were the best predictors of obesity in females.The level of adiposity in Cracow adolescents increased during the last decade. However, it is still lower than in other well-developed societies struggling with obesity epidemics

ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

Myofibroblastic cancer-associated fibroblast (myoCAF)-rich tumors generally contain few T cells and respond poorly to immune-checkpoint blockade. Although myoCAFs are associated with poor outcome in most solid tumors, the molecular mechanisms regulating myoCAF accumulation remain unclear, limiting the potential for therapeutic intervention. Here, we identify ataxia-telangiectasia mutated (ATM) as a central regulator of the myoCAF phenotype. Differentiating myofibroblasts in vitro and myoCAFs cultured ex vivo display activated ATM signaling, and targeting ATM genetically or pharmacologically could suppress and reverse differentiation. ATM activation was regulated by the reactive oxygen species-producing enzyme NOX4, both through DNA damage and increased oxidative stress. Targeting fibroblast ATM in vivo suppressed myoCAF-rich tumor growth, promoted intratumoral CD8 T-cell infiltration, and potentiated the response to anti-PD-1 blockade and antitumor vaccination. This work identifies a novel pathway regulating myoCAF differentiation and provides a rationale for using ATM inhibitors to overcome CAF-mediated immunotherapy resistance.SignificanceATM signaling supports the differentiation of myoCAFs to suppress T-cell infiltration and antitumor immunity, supporting the potential clinical use of ATM inhibitors in combination with checkpoint inhibition in myoCAF-rich, immune-cold tumors

Sex- and age-related differences in the management and outcomes of chronic heart failure: an analysis of patients from the ESC HFA EORP Heart Failure Long-Term Registry

Aims: This study aimed to assess age- and sex-related differences in management and 1-year risk for all-cause mortality and hospitalization in chronic heart failure (HF) patients. Methods and results: Of 16 354 patients included in the European Society of Cardiology Heart Failure Long-Term Registry, 9428 chronic HF patients were analysed [median age: 66 years; 28.5% women; mean left ventricular ejection fraction (LVEF) 37%]. Rates of use of guideline-directed medical therapy (GDMT) were high (angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists: 85.7%, 88.7% and 58.8%, respectively). Crude GDMT utilization rates were lower in women than in men (all differences: P\ua0 64 0.001), and GDMT use became lower with ageing in both sexes, at baseline and at 1-year follow-up. Sex was not an independent predictor of GDMT prescription; however, age >75 years was a significant predictor of GDMT underutilization. Rates of all-cause mortality were lower in women than in men (7.1% vs. 8.7%; P\ua0=\ua00.015), as were rates of all-cause hospitalization (21.9% vs. 27.3%; P\ua075 years. Conclusions: There was a decline in GDMT use with advanced age in both sexes. Sex was not an independent predictor of GDMT or adverse outcomes. However, age >75 years independently predicted lower GDMT use and higher all-cause mortality in patients with LVEF 6445%

Overlooked crisis leading to rebellion

W tekście podejmujemy próbę zastanowienia się nad przyczynami braku buntu wobec kryzysu systemu edukacji w Polsce. W związku z tym zwracamy uwagę na systemowe błędy prowadzenia badań ilościowych wynikłe z braku odpowiedniej wiedzy zarówno wśród tych, którzy zlecają analizy jak i tych, którzy je wykonują oraz analizujemy błędy polskich badań będące skutkiem naśladownictwa pomiarów międzynarodowych. W podsumowaniu, prezentując jedno studium przypadku uczennicy wykluczonej z systemu edukacji przedstawiamy cel dalszych, niezbędnych pomiarów tego systemu.The article presents conflicts occurring in education. The authors explain why, despite numerous studies, it is difficult to notice the true picture of the entire system. According to the authors, the sources of ignorance lie in the erroneous rules of the school and academic education, and in the imitation of international measurements (in educational studies in Poland). The description, cited at the end of the article, is the first of several case studies that will be mainly used in the following articles, presenting actions, which minimize the effects of the crisis of the system of education.Marek Piotrowski: [email protected]żbieta Kucińska: [email protected] Piotrowska: [email protected] Piotrowski - Uniwersytet WarszawskiElżbieta Kucińska - Zespół Diagnostyczno-Reedukacyjny w Młodzieżowym Ośrodku Socjoterapii nr 2 „Kąt” w WarszawieKlaudia Piotrowska - Zespół Szkół STO4 w WarszawieBonstingl J., Szkoły jakości. Wprowadzenie do Total Quality Management w edukacji, Wydawnictwo CODN, Warszawa 1998.Centralna Komisja Egzaminacyjna, Osiągnięcia uczniów kończących gimnazjum w roku 2009, Warszawa 2009.Centralna Komisja Egzaminacyjna, Osiągnięcia uczniów kończących gimnazjum w roku 2012, Warszawa 2012.Dagiel M. i in., Raport OBUT 2011, A. Pregler, E. Wiatrak (red.), Centralna Komisja Egzaminacyjna, Warszawa 2011.Dąbrowski M., Żytko M., Badanie umiejętności podstawowych uczniów trzecich klas szkoły podstawowej RAPORT Z BADANIA ILOŚCIOWEGO, Centralna Komisja Egzaminacyjna, Warszawa 2007.Dudzikowa M., Użyteczność pojęcia działań pozornych jako kategorii analitycznej. Egzemplifikacja z obszaru edukacji (i nie tylko), [w:] Sprawcy i/lub ofiary działań pozornych w edukacji, M. Dudzikowa, K. Knasiecka-Falbierska (red.), Oficyna Wydawnicza Impuls, Kraków 2012.IBO, Diploma Programme curriculum framework, International Baccalaureate Organization, http://www.ibo.org/diploma/curriculum/.IBO, Individuals and societies, International Baccalaureate Organization, http://www.ibo.org/diploma/curriculum/group3/.IBO, Mathematics SL guide, International Baccalaureate Organization, Genewa 2014.IBO, Sciences, International Baccalaureate Organization, http://www.ibo.org/diploma/curriculum/group4/SEHS.cfm.Popowicz K., IB – dobre praktyki, TOK, https://sites.google.com/site/ibdobrepraktyki/tok.Jędrzejewski M., My śmiecie – git ludzie, skini, sataniści, krysznaici, LAWSONIA, Warszawa 1993.Kasprzak P., Cud nad Wisłą 2012, Oświatowa Fundacja Filmowa, Warszawa 2014.Konarzewski K., TIMSS i PIRLS 2011. Osiągnięcia szkolne polskich trzecioklasistów w perspektywie międzynarodowej, CKE, Warszawa 2012.Kondratek B., Teorie odpowiedzi na pozycje testowe oraz klasyczna teoria testów, Uniwersytet Śląski, „Biuletyn Wydawniczy” 2009, nr 9.Kućmierowska B., Statystyczny drogowskaz 1. Praktyczne wprowadzenie do wnioskowania statystycznego, S. Bedyńska, M. Cypryańska (red.), Wydawnictwo Akademickie Sedno, Szkoła Wyższa Psychologii Społecznej, Warszawa 2012.Lackowski J., Niespełnione nadzieje maturalnych reformatorów, Ośrodek Myśli Politycznej 201313-09-28, http://www.omp.org.pl/artykul.php?artykul=31317.Lagemaat R., Theory of knowledge for the IB Diploma, Cambridge University Press, Cambridge 2011.Lutyński J., Działania pozorne, [w:] Nauka i polskie problemy. Komentarz socjologa, Państwowy Instytut Wydawniczy, Warszawa 1990.Ministerstwo Edukacji Narodowej, Program Międzynarodowej Oceny Umiejętności Uczniów OECD PISA, Wyniki badań w Polsce 2012, ifispan.waw.pl.Mourshed M., Chijioke C., Barber M., Jak najlepiej doskonalone systemy szkolne na świecie stają się jeszcze lepsze, McKinsey & Company 2007, przekł. Centrum Edukacji Obywatelskiej, Warszawa 2012.OECD, Who are the strong performers and successful reformers in education?, PISA IN FOCUS 2013, nr 11.Parlament Europejski, Kompetencje kluczowe w uczeniu się przez całe życie. Europejskie ramy odniesienia 2006 r., http://europa.eu/legislation_summaries/education_training_youth/lifelong_learning/c1111090_pl.htm.Piotrowski M., Od TQM do żandarma, czyli pod prąd, VEDA, Warszawa 2013.Piotrowski M., Brak i lekceważenie kapitału społecznego przyczyną niskiej skuteczności instytucji edukacyjnych i nie tylko, cz. I, „Kwartalnik Pedagogiczny” 2015, w druku.Piotrowski M., Pomiar dydaktyczny i polityka projakościowa gminy w obszarze oświaty, [w:] Biblioteczka Oświaty Samorządowej, t. 7, Decentralizacja oświaty, M. Herbst (red.), Centrum Interdyscyplinarne Modelowania Matematycznego i Komputerowego, Uniwersytet Warszawski, Warszawa 2012.Putkiewicz E., Korepetycje – szara strefa edukacji, Instytut Spraw Publicznych, Warszawa 2005.Śliwerski B., „Sformatowana” przez MEN edukacja historyczna Polaków – nie tylko w debacie publicznej, 24 marca 2012 1http://sliwerski-pedagog.blogspot.com/201212/03/sformatowana-przez-men-edukacja.html.1(3)253

Occurrence and Variety of β-Lactamase Genes among Aeromonas spp. Isolated from Urban Wastewater Treatment Plant

Members of the genus Aeromonas that commonly occur in various aquatic ecosystems are taken into account as vectors spreading antibiotic resistance genes (ARGs) in the environment. In our study strains of Aeromonas spp. (n = 104) not susceptible to ampicillin were isolated from municipal sewage of different levels of purification – raw sewage, activated sludge and treated wastewater. The crucial step of the study was the identification of β-lactamase resistance genes. The identified genes encode β-lactamases from 14 families – blaTEM, blaOXA, blaSHV, blaCTX-M, blaMOX, blaACC, blaFOX, blaGES, blaPER, blaV EB, blaKPC, cphA, imiH, and cepH. There were no significant differences in number of identified ARGs between isolation points. BlaOXA, blaFOX variants and, characteristic for Aeromonas genus, metallo-β-lactamase cphA-related genes were the most commonly identified types of β-lactam resistance determinants. Moreover, we found four extended-spectrum β-lactamases (blaSHV -11, blaCTX-M-27, blaCTX-M-98, and blaPER-4) – and seven AmpC (blaACC, blaFOX-2-like, blaFOX-3, blaFOX-4-like, blaFOX-9, blaFOX-10-like, and blaFOX-13-like) types and variants of genes that had never been found among Aeromonas spp. before. Five of the β-lactamases families (blaTEM, blaOXA, blaFOX, blaV EB, and cphA) were identified in all three isolation sites, which supports the hypothesis that wastewater treatment plants (WWTPs) are hot spots of ARGs dissemination. The obtained ARGs sequences share high identity with previously described β-lactamases, but new variants of those genes have to be considered as well. Characterization of antibiotic susceptibility was performed using disk the diffusion method with 12 different antibiotics according to CLSI guidelines. Over 60% of the strains are unsusceptible to cefepime and chloramphenicol and the majority of the strains have a multidrug resistance phenotype (68%). Finally, analysis of plasmid profiles among the resistant strains showed that 62% of the isolates from all three points of the WWTP carry plasmids of different sizes. Among some of the isolated plasmids blaFOX-4-like and blaGES genes have been found. To sum up, the results strongly suggest that Aeromonas spp. can be considered as agents of antibiotic resistance dissemination from wastewater to the natural environment