Pharmacokinetics, clinical and safety outcomes of Pyronaridine/artesunate Treatment of Acute Plasmodium falciparum Malaria in Uganda

Presented at the conference of the American Society of Tropical Medicine and Hygiene 200

Pride of the South: Risk Analysis for Marine Biosecurity in Fiordland

This paper describes a model used to assess alternative scenarios for managing the marine biosecurity risk to Fiordland from vessel traffic. Scenarios are assessed in terms of risk reduction per dollar spent. To keep the analysis manageable, we focus on vessel risks from hull fouling, as this is considered the primary pathway of vessel-related spread. Our analysis includes evaluation of the costs and benefits of different types of vector treatment as well as the possibility of continued vessel monitoring and control of pest populations in Bluff Harbour to reduce the risk of vector infection.Fiordland, marine biosecurity, risk reduction, benefit cost analysis, management options, Bluff, Agricultural and Food Policy, Environmental Economics and Policy, Food Security and Poverty, Health Economics and Policy, Land Economics/Use, Livestock Production/Industries, Research Methods/ Statistical Methods,

Irish Post-crisis Migratory and Demographic Patterns

Between 2008 and 2009, the Irish economic crisis directly impacted migratory flows, the very ones which had been deeply modified during the boom years. As was expected, the crisis triggered the return of some emigration flows which need to be quantified and qualified. Has it also reduced the in-coming flows of foreign residents and in what way will these migrations change the Irish population in the middle and long term? The following article answers this double question and provides the starting points for a further analysis of the topic as new data become available.Entre 2008 et 2014, la crise économique irlandaise a eu un impact direct sur les flux migratoires, ceux-là mêmes qui avaient été fortement modifiés durant la période de forte expansion. Ainsi, comme on pouvait s’y attendre, la crise a entraîné la reprise de l’émigration et il s’agit de quantifier et qualifier ces mouvements. A-t-elle dans le même temps réduit l’afflux de résidents étrangers sur le territoire et en quoi ces mouvements de population transforment-ils à court et moyen terme la composition de la population irlandaise ? L’article apportera des éléments de réponse à ces interrogations en dressant un premier état des lieux afin de poser les jalons d’une analyse plus détaillée, au fur et à mesure que de nouvelles données seront disponibles

Strong Mixing and Recirculation in the Northwestern Argentine Basin

The Atlantic component of the Meridional Overturning Circulation (AMOC) is a key contributor to the global meridional transport of volume, salt, and heat, and thus plays a central role in global climate. As part of ongoing efforts to monitor the intensity and variability of the AMOC in the South Atlantic, hydrographic sections have been regularly occupied since 2009 near the western boundary along a zonal line at 34.5°S. Here this high-quality, high-resolution data set is analyzed to establish the average hydrographic conditions of the northwestern Argentine Basin and the water mass spatial and temporal variability. The water mass analysis also reveals the pathways of the flow in this region, which are further corroborated by full-depth direct velocity measurements. The repeated hydrographic sections capture an extremely rich vertical structure, characterized by seven distinct water mass layers of northern and southern origin, each with unique property signatures. Almost all of these layers exhibit a sharp zonally banded structure, which is indicative of recirculation cells offshore from the western boundary. The circulation at intermediate levels includes a previously undetected recirculation cell confined very close to the western boundary and superimposed on the classical intermediate water pathway beneath the South Atlantic subtropical gyre. The deep level flow is characterized by the Deep Western Boundary Current (DWBC) and a northward recirculation ~500 km east from the slope.Fil: Valla, Daniel. Ministerio de Defensa. Armada Argentina. Servicio de Hidrografía Naval; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias de la Atmósfera y los Océanos; ArgentinaFil: Piola, Alberto Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias de la Atmósfera y los Océanos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Defensa. Armada Argentina. Servicio de Hidrografía Naval; ArgentinaFil: Meinen, Christopher S.. Atlantic Oceanographic and Meteorological Laboratory; Estados UnidosFil: Campos, Edmo. Universidade de Sao Paulo; Brasi

Satellite Altimetry and Current-Meter Velocities in the Malvinas Current at 41°S: Comparisons and Modes of Variations

Three year long current-meter arrays were deployed in the Malvinas Current at 418S below a satellite altimeter track at about 10 years intervals. Surface geostrophic velocities (SGV) derived from satel- lite altimetric data are compared with the in situ velocities at the upper current meter (􏰁300 m). Multisatel- lite gridded SGV compare better with in situ observations than along-track SGV. In spite of the proximity of the moorings to the complex Brazil-Malvinas Confluence (BMC) region, satellite SGV are significantly corre- lated with the 20 day low-passed in situ velocities (0.85 for along-isobaths velocities, 0.8 for cross-isobaths velocities). The recent in situ measurement period (2014?2015) stands out in the altimetry record with a long-lasting (4 months) high level of eddy kinetic energy at the mooring site and a southernmost location of the Subantarctic Front (SAF). The first two modes of variations of sea level anomaly (SLA) over the BMC remarkably match the first two modes of the low-passed in situ velocities. The first mode is associated with a latitudinal migration of the SAF, and the second with a longitudinal displacement of the Brazil Current overshoot. The two modes dominate the 24 year long record of SLA in the BMC, with energy peaks at the annual and semiannual periods for the first mode and at 3?5 months for the second mode. The SLA over the Southwest Atlantic was regressed onto the two confluence modes of SLA variations and showed remarkable standing wave train like structures in the Argentine Basin.Fil: Ferrari, Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones del Mar y la Atmósfera. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones del Mar y la Atmósfera; ArgentinaFil: Artana, Camila Indira. Universite de Paris VI; FranciaFil: Saraceno, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones del Mar y la Atmósfera. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones del Mar y la Atmósfera; ArgentinaFil: Piola, Alberto Ricardo. Ministerio de Defensa. Armada Argentina. Servicio de Hidrografía Naval; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Provost, Christine. Universite de Paris VI; Franci

How to Reduce Complexity in the Licensing Landscape of Standardised Technology

The innovation ecosystem is a fundamental driver of economic development and societal wellbeing. For this reason, key innovations such as 5G and IoT (Internet of Things), which are expected to bring significant benefits to our society and the world economy, should be supported by a standardization effort that allows different infrastructures, services and devices to interoperate in order to facilitate the diffusion and widespread deployment of new technologies on the market and avoid the risk of lock-in into competing, proprietary technologies. Standardization is fundamental to allow interoperability and the worldwide success of new technologies. Standardization bodies have the technical and administrative task to choose the best technology made available by innovators who participate in the standardization efforts. The latter are then rewarded for their contributions to standardization through patent licensing. However, with the ever-increasing complexity in technological standards, licensing activities are often quite complicated, and this causes friction between patent owners and implementers. The article proposes how to solve this complex situation, analysing the role of the FRAND commitment; which factors to be considered when setting a FRAND royalty rate; and how the different interests of innovators (patent owners/licensors) and implementers (licensees) should be well balanced, by means of patent pooling, or injunctions, thus promoting the level playing field that is at the core of fair market competition. This article offers insights from leading market participants who have engaged in licensing of standard essential patents, are developing frameworks to address the challenges of licensing of new technologies covering Internet of Things and application of cellular technologies in the automotive sector; and have actively litigated cases that help shape today’s negotiating process for SEPs. The first part of this article describes Europe’s ambitions in its Digital Agenda and sets out the Inventive Loop (a company’s R&D resulting in patented innovations that when standardised can be licensed for royalties that in turn fund further R&D). It then summarizes the exclusive right available to a patent owner, subject to compulsory licensing and to the holder’s FRAND promise if his innovation is essential to a standard. The article goes on to examines different methodologies for calculating a FRAND royalty rate and its application to new industrial sectors, such as through the adoption by automakers of new cellular mobility technologies. The final part of the article discusses two mechanisms to promote SEP licensing: the judicially created framework for SEP licensing negotiations (as recently set out in Sisvel v Haier) and in patent pools. It assesses a further recent judicial development – anti-suit injunctions – where the exercise of jurisdiction by one court may be harmful to the sovereignty of another. Alternative dispute resolution processes, such as arbitration, may provide a mechanism to resolve global FRAND licensing disputes and reduce these territorial conflicts. The article notes that standard setting organizations could serve as a platform to foster pool formation and to encourage arbitration

Un mar compartido

Existen pocos ámbitos más reveladores que el mar para entender las virtudes de la cooperación internacional en materia científica. En las ciencias marinas esta cooperación es más que deseable: es imprescindible para poder contestar preguntas relacionadas con el movimiento de las corrientes, el aporte de los ríos, los ciclos migratorios de las especies, las pesquerías, etc. Se analiza la importancia de los proyectos conjuntos donde participaron países latinoamericanos, algunos con éxitos, y sobre todo, la importancia de la continuidad. Se detallan un amplio conjunto de recomendaciones que surgieron de varias reuniones sobre ciencia, tecnología y sociedad (CTS) celebradas en la Argentina, Uruguay y Brasil sobre la cooperación científica entre países que comportan el mismo ambiente marino, como es el Atlántico sudoccidental

ANALISIS ASUHAN KEPERAWATAN PADA PASIEN HARGA DIRI RENDAH KRONIS DENGAN INTERVENSI AFIRMASI POSITIF

Introduction: A person with chronically low self-esteem is at risk of withdrawing from social circles. So it is necessary to be given long-term therapy to control his self-confidence by intervening positive affirmations. Method: The research method uses a case study design with a nursing process approach. The subjects in this study were 3 patients in the working area of the Central City Health Center of Gorontalo City with a diagnosis of chronic low self-esteem Data collection techniques were obtained from interviews and distribution of questionnaires to see differences in signs and symptoms of chronic low self-esteem in patients before positive affirmation intervention and after positive affirmation intervention. The study was conducted during a 3-day visit. Results: The results of this study showed that after being given the Positive Affirmation technique intervention, results were obtained In Nn.HM and Mr.YD experienced a decrease in signs and symptoms of Chronic Low Self-Esteem, the patient calmed down and felt more comfortable than before. While in Ms.NM only a slight change in signs and symptoms experienced after being given this intervention, because there was no good cooperation between the patient's parents who were busy working with patients at home. Conclusion: This study shows that after the intervention of the Positive Affirmation technique is given a decrease in signs and symptoms in patients with Chronic Low Self-Esteem so that the intervention of the Positive Affirmation technique can be used as one of the interventions in patients with Chronic Low Self-Esteem

Distribution of sea-air CO 2 fluxes in the Patagonian Sea: Seasonal, biological and thermal effects

Sea-air CO2 fluxes (FCO2) in the Patagonian Sea (PS) were studied using observations collected in 2000-2006. Based on the PS frontal structures and the thermal and biological contributions to FCO2 we present a regional subdivision between distinct regimes that provide new insights on the processes that control these fluxes. The coastal regime (CR) is a net source of atmospheric CO2 (4.9 x 10-3mol.m-2.d-1) while the open shelf regime (SHR) is a net CO2 sink (-6.0 x 10-3mol.m-2.d-1). The interface between these two regions closely follows the location of along-shore fronts. In addition, based on the nature of the processes that drive the FCO2, the PS is subdivided between northern (NR) and southern (SR) regions. Both, NR and SR are CO2 sinks, but the CO2 uptake is significantly higher in NR (-6.4 x 10-3mol.m-2.d-1) than in SR (-0.5 x 10-3mol.m-2.d-1). The data reveal a strong seasonality in FCO2. The mean CO2 capture throughout the PS in austral spring is -5.8 x 10-3mol.m-2.d-1, reaching values lower than -50 x 10-3mol.m-2.d-1 in NR, while in winter FCO2 is close to equilibrium in SR. The analysis of the biological and thermal effects (BE and TE, respectively) on seasonal pCO2 variability indicates that regions of CO2 emission are dominated by the TE while regions of CO2 uptake are dominated by the BE. Our results indicate that the biological pump is the dominant process determining the sea-air CO2 flux in the PS.Fil: Kahl, Lucía Carolina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias de la Atmósfera y los Océanos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Defensa. Armada Argentina. Servicio de Hidrografía Naval. Departamento Oceanografía; ArgentinaFil: Bianchi, Alejandro A.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias de la Atmósfera y los Océanos; Argentina. Ministerio de Defensa. Armada Argentina. Servicio de Hidrografía Naval. Departamento Oceanografía; ArgentinaFil: Osiroff, Ana Paula. Ministerio de Defensa. Armada Argentina. Servicio de Hidrografía Naval. Departamento Oceanografía; ArgentinaFil: Pino, Diana Ruiz. Universite Pierre et Marie Curie; FranciaFil: Piola, Alberto Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias de la Atmósfera y los Océanos; Argentina. Ministerio de Defensa. Armada Argentina. Servicio de Hidrografía Naval. Departamento Oceanografía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin