Randomized trial on adjuvant treatment with FOLFIRI followed by docetaxel and cisplatin versus 5-fluorouracil and folinic acid for radically resected gastric cancer

Some trial have demonstrated a benefit of adjuvant fluoropirimidine with or without platinum compounds compared with surgery alone. ITACA-S study was designed to evaluate whether a sequential treatment of FOLFIRI [irinotecan plus 5-fluorouracil/folinic acid (5-FU/LV)] followed by docetaxel plus cisplatin improves disease-free survival in comparison with 5-FU/LV in patients with radically resected gastric cancer. Patients with resectable adenocarcinoma of the stomach or gastroesophageal junction were randomly assigned to either FOLFIRI (irinotecan 180 mg/m(2) day 1, LV 100 mg/m(2) as 2 h infusion and 5-FU 400 mg/m(2) as bolus, days 1 and 2 followed by 600 mg/m(2)/day as 22 h continuous infusion, q14 for four cycles) followed by docetaxel 75 mg/m(2) day 1, cisplatin 75 mg/m(2) day 1, q21 for three cycles (sequential arm) or De Gramont regimen (5-FU/LV arm). From February 2005 to August 2009, 1106 patients were enrolled, and 1100 included in the analysis: 562 in the sequential arm and 538 in the 5-FU/LV arm. With a median follow-up of 57.4 months, 581 patients recurred or died (297 sequential arm and 284 5-FU/LV arm), and 483 died (243 and 240, respectively). No statistically significant difference was detected for both disease-free [hazard ratio (HR) 1.00; 95% confidence interval (CI): 0.85-1.17; P = 0.974] and overall survival (OS) (HR 0.98; 95% CI: 0.82-1.18; P = 0.865). Five-year disease-free and OS rates were 44.6% and 44.6%, 51.0% and 50.6% in the sequential and 5-FU/LV arm, respectively. A more intensive regimen failed to show any benefit in disease-free and OS versus monotherapy

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

CH4 and CO2 utilisation by unsteady-state operation

CH4 and CO2 are ideal candidates in the context of C1 chemistry as alternatives to oil-based feedstocks for chemicals and fuels production, due to their abundancy, low cost and potential to develop a closed carbon cycle.Large scale utilisation of CO2 in the chemical industry is currently limited to a few applications (e.g. synthesis of urea, carboxylic acids, food industry) and generally requires high purity feedstock. Integrated processes that combine CO2 capture from diluted sources (e.g. industrial flue gases, air) and its conversion to value-added chemicals represent a solution to enhance the utilisation of CO2 and mitigate its emissions. CH4 is an abundant hydrocarbon with diversified sources ranging from fossil-based (natural gas, shale gas) to renewable ones (biomass, biogas), which can potentially substitute oil for the synthesis of valuable chemicals and fuels, including higher hydrocarbons. At the moment, however, CH4 utilisation is circumscribed to combustion for heat and energy production or energy-intensive production of H2 and syngas (H2 + CO) via steam reforming, resulting in a high carbon footprint.In general, the thermodynamic stability of CO2 and CH4 molecules imposes severe limitations to their exploitation as chemical feedstocks, in terms of low conversion efficiencies and control on the selectivity of products. Their efficient conversion requires harsh reaction conditions (high temperatures and pressures, highly chemically reactive substances) at which the stability of the desired products is threatened, resulting in low selectivity. In this scenario, catalysis is essential to identify functional materials and develop new catalytic processes able to maximise the selective conversion of CO2 and CH4 feedstocks to value-added products.Unsteady-state operation in catalysis is an option to overcome the thermodynamic constraints imposed by the conventional steady-state operation. Integrated CO2 capture and conversion, sorption-enhanced reactions, chemical looping combustion are examples of intrinsically unsteady-state catalytic processes that demonstrated enhanced performances compared to their steady state analogues. Moreover, the analysis of the transient catalytic behaviour developed in unsteady-state conditions leads to a deeper understanding of the catalytic processes in terms of identification of specific reactant-catalyst interactions, the steps involved in products formation and the mechanism of catalyst deactivation.This dissertation deals with the catalytic activation of CO2 and CH4 molecules targeting at their valorisation to important chemical commodities as CO (syngas) and light hydrocarbons. Unsteady-state catalysis is explored as a means to overcome thermodynamic constraints associated to the conventional CO2 and CH4 conversion routes....ChemE/Catalysis Engineerin

Catalytic Oxidative Coupling of Methane: Heterogeneous or Homogeneous Reaction?

Direct valorization of methane via oxidative coupling of methane (OCM) is an encouraging alternative to conventional oil-based processes for the production of light hydrocarbons (ethane and ethylene). Abundant, inexpensive simple oxides such as MgO and La2O3 possess the ability to selectively activate methane. However, during OCM, the selective conversion to ethane and the following dehydrogenation to ethylene are threatened by the thermodynamically favored partial and total oxidation reactions to form CO and CO2, respectively. With the aid of spatially resolved operando analysis of temperature and gas concentration along the catalytic bed, we demonstrate the relevance of highly exothermic reaction paths developed in the gas phase, i.e., the homogeneous reaction, during OCM conditions at the front of the catalytic bed, largely determining the total C2 yield obtained on those systems. With the new insights provided by the analysis of temperature and concentration gradients along the bed, we redefine the positive effect of promoters (Li, Sr), which enhance the influence of catalyst surfaces. The effect of promoters is recognized in the suppression of the exothermic oxidation paths leading to undesired COx, thus limiting the formation of hotspots and driving the reaction toward the desired C2 products.ChemE/Catalysis Engineerin

Enabling complete conversion of CH₄ and CO₂ in dynamic coke-mediated dry reforming (DC-DRM) on Ni catalysts

Dynamic coke-mediated dry reforming of methane (DC-DRM) is an unsteady-state strategy to overcome the limitations of co-feed operation, including the fast deactivation of the catalysts and the loss of valuable H2 in the reverse water gas-shift reaction. This paper proves the feasibility of DC-DRM on Ni-based catalytic systems, identifying suitable metal oxides supports and evaluating the role of metallic promoters. A La-promoted Ni/ZrO2 catalyst exhibited excellent and stable catalytic performances at 800 °C approaching complete conversion of the CH4 and CO2 reactant pulses in the reaction loop, and separation of the H2 and CO product streams. Adding the redox functionality of reducible oxides (TiO2) in the catalyst support is demonstrated as a powerful tool to enable direct formation of syngas in the methane pulse with control on the H2/CO ratio.ChemE/Catalysis Engineerin

On the use of filament-based free wake panel methods for preliminary design of propeller-wing configurations

With distributed propulsion and electric vertical take-off and landing aircraft on the rise, fast and accurate methods to simulate propeller slipstreams and their interaction with aircraft components are needed. In this work, we compare results obtained with a filament-based free wake panel method to experimental and previously validated numerical data. In particular, we study a propeller-wing configuration at zero angle of attack and the aerodynamics of the blade-resolved slipstream interaction with the wing. We use a prescribed wake on the wing and a free wake on the propeller, which greatly accelerate the computations. Results indicate that, while forces are overpredicted due to the inviscid nature of the panel method, the free wake is able to capture the slipstream deformation and shearing with remarkable success. We find that a filament-based free wake panel method can be a useful tool for propeller-wing interaction in preliminary aircraft design.Wind Energ

Surging Wind Turbine Simulations with a Free Wake Panel Method

We investigate the aerodynamics of a surging wind turbine with numerical simulations based on a free wake panel method. We start by demonstrating the method's capability to simulate a plunging airfoil, which provides some insights that are later used to interpret results of a surging rotor. We then validate the method on a non-surging wind turbine and discuss the strengths and weaknesses of our approach. Next, we focus on the UNAFLOW case: a surging wind turbine which was modelled experimentally and with various numerical methods. Good agreement with experimental data is observed for amplitude and phase of the thrust with surge motion. For the first time, we achieve numerical results of a wind turbine wake that accurately reproduce experimentally verified effects of surging motion. Finally, we extend our simulations beyond the frequency range of the UNAFLOW experiments and reach results that do not follow a quasi-steady response. Using the plunging airfoil data, we justify the behavior observed in the non-linear range. Our work seeks to contribute a different method to the pool of results for the UNAFLOW case, while extending the analysis to conditions that have not been simulated before. Wind Energ

Free Wake Panel Method Simulations of a Highly Flexible Wing at Flutter

This paper shows fluid structure interaction simulations of a highly flexible wing at various flow conditions, including flutter regime. This is achieved with two-way time domain coupling of a geometrically exact beam structural model and a 3D free wake panel method, modelling the outer surface of the wing, which allow for non-linear effects of the geometry deformation and the flow to be taken into account. Static and aeroelastic wing deflections are compared to experimental data of the Pazy wing with good accuracy. Two regions of flutter onset are predicted within the experimental range. An analysis of the flutter modes is performed. This serves as a step towards mid-fidelity simulations for more complex configurations, including fuselage effects and tail interactions.Wind Energ

Free wake panel method simulations of a highly flexible wing in flutter and gusts

This paper presents low speed fluid structure interaction simulations of a highly flexible wing at various flow conditions, including flutter and excitation from sinusoidal gusts. Such wings are becoming more relevant in recent years, due to their potential for improving aerodynamics and reducing weight, while their flutter characteristics are particularly challenging to address, as the modal properties of the wings change as deflections increase. Calculations are based on time domain coupling of a geometrically exact beam structural model and a 3D free wake panel method, modeling the outer surface of the wing, which allow for nonlinear effects in terms of geometrical deformations and the flow at low computational cost. Static and aeroelastic wing deflections are in line with experimental data of the Pazy wing, which is a benchmark for highly flexible wings from Technion. Two flutter mechanisms are predicted within 1 to 3 m/s of the experimental range. An analysis of the flutter modes is performed, showing that the second torsion mode plays a role in flutter, something that had not been published before. Limit cycle oscillations are achieved and are shown to compare well with reference data, with the frequency being within 1% of the experimental value. Finally, results of gust simulations of the Pazy wing are compared to data from experiments and corrections for the wind tunnel measurements are proposed, which should facilitate future validation efforts. This work serves as a contribution to the Pazy wing dataset and is a step towards mid-fidelity simulations for more complex configurations.Wind Energ

Impact of Promoter Addition on the Regeneration of Ni/Al₂O₃ Dry Reforming Catalysts

Industrial-scale reforming of methane is typically carried out with an excess of oxidant to suppress coking of the catalyst. On the other hand, many academic studies on dry reforming employ a CO2/CH4 ratio of unity to quickly observe coking which can be reduced by adding a catalyst promoter. In this work, Ni/Al2O3 catalysts were tested for dry reforming of methane (CO2/CH4=1) with additional regeneration steps to test the resistance against an oxidation treatment. Thereby, we wanted to evaluate catalyst stability for industrial relevance. The effects of three promoters, Cr, Mn and Fe, that differ in their degree of CO2 interaction, are compared. A higher iron loading on Ni/Al2O3 leads to higher stability in dry reforming with lower coke formation. However, the higher the concentration of a promoter with high CO2 affinity, the quicker the catalyst is oxidized during regeneration with CO2. Subsequent reduction of a catalyst oxidized with CO2 leads to considerable sintering in all cases. This sintering induces formation of more coke during dry reforming. On such sintered samples only highly effective promoters in large concentrations still have a noticeable effect compared to unpromoted Ni/Al2O3.ChemE/Inorganic Systems EngineeringChemE/Catalysis EngineeringChemE/Algemee