286 research outputs found
New mechanism for impurity-induced step bunching
Codeposition of impurities during the growth of a vicinal surface leads to an
impurity concentration gradient on the terraces, which induces corresponding
gradients in the mobility and the chemical potential of the adatoms. Here it is
shown that the two types of gradients have opposing effects on the stability of
the surface: Step bunching can be caused by impurities which either lower the
adatom mobility, or increase the adatom chemical potential. In particular,
impurities acting as random barriers (without affecting the adatom binding)
cause step bunching, while for impurities acting as random traps the
combination of the two effects reduces to a modification of the attachment
boundary conditions at the steps. In this case attachment to descending steps,
and thus step bunching, is favored if the impurities bind adatoms more weakly
than the substrate.Comment: 7 pages, 3 figures. Substantial revisions and correction
UV light induced accumulation of variability in a diploid strain of Aspergillus nidulans
The accumulated variability in asexual species was evaluated in Aspergillus nidulans diploid cells after repeated cycles of UV irradiation. The results show that diploid cells can accumulate a very high genetic variability in the heterozygous condition as previously shown with the base analog 6-N-hydroxylaminopurine (HAP)
Labyrinthine Island Growth during Pd/Ru(0001) Heteroepitaxy
Using low energy electron microscopy we observe that Pd deposited on Ru only
attaches to small sections of the atomic step edges surrounding Pd islands.
This causes a novel epitaxial growth mode in which islands advance in a
snakelike motion, giving rise to labyrinthine patterns. Based on density
functional theory together with scanning tunneling microscopy and low energy
electron microscopy we propose that this growth mode is caused by a surface
alloy forming around growing islands. This alloy gradually reduces step
attachment rates, resulting in an instability that favors adatom attachment at
fast advancing step sections
Unidimensional model of the ad-atom diffusion on a substrate submitted to a standing acoustic wave I. Derivation of the ad-atom motion equation
The effect of a standing acoustic wave on the diffusion of an ad-atom on a
crystalline surface is theoretically studied. We used an unidimensional space
model to study the ad-atom+substrate system. The dynamic equation of the
ad-atom, a Generalized Langevin equation, is analytically derived from the full
Hamiltonian of the ad-atom+substrate system submitted to the acoustic wave. A
detailed analysis of each term of this equation, as well as of their
properties, is presented. Special attention is devoted to the expression of the
effective force induced by the wave on the ad-atom. It has essentially the same
spatial and time dependences as its parent standing acoustic wave
Genotoxic activity of 2-amino-N-hydroxylaminopurine (AHA) in Aspergillus nidulans
In Aspergillus nidulans, as well as in other eukaryotic cells, not all base analogs are mutagenic. For example, 2-aminopurine (2-AP) is non-mutagenic or weakly mutagenic for eukaryotes while it is mutagenic for bacteria. Because of their potential use in genetical research, an effort has been made to find base analogs mutagenic for eukaryotic cells. Work in this field has been successful: in fact, 6- hydroxylamino-purine (HAP) and 2-amino-N-hydroxylaminopurine (AHA) have been found mutagenic for yeast as well as for other eukaryotic cells. (Pavlov et al. 1991, Mut. Res. 253:33-46). In particular, Brockman et al. (Mut. Res. 177:61-75, 1987) tested the mutagenic activity of HAP and AHA in Neurospora crassa and found that AHA is about equally mutagenic as HAP at low doses but more mutagenic at high doses. In this paper we report the genotoxic activity of AHA in A. nidulans. In this mold, we have tested AHA-induced lethality and mutagenic and recombinogenic effect
SARS-CoV-2 infection prevalence in people experiencing homelessness
Objective: People experiencing homelessness have peculiar characteristics that make them more vulnerable to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission and to more serious forms of Coronavirus Disease 19 (COVID-19). The aim of this study was to evaluate the prevalence of SARS-CoV-2 infection in the homeless population assisted by the primary care services of the Eleemosynaria Apostolica, Vatican City. Patients and methods: Persons experiencing homelessness and the volunteers assisting them were tested for COVID-19 through PCR and antigen rapid test between October 1st, 2020, and June 5th, 2021, in the clinical facilities of the Eleemosynaria Apostolica. Results: A total of 1665 subjects from 96 different countries in five continents were included in the study; age range was 1-90 years. Overall, 2315 COVID-19 tests through nasopharyngeal swab were performed; 1052 Polymerase Chain Reaction (PCR) tests and 1263 antigen rapid tests. Nearly 40% of the subjects underwent both tests (n=650, 39.04%), 402 were tested with PCR test only (24.14%) and 613 with antigen test only (36.8%). PCR tests were negative in 966 cases and positive in 86 (8.17%), while antigen tests were negative in 1205 cases and positive in 58 (4.59%). The number of positive cases varied over time, with a drastic increase during the winter months of 2020 and a progressive decrease over 2021. Among positive cases, 24.41% were symptomatic; symptoms included fever, breathing difficulties, anosmia/hyposmia, cough, headache, and diarrhea. Conclusions: This study reported an overall prevalence of SARS-CoV-2 infection in our sample slightly above 8%. Additional data on viral genome through sequencing of SARS-CoV-2 in positive cases are of utmost importance to help identify variants and implement specific infection control measures
The microenvironment’s role in mycosis fungoides and sézary syndrome: From progression to therapeutic implications
Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment’s role in MF/SS. Results and Conclusions: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues
The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study
Persistence and survival in equilibrium step fluctuations
Results of analytic and numerical investigations of first-passage properties
of equilibrium fluctuations of monatomic steps on a vicinal surface are
reviewed. Both temporal and spatial persistence and survival probabilities, as
well as the probability of persistent large deviations are considered. Results
of experiments in which dynamical scanning tunneling microscopy is used to
evaluate these first-passage properties for steps with different microscopic
mechanisms of mass transport are also presented and interpreted in terms of
theoretical predictions for appropriate models. Effects of discrete sampling,
finite system size and finite observation time, which are important in
understanding the results of experiments and simulations, are discussed.Comment: 30 pages, 12 figures, review paper for a special issue of JSTA
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