Constraints on large scalar multiplets from perturbative unitarity

We determine the constraints on the isospin and hypercharge of a scalar electroweak multiplet from partial-wave unitarity of tree-level scattering diagrams. The constraint from SU(2)_L interactions yields T <= 7/2 (i.e., n <= 8) for a complex scalar multiplet and T <= 4 (i.e., n <= 9) for a real scalar multiplet, where n = 2T+1 is the number of isospin states in the multiplet.Comment: 10 pages, 1 figure. v2: refs added, minor additions to text, submitted to PR

The role of feedback in shaping the structure of the interstellar medium

We present an analysis of the role of feedback in shaping the neutral hydrogen (H I) content of simulated disc galaxies. For our analysis, we have used two realizations of two separate Milky Way-like (similar to L star) discs - one employing a conservative feedback scheme (McMaster Unbiased Galaxy Survey), the other significantly more energetic [Making Galaxies In a Cosmological Context (MaGICC)]. To quantify the impact of these schemes, we generate zeroth moment (surface density) maps of the inferred H I distribution; construct power spectra associated with the underlying structure of the simulated cold interstellar medium, in addition to their radial surface density and velocity dispersion profiles. Our results are compared with a parallel, self-consistent, analysis of empirical data from The H I Nearby Galaxy Survey (THINGS). Single power-law fits (P proportional to k(gamma)) to the power spectra of the stronger feedback (MaGICC) runs (over spatial scales corresponding to similar to 0.5 to similar to 20 kpc) result in slopes consistent with those seen in the THINGS sample (gamma similar to -2.5). The weaker feedback (MUGS) runs exhibit shallower power-law slopes (gamma similar to -1.2). The power spectra of the MaGICC simulations are more consistent though with a two-component fit, with a flatter distribution of power on larger scales (i.e. gamma similar to -1.4 for scales in excess of similar to 2 kpc) and a steeper slope on scales below similar to 1 kpc (gamma similar to -5), qualitatively consistent with empirical claims, as well as our earlier work on dwarf discs. The radial H I surface density profiles of the MaGICC discs show a clear exponential behaviour, while those of the MUGS suite are essentially flat; both behaviours are encountered in nature, although the THINGS sample is more consistent with our stronger (MaGICC) feedback runs

Constraining sub-grid physics with high-redshift spatially-resolved metallicity distributions

Aims. We examine the role of energy feedback in shaping the distribution of metals within cosmological hydrodynamical simulations of L* disc galaxies. While negative abundance gradients today provide a boundary condition for galaxy evolution models, in support of inside-out disc growth, empirical evidence as to whether abundance gradients steepen or flatten with time remains highly contradictory. Methods. We made use of a suite of L* discs, realised with and without "enhanced" feedback. All the simulations were produced using the smoothed particle hydrodynamics code Gasoline, and their in situ gas-phase metallicity gradients traced from redshift z similar to 2 to the present-day. Present-day age-metallicity relations and metallicity distribution functions were derived for each system. Results. The "enhanced" feedback models, which have been shown to be in agreement with a broad range of empirical scaling relations, distribute energy and re-cycled ISM material over large scales and predict the existence of relatively "flat" and temporally invariant abundance gradients. Enhanced feedback schemes reduce significantly the scatter in the local stellar age-metallicity relation and, especially, the [O/Fe]-[Fe/H] relation. The local [O/Fe] distribution functions for our L* discs show clear bimodality, with peaks at [O/Fe] = -0.05 and +0.05 (for stars with [Fe/H] > -1), consistent with our earlier work on dwarf discs. Conclusions. Our results with "enhanced" feedback are inconsistent with our earlier generation of simulations realised with "conservative" feedback. We conclude that spatially-resolved metallicity distributions, particularly at high-redshift, offer a unique and under-utilised constraint on the uncertain nature of stellar feedback processes

Proceedings of the workshop "Standard Model at the LHC" University College London 30 March - 1 April 2009

Proceedings from a 3-day discussion on Standard Model discoveries with the first LHC dataComment: 9 contributions to the proceedings of the LHC Standard Model worksho

Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells

© The Author(s) 2016. Acquired resistance to conventional and targeted therapies is becoming a major hindrance in cancer management. It is increasingly clear that cancer cells are able to evolve and rewire canonical signalling pathways to their advantage, thus evading cell death and promoting cell invasion. The Axl receptor tyrosine kinase (RTK) has been shown to modulate acquired resistance to EGFR-targeted therapies in both breast and lung cancers. Glioblastoma multiforme (GBM) is a highly infiltrative and invasive form of brain tumour with little response to therapy. Both Axl and EGFR have been identified as major players in gliomagenesis and invasiveness. However, the mechanisms underlying a potential signalling crosstalk between EGFR and Axl RTKs are unknown. The purpose of this study was to investigate this novel and unconventional interaction among RTKs of different families in human GBM cells. With the use of western blotting, in vitro kinase activity, co-immunoprecipitation and bimolecular fluorescence complementation assays, we show that EGF stimulates activation of Axl kinase and that there is a hetero-interaction between the two RTKs. Through small interfering RNA knockdown and quantitative PCR screening, we identified distinct gene expression patterns in GBM cells that were specifically regulated by signalling from EGFR-EGFR, Axl-Axl and EGFR-Axl RTK parings. These included genes that promote invasion, which were activated only via the EGFR-Axl axis (MMP9), while EGFR-EGFR distinctly regulated the cell cycle and Axl-Axl regulated invasion. Our findings provide critical insights into the role of EGFR-Axl hetero-dimerisation in cancer cells and reveal regulation of cell invasion via Axl as a novel function of EGFR signalling

What works to boost social relations and community wellbeing? A scoping review of the evidence

Background: Social relations are recognized as an important determinant of individual & community wellbeing. The UK What Works Wellbeing Centre chose “boosting social relations” as a priority topic for systematic review. First, a scoping review was undertaken to identify evidence gaps. Methods: We searched: Cochrane database of systematic reviews, DARE, Campbell Library, DoPHER (EPPI-Centre), Joanne Briggs Institute, MEDLINE, IDOX, CINAHL, PsycINFO, Social Policy & Practice, Social Care Online; relevant websites. Inclusion criteria: Population – communities in OECD countries; Intervention - Any community-based intervention, change in policy, organisation or environment that were designed to boost social relations within the community; Outcomes – social relations, community wellbeing or related synonyms; Study design – systematic & non-systematic reviews published between 2005 and 2016. Studies were selected & data extracted by 3 reviewers, and summarised narratively. Results: 11,257 titles and abstracts were screened, 182 obtained in full & 29 included. Existing evidence tells us: Targeted group interventions that foster social networks & provide meaningful roles can reduce social isolation and/ or loneliness in older people; Volunteering can improve physical & mental health & wellbeing in older people; Effective community engagement produces sustainable improvements in community health & individual wellbeing. Evidence gaps: Interventions for social isolation &/ or loneliness in adults aged up to 65 years; Volunteering in people aged up to 65 years; Social network analyses; Community infrastructure (places & spaces). Stakeholder consultations identified community infrastructure (places & spaces) as the most useful topic for systematic review. Conclusions: A systematic scoping review of reviews, with stakeholder consultation, identified community infrastructure (places & spaces) as an evidence gap. Early findings from the resulting systematic review will be presented

Discovery of an X-ray Jet and Extended Jet Structure in the Quasar PKS 1055+201

This letter reports rich X-ray jet structures found in the Chandra observation of PKS 1055+201. In addition to an X-ray jet coincident with the radio jet we detect a region of extended X-ray emission surrounding the jet as far from the core as the radio hotspot to the North, and a similar extended X-ray region along the presumed path of the unseen counterjet to the Southern radio lobe. Both X-ray regions show a similar curvature to the west, relative to the quasar. We interpret this as the first example where we separately detect the X-ray emission from a narrow jet and extended, residual jet plasma over the entire length of a powerful FRII jet.Comment: Accepted for publication in Ap. J. Letters. 4 pages, 3 figure

The stellar metallicity distribution of disc galaxies and bulges in cosmological simulations

By means of high-resolution cosmological hydrodynamical simulations of Milky Way-like disc galaxies, we conduct an analysis of the associated stellar metallicity distribution functions (MDFs). After undertaking a kinematic decomposition of each simulation into spheroid and disc sub-components, we compare the predicted MDFs to those observed in the solar neighbourhood and the Galactic bulge. The effects of the star formation density threshold are visible in the star formation histories, which show a modulation in their behaviour driven by the threshold. The derived MDFs show median metallicities lower by 0.2-0.3 dex than the MDF observed locally in the disc and in the Galactic bulge. Possible reasons for this apparent discrepancy include the use of low stellar yields and/or centrally-concentrated star formation. The dispersions are larger than the one of the observed MDF; this could be due to simulated discs being kinematically hotter relative to the Milky Way. The fraction of low metallicity stars is largely overestimated, visible from the more negatively skewed MDF with respect to the observational sample. For our fiducial Milky Way analog, we study the metallicity distribution of the stars born "in situ" relative to those formed via accretion (from disrupted satellites), and demonstrate that this low-metallicity tail to the MDF is populated primarily by accreted stars. Enhanced supernova and stellar radiation energy feedback to the surrounding interstellar media of these pre-disrupted satellites is suggested as an important regulator of the MDF skewness.Comment: 20 pages, 14 figures, MNRAS, accepte