4,762 research outputs found

    Grandpa Dyczewski

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    Probing the reactivity of a 2,2′-bipyridyl-3,3′-bis-imine ligand by X-ray crystallography

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    The reactivity of a Schiff-base bis-imine ligand 3 is probed by X-ray diffraction studies. Its susceptibility to hydrolysis, oxidation and nucleophilic addition reactions is demonstrated by the isolation of the methanol adduct 4 and two diazapene heterocycles 5 and 6. This reactivity is also reflected in the molecular structures of two coordination complexes isolated by the reaction of 3 with MIJhfac)2 salts, to afford [Cu(5)-(hfac)(tfa)] (8) and [Zn(6)(hfac)2] (9)

    Central Exclusive Di-jet Production at the Tevatron

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    We perform a phenomenological analysis of dijet production in double pomeron exchange at the Tevatron. We find that the CDF Run I results do not rule out the presence of an exclusive dijet component, as predicted by Khoze, Martin and Ryskin (KMR). With the high statistics CDF Run II data, we predict that an exclusive component at the level predicted by KMR may be visible, although the observation will depend on accurate modelling of the inclusive double pomeron exchange process. We also compare to the predictions of the DPEMC Monte Carlo, which contains a non-perturbative model for the central exclusive process. We show that the perturbative model of KMR gives different predictions for the di-jet ET dependence in the high di-jet mass fraction region than non-perturbative models.Comment: 17 pages, 15 figure

    Assessing the Exchange of Knowledge Between Operations Management and other Fields: Some Challenges and Opportunities

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    Addressing a suspicion that the field of Operations Management (OM) draws substantially more knowledge from non-OM journals than those journals draw from OM journals in return, we studied the citations of the top 30 research journals of interest to our field. We conducted citation analyses of the three oldest OM journals over three decades in comparison to the 27 other journals representing the fields of Management, Operations Research/Management Science (OR/MS), Marketing, Practice, and Engineering. We examined both the entire 30-year period and then each decade separately. Our suspicions were confirmed—although citations from these 27 journals to these three OM journals have increased by a factor of 7 over the three decades, we in OM still cite these journals about twenty-five times more often than they cite our journals, giving an indication of the knowledge development and flows among these fields. We then describe some challenges for the field of OM in providing more research knowledge to other fields but also some opportunities that OM should be able to capitalize on, such as our historic ties to practice and our escalating research in strategic and organizational issues

    A Conceptual Framework for Servitization in Industry 4.0: Distilling Directions for Future Research

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    Purpose: This paper focusses on developing further the recent conceptual frameworks of competitive dynamics and business-to-business value ecosystems considering the changing environment of Industry 4.0 and the particular perspective of servitization. Design/Methodology/Approach: This a conceptual paper that reviews and syntheses business model concepts in relation to competitive dynamics, collaborative business ecosystems and supply chain as evolving and reshaping manufacturing and services within Industry 4.0. Findings: The transformation of organizations in light of Industry 4.0 has led to a reframing of business models and practices, such as stakeholder value and supply chain relationships cooperating within a highly dynamic environment. In an attempt to consider the implications that Industry 4.0 has, particularly from the service perspective, this work attempts to distil directions for future research. Originality/Value: Previous studies on Industry 4.0 have articulated the reasoning about the benefits of Industry 4.0, with its paradigm shift to cyber-physical systems and revised business models. The intention of this paper, is to be able to further define collaboration and value ecosystems in order to show the interdependence and integration between organisations as applied to servitization within Industry 4.0. Moreover, this paper seeks to begin to articulate how research can be conducted to determine the degree to which the change and paradigm shift has become a reality

    Health and welfare profile of Australian baby boomers who live in rented accommodation – implications for the future

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    Incorrect spelling of Helen Barrie on the publication, left Statement of responsibility to reflect incorrect pdf.Baby boomers who rent are often overlooked as an important sub-group. We aimed to assess the chronic conditions, risk factors, socio-economic factors and other health-related factors associated with renting in private or public housing. Data from telephone interviews conducted each month in South Australia between and were combined. Prevalence estimates were assessed for each risk factor and chronic condition by housing status. The association between housing status and variables of interest were analysed using logistic regression models adjusting for multiple covariates (age, gender, income, smoking, physical activity, area and year of data collection). Overall, per cent of the baby boomers interviewed were renting, either privately or using government-subsided housing. The health profile of renters (both private and public) was poorer overall, with renters more likely to have all of the chronic conditions and ten risk factors assessed. For public renters the relationships were maintained even after controlling for socio-economic and risk factor variables for all chronic diseases except osteoporosis. This research has provided empirical evidence of the considerable differences in health, socio-economic indicators and risk factors between baby boomers who rent and those who own, or are buying, their own homes.Anne W. Taylor, Rhiannon Pilkington, Eleonora Dal Grande, Constance Kourbelis and Helen Barr

    Comparative gene expression profiling of ADAMs, MMPs, TIMPs, EMMPRIN, EGF-R and VEGFA in low grade meningioma

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    MMPs (matrix metalloproteinases), ADAMs (a disintegrin and metalloproteinase) and TIMPs (tissue inhibitors of metalloproteinases) are implicated in invasion and angiogenesis: both are tissue remodeling processes involving regulated proteolysis of the extracellular matrix, growth factors and their receptors. The expression of these three groups and their correlations with clinical behaviour has been reported in gliomas but a similar comprehensive study in meningiomas is lacking. In the present study, we aimed to evaluate the patterns of expression of 23 MMPs, 4 TIMPs, 8 ADAMs, selective growth factors and their receptors in 17 benign meningiomas using a quantitative real-time polymerase chain reaction (qPCR). Results indicated very high gene expression of 13 proteases, inhibitors and growth factors studied: MMP2 and MMP14, TIMP-1, -2 and -3, ADAM9, 10, 12, 15 and 17, EGF-R, EMMPRIN and VEGF-A, in almost every meningioma. Expression pattern analysis showed several positive correlations between MMPs, ADAMs, TIMPs and growth factors. Furthermore, our findings suggest that expression of MMP14, ADAM9, 10, 12, 15 and 17, TIMP-2, EGF-R and EMMPRIN reflects histological subtype of meningioma such that fibroblastic subtype had the highest mRNA expression, transitional subtype was intermediate and meningothelial type had the lowest expression. In conclusion, this is the first comprehensive study characterizing gene expression of ADAMs in meningiomas. These neoplasms, although by histological definition benign, have invasive potential. Taken together, the selected elevated gene expression pattern may serve to identify targets for therapeutic intervention or indicators of biological progression and recurrence
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