904 research outputs found

    The Analytic of Finitude and the History of Subjectivity

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    In one of his last texts, Foucault defined his philosophical enterprise as an ?analysis of the conditions in which certain relations between subject and object are formed or modified, insofar as they are constitutive of a possible knowledge,? or again as ?the manner in which the emergence of games of truth constituted, for a particular time and place and certain individuals, the historical a priori of a possible experience.? Despite its eclipse during the genealogical period, the notion of the historical a priori is thus reaffirmed as central by later Foucault. There is, however, an essential modification with respect to its archaeological problematisation: In The Order of Things, the various historical a priori were characterized by specific relations between being and language, relations in which the subject of knowledge did not always or necessarily have a place. The Renaissance episteme was defined by the homogeneity of words and things, and its Classical counterpart by the transparent distance between being and representation, which excluded any positioning for the subject (the missing ?place of the king?). Within the archaeological configuration, only the contemporary historical a priori was characterized by the invention of a new position for the subject of knowledge, that of Man, which according to Foucault generated the Analytic of Finitude and ultimately resulted in the ?anthropological sleep? criticised at the end of The Order of Things. So although later Foucault refocuses his work around the notion of the historical a priori, he gives the notion a considerable twist whereby the conditions of truth saying are no longer referred back to an implicit connection between being and language, but to the various relations historically established between ?modes of subjectivation? and ?modes of objectification.

    RF System Upgrades to the Advanced Photon Source Linear Accelerator in Support of the Fel Operation

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    The S-band linear accelerator, which was built to be the source of particles and the front end of the Advanced Photon Source injector, is now also being used to support a low-energy undulator test line (LEUTL) and to drive a free-electron laser (FEL). The more severe rf stability requirements of the FEL have resulted in an effort to identify sources of phase and amplitude instability and implement corresponding upgrades to the rf generation chain and the measurement system. Test data and improvements implemented and planned are describedComment: LC 2000 (3 pages, 6 figures

    Studying the Pathogenesis of Ulcerative Colitis Under the Influence of Plumbagin

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    Ulcerative colitis (UC) is a chronic disease in humans that causes inflammation and ulceration of the inner lining of the colon and rectum. Approximately 5% of these patients develop colon cancer in the long term. Lack of effective treatments for patients with ulcerative colitis necessitates a search for the development of an effective alternative therapy. In an acute model, UC was induced in five groups (each of 5 replicates) of 10-week-old female C57BL/6 mice by DSS administration for 7 days. Plumbagin (PL) was administered via drinking water to four diseased groups @ 2-10 mg/Kg (body weight) for another 7 days. PL was replaced by regular water in control. Clinical symptoms (diarrhea, occult blood, anal bleeding, and body weight change) and the size of isolated colon were recorded for comparison between experimental and control groups. Groups receiving PL @ 4 and 6 mg/Kg (body weight) displayed remissions in clinical markers of the disease. The effect of PL was also examined in the acute model where administration of PL @ 8 and 10 mg/Kg (body weight) resulted in better amelioration in disease symptoms. Histopathological evaluation of the colon indicated less disruption of crypts and goblet cells in the mucosa with the above doses of PL. A marked reduction in the blood levels of inflammatory cytokines (IFN-γ, and IL-17) was also observed under these treatments

    Testing and Implementation Progress on the Advanced Photon Source (APS) Linear Accelerator (Linac) High-Power S-band Switching System

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    An S-band linear accelerator is the source of particles and the front end of the Advanced Photon Source injector. In addition, it supports a low-energy undulator test line (LEUTL) and drives a free-electron laser (FEL). A waveguide-switching and distribution system is now under construction. The system configuration was revised to be consistent with the recent change to electron-only operation. There are now six modulator-klystron subsystems, two of which are being configured to act as hot spares for two S-band transmitters each, so that no single failure will prevent injector operation. The two subsystems are also used to support additional LEUTL capabilities and off-line testing. Design considerations for the waveguide-switching subsystem, topology selection, control and protection provisions, high-power test results, and current status are describedComment: Linac 2000 paper No. THE07 3 pages with 3 figure

    Prevalência e formas clínicas de Trypanosoma cruzi em candidatos a doadores de sangue no Brasil

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    A prevalência e a manifestação das formas clinicas de Trypanosoma cruzi foram avaliadas em candidatos a doadores de sangue atendidos em um hospital geral de Nova Iguaçu, Rio de Janeiro, Brasil, no período de janeiro de 1997 a abril de 1999. A pesquisa sorológica foi realizada por meio do teste de hemaglutinação indireta e confirmada pelo ELISA. Os dados foram coletados considerando os exames clínicos, eletrocardiograma convencional, radiografia de tórax e ecocardiografia. Os resultados demonstraram que, apesar da prevalência ser de 1,17% (128 pacientes), principalmente entre homens com idade igual ou superior a 40 anos, 70,8%, principalmente de homens entre 19 e 39 anos, demonstraram alterações que permitiram o diagnóstico de cardiopatias e/ou esofagopatias, ratificando mais uma vez sua importância nos centros urbanos.The prevalence and clinical forms of Trypanosoma cruzi were evaluated among blood donor candidates attended at a general hospital in Rio de Janeiro, Brazil, from January 1997 to April 1999. The investigation was done by means of the indirect hemagglutination test and was confirmed via ELISA. Data were collected from clinical examinations, conventional electrocardiogram, chest radiography and echocar-diography. The results showed that despite Trypanosoma cruzi prevalence of 1.17% (128 patients), mainly in males aged 40 years or over, 70.8% of these patients, mainly males aged 19 to 39 years, demonstrated abnormalities that allowed the diagnosis of cardiopathy and/or esophagopathy. This once again corroborates the importance of Trypanosoma cruzi infection in urban centers

    Geometrically induced modification of surface plasmons in the optical and telecom regimes

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    We demonstrate that the introduction of a subwavelength periodic modulation into a metallic structure strongly modifies the guiding characteristics of the surface plasmon modes supported by the system. Moreover, it is also shown how a new type of a tightly confined surface plasmon polariton mode can be created by just milling a periodic corrugation into a metallic ridge placed on top of a metal surface
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