109 research outputs found
High Temperature Compact Heat Exchangers: Performance of Advanced Metallic Recuperators for Power Plants
Origin of magnetism and quasiparticles properties in Cr-doped TiO
Combining LSDA+ and an analysis of superexchange interactions beyond DFT,
we describe the magnetic ground states in rutile and anatase Cr-doped TiO.
In parallel, we correct our LSDA+ ground state through GW corrections
(@LSDA+) that reproduce the position of impurity states and the band
gaps in satisfying agreement with experiments. Because of the different
topological coordinations of Cr-Cr bonds in the ground states of rutile and
anatase, superexchange interactions induce either ferromagnetic or
antiferromagnetic couplings of Cr ions. In Cr-doped anatase, this interaction
leads to a new mechanism which stabilizes a ferromagnetic ground state, in
keeping with experimental evidence, without the need to invoke F-center
exchange.Comment: 5<pages, 4 figure
A nosocomial measles outbreak in Italy, February-April 2017
We describe a nosocomial outbreak of measles that occurred in an Italian hospital during the first months of 2017, involving 35 persons and including healthcare workers, support personnel working in the hospital, visitors and community contacts. Late diagnosis of the first case, support personnel not being promptly recognised as hospital workers and diffusion of the infection in the emergency department had a major role in sustaining this outbreak
Experimental analysis of a CO2 heat pump for instantaneous domestic hot water production
Abstract
The performance of a CO2 (R744) heat pump (HP) depends strongly on the application and on the environmental operating conditions. In particular, the CO2 HP becomes competitive compared to traditional heat pumps using halogenated refrigerants in applications characterized by a high hot water demand (hospitals, sport centres, etc.). This paper deals with the experimental analysis of an air-to-water commercial R744 HP tested in ENEA laboratories for instantaneous production of domestic hot water (DHW). The results show that HP efficiency is strongly affected by the inlet water temperature at the gas cooler. A test equipment capable of maintaining the ambient temperature at a desired value (between -10 °C and +20 °C), and managing water flow and water temperature (between 15 °C and 45 °C) is used to evaluate the machine COP as a function of the boundary conditions (inlet gas cooler water temperature, water flow rate, external ambient temperature). The analysis shows the considerable potential of R744 heat pumps for the instantaneous production of DHW, combining a high performance and relevant energy saving. As well, it points out that, to maximize the COP it is necessary to combine the HP with a high stratification storage system, which ensures a suited inlet water temperature, and with a correct value of water flow
Estudo etnobotânico junto aos ervatários da área central de Pelotas-RS.
bitstream/item/34841/1/documento-205.pd
Radiosensitization of DNA in presence of Pt(II)-based compounds
X-ray irradiation of plasmid DNA in presence of platinum (II)-based compounds was carried out in order to assess the radiosensitization capabilities of these drugs. In present investigations pBR322 plasmid DNA was used to monitor effectiveness of chosen compounds in inducing strand breaks. Samples were incubated in presence of potential radiosensitisers: platinum (II) bromide and cis-diamminedibromoplatinum (II). The results were examined against a common cancer chemotherapy drug cis-diamminedichloroplatinum (II). It was found that platinum (II) bromide can greatly increase the levels of single- and double-strand break formation observed in the irradiated samples with respect to the samples containing platinum as a radiosensitizer only, possessing very little chemotherapeutic activity. The suggested drugs exhibit much higher level of radiosensitivity than widely used cisplatin and thus may be good candidates for cancer treatment
Active safety systems for powered two-wheelers: A systematic review
Objective: Active safety systems, of which antilock braking is a prominent example, are going to play an important role to improve powered two-wheeler (PTW) safety. This paper presents a systematic review of the scientific literature on active safety for PTWs. The aim was to list all systems under development, identify knowledge gaps and recognize promising research areas that require further efforts. Methods: A broad search using "safety" as the main keyword was performed on Scopus, Web of Science and Google Scholar, followed by manual screening to identify eligible papers that underwent a full-text review. Finally, the selected papers were grouped by general technology type and analyzed via structured form to identify the following: specific active safety system, study type, outcome type, population/sample where applicable, and overall findings. Results: Of the 8,000 papers identified with the initial search, 85 were selected for full-text review and 62 were finally included in the study, of which 34 were journal papers. The general technology types identified included antilock braking system, autonomous emergency braking, collision avoidance, intersection support, intelligent transportation systems, curve warning, human machine interface systems, stability control, traction control, and vision assistance. Approximately one third of the studies considered the design and early stage testing of safety systems (n. 22); almost one fourth (n.15) included evaluations of system effectiveness. Conclusions: Our systematic review shows that a multiplicity of active safety systems for PTWs were examined in the scientific literature, but the levels of development are diverse. A few systems are currently available in the series production, whereas other systems are still at the level of early-stage prototypes. Safety benefit assessments were conducted for single systems, however, organized comparisons between systems that may inform the prioritization of future research are lacking. Another area of future analysis is on the combined effects of different safety systems, that may be capitalized for better performance and to maximize the safety impact of new technologies
Novel Aptamer-Nanoparticle Bioconjugates Enhances Delivery of Anticancer Drug to MUC1-Positive Cancer Cells In Vitro
MUC1 protein is an attractive target for anticancer drug delivery owing to its overexpression in most adenocarcinomas. In this study, a reported MUC1 protein aptamer is exploited as the targeting agent of a nanoparticle-based drug delivery system. Paclitaxel (PTX) loaded poly (lactic-co-glycolic-acid) (PLGA) nanoparticles were formulated by an emulsion/evaporation method, and MUC1 aptamers (Apt) were conjugated to the particle surface through a DNA spacer. The aptamer conjugated nanoparticles (Apt-NPs) are about 225.3 nm in size with a stable in vitro drug release profile. Using MCF-7 breast cancer cell as a MUC1-overexpressing model, the MUC1 aptamer increased the uptake of nanoparticles into the target cells as measured by flow cytometry. Moreover, the PTX loaded Apt-NPs enhanced in vitro drug delivery and cytotoxicity to MUC1+ cancer cells, as compared with non-targeted nanoparticles that lack the MUC1 aptamer (P<0.01). The behavior of this novel aptamer-nanoparticle bioconjugates suggests that MUC1 aptamers may have application potential in targeted drug delivery towards MUC1-overexpressing tumors
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Water Vapor Vertical Profiles on Mars in Dust Storms Observed by TGO/NOMAD
It has been suggested that dust storms efficiently transport water vapor from the near‐surface to the middle atmosphere on Mars. Knowledge of the water vapor vertical profile during dust storms is important to understand water escape. During Martian Year 34, two dust storms occurred on Mars: a global dust storm (June to mid‐September 2018) and a regional storm (January 2019). Here we present water vapor vertical profiles in the periods of the two dust storms (Ls = 162–260° and Ls = 298–345°) from the solar occultation measurements by Nadir and Occultation for Mars Discovery (NOMAD) onboard ExoMars Trace Gas Orbiter (TGO). We show a significant increase of water vapor abundance in the middle atmosphere (40–100 km) during the global dust storm. The water enhancement rapidly occurs following the onset of the storm (Ls~190°) and has a peak at the most active period (Ls~200°). Water vapor reaches very high altitudes (up to 100 km) with a volume mixing ratio of ~50 ppm. The water vapor abundance in the middle atmosphere shows high values consistently at 60°S‐60°N at the growth phase of the dust storm (Ls = 195°–220°), and peaks at latitudes greater than 60°S at the decay phase (Ls = 220°–260°). This is explained by the seasonal change of meridional circulation: from equinoctial Hadley circulation (two cells) to the solstitial one (a single pole‐to‐pole cell). We also find a conspicuous increase of water vapor density in the middle atmosphere at the period of the regional dust storm (Ls = 322–327°), in particular at latitudes greater than 60°S
A legislação ambiental como foco de conflitos: uma análise a partir das representações sociais da natureza dos pequenos agricultores em Minas Gerais, Brasil
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