Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease

Background: Neuronal and synaptic function in Alzheimer's disease (AD) is measured in vivo by glucose metabolism using positron emission tomography (PET). Objective: We hypothesized that neuronal activation as measured by PET is a more sensitive index of neuronal dysfunction than activity during rest. We investigated if the correlations between dementia severity as measured with the Mini Mental State Examination (MMSE) and glucose metabolism are an artifact of brain atrophy. Method: Glucose metabolism was measured using {[}F-18]fluorodeoxyglucose PET during rest and activation due to audiovisual stimulation in 13 mild to moderate AD patients (MMSE score >= 17). PET data were corrected for brain atrophy. Results: In the rest condition, glucose metabolism was correlated with the MMSE score primarily within the posterior cingulate and parietal lobes. For the activation condition, additional correlations were within the primary and association audiovisual areas. Most local maxima remained significant after correcting for brain atrophy. Conclusion: PET activity measured during audiovisual stimulation was more sensitive to functional alterations in glucose metabolism in AD patients compared to the resting PET. The association between glucose metabolism and MMSE score was not dependent on brain atrophy. Copyright (C) 2005 S. Karger AG, Basel

Implementation of the Damages Directive in England & Wales

The Dossier discusses the questions arising from the need to implement the EU Damages Directive 2014/104/EU in several European Member States. My contribution focuses on the need for implementation in England & Wales

Precessing jets from a moving source and bright X-ray filaments in galaxy clusters

We present hydrodynamical calculations carried out with the 3D yguazu-a code of a precessing jet model, which interacts with a plane parallel wind. This scenario describes an extragalactic jet, in which the jet source is in motion with respect to the surrounding intra-cluster medium. From the numerical results, synthetic emission maps and spectra in X-ray band were obtained. We compare these predictions with observations of the radio jets emanating from the radio-galaxy 4C 26.42 (in the Abell 1795 galaxy cluster). We find that the general morphology of the radio jets can be described by a point-symmetric precessing jet system interacting with a plane parallel wind (i.e., the intra-cluster medium flowing past the galaxy). We also find that our synthetic X-ray emission maps reproduce the observed large scale structures (with sizes of the order of tens of kpc).Comment: Accepted for publication in A&A - 7 Pages, 6 figure

X-ray absorption by Broad Line Region Clouds in Mrk 766

We present a new analysis of a 9-day long XMM-Newton monitoring of the Narrow Line Seyfert 1 galaxy Mrk 766. We show that the strong changes in spectral shape which occurred during this observation can be interpreted as due to Broad Line Region clouds crossing the line of sight to the X-ray source. Within the occultation scenario, the spectral and temporal analysis of the eclipses provides precise estimates of the geometrical structure, location and physical properties of the absorbing clouds. In particular, we show that these clouds have cores with column densities of at least a few 10^23 cm^-2 and velocities in the plane of the sky of the order of thousands km/s. The three different eclipses monitored by XMM-Newton suggest a broad range in cloud velocities (by a factor ~4-5). Moreover, two iron absorption lines clearly associated with each eclipse suggest the presence of highly ionized gas around the obscuring clouds, and an outflow component of the velocity spanning from 3,000 to 15,000 km/sComment: 10 pages, 7 figures. Accepted for publication in MNRA

"Comets" orbiting a black hole

We use a long (300 ksec), continuous Suzaku X-ray observation of the active nucleus in NGC1365 to investigate the structure of the circumnuclear BLR clouds through their occultation of the X-ray source. The variations of the absorbing column density and of the covering factor indicate that the clouds surrounding the black hole are far from having a spherical geometry (as sometimes assumed), instead they have a strongly elongated and cometary shape, with a dense head (n=10^11 cm^-3) and an expanding, dissolving tail. We infer that the cometary tails must be longer than a few times 10^13 cm and their opening angle must be smaller than a few degrees. We suggest that the cometary shape may be a common feature of BLR clouds in general, but which has been difficult to recognize observationally so far. The cometary shape may originate from shocks and hydrodynamical instabilities generated by the supersonic motion of the BLR clouds into the intracloud medium. As a consequence of the mass loss into their tail, we infer that the BLR clouds probably have a lifetime of only a few months, implying that they must be continuously replenished. We also find a large, puzzling discrepancy (two orders of magnitude) between the mass of the BLR inferred from the properties of the absorbing clouds and the mass of the BLR inferred from photoionization models; we discuss the possible solutions to this discrepancy.Comment: Accepted for publication in A&A. 11 pages, 9 figure

A unified accretion-ejection paradigm for Black Hole X-ray Binaries

We present a new picture for the central regions of Black Hole X-ray Binaries. In our view, these central regions have a multi-flow configuration which consists in (1) an outer standard accretion disc down to a transition radius r_J, (2) an inner magnetized accretion disc below r_J driving (3) a non relativistic self-collimated electron-proton jet surrounding, when adequate conditions for pair creation are met, (4) a ultra relativistic electron-positron beam. This accretion-ejection paradigm provides a simple explanation to the canonical spectral states by varying the transition radius r_J and disc accretion rate independently. Large values of r_J correspond to the Quiescent state for low $\dot m$ and the Hard state for larger $\dot m$. These states are characterized by the presence of a steady electron-proton MHD jet emitted by the disc below r_J. The hard X-ray component is expected to form at the jet basis. When r_j becomes smaller than the marginally stable orbit r_i, the whole disc resembles a standard accretion disc, characteristic of the Soft state. Intermediate states correspond to situations where r_J ~ r_i. At large $\dot m$, an unsteady pair cascade process is triggered within the jet axis, giving birth to ejection of relativistic pair blobs. This would correspond to the luminous intermediate state, with its associated superluminal motions. The variation of r_J independently of $\dot m$ is a necessary ingredient in this picture, arising from the presence of a large scale vertical magnetic field threading the disc.Comment: 15 pages, 2 figures. Accepted by A&A main journa

Non-Thermal Emission from AGN Coronae

Accretion disk coronae are believed to account for X-ray emission in Active Galactic Nuclei (AGNs). In this paper the observed emission is assumed to be due to a population of relativistic, non-thermal electrons (e.g. produced in a flare) injected at the top of an accretion disk magnetic loop. While electrons stream along magnetic field lines their energy distribution evolves in time essentially because of inverse Compton and synchrotron losses. The corresponding time dependent emission due, in the X-ray energy range, to the inverse Compton mechanism, has been computed. Since the typical decay time of a flare is shorter than the integration time for data acquisition in the X-ray domain, the resulting spectrum is derived as the temporal mean of the real, time-dependent, emission, as originated by a series of consecutive and identical flares. The model outcome is compared to both the broad band BeppoSAX X-ray data of the bright Seyfert 1 NGC 5548, and to a few general X-ray spectral properties of Seyfert 1s as a class. The good agreement between model and observations suggests that the presently proposed non-thermal, non-stationary model could be a plausible explanation of AGN X-ray emission, as an alternative to thermal coronae models.Comment: 15 pages, 4 postscript figure