Residential equilibrium in a multifractal metropolitan area

A residential location model derived from urban economics is combined with the geometry of a multifractal Sierpinski carpet to represent and model a metropolitan area. This area is made up of a system of built-up patches hierarchically organised around a city centre, and green areas arranged in an inverse hierarchical order (large open-spaces in the periphery). An analytical solution is obtained by using a specific geographic coding system for computing distances. The values of the parameters used in the model are based on the French medium sized metropolitan areas; a realistic benchmark is proposed and comparative-statics simulations are performed. The results show that the French peri-urbanisation process (which took place from 1970 onward) can be explained by an increase in income and a reduction in transport costs. Nevertheless, changes in household preferences, in particular an increased taste for open spaces, can also contribute to urban sprawl by making the gradient of land rents less steep and by making peripheral household locations more desirableperi-urban, residential localisation, fractal geometry, amenities

Autoxidation Chemistry: Bridging the Gap Between Homogeneous Radical Chemistry and (Heterogeneous) Catalysis

During the autoxidation of cyclohexane, abstraction of the αH-atom of the hydroperoxide product by chain-carrying peroxyl radicals produces both the desired alcohol and ketone products, as well as the majority of by-products. Rationalizing the impact of this reaction, one should aim for a (catalytic) destruction of this hydroperoxide without the intervention of peroxyl chain-carriers. Starting from these new insights in the molecular mechanism, attempts for rational catalyst design are initiate

Autoxidation of Hydrocarbons: From Chemistry to Catalysis

This contribution summarizes our recent efforts to unravel the radical chemistry of autoxidations. Abstraction of the weakly bonded αH-atom of the primary hydroperoxide product by chain carrying peroxyl radicals is identified as the source of major end products such as alcohol and ketone/aldehyde. In the case of cyclohexane autoxidation, this reaction is even responsible for the majority of ring-opened by-products. In a second part, different approaches to autoxidation catalysis are discussed, ranging from transition metal ion catalysis to organocatalysis with immobilized N-hydroxyphthalimid

Residential Equilibrium in a Multifractal Metropolitan Area.

In this paper, an urban economic model of residential location is combined with multifractal geometry (Sierpinski carpet) in order to model and analyse the spatial structure of a metropolitan area. This area is made of an urban system organised hierarchically around a central CBD, as well as of green spaces that have an inverse hierarchical organisation. The properties of the model are studied by means of analytical solutions. Then, simulation are made, which are based of French urban realities. This enables one to choose realistic parameters and to analyse the effects of several modelling assumptions (changes in preferences, economic shocks, …). The modelling results show that French periurbanisation of the last 30 years can be explained by the increase in income and by the decrease in transportation costs, probably without any changes in households preferences

Interplay between toroidal rotation and flow shear in turbulence stabilisation

International audienceThe interplay between toroidal rotation u, parallel flow shear u ′ and perpendicular flow shear γE in the stabilisation of tokamak turbulence is investigated in non-linear flux-tube gyrokinetic simulations. The simulations are performed for a reference L-mode DIII-D plasma (the so-called shortfall case) at r/a = 0.8, varying the flow parameters around their nominal values. Depending on the respective signs of u, u ′ and γE, turbulence is found to be enhanced, reduced or unchanged. When the coupling is favorable, the overall effect on the non-linear heat fluxes can be very large, even at moderate flow values. The ion heat flux is for instance decreased by a factor of three when the direction of the parallel flow shear is reversed with respect to its nominal value. Even more surprising, keeping u ′ and γE at their nominal values, the ion heat flux decreases by more than 50% when the toroidal flow is reversed. The relevance of this mechanism in the experiments which depends on the ability to decouple u, u ′ and γE is discussed. The interplay between u and u ′ observed in the non-linear simulations qualitatively follows the linear stability results and is interpreted in the frame of a simple fluid model

Phase I, randomized, observer-blind, placebo-controlled studies to evaluate the safety, reactogenicity and immunogenicity of an investigational non-typeable Haemophilus influenzae (NTHi) protein vaccine in adults

Background: Non-typeable Haemophilus influenzae (NTHi) is a major cause of various respiratory diseases. The development of an effective vaccine against NTHi mandates new approaches beyond conjugated vaccines as this opportunistic bacterium is non-encapsulated. Here we report on the safety, reactogenicity and immunogenicity of a multi-component investigational vaccine based on three conserved surface proteins from NTHi (proteins D [PD],E [PE] and Pilin A [PilA]) in two observer-blind phase I studies. Methods: In the first study (NCT01657526), 48 healthy 18-40 year-olds received two vaccine formulations (10 or 30 mu g of each antigen [PD and a fusion protein PE-PilA]) or saline placebo at months 0 and 2. In the second study (NCT01678677), 270 50-70 year-olds, current or former smokers, received eight vaccine formulations (10 or 30 mu g antigen/dose non-adjuvanted or adjuvanted with alum, AS01(E) or ASO4(c)) or saline placebo at months 0,2 and 6 (plain and alum-adjuvanted groups) and at months 0 and 2 (AS-adjuvanted groups). Solicited and unsolicited adverse events (AEs) were recorded for 7 and 30 days post-vaccination, respectively; potential immune-mediated diseases (pIMDs) and serious AEs (SAEs) throughout the studies. Humoral and antigen-specific T-cell immunity (in study 2 only) responses were assessed up to 12 months post-vaccination. Results: Observed reactogenicity was highest in the AS-adjuvanted groups but no safety concerns were identified with any of the NTHi vaccine formulations. One fatal SAE (cardiac arrest) not considered related to vaccination, and one pIMD (non-serious psoriasis) in the Placebo group, were reported post-dose 3 in Study 2. All formulations generated a robust antibody response while the AS01-adjuvanted formulations produced the highest humoral and cellular immune responses. Conclusion: This study confirms that the NTHi vaccine formulations had an acceptable reactogenicity and safety profile and were immunogenic in adults. These results justify further clinical development of this NTHi vaccine candidate

Non-renormalization conditions for four-gluon scattering in supersymmetric string and field theory

The constraints imposed by maximal supersymmetry on multi-loop contributions to the scattering of four open superstrings in the U(N) theory are examined by use of the pure spinor formalism. The double-trace term k^2 t_8(tr F^2)^2 (where k represents an external momentum and F the Yang--Mills field strength) only receives contributions from L<=2 (where L is the loop number) while the single-trace term k^2 t_8(tr F^4) receives contributions from all L. We verified these statements up to L=5, but arguments based on supersymmetry suggest they extend to all L. This explains why the single-trace contributions to low energy maximally supersymmetric Yang--Mills field theory are more divergent in the ultraviolet than the double-trace contributions. We also comment further on the constraints on closed string amplitudes and their implications for ultraviolet divergences in N=8 supergravity.Comment: 25 pages. 2 eps figures. Harvmac format. v2 qualifications regarding comments on closed strings. References adde