Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study

Purpose: The aim of this study was to compare the inflammatory and lipid profile of patients with and without peri-implantitis. / Methods: A cross-sectional biochemical study was carried out in which blood samples were collected from 16 patients with peri-implantitis and from 31 subjects with healthy implants. Clinical peri-implant parameters were obtained from all subjects. Levels of tumor necrosis factor-alpha and interleukin-10 (IL-10) were measured in serum. Lipid fractions, glucose and creatinine levels, and complete blood count were also assessed. / Results: After controlling for a history of periodontitis, statistically significant differences between peri-implantitis patients and controls were found for total cholesterol (estimated adjusted mean difference, 76.4 mg/dL; 95% confidence interval [CI], 39.6, 113.2 mg/dL; P<0.001), low-density lipoprotein (LDL) cholesterol (estimated adjusted mean difference, 57.7 mg/dL; 95% CI, 23.8, 91.6 mg/dL; P<0.001), white blood cells (WBC) (estimated adjusted mean difference, 2.8×103/μL; 95% CI, 1.6, 4.0×103/μL; P<0.001) and IL-10 (estimated adjusted mean difference, −10.4 pg/mL; 95% CI, −15.8, −5.0 pg/mL; P<0.001). The peri- implant probing pocket depth (PPD) was modestly positively correlated with total cholesterol (r=0.512; P<0.001), LDL cholesterol (r=0.463; P=0.001), and WBC (r=0.519; P<0.001). A moderate negative correlation was observed between IL-10 and PPD (r=0.609; P<0.001). / Cardiovascular diseases; Dyslipidemias; Peri-implantitis; Inflammation; Leukocytes Conclusions: Otherwise healthy individuals with peri-implantitis showed increased low- grade systemic inflammation and dyslipidemia

Payao: a community platform for SBML pathway model curation

Summary: Payao is a community-based, collaborative web service platform for gene-regulatory and biochemical pathway model curation. The system combines Web 2.0 technologies and online model visualization functions to enable a collaborative community to annotate and curate biological models. Payao reads the models in Systems Biology Markup Language format, displays them with CellDesigner, a process diagram editor, which complies with the Systems Biology Graphical Notation, and provides an interface for model enrichment (adding tags and comments to the models) for the access-controlled community members

Prevention of mucositis in bone marrow transplantation: A double blind randomised controlled trial of sucralfate

Mucositis is still a leading side effect of high dose chemotherapy and irradiation delivered in autologous and allogeneic bone marrow transplantation. In this double blind randomised study, we tested the efficacy of sucralfate for the prevention of mucositis induced by such conditioning treatments. Treatment was started one day before conditioning regimen and patients were prospectively evaluated. The main endpoint was severe mucositis that was more frequent in the placebo group than in the sucralfate group (47% vs. 29%, P = 0.07). This trend was confirmed after adjustment on total body irradiation (TBI) (P = 0.06), the sole stratification parameter. Interestingly, patients receiving sucralfate showed a significant reduction of diarrhoea (25% vs. 53%, P = 0.005). Overall, the preventive administration of sucralfate appears to be an effective proce dure to diminish the occurrence of severe oral and intestinal mucositis in patients treated by high dose chemotherapy alone or combined with TBI before bone marrow transplantatio

Percepción del saber pedagógico en radiología

Este texto hace una reflexión sobre el conocimiento pedagógico aplicado sobre el programa de tecnología en radiología e imágenes diagnósticas. Los docentes del programa lo realizaron en el marco del módulo de fundamentación pedagógica y curricular. Es producto de la experiencia propia, la observación, la discusión y el análisis de diferentes autores que citan la pedagogía y sus prácticas, así mismo se conceptualizó la práctica de enseñanza-aprendizaje. Se puso hincapié en los conceptos de la pedagogía, la enseñanza, la educación y la didáctica, fundamentos teóricos que toman en cuenta el desarrollo personal 13 y profesional de los docentes. El currículo se retroalimentó interactuando con el estudiante y el entorno.AbstractThis paper was intended to make an informed analysis of the pedagogic knowledge applied in the technology program in radiology and diagnostic images  ade by the group of teachers from the same program, under the reasoning module teaching and curriculum, through the experience, observation, discussion  nd analysis of different authors who cite the pedagogy and practices. It was conceptualized on teaching and learning practices taking the concepts of pedagogy, teaching, education and teaching, as key elements to take into account the personal and professional development of teachers, their interaction with the student and the environment, so; that can be fed back into the curriculum

Percepción del saber pedagógico en radiología

Este texto hace una reflexión sobre el conocimiento pedagógico aplicado sobre el programa de tecnología en radiología e imágenes diagnósticas. Los docentes del programa lo realizaron en el marco del módulo de fundamentación pedagógica y curricular. Es producto de la experiencia propia, la observación, la discusión y el análisis de diferentes autores que citan la pedagogía y sus prácticas, así mismo se conceptualizó la práctica de enseñanza-aprendizaje. Se puso hincapié en los conceptos de la pedagogía, la enseñanza, la educación y la didáctica, fundamentos teóricos que toman en cuenta el desarrollo personal 13 y profesional de los docentes. El currículo se retroalimentó interactuando con el estudiante y el entorno.AbstractThis paper was intended to make an informed analysis of the pedagogic knowledge applied in the technology program in radiology and diagnostic images  ade by the group of teachers from the same program, under the reasoning module teaching and curriculum, through the experience, observation, discussion  nd analysis of different authors who cite the pedagogy and practices. It was conceptualized on teaching and learning practices taking the concepts of pedagogy, teaching, education and teaching, as key elements to take into account the personal and professional development of teachers, their interaction with the student and the environment, so; that can be fed back into the curriculum

Reflexiones sobre el estudio de la historia ecuatoriana

La prehistoria de la que no existen documentos escritos debe ser estudiada a través de las ciencias auxiliares de la historia, como son la arqueología y la etnografía, caso contrario se tendrá que conformarse con simples tradiciones y leyendas, que no siempre rigen la verdad de los hechos. La primera historia de nuestro país y también la primera que se refirió a nuestra prehistoria, es la que escribió el jesuita riobambeño Padre Juan de Velasco por el año 1789, cuando se encontraba en Europa, sufriendo la expulsión de la compañía de Jesús, decretada para las colonias de la américa española por el Rey Carlos III. Su obra se publicó entre 1941 y 1844

hiPathDB: a human-integrated pathway database with facile visualization

One of the biggest challenges in the study of biological regulatory networks is the systematic organization and integration of complex interactions taking place within various biological pathways. Currently, the information of the biological pathways is dispersed in multiple databases in various formats. hiPathDB is an integrated pathway database that combines the curated human pathway data of NCI-Nature PID, Reactome, BioCarta and KEGG. In total, it includes 1661 pathways consisting of 8976 distinct physical entities. hiPathDB provides two different types of integration. The pathway-level integration, conceptually a simple collection of individual pathways, was achieved by devising an elaborate model that takes distinct features of four databases into account and subsequently reformatting all pathways in accordance with our model. The entity-level integration creates a single unified pathway that encompasses all pathways by merging common components. Even though the detailed molecular-level information such as complex formation or post-translational modifications tends to be lost, such integration makes it possible to investigate signaling network over the entire pathways and allows identification of pathway cross-talks. Another strong merit of hiPathDB is the built-in pathway visualization module that supports explorative studies of complex networks in an interactive fashion. The layout algorithm is optimized for virtually automatic visualization of the pathways. hiPathDB is available at http://hiPathDB.kobic.re.kr

Mining Biological Pathways Using WikiPathways Web Services

WikiPathways is a platform for creating, updating, and sharing biological pathways [1]. Pathways can be edited and downloaded using the wiki-style website. Here we present a SOAP web service that provides programmatic access to WikiPathways that is complementary to the website. We describe the functionality that this web service offers and discuss several use cases in detail. Exposing WikiPathways through a web service opens up new ways of utilizing pathway information and assisting the community curation process

An agent-based industrial cyber-physical system deployed in an automobile multi-stage production system

Industrial Cyber-Physical Systems (CPS) are promoting the development of smart machines and products, leading to the next generation of intelligent production systems. In this context, Artificial Intelligence (AI) is posed as a key enabler for the realization of CPS requirements, supporting the data analysis and the system dynamic adaptation. However, the centralized Cloud-based AI approaches are not suitable to handle many industrial scenarios, constrained by responsiveness and data sensitivity. Edge Computing can address the new challenges, enabling the decentralization of data analysis along the cyber-physical components. In this context, distributed AI approaches such as those based on Multi-agent Systems (MAS) are essential to handle the distribution and interaction of the components. Based on that, this work uses a MAS approach to design cyber-physical agents that can embed different data analysis capabilities, supporting the decentralization of intelligence. These concepts were applied to an industrial automobile multi-stage production system, where different kinds of data analysis were performed in autonomous and cooperative agents disposed along Edge, Fog and Cloud computing layers. © 2020, Springer Nature Switzerland AG.info:eu-repo/semantics/publishedVersio

The scale of population structure in Arabidopsis thaliana

The population structure of an organism reflects its evolutionary history and influences its evolutionary trajectory. It constrains the combination of genetic diversity and reveals patterns of past gene flow. Understanding it is a prerequisite for detecting genomic regions under selection, predicting the effect of population disturbances, or modeling gene flow. This paper examines the detailed global population structure of Arabidopsis thaliana. Using a set of 5,707 plants collected from around the globe and genotyped at 149 SNPs, we show that while A. thaliana as a species self-fertilizes 97% of the time, there is considerable variation among local groups. This level of outcrossing greatly limits observed heterozygosity but is sufficient to generate considerable local haplotypic diversity. We also find that in its native Eurasian range A. thaliana exhibits continuous isolation by distance at every geographic scale without natural breaks corresponding to classical notions of populations. By contrast, in North America, where it exists as an exotic species, A. thaliana exhibits little or no population structure at a continental scale but local isolation by distance that extends hundreds of km. This suggests a pattern for the development of isolation by distance that can establish itself shortly after an organism fills a new habitat range. It also raises questions about the general applicability of many standard population genetics models. Any model based on discrete clusters of interchangeable individuals will be an uneasy fit to organisms like A. thaliana which exhibit continuous isolation by distance on many scales